Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals Edited by James F. Collins AMSTERDAM • BOSTON • HEIDELBERG • LONDON • NEW ORK • OFORD • PARIS SAN DIEGO • SAN FRANCISCO • SINGAPORE • SDNE • TOKO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 125 London Wall, London EC2Y 5AS, United Kingdom 525 B Street, Suite 1800, San Diego, CA 92101-4495, United States 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom Copyright © 2017 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. 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Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library ISBN: 978-0-12-802168-2 For information on all Academic Press publications visit our website at https://www.elsevier.com/ Publisher: Nikki Levy Acquisition Editor: Megan Ball Editorial Project Manager: Jaclyn Truesdell Production Project Manager: Lisa Jones Designer: Victoria Pearson Typeset by TNQ Books and Journals List of Contributors Abedalrazaq Alkukhun Yale University School of Ralph Marsland Duckworth Teesside University, Medicine, New Haven, CT, United States Middlesbrough, United Kingdom; Newcastle University, Gregory Jon Anderson QIMR Berghofer Medical Newcastle-upon-Tyne, United Kingdom Research Institute, Australia Lynnette Robyn Ferguson University of Auckland, Tayze T. Antunes University of Ottawa, Ottawa, ON, Auckland, New Zealand Canada David Michael Frazer QIMR Berghofer Medical Research Michael Aschner Albert Einstein College of Medicine, Institute, Australia New York, NY, United States Toshiyuki Fukada Tokushima Bunri University, Tokushima, Terry J. Aspray Newcastle University, Newcastle upon Japan; Showa University, Tokyo, Japan; RIKEN Center for Tyne, Tyne and Wear, United Kingdom; Freeman Integrative Medical Sciences, Yokohama, Japan Hospital, Newcastle upon Tyne, Tyne and Wear, United Kazuhisa Fukue Kyoto University, Kyoto, Japan Kingdom Priyanka V. Gangodkar GenePath Dx (Causeway Thomas Bartnikas Brown University, Providence, Rhode Healthcare Private Limited), Pune, India Island, United States Eduardo Garcia-Fuentes Institute of Biomedical Abdel A. Belaidi The University of Melbourne, Parkville, Research of Malaga (IBIMA), Regional University VIC, Australia Hospital, Malaga, Spain; CIBEROBN, Institute of Roberto Bravo-Sagua Universidad de Chile, Santiago, Health Carlos III, Malaga, Spain Chile Michael D. Garrick University at Buffalo, Buffalo, NY, Gregory A. Brent David Geffen School of Medicine at United States UCLA, Los Angeles, CA, United States John P. Geibel Yale University School of Medicine, New George J. Brewer University of Michigan, Ann Arbor, MI, Haven, CT, United States United States Fayez K. Ghishan University of Arizona, Tucson, AZ, Mona S. Calvo U.S. Food and Drug Administration, United States Laurel, MD, United States Vadim N. Gladyshev Harvard Medical School, Boston, Bradley Allen Carlson National Institutes of Health, MA, United States Bethesda, MD, United States A. Grubman The University of Melbourne, Parkville, VIC, Wen-Hsing Cheng Mississippi State University, Australia Mississippi, MS, United States Thomas E. Gunter University of Rochester, Rochester, Sylvia Christakos Rutgers, The State University of NY, United States New Jersey, New Jersey Medical School, Newark, NJ, Hajo Haase Berlin Institute of Technology, Berlin, United States Germany Mariana Cifuentes Universidad de Chile, Santiago, Chile Dolph Lee Hatfield National Institutes of Health, James F. Collins University of Florida, Gainesville, FL, Bethesda, MD, United States United States Ka He Indiana University, Bloomington, IN, United Puneet Dhawan Rutgers, The State University of New States Jersey, New Jersey Medical School, Newark, NJ, United Carolina Herrera Brown University, Providence, Rhode States Island, United States xiii xiv List of Contributors Kayo Ikuta Tokushima University, Tokushima, Japan Thirayost Nimmanon Cardiff University, Cardiff, United Francisco J. Rios University of Glasgow, Glasgow, Kingdom; Phramongkutklao College of Medicine, Scotland Bangkok, Thailand Sami Judeeba Yale University School of Medicine, Yukina Nishito Kyoto University, Kyoto, Japan New Haven, CT, United States Tanara Vieira Peres Albert Einstein College of Medicine, Lillian J. Juttukonda Vanderbilt University Medical New York, NY, United States Center, Nashville, TN, United States Anne-Laure Perraud National Jewish Health, Denver, Taiho Kambe Kyoto University, Kyoto, Japan CO, United States; University of Colorado Denver, Denver, CO, United States Ichiro Kaneko Tokushima University, Tokushima, Japan Michael Pettiglio Brown University, Providence, Rhode Yujian James Kang Sichuan University, Chengdu, Island, United States Sichuan, China; University of Louisville, School of Medicine, Louisville, KY, United States Nikhil D. Phadke GenePath Dx (Causeway Healthcare Private Limited), Pune, India Nishi Karunasinghe University of Auckland, Auckland, New Zealand Ananda S. Prasad Wayne State University School of Medicine, Detroit, MI, United States Anuradha V. Khadilkar Jehangir Medical Research Institute Jehangir Hospital, Pune, India Vijayababu M. Radhakrishnan University of Arizona, Tucson, AZ, United States Pawel R. Kiela University of Arizona, Tucson, AZ, United States Marcela Reyes Universidad de Chile, Santiago, Chile Katerine S. Knust Universidade Federal do Estado do Rio Loren Warren Runnels Rutgers-Robert Wood Johnson de Janeiro (UNIRIO), Rio de Janeiro, Brazil Medical School, Piscataway, NJ, United States Mitchell D. Knutson University of Florida, Gainesville, Carsten Schmitz University of Colorado Denver, Denver, FL, United States CO, United States; National Jewish Health, Denver, CO, United States Yuko Komiya Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, United States Guenter Schwarz University of Cologne, Cologne, Germany Daniel Laubitz University of Arizona, Tucson, AZ, United States Hiroko Segawa Tokushima University, Tokushima, Japan Sergio Lavandero Universidad de Chile, Santiago, Chile; Yatrik Madhukar Shah University of Michigan, Ann University of Texas Southwestern Medical Center, Arbor, MI, United States Dallas, TX, United States Eric P. Skaar Vanderbilt University Medical Center, Xin Gen Lei Cornell University, Ithaca, NY, United States Nashville, TN, United States Laura Soldati Università degli Studi of Milan, Milan, Angela M. Leung UCLA David Geffen School of Italy Medicine, Los Angeles, CA, United States; VA Greater Los Angeles Healthcare System, Los Angeles, CA, Michael Stowasser The University of Queensland, School United States of Medicine, Brisbane, QLD, Australia Anna Milanesi David Geffen School of Medicine at Sawako Tatsumi Tokushima University, Tokushima, Japan UCLA, Los Angeles, CA, United States Kathryn M. Taylor Cardiff University, Cardiff, United Ken-ichi Miyamoto Tokushima University, Tokushima, Kingdom Japan Ryuta Tobe National Institutes of Health, Bethesda, MD, Augusto C. Montezano University of Glasgow, Glasgow, United States Scotland Rhian M. Touyz University of Glasgow, Glasgow, Stefano Mora IRCCS San Raffaele Scientific Institute, Scotland Milan, Italy Cari Lewis Tsinovoi Indiana University, Bloomington, Armando Salim Munoz-Abraham Yale University IN, United States School of Medicine, New Haven, CT, United States Petra Akiko Tsuji Towson University, Towson, MD, Forrest Harold Nielsen USDA, ARS, Grand Forks United States Human Nutrition Research Center, Grand Forks, ND, Jaime Uribarri The Icahn School of Medicine at Mount United States Sinai, New York, NY, United States List of Contributors xv Inés Velasco Hospital Riotinto, Huelva, Spain A.R. White The University of Melbourne, Parkville, VIC, Vaishali Veldurthy Rutgers, The State University of New Australia Jersey, New Jersey Medical School,