Cell Mechanics ME 339

Cell Mechanics ME 339

<p> Cell Mechanics ME 339 TuTh 3:15-4:30, 380-380D Office Hours: by appointment</p><p>Instructors: Christopher Jacobs ([email protected]) Ellen Kuhl ([email protected]) Ronald Kwon ([email protected]) Yufen Shi (TA) ([email protected])</p><p>Grading: Homeworks 30% Midterm 30% Final/Project 40% No Curve</p><p>09/25Tu Class overview and introduction to cell biology (Jacobs) Overview of the cell Basic biochemistry Membranes Organelles Protein synthesis</p><p>09/27Th Introduction to cytoskeletal biology (Kwon) Monomer structure Polymer structure Polymerization kinetics Cytoskeletal microstructure and regulation</p><p>10/02Tu Introduction to solid mechanics (Kuhl) Equilibrium, Stress Kinematics, Strain Material behavior, Hooke’s Law Stress resultants, Forces</p><p>10/04Th Introduction to biopolymers (Kuhl) General theory of beams, Euler Bernoulli theory Deformation modes: Bending and buckling</p><p>10/09Tu Polymer physics (Kwon) Introduction to statistical mechanics Random walk</p><p>10/11Th Polymer physics (Kwon) Gaussian chain Entropic spring 10/16Tu Polymer physics (Kwon) Freely jointed chain Worm like chain Persistence length Examples</p><p>10/18Th Cytoskeletal mechanics (Kwon) Rubber elasticity: affine network Implications of microstructure: the red blood cell cytoskeletal network</p><p>10/23Tu Cytoskeletal mechanics (Kwon) Mechanics of filopodia Tensegrity</p><p>10/25Th Pipette aspiration and whole cell mechanics cont’d (Kwon) Liquid drop model and Law of Laplace Aspiration of cells Aspiration of lipid vesicles Measurement of surface tension and areal expansion modulus</p><p>10/30Tu Introduction to biomembranes (Kuhl) Lipid bilayers Soap bubbles Cell membranes General theory of plates and shells, Kirchhoff Love theory</p><p>11/01Th Biomembranes cont’d (Kuhl) In plane deformation Deformation modes: Tension and shear, Laplace equation</p><p>11/06Tu Biomembranes cont’d (Kuhl) Out of plane deformation Deformation modes: Bending, Kirchhoff plates</p><p>11/08Th Mechanotransduction (Jacobs) Physical signals Cellular transduction 2nd messengers Intracellular signaling Kinases/Phosphatases Transcription factors Microscopy (bright field, phase contrast, DIC, fluorescent) Calcium imaging 11/13Tu Mechanotransduction cont’d (Jacobs) Second messengers Volume regulation and ion channels Bone: Piezoelectric field Direct deformation</p><p>11/15Th Midterm</p><p>11/20Tu No class</p><p>11/22Th No class</p><p>11/27Tu Mechanotransduction cont’d (Jacobs) Flow due to loading Signaling downstream of flow Molecular mechanisms Molecular dynamics, microfabrication, etc – the future</p><p>11/29Th Class projects</p><p>12/04 Tu Class projects</p><p>12/06 Th Class projects</p><p>Additional reading  Boal, D. “Mechanics of the Cell”, Cambridge University Press, Cambridge, 2002  Howard, J. “Mechanics of Motor Proteins and the Cytoskeleton”, Sinauer Publ., 2001</p>

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    3 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us