<p>Cristina Airoldi –Publication list January 2015</p><p>Cristina Airoldi</p><p>Bergamo, February 13, 1979 via Antonio Gramsci 5/c, 23879, Verderio, LC, ITALY cell. +39 3287184950 tel. +39 02 6448 3422; 3303 [email protected]</p><p>Publications: 1. Peri F., Airoldi C., Colombo S., Martegani E., Van Neuren A. S., Stein M., Marinzi C., Nicotra F., Design, Synthesis and Biological Evaluation of Sugar-Derived Ras Inhibitors, ChemBioChem, 2005, 6, 1839-1848. 2. Peri F., Airoldi C., Colombo S., Mari S., Jimenez-Barbero J., Martegani M., Nicotra F., Sugar-derived Ras inhibitors: Group Epitope Mapping by NMR Spectroscopy and Biological Evaluation, Eur. J. Org. Chem., 2006, 16, 3707-3720. 3. Nicotra F., Airoldi C., Cardona F. Synthesis of C- and S-Glycosides, in Comprehensive Glycoscience, Kamerling J. P. Ed., Elsevier, 2007, 647-683. 4. Cipolla L., Reis Fernandes M., Gregori M., Airoldi C. and. Nicotra F., Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars, Carbohydr. Res., 2007, 342, 12-13, 1813-1830. 5. Airoldi C., Palmioli A., D’Urzo A., Colombo S., Vanoni M., Martegani E., and Peri F., Glucose-derived Ras pathway inhibitors: evidence of Ras-ligand binding and Ras-GEF (Cdc25) interaction inhibition, ChemBioChem, 2007, 8, 1376-1379. 6. Nicotra F., La Ferla B., Airoldi C. Aminated Sugars, Synthesis and Biological Activity, In “Amino Group Chemistry, Ricci A. Ed., Wiley-VCH, 2008, 257-304. 7. Araujo A. C., Nicotra F., Airoldi C., Costa B., Giagnoni G., Fumagalli P., Cipolla L., Synthesis and biological evaluation of novel rigid 1,4-benzodiazepine-2,5-dione chimeric scaffolds, Eur. J. Org. Chem., 2008, 635–639. 8. Cipolla L., Peri F., Airoldi C., Glycoconjugates in cancer therapy. Anti Canc Agents Med Chem, 2008, 8, 1, 92-121. 9. Cipolla L., Airoldi C., Galliani P., Polissi A., Nicotra F., Re LPS biogenetic pathway: Enzyme characterisation and Synthetic efforts towards inhibitors, Curr. Org. Chem., 2008, 12, 7, 576-600. 10. Cipolla L., Araújo A. C., Airoldi C., Bini D., Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs, Anti Canc Agents Med Chem, 2009, 9, 1, 1-31. 11. Cipolla L., Polissi A., Airoldi C., Galliani P., Sperandeo P. and Nicotra F., The Kdo biosynthetic pathway toward OM biogenesis as target in antibacterial drug design and development, Curr. Drug Discovery Technol., 2009, 6, 1, 19-33.</p><p>1 Cristina Airoldi –Publication list January 2015</p><p>12. Mueller C., Gomez-Zurita Frau M. A., Ballinari D., Colombo S., Bitto A., Martegani E., Airoldi C., van Neuren A. S., Stein M., Weiser J., Battistini C. and Peri F., Design, Synthesis and Biological Evaluation of Levoglucosenone-derived Ras Activation Inhibitors, ChemMedChem, 2009, 4, 524-528.</p><p>13. La Ferla B., Russo L., Airoldi C., Nicotra F., Solid-phase supported mimic of GDP-L-galactose, Tetrahedron: Asymmetry, 2009, 20, 744–745. 14. Palmioli A. Sacco E., Airoldi C., Di Nicolantonio F., D'Urzo A., Shirasawa S., Sasazuki T., Di Domizio A., De Gioia L., Martegani E., Bardelli A., Peri F., Vanoni M., Selective cytotoxicity of a byclic Ras inhibitor in cancer cells expressing K-RasG13D, Biochem. Biophys. Res. Commun., 2009, 386, 593-597. 15. Nicotra F., Cipolla L., La Ferla B., Airoldi C., Zona C., Orsato A., Shaikh N., Russo L., Carbohydrate scaffolds in chemical genetic studies, J. Biotechnol., 2009, 144, 3, 234-241. 16. Airoldi C., Merlo S., Nicotra F., Synthesis of 3-deoxy-D-threopentofuranose 5-phosphate a substrate of arabinose 5-phosphate isomerase, J. Carbohydr. Chem., 2010, 29, 30–38. 17. Airoldi C., Sommaruga S., Merlo S., Sperandeo P., Cipolla L., Polissi A., Nicotra F., Targeting Bacterial Membranes: NMR Spectroscopy Characterization of Substrate Recognition and Binding Requirements of D-arabinose 5 Phosphate Isomerase, Chem. Eur. J., 2010, 16, 6, 1897-1902. 18. Colombo S., Palmioli A., Airoldi C., Tisi R., Fantinato S., Olivieri S., De Gioia L., Martegani E., Peri F., Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors, Curr. cancer drug targets, 2010, 10, 2, 192-199. 19. Cipolla L., La Ferla B., Airoldi C., Zona C., Orsato A., Shaikh N., Russo L., Nicotra F., Carbohydrate Mimetics and Scaffolds: Sweet Spots in Medicinal Chemistry, Future Med. Chem., 2010, 2, 4, 587-599. 20. Re F., Airoldi C., Zona C., Quattrocchi N., La Ferla B., Nicotra F., Masserini M., Beta Amyloid Aggregation Inhibitors: Small Molecules as Candidate Drugs for Therapy of Alzheimer’s Disease, Curr. Med. Chem., 2010, 17, 27, 2990-3006. 21. Airoldi C., Colombo L., Manzoni C., Sironi E., Natalello A., Doglia S. M., Forloni G., Tagliavini F., Del Favero E., Cantù L., Nicotra F., Salmona M., Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction, Org. Biomol. Chem., 2011, 9, 463-472. 22. Cipolla L., Airoldi C., Bini D., Gregori M., Marcelo F., Jimenez Barbero J., Nicotra F., Fructose-based proline analogues: exploring the prolyl trans/cis-amide rotamer population in model peptides, Eur. J. Org. Chem. 2011, 128–136. 23. La Ferla B., Airoldi C., Zona C., Orsato A., Cardona F., Merlo S., Sironi E., D’Orazio G., Nicotra F. Natural glycoconjugates with antitumor activity, Nat. Prod. Rep., 2011, 28, 630-648. 24. Cipolla L., Polissi A., Airoldi C., Gabrielli L., Merlo S., Nicotra F., New targets for antibacterial design: Kdo biosynthesis and LPS machinery transport to the cell surface, Curr. Med. Chem., 2011, 18, 830-852. 25. Araújo A. C., P. Rauter A. Nicotra F., Airoldi C., Costa B., Cipolla L., Sugar-Based Enantiomeric and</p><p>Conformationally Constrained Pyrrolo[2,1-c][1,4]-Benzodiazepines as Potential GABAA Ligands, J. Med. Chem., 2011, 54, 1266-1275.</p><p>2 Cristina Airoldi –Publication list January 2015</p><p>26. Airoldi C., Sommaruga S., Merlo S., Sperandeo P., Cipolla L., Polissi A., Nicotra F., Targeting</p><p>Bacterial Membranes: Identification of Pseudomonas aeruginosa D-Arabinose-5P Isomerase and NMR Characterisation of its Substrate Recognition and Binding Properties, ChemBioChem, 2011, 12, 719–727. 27. Airoldi C., Sironi E., La Ferla B., Cardona F., Nicotra F., Aβ monomers, oligomers and fibrils: Structural Features, Curr. Bioact. Compd., 2011, 7, 3, 198-213. 28. Airoldi C., Cardona F., Sironi E., Colombo L., Salmona M., Silva A., Nicotra F., La Ferla B., cis-glyco- fused benzopyran compounds as new amyloid-β peptide ligands, Chem. Commun., 2011, 47, 10266– 10268. 29. Manzoni C., Colombo L., Bigini B., Diana V., Cagnotto A., Messa M., Lupi M., Bonetto V., Pignataro M., Airoldi C., Sironi E., Williams A., Salmona M., The molecular assembly of amyloid Aβ controls its neurotoxicity and binding to cellular proteins, PlosOne, 2011, 6, 9, e24909. 30. Airoldi C.,* Zona C., Sironi E., Colombo L., Messa M., Aurilia D., Gregori M., Masserini M., Salmona M., Nicotra F., La Ferla B.,* Curcumin derivatives as new ligands of Aβ peptides, J. Biotechnol., 2011, 156, 317-324. 31. Airoldi C.,* Giovannardi S., La Ferla B., Jiménez-Barbero J., Nicotra F.,* Saturation Transfer Difference NMR experiments of membrane proteins in living cells under HR-MAS conditions: The interaction of the SGLT1 cotransporter with its ligands, Chem. Eur. J., 2011, 17, 48, 13395-13399. 32. Chiaradonna F., Moresco R.M., Airoldi C., Gaglio D., Palorini R., Nicotra F., Messa C., Alberghina L., From cancer metabolism to new biomarkers and drug targets, Biotechnol. Adv., 2012, 30, 30-51. 33. Le Droumaguet B., Nicolas J., Brambilla D., Mura S., Maksimenko A., De Kimpe L., Salvati E., Zona C., Airoldi C., Canovi M., Gobbi M., Noiray M., La Ferla B., Nicotra F., Scheper W., Flores O., Masserini M., Andrieux K., Couvreur P., Versatile and Efficient Targeting Using a Single Nanoparticulate Platform: Application to Cancer and Alzheimer's Disease, ACSNano, 2012, 6, 7, 5866- 5879. 34. Airoldi C.,* Merlo S., Sironi E., Nicotra F., Jiménez-Barbero J.,* NMR Protein-Ligand Interaction Studies under Non-Homogeneous Conditions for Biomaterial Generation: A Model For Artificial Lectin- Carbohydrate Recognition, J. Mater. Sci. Eng. B, 2012, 2 , 12, 618-625. 35. Airoldi C.,* Sironi E., Dias C., Marcelo F., Martins A., Rauter A. P., Nicotra F., Jimenez-Barbero J., Natural Compounds against Alzheimer´s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR, Chem. Asian J., 2013, 8, 3, 596-602. 36. Airoldi C., Cardona F., Sironi E., Colombo L., Salmona M., Cambianica I., Ornaghi F., Sancini G., Nicotra F., La Ferla B., Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease, Pure Appl. Chem., 2013, 85, 9, 1813-1823.</p><p>3 Cristina Airoldi –Publication list January 2015</p><p>37. Gabrielli L., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Cipolla L., Phosphonate analogues of arabinose 5-phosphate: putative ligands for arabinose 5-phosphate isomerases?, 2013, Eur. J. Org. Chem., 34, 7776–7784. 38. Airoldi C.,* Merlo S., Sironi E., NMR molecular recognition studies for the elucidation of protein and nucleic acid structure and function, in e-Book Series on Application of NMR Spectroscopy in "Molecular Identification", Bentham Science Publishers, USA, 2014, in press. 39. Gabrielli L., Merlo S., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Holler T. P., Woodard R. W. Cipolla L., Arabinose 5-phosphate isomerase as a target for antibacterial design: studies with substrate analogues and inhibitors, Bioorg. Med. Chem., 2014, 22, 8, 2576-2583. 40. Cipolla L., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Gabrielli L., Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five, Carb. Res, 2014, in press. 41. Merlo S., Sironi E., Colombo L., Cardona F., Martorana A. M., Salmona M., La Ferla B., Airoldi C.* Cis-glyco-fused benzopyran compounds as hit compounds for the development of new therapeutic and diagnostic tools against neurodegenerative diseases, ChemPlusChem, 2014, DOI: 10.1002/cplu.201400035. invited for a special issue title “Early Career Series” http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2192-6506/homepage/2688_earlycareer.html 42. La Ferla B., Airoldi C., D’Orazio G., 2014, “Curcumin derivatives: Aβ-ligands as potential diagnostic and therapeutic tools for Alzheimer disease”. In Curcumin, Synthesis, Emerging Role in Pain Management and Health Implications (pp. 87-101). Daniel Loic Pouliquen. 43. Airoldi C., Mourtas S., Cardona F., Zona C., Sironi E., D’Orazio G., Markoutsa E., Nicotra F., Antimisiaris S. G., La Ferla B., Nanoliposomes presenting on surface a cis-glycofused benzopyran compound display binding affinity and aggregation inhibition ability towards Amyloid β 1-42 peptide, Eur. J. Med. Chem., 2014, 85, 43-50. 44. Sironi E., Colombo L., Lompo A., Messa M., Bonanomi M., Regonesi M. E., Salmona M., Airoldi C.*, Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126 and ataxin-3 oligomers, Chem. Eur. J., 2014, 20, 13793–13800. 45. Jesus A. R., Dias C., Matos A. M., de Almeida R. F. M., Viana A. S., Marcelo F., Ribeiro R. T., Macedo M. P., Airoldi C., Nicotra F., Martins A., Cabrita E. J., Jiménez-Barbero J., Pilar Rauter A., 8-β-D- Glucopyranosylgenistein: Synthesis, Antidiabetic Activity and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid β-Peptide (1-42), J. Med. Chem., 2014, 57, 9463–9472. 46. Airoldi C.*, Tripodi F., Guzzi G., Nicastro R., Coccetti P.*, NMR analysis for budding yeast metabolomics: a rapid method for sample preparation, Molecular Biosystems, 2015, DOI: 10.1039/C4MB00452C. *corresponding author</p><p>Patents:</p><p>4 Cristina Airoldi –Publication list January 2015</p><p>1. Nicotra F., Airoldi C., La Ferla B., Jimenez-Barbero J., Giovannardi S., NMR based method with HR- MAS probe on intact cells. 2010, RM2010A000647; 2011, WO/2012/077087. 2. Nicotra F., Masserini M., La Ferla B., Airoldi C., Cardona F., Sironi E., New tricyclic compounds, process for their manufacture and their use as ligands of the beta amyloid peptides. 2011, RM2011A00026; 2012, WO 2012164476 A1. 3. Grases Santos Silva Rauter A. P., Xavier de Jesus A. R., Mendes Martin A. I., dos Santos Dias C. A., Tavares Ribeiro R. J., Borges de Lemos Macedo M. P., Guerra Justino J. A., Mota Filipe H. D., Amaro Pinto R. M., Nogueira Sepodes B. M., Patrício Goulart de Medeiros M. A., Jimenéz Barbero J., Airoldi C., Nicotra F. New C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. Therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents, 2012, PT106202; 2013, WO 2013132470 A2.</p><p>Other publications: 1. Airoldi C., Global Scientific Challenges: Perspectives from Young Scientists, Chemistry International - The News Magazine of the International Union of Pure and Applied Chemistry (IUPAC), 2007, 28, 5, 24-26.</p><p>Milano, January 13, 2015</p><p>5</p>