<p> SUPPLEMENTARY DATA</p><p>Table S1. ICD-9-CM codes used to identify cancer location and cases of VTE in patients undergoing chemotherapy in the United States IMPACT database population</p><p>Code Definition</p><p>Cancer location codes 162 (162.0–162.9) Malignant neoplasm of the trachea, bronchus, and lung 151 (151.0–151.9) Malignant neoplasm of the stomach 153 (153.0–153.9) Malignant neoplasm of the colon 154 (154.0–154.8) Malignant neoplasm of the rectum, rectosigmoid junction, and anus 157 (157.0–157.9) Malignant neoplasm of the pancreas 188 (188.0–188.9) Malignant neoplasm of the bladder 183.0 Malignant neoplasm of the ovary</p><p>Codes used in definition A - the ‘all-inclusive’ analysis - of VTE events 451.1 Of deep vessels of lower extremities 451.11 Deep vein thrombosis, femoral 451.19 Deep vein thrombosis, other leg veins 451.20 Of lower extremities, unspecified 451.81 Iliac vein 451.83 Deep veins, upper extremities 451.84 Upper extremities, unspecified 451.90 Of unspecified site 453.4 Venous embolism and thrombosis of deep vessels of lower extremity 453.41 Venous embolism and thrombosis of deep vessels of proximal lower extremity 453.42 Venous embolism and thrombosis of deep vessels of distal lower extremity 453.8 Of other specified veins 453.9 Of unspecified site 997.2 Peripheral vascular complications not elsewhere classified 415.1 Pulmonary embolism and infarction 415.11 Iatrogenic pulmonary embolism and infarction 415.12 Other pulmonary embolism and infarction 415.19 Other</p><p>Surgery codes excluded from VTE definition C ICD-9-CM codes according to location of surgery Lung 32.2 Local excision or destruction of lesion or tissue of lung 32.20 Thoracoscopic excision of lesion or tissue of lung Thoracoscopic wedge resection 32.21 Plication of emphysematous bleb 32.22 Lung volume reduction surgery 32.23 Open ablation of lung lesion or tissue</p><p>1 32.24 Percutaneous ablation of lung lesion or tissue 32.25 Thoracoscopic ablation of lung lesion or tissue 32.26 Other and unspecified ablation of lung lesion or tissue 32.27 Bronchoscopic bronchial thermoplasty, ablation of airway smooth muscle 32.28 Endoscopic excision or destruction of lesion or tissue of lung 32.29 Other local excision or destruction of lesion or tissue of lung; resection of lung: NOS, wedge 32.3 Segmental resection of lung; partial lobectomy 32.30 Thoracoscopic segmental resection of lung 32.39 Other and unspecified segmental resection of lung 32.4 Lobectomy of lung; lobectomy with segmental resection of adjacent lobes of lung 32.41 Thoracoscopic lobectomy of lung 32.49 Other lobectomy of lung 32.5 Pneumonectomy Excision of lung NOS Pneumonectomy (with mediastinal dissection) 32.50 Thoracoscopic pneumonectomy 32.59 Other and unspecified pneumonectomy 32.6 Radical dissection of thoracic structures; Block [en bloc] dissection of bronchus, lobe of lung, brachial plexus, intercostal structure, ribs (transverse process), and sympathetic nerves 32.9 Other excision of lung</p><p>Stomach 43.5 Partial gastrectomy with anastomosis to esophagus; proximal gastrectomy 43.6 Partial gastrectomy with anastomosis to duodenum; Billroth I operation; distal gastrectomy; gastropylorectomy 43.7 Partial gastrectomy with anastomosis to jejunum; Billroth II operation 43.8 Other partial gastrectomy 43.81 Partial gastrectomy with jejunal transposition; Henley jejunal transposition operation; code also any synchronous intestinal resection (45.51) 43.82 Laparoscopic vertical (sleeve) gastrectomy 43.89 Open and other partial gastrectomy; partial gastrectomy with bypass gastrogastrostomy; sleeve resection of stomach 43.9 Total gastrectomy 43.91 Total gastrectomy with intestinal interposition 43.99 Other total gastrectomy; complete gastroduodenectomy; esophagoduodenostomy with complete gastrectomy; esophagogastrectomy NOS; esophagojejunostomy with complete gastrectomy; radical gastrectomy</p><p>Large intestine 45.7 Open and other partial excision of large intestine 45.71 Open and other multiple segmental resection of large intestine; segmental resection for multiple traumatic lesions of large intestine</p><p>2 45.72 Open and other cecectomy; resection of cecum and terminal ileum 45.73 Open and other right hemicolectomy; Ileocolectomy Right radical colectomy 45.74 Open and other resection of transverse colon 45.75 Open and other left hemicolectomy 45.76 Open and other sigmoidectomy 45.79 Other and unspecified partial excision of large intestine; enterocolectomy NEC 45.8 Total intra-abdominal colectomy; excision of cecum, colon, and sigmoid 45.81 Laparoscopic total intra-abdominal colectomy 45.82 Open total intra-abdominal colectomy 45.83 Other and unspecified total intra-abdominal colectomy 48.5 Abdominoperineal resection of rectum; combined abdominoendorectal resection; complete proctectomy 48.5 Abdominoperineal resection of the rectum, not otherwise specified 48.51 Laparoscopic abdominoperineal resection of the rectum 48.52 Open abdominoperineal resection of the rectum 48.59 Other abdominoperineal resection of the rectum 48.6 Other resection of rectum; code also any synchronous anastomosis other than end-to-end (45.90, 45.92–45.95) 48.61 Transsacral rectosigmoidectomy 48.62 Anterior resection of rectum with synchronous colostomy 48.63 Other anterior resection of rectum 48.64 Posterior resection of rectum 48.65 Duhamel resection of rectum Duhamel abdominoperineal pull-through 48.69 Other resection of rectum Partial proctectomy Rectal resection NOS</p><p>Pancreas 52.5 Partial pancreatectomy 52.51 Proximal pancreatectomy; excision of head of pancreas (with part of body); proximal pancreatectomy with synchronous duodenectomy 52.52 Distal pancreatectomy; excision of tail of pancreas (with part of body) 52.53 Radical subtotal pancreatectomy 52.59 Other partial pancreatectomy 52.6 Total pancreatectomy; pancreatectomy with synchronous duodenectomy 52.7 Radical pancreaticoduodenectomy; one-stage pancreaticoduodenal resection with choledochojejunal anastomosis, pancreaticojejunal anastomosis, and gastrojejunostomy; two-stage pancreaticoduodenal resection (first stage) (second stage); radical resection of the pancreas; Whipple procedure</p><p>Urinary bladder 57.6 Partial cystectomy; excision of bladder dome; trigonectomy; wedge resection of bladder 57.7 Total cystectomy</p><p>3 57.71 Radical cystectomy; pelvic exenteration in male; removal of bladder, prostate, seminal vesicles, and fat; removal of bladder, urethra, and fat in a female Code also includes any: lymph node dissection (40.3, 40.5) urinary diversion (56.51–56.79) 57.79 Other total cystectomy</p><p>Ovary 65.39 Other unilateral oophorectomy 65.49 Other unilateral salpingo-oophorectomy 65.51 Other removal of both ovaries at same operative episode; female castration 65.52 Other removal of remaining ovary; removal of solitary ovary 65.61 Other removal of both ovaries and tubes at same operative episode 65.62 Other removal of remaining ovary and tube; removal of solitary ovary and tube</p><p>ICD-9-CM codes according to surgical procedure Thoracotomy 33.32 Artificial pneumothorax for collapse of lung; thoracotomy for collapse of lung 34.03 Reopening of recent thoracotomy site 37.33 Excision or destruction of other lesion or tissue of heart, open approach ablation or incision of heart tissue (cryoablation) (electrocurrent) (laser) (microwave) (radiofrequency) (resection) (ultrasound), open chest approach; Cox-maze procedure; Maze procedure; that by median sternotomy; that by thoracotomy without use of thoracoscope 37.37 Excision or destruction of other lesion or tissue of heart, thoracoscopic approach Ablation or incision of heart tissue (cryoablation) (electrocautery) (laser) (microwave) (radiofrequency) (resection) (ultrasound), via thoracoscope; Modified maze procedure, thoracoscopic approach; That via thoracoscopically-assisted approach (without thoracotomy) (with port access) (with sub-xiphoid incision) 37.74 Insertion or replacement of epicardial lead [electrode] into epicardium Insertion or replacement of epicardial lead by: sternotomy; thoracotomy 37.94 Implantation or replacement of automatic cardioverter/defibrillator, total system [AICD]; implantation of defibrillator with leads (epicardial patches), formation of pocket (abdominal fascia) (subcutaneous), any transvenous leads, intraoperative procedures for evaluation of lead signals, and obtaining defibrillator threshold measurements.Techniques: lateral thoracotomy; medial sternotomy; subxiphoid procedure. Code also extracorporeal circulation, if performed (39.61); code also includes any concomitant procedure [e.g., coronary bypass) (36.00–36.19)</p><p>Sigmoidoscopy 17.36 Laparoscopic sigmoidectomy 45.76 Open and other sigmoidectomy</p><p>4 Laparotomy 54.1 Laparotomy 54.12 Reopening of recent laparotomy site; reopening of recent laparotomy site for: control of hemorrhage; exploration; incision of hematoma 54.19 Other laparotomy; drainage of intraperitoneal abscess or hematoma</p><p>Colostomy 45.41 Excision of lesion or tissue of large intestine; excision of redundant mucosa of colostomy 46.03 Exteriorization of large intestine; exteriorization of intestine NOS; first stage Mikulicz exteriorization of intestine; loop colostomy 46.1 Colostomy; code also any synchronous resection (45.49, 45.71–45.79, 45.8) 46.10 Colostomy, not otherwise specified 46.11 Temporary colostomy 46.13 Other permanent colostomy 46.14 Delayed opening of colostomy 46.52 Closure of stoma of large intestine; closure or take-down of: cecostomy; colostomy; sigmoidostomy 46.85 Dilation of intestine; dilation (balloon) of duodenum; dilation (balloon) of jejunum; endoscopic dilation (balloon) of large intestine; that through rectum or colostomy 48.62 Anterior resection of rectum with synchronous colostomy 56.71 Urinary diversion to intestine; anastomosis of ureter to intestine; internal urinary diversion NOS; code also includes any synchronous colostomy (46.10–46.13) 68.8 Pelvic evisceration; removal of ovaries, tubes, uterus, vagina, bladder and urethra (with removal of sigmoid colon and rectum). Code also includes any synchronous: colostomy (46.12–46.13); lymph gland dissection (40.3, 40.5); urinary diversion (56.51–56.79)</p><p>Gastric bypass 43.89 Open and other partial gastrectomy; partial gastrectomy with bypass gastrogastrostomy; sleeve resection of stomach 44.31 High gastric bypass; Printen and Mason gastric bypass 44.38 Laparoscopic gastroenterostomy; Bypass: gastroduodenostomy, gastroenterostomy, gastrogastrostomy; Laparoscopic gastrojejunostomy without gastrectomy NEC 44.39 Other gastroenterostomy. Bypass: gastroduodenostomy; gastroenterostomy; gastrogastrostomy; gastrojejunostomy without gastrectomy NOS</p><p>CPT codes according to location 58805 Drainage of ovarian cyst(s), unilateral or bilateral, (separate procedure); abdominal approach 58820 Drainage of ovarian abscess; vaginal approach, open 58822 Drainage of ovarian abscess; abdominal approach 58825 Transposition, ovary(s)</p><p>5 58920 Wedge resection or bisection of ovary, unilateral or bilateral 58925 Ovarian cystectomy, unilateral or bilateral 58940 Oophorectomy, partial or total, unilateral or bilateral; 58943 Oophorectomy, partial or total, unilateral or bilateral; for ovarian, tubal or primary peritoneal malignancy, with para-aortic and pelvic lymph node biopsies, peritoneal washings, peritoneal biopsies, diaphragmatic assessments, with or without salpingecto 58950 Resection (initial) of ovarian, tubal or primary peritoneal malignancy with bilateral salpingo-oophorectomy and omentectomy; 58951 Resection (initial) of ovarian, tubal or primary peritoneal malignancy with bilateral salpingo-oophorectomy and omentectomy; with total abdominal hysterectomy, pelvic and limited para-aortic lymphadenectomy 58952 Resection (initial) of ovarian, tubal or primary peritoneal malignancy with bilateral salpingo-oophorectomy and omentectomy; with radical dissection for debulking (i.e. radical excision or destruction, intra- abdominal or retroperitoneal tumors) 58953 Bilateral salpingo-oophorectomy with omentectomy, total abdominal hysterectomy and radical dissection for debulking; 58954 Bilateral salpingo-oophorectomy with omentectomy, total abdominal hysterectomy and radical dissection for debulking; with pelvic lymphadenectomy and limited para-aortic lymphadenectomy 58956 Bilateral salpingo-oophorectomy with total omentectomy, total abdominal hysterectomy for malignancy 58957 Resection (tumor debulking) of recurrent ovarian, tubal, primary peritoneal, uterine malignancy (intra-abdominal, retroperitoneal tumors), with omentectomy, if performed; 58958 Resection (tumor debulking) of recurrent ovarian, tubal, primary peritoneal, uterine malignancy (intra-abdominal, retroperitoneal tumors), with omentectomy, if performed; with pelvic lymphadenectomy and limited para-aortic lymphadenectomy 58960 Laparotomy, for staging or restaging of ovarian, tubal, or primary peritoneal malignancy (second look), with or without omentectomy, peritoneal washing, biopsy of abdominal and pelvic peritoneum, diaphragmatic assessment with pelvic and limited para-aorti 51020 Cystotomy or cystostomy; with fulguration and/or insertion of radioactive material 51030 Cystotomy or cystostomy; with cryosurgical destruction of intravesical lesion 51040 Cystostomy, cystotomy with drainage 51045 Cystotomy, with insertion of ureteral catheter or stent (separate procedure) 51050 Cystolithotomy, cystotomy with removal of calculus, without vesical neck resection 51060 Transvesical ureterolithotomy 51065 Cystotomy, with calculus basket extraction and/or ultrasonic or electrohydraulic fragmentation of ureteral calculus 51080 Drainage of perivesical or prevesical space abscess 51500 Excision of urachal cyst or sinus, with or without umbilical hernia repair 51520 Cystotomy; for simple excision of vesical neck (separate procedure)</p><p>6 51525 Cystotomy; for excision of bladder diverticulum, single or multiple (separate procedure) 51530 Cystotomy; for excision of bladder tumor 51535 Cystotomy for excision, incision, or repair of ureterocele 51550 Cystectomy, partial; simple 51555 Cystectomy, partial; complicated (e.g. postradiation, previous surgery, difficult location) 51565 Cystectomy, partial, with reimplantation of ureter(s) into bladder (ureteroneocystostomy) 51570 Cystectomy, complete; (separate procedure) 51575 Cystectomy, complete; with bilateral pelvic lymphadenectomy, including external iliac, hypogastric, and obturator nodes 51580 Cystectomy, complete, with ureterosigmoidostomy or ureterocutaneous transplantations; 51585 Cystectomy, complete, with ureterosigmoidostomy or ureterocutaneous transplantations; with bilateral pelvic lymphadenectomy, including external iliac, hypogastric, and obturator nodes 51590 Cystectomy, complete, with ureteroileal conduit or sigmoid bladder, including intestine anastomosis; 51595 Cystectomy, complete, with ureteroileal conduit or sigmoid bladder, including intestine anastomosis; with bilateral pelvic lymphadenectomy, including external iliac, hypogastric, and obturator nodes 51596 Cystectomy, complete, with continent diversion, any open technique, using any segment of small and/or large intestine to construct neobladder 51597 Pelvic exenteration, complete, for vesical, prostatic or urethral malignancy, with removal of bladder and ureteral transplantations, with or without hysterectomy and/or abdominoperineal resection of rectum and colon and colostomy, or any combination there 51710 Change of cystostomy tube; complicated 51800 Cystoplasty or cystourethroplasty, plastic operation on bladder and/or vesical neck (anterior y-plasty, vesical fundus resection), any procedure, with or without wedge resection of posterior vesical neck 51820 Cystourethroplasty with unilateral or bilateral ureteroneocystostomy 51840 Anterior vesicourethropexy, or urethropexy (e.g. Marshall-Marchetti- Krantz, Burch); simple 51841 Anterior vesicourethropexy, or urethropexy (e.g. Marshall-Marchetti- Krantz, Burch); complicated (e.g. secondary repair) 51845 Abdomino-vaginal vesical neck suspension, with or without endoscopic control (e.g. stamey, raz, modified pereyra) 51865 Cystorrhaphy, suture of bladder wound, injury or rupture; complicated 51880 Closure of cystostomy (separate procedure) 51900 Closure of vesicovaginal fistula, abdominal approach 51920 Closure of vesicouterine fistula; 51925 Closure of vesicouterine fistula; with hysterectomy 51940 Closure, exstrophy of bladder 51960 Enterocystoplasty, including intestinal anastomosis 51980 Cutaneous vesicostomy 51990 Laparoscopy, surgical; urethral suspension for stress incontinence</p><p>7 51992 Laparoscopy, surgical; sling operation for stress incontinence (e.g. fascia or synthetic) 51999 Unlisted laparoscopy procedure, bladder 52317 Litholapaxy: crushing or fragmentation of calculus by any means in bladder and removal of fragments; simple or small (less than 2.5 cm) 52318 Litholapaxy: crushing or fragmentation of calculus by any means in bladder and removal of fragments; complicated or large (over 2.5 cm) 52500 Transurethral resection of bladder neck (separate procedure) 32035 Thoracostomy; with rib resection for empyema 32036 Thoracostomy; with open flap drainage for empyema 32100 Thoracotomy, major; with exploration and biopsy 32110 Thoracotomy, major; with control of traumatic hemorrhage and/or repair of lung tear 32120 Thoracotomy, major; for postoperative complications 32124 Thoracotomy, major; with open intrapleural pneumonolysis 32140 Thoracotomy, major; with cyst(s) removal, with or without a pleural procedure 32141 Thoracotomy, major; with excision-plication of bullae, with or without any pleural procedure 32150 Thoracotomy, major; with removal of intrapleural foreign body or fibrin deposit 32151 Thoracotomy, major; with removal of intrapulmonary foreign body 32160 Thoracotomy, major; with cardiac massage 32200 Pneumonostomy; with open drainage of abscess or cyst 32201 Pneumonostomy; with percutaneous drainage of abscess or cyst 32215 Pleural scarification for repeat pneumothorax 32220 Decortication, pulmonary (separate procedure); total 32225 Decortication, pulmonary (separate procedure); partial 32310 Pleurectomy, parietal (separate procedure) 32320 Decortication and parietal pleurectomy 32440 Removal of lung, total pneumonectomy; 32442 Removal of lung, total pneumonectomy; with resection of segment of trachea followed by broncho-tracheal anastomosis (sleeve pneumonectomy) 32445 Removal of lung, total pneumonectomy; extrapleural 32480 Removal of lung, other than total pneumonectomy; single lobe (lobectomy) 32482 Removal of lung, other than total pneumonectomy; 2 lobes (bilobectomy) 32484 Removal of lung, other than total pneumonectomy; single segment (segmentectomy) 32486 Removal of lung, other than total pneumonectomy; with circumferential resection of segment of bronchus followed by broncho-bronchial anastomosis (sleeve lobectomy) 32488 Removal of lung, other than total pneumonectomy; all remaining lung following previous removal of a portion of lung (completion pneumonectomy) 32491 Removal of lung, other than total pneumonectomy; excision-plication of emphysematous lung(s) (bullous or non-bullous) for lung volume </p><p>8 reduction, sternal split or transthoracic approach, with or without any pleural procedure 32500 Removal of lung, other than total pneumonectomy; wedge resection, single or multiple 32501 Resection and repair of portion of bronchus (bronchoplasty) when performed at time of lobectomy or segmentectomy (List separately in addition to code for primary procedure) 32503 Resection of apical lung tumor (e.g. Pancoast tumor), including chest wall resection, rib(s) resection(s), neurovascular dissection, when performed; without chest wall reconstruction(s) 32504 Resection of apical lung tumor (e.g. Pancoast tumor), including chest wall resection, rib(s) resection(s), neurovascular dissection, when performed; with chest wall reconstruction 32540 Extrapleural enucleation of empyema (empyemectomy) 32650 Thoracoscopy, surgical; with pleurodesis (e.g. mechanical or chemical) 32651 Thoracoscopy, surgical; with partial pulmonary decortication 32652 Thoracoscopy, surgical; with total pulmonary decortication, including intrapleural pneumonolysis 32653 Thoracoscopy, surgical; with removal of intrapleural foreign body or fibrin deposit 32654 Thoracoscopy, surgical; with control of traumatic hemorrhage 32655 Thoracoscopy, surgical; with excision-plication of bullae, including any pleural procedure 32656 Thoracoscopy, surgical; with parietal pleurectomy 32657 Thoracoscopy, surgical; with wedge resection of lung, single or multiple 32658 Thoracoscopy, surgical; with removal of clot or foreign body from pericardial sac 32659 Thoracoscopy, surgical; with creation of pericardial window or partial resection of pericardial sac for drainage 32660 Thoracoscopy, surgical; with total pericardiectomy 32661 Thoracoscopy, surgical; with excision of pericardial cyst, tumor, or mass 32662 Thoracoscopy, surgical; with excision of mediastinal cyst, tumor, or mass 32663 Thoracoscopy, surgical; with lobectomy, total or segmental 32664 Thoracoscopy, surgical; with thoracic sympathectomy 32665 Thoracoscopy, surgical; with esophagomyotomy (heller type) 32800 Repair lung hernia through chest wall 32810 Closure of chest wall following open flap drainage for empyema (clagett type procedure) 32815 Open closure of major bronchial fistula 32820 Major reconstruction, chest wall (posttraumatic) 32850 Donor pneumonectomy(s) (including cold preservation), from cadaver donor 32851 Lung transplant, single; without cardiopulmonary bypass 32852 Lung transplant, single; with cardiopulmonary bypass 32853 Lung transplant, double (bilateral sequential or en bloc); without cardiopulmonary bypass 32854 Lung transplant, double (bilateral sequential or en bloc); with cardiopulmonary bypass</p><p>9 32855 Backbench standard preparation of cadaver donor lung allograft prior to transplantation, including dissection of allograft from surrounding soft tissues to prepare pulmonary venous/atrial cuff, pulmonary artery, and bronchus; unilateral 32856 Backbench standard preparation of cadaver donor lung allograft prior to transplantation, including dissection of allograft from surrounding soft tissues to prepare pulmonary venous/atrial cuff, pulmonary artery, and bronchus; bilateral 32900 Resection of ribs, extrapleural, all stages 32905 Thoracoplasty, schede type or extrapleural (all stages); 32906 Thoracoplasty, schede type or extrapleural (all stages); with closure of bronchopleural fistula 32940 Pneumonolysis, extraperiosteal, including filling or packing procedures 32960 Pneumothorax, therapeutic, intrapleural injection of air 32997 Total lung lavage (unilateral) 32998 Ablation therapy for reduction or eradication of 1 or more pulmonary tumor(s) including pleura or chest wall when involved by tumor extension, percutaneous, radiofrequency, unilateral 32999 Unlisted procedure, lungs and pleura 44050 Reduction of volvulus, intussusception, internal hernia, by laparotomy 44110 Excision of 1 or more lesions of small or large intestine not requiring anastomosis, exteriorization, or fistulization; single enterotomy 44111 Excision of one or more lesions of small or large intestine not requiring anastomosis, exteriorization, or fistulization; multiple enterotomies 44140 Colectomy, partial; with anastomosis 44141 Colectomy, partial; with skin level cecostomy or colostomy 44143 Colectomy, partial; with end colostomy and closure of distal segment (hartmann type procedure) 44144 Colectomy, partial; with resection, with colostomy or ileostomy and creation of mucofistula 44145 Colectomy, partial; with coloproctostomy (low pelvic anastomosis) 44146 Colectomy, partial; with coloproctostomy (low pelvic anastomosis), with colostomy 44147 Colectomy, partial; abdominal and transanal approach 44150 Colectomy, total, abdominal, without proctectomy; with ileostomy or ileoproctostomy 44151 Colectomy, total, abdominal, without proctectomy; with continent ileostomy 44155 Colectomy, total, abdominal, with proctectomy; with ileostomy 44156 Colectomy, total, abdominal, with proctectomy; with continent ileostomy 44157 Colectomy, total, abdominal, with proctectomy; with ileoanal anastomosis, includes loop ileostomy, and rectal mucosectomy, when performed 44158 Colectomy, total, abdominal, with proctectomy; with ileoanal anastomosis, creation of ileal reservoir (S or J), includes loop ileostomy, and rectal mucosectomy, when performed 44160 Colectomy, partial, with removal of terminal ileum with ileocolostomy 44180 Laparoscopy, surgical, enterolysis (freeing of intestinal adhesion) </p><p>10 (separate procedure) 44186 Laparoscopy, surgical; jejunostomy (e.g. for decompression or feeding) 44187 Laparoscopy, surgical; ileostomy or jejunostomy, non-tube 44188 Laparoscopy, surgical, colostomy or skin level cecostomy 44202 Laparoscopy, surgical; enterectomy, resection of small intestine, single resection and anastomosis 44203 Laparoscopy, surgical; each additional small intestine resection and anastomosis (List separately in addition to code for primary procedure) 44204 Laparoscopy, surgical; colectomy, partial, with anastomosis 44205 Laparoscopy, surgical; colectomy, partial, with removal of terminal ileum with ileocolostomy 44206 Laparoscopy, surgical; colectomy, partial, with end colostomy and closure of distal segment (Hartmann type procedure) 44207 Laparoscopy, surgical; colectomy, partial, with anastomosis, with coloproctostomy (low pelvic anastomosis) 44208 Laparoscopy, surgical; colectomy, partial, with anastomosis, with coloproctostomy (low pelvic anastomosis) with colostomy 44210 Laparoscopy, surgical; colectomy, total, abdominal, without proctectomy, with ileostomy or ileoproctostomy 44211 Laparoscopy, surgical; colectomy, total, abdominal, with proctectomy, with ileoanal anastomosis, creation of ileal reservoir (S or J), with loop ileostomy, includes rectal mucosectomy, when performed 44212 Laparoscopy, surgical; colectomy, total, abdominal, with proctectomy, with ileostomy 44213 Laparoscopy, surgical, mobilization (take-down) of splenic flexure performed in conjunction with partial colectomy (List separately in addition to primary procedure) 44227 Laparoscopy, surgical, closure of enterostomy, large or small intestine, with resection and anastomosis 44238 Unlisted laparoscopy procedure, intestine (except rectum) 44300 Placement, enterostomy or cecostomy, tube open (e.g. for feeding or decompression) (separate procedure) 44310 Ileostomy or jejunostomy, non-tube 44312 Revision of ileostomy; simple (release of superficial scar) (separate procedure) 44314 Revision of ileostomy; complicated (reconstruction in-depth) (separate procedure) 44316 Continent ileostomy (kock procedure) (separate procedure) 44320 Colostomy or skin level cecostomy; 44322 Colostomy or skin level cecostomy; with multiple biopsies (e.g. for congenital megacolon) (separate procedure) 44340 Revision of colostomy; simple (release of superficial scar) (separate procedure) 44345 Revision of colostomy; complicated (reconstruction in-depth) (separate procedure) 44346 Revision of colostomy; with repair of paracolostomy hernia (separate procedure)</p><p>11 44604 Suture of large intestine (colorrhaphy) for perforated ulcer, diverticulum, wound, injury or rupture (single or multiple perforations); without colostomy 44605 Suture of large intestine (colorrhaphy) for perforated ulcer, diverticulum, wound, injury or rupture (single or multiple perforations); with colostomy 44615 Intestinal stricturoplasty (enterotomy and enterorrhaphy) with or without dilation, for intestinal obstruction 44620 Closure of enterostomy, large or small intestine; 44625 Closure of enterostomy, large or small intestine; with resection and anastomosis other than colorectal 44626 Closure of enterostomy, large or small intestine; with resection and colorectal anastomosis (e.g. closure of hartmann type procedure) 44640 Closure of intestinal cutaneous fistula 44650 Closure of enteroenteric or enterocolic fistula 44660 Closure of enterovesical fistula; without intestinal or bladder resection 44661 Closure of enterovesical fistula; with intestine and/or bladder resection 44680 Intestinal plication (separate procedure) 44700 Exclusion of small intestine from pelvis by mesh or other prosthesis, or native tissue (e.g. bladder or omentum) 44701 Intraoperative colonic lavage (list separately in addition to code for primary procedure) 45020 Incision and drainage of deep supralevator, pelvirectal, or retrorectal abscess 45108 Anorectal myomectomy 45110 Proctectomy; complete, combined abdominoperineal, with colostomy 45111 Proctectomy; partial resection of rectum, transabdominal approach 45112 Proctectomy, combined abdominoperineal, pull-through procedure (e.g. colo-anal anastomosis) 45113 Proctectomy, partial, with rectal mucosectomy, ileoanal anastomosis, creation of ileal reservoir (s or j), with or without loop ileostomy 45114 Proctectomy, partial, with anastomosis; abdominal and transsacral approach 45116 Proctectomy, partial, with anastomosis; transsacral approach only (kraske type) 45119 Proctectomy, combined abdominoperineal pull-through procedure (e.g. colo-anal anastomosis), with creation of colonic reservoir (e.g. J-pouch), with diverting enterostomy when performed 45120 Proctectomy, complete (for congenital megacolon), abdominal and perineal approach; with pull-through procedure and anastomosis (e.g. swenson, duhamel, or soave type operation) 45121 Proctectomy, complete (for congenital megacolon), abdominal and perineal approach; with subtotal or total colectomy, with multiple biopsies 45123 Proctectomy, partial, without anastomosis, perineal approach 45126 Pelvic exenteration for colorectal malignancy, with proctectomy (with or without colostomy), with removal of bladder and ureteral transplantations, and/or hysterectomy, or cervicectomy, with or without removal of tube(s), with or without removal of ovary( 45130 Excision of rectal procidentia, with anastomosis; perineal approach</p><p>12 45135 Excision of rectal procidentia, with anastomosis; abdominal and perineal approach 45136 Excision of ileoanal reservoir with ileostomy 45150 Division of stricture of rectum 45160 Excision of rectal tumor by proctotomy, transsacral or transcoccygeal approach 45170 Code deleted for 2010. To report, see 45171, 45172. Excision of rectal tumor, transanal approach 45171 Excision of rectal tumor, transanal approach; not including muscularis propria (i.e. partial thickness) 45172 Excision of rectal tumor, transanal approach; including muscularis propria (i.e. full thickness) 45190 Destruction of rectal tumor (e.g. electrodesiccation, electrosurgery, laser ablation, laser resection, cryosurgery) transanal approach 45395 Laparoscopy, surgical; proctectomy, complete, combined abdominoperineal, with colostomy 45397 Laparoscopy, surgical; proctectomy, combined abdominoperineal pull- through procedure (e.g. colo-anal anastomosis), with creation of colonic reservoir (e.g. J-pouch), with diverting enterostomy, when performed 45400 Laparoscopy, surgical; proctopexy (for prolapse) 45402 Laparoscopy, surgical; proctopexy (for prolapse), with sigmoid resection 45499 Unlisted laparoscopy procedure, rectum 45500 Proctoplasty; for stenosis 45505 Proctoplasty; for prolapse of mucous membrane 45520 Perirectal injection of sclerosing solution for prolapse 45540 Proctopexy (e.g. for prolapse); abdominal approach 45541 Proctopexy (e.g. for prolapse); perineal approach 45550 Proctopexy (e.g. for prolapse); with sigmoid resection, abdominal approach 45560 Repair of rectocele (separate procedure) 45562 Exploration, repair, and presacral drainage for rectal injury; 45563 Exploration, repair, and presacral drainage for rectal injury; with colostomy 45800 Closure of rectovesical fistula; 45805 Closure of rectovesical fistula; with colostomy 45820 Closure of rectourethral fistula; 45825 Closure of rectourethral fistula; with colostomy 45900 Reduction of procidentia (separate procedure) under anesthesia 45910 Dilation of rectal stricture (separate procedure) under anesthesia other than local 45915 Removal of fecal impaction or foreign body (separate procedure) under anesthesia 45999 Unlisted procedure, rectum 43500 Gastrotomy; with exploration or foreign body removal 43501 Gastrotomy; with suture repair of bleeding ulcer 43502 Gastrotomy; with suture repair of pre-existing esophagogastric laceration (e.g. mallory-weiss) 43510 Gastrotomy; with esophageal dilation and insertion of permanent </p><p>13 intraluminal tube (e.g. celestin or mousseaux-barbin) 43520 Pyloromyotomy, cutting of pyloric muscle (fredet-ramstedt type operation) 43610 Excision, local; ulcer or benign tumor of stomach 43611 Excision, local; malignant tumor of stomach 43620 Gastrectomy, total; with esophagoenterostomy 43621 Gastrectomy, total; with Roux-en-Y reconstruction 43622 Gastrectomy, total; with formation of intestinal pouch, any type 43631 Gastrectomy, partial, distal; with gastroduodenostomy 43632 Gastrectomy, partial, distal; with gastrojejunostomy 43633 Gastrectomy, partial, distal; with Roux-en-Y reconstruction 43634 Gastrectomy, partial, distal; with formation of intestinal pouch 43635 Vagotomy when performed with partial distal gastrectomy (List separately in addition to code(s) for primary procedure) 43640 Vagotomy including pyloroplasty, with or without gastrostomy; truncal or selective 43641 Vagotomy including pyloroplasty, with or without gastrostomy; parietal cell (highly selective) 43644 Laparoscopy, surgical, gastric restrictive procedure; with gastric bypass and Roux-en-Y gastroenterostomy (roux limb 150 cm or less) 43645 Laparoscopy, surgical, gastric restrictive procedure; with gastric bypass and small intestine reconstruction to limit absorption 43647 Laparoscopy, surgical; implantation or replacement of gastric neurostimulator electrodes, antrum 43648 Laparoscopy, surgical; revision or removal of gastric neurostimulator electrodes, antrum 43651 Laparoscopy, surgical; transection of vagus nerves, truncal 43652 Laparoscopy, surgical; transection of vagus nerves, selective or highly selective 43653 Laparoscopy, surgical; gastrostomy, without construction of gastric tube (e.g. stamm procedure) (separate procedure) 43659 Unlisted laparoscopy procedure, stomach 43750 Code deleted for 2008. To report percutaneous gastrostomy tube insertion, use 43246 Percutaneous placement of gastrostomy tube 43752 Naso- or oro-gastric tube placement, requiring physician's skill and fluoroscopic guidance (includes fluoroscopy, image documentation and report) 43770 Laparoscopy, surgical, gastric restrictive procedure; placement of adjustable gastric restrictive device (e.g. gastric band and subcutaneous port components) 43771 Laparoscopy, surgical, gastric restrictive procedure; revision of adjustable gastric restrictive device component only 43772 Laparoscopy, surgical, gastric restrictive procedure; removal of adjustable gastric restrictive device component only 43773 Laparoscopy, surgical, gastric restrictive procedure; removal and replacement of adjustable gastric restrictive device component only 43774 Laparoscopy, surgical, gastric restrictive procedure; removal of </p><p>14 adjustable gastric restrictive device and subcutaneous port components 43775 Laparoscopy, surgical, gastric restrictive procedure; longitudinal gastrectomy (i.e. sleeve gastrectomy) 43800 Pyloroplasty 43810 Gastroduodenostomy 43820 Gastrojejunostomy; without vagotomy 43825 Gastrojejunostomy; with vagotomy, any type 43830 Gastrostomy, open; without construction of gastric tube (e.g. stamm procedure) (separate procedure) 43831 Gastrostomy, open; neonatal, for feeding 43832 Gastrostomy, open; with construction of gastric tube (e.g. janeway procedure) 43840 Gastrorrhaphy, suture of perforated duodenal or gastric ulcer, wound, or injury 43842 Gastric restrictive procedure, without gastric bypass, for morbid obesity; vertical-banded gastroplasty 43843 Gastric restrictive procedure, without gastric bypass, for morbid obesity; other than vertical-banded gastroplasty 43845 Gastric restrictive procedure with partial gastrectomy, pylorus-preserving duodenoileostomy and ileoileostomy (50 to 100 cm common channel) to limit absorption (biliopancreatic diversion with duodenal switch) 43846 Gastric restrictive procedure, with gastric bypass for morbid obesity; with short limb (150 cm or less) Roux-en-Y gastroenterostomy 43847 Gastric restrictive procedure, with gastric bypass for morbid obesity; with small intestine reconstruction to limit absorption 43848 Revision, open, of gastric restrictive procedure for morbid obesity, other than adjustable gastric restrictive device (separate procedure) 43850 Revision of gastroduodenal anastomosis (gastroduodenostomy) with reconstruction; without vagotomy 43855 Revision of gastroduodenal anastomosis (gastroduodenostomy) with reconstruction; with vagotomy 43860 Revision of gastrojejunal anastomosis (gastrojejunostomy) with reconstruction, with or without partial gastrectomy or intestine resection; without vagotomy 43865 Revision of gastrojejunal anastomosis (gastrojejunostomy) with reconstruction, with or without partial gastrectomy or intestine resection; with vagotomy 43870 Closure of gastrostomy, surgical 43880 Closure of gastrocolic fistula 43881 Implantation or replacement of gastric neurostimulator electrodes, antrum, open 43882 Revision or removal of gastric neurostimulator electrodes, antrum, open 43886 Gastric restrictive procedure, open; revision of subcutaneous port component only 43887 Gastric restrictive procedure, open; removal of subcutaneous port component only 43888 Gastric restrictive procedure, open; removal and replacement of subcutaneous port component only 43999 Unlisted procedure, stomach</p><p>15 48000 Placement of drains, peripancreatic, for acute pancreatitis; 48001 Placement of drains, peripancreatic, for acute pancreatitis; with cholecystostomy, gastrostomy, and jejunostomy 48020 Removal of pancreatic calculus 48105 Resection or debridement of pancreas and peripancreatic tissue for acute necrotizing pancreatitis 48120 Excision of lesion of pancreas (e.g. cyst, adenoma) 48140 Pancreatectomy, distal subtotal, with or without splenectomy; without pancreaticojejunostomy 48145 Pancreatectomy, distal subtotal, with or without splenectomy; with pancreaticojejunostomy 48146 Pancreatectomy, distal, near-total with preservation of duodenum (child- type procedure) 48148 Excision of ampulla of vater 48150 Pancreatectomy, proximal subtotal with total duodenectomy, partial gastrectomy, choledochoenterostomy and gastrojejunostomy (whipple- type procedure); with pancreatojejunostomy 48152 Pancreatectomy, proximal subtotal with total duodenectomy, partial gastrectomy, choledochoenterostomy and gastrojejunostomy (whipple- type procedure); without pancreatojejunostomy 48153 Pancreatectomy, proximal subtotal with near-total duodenectomy, choledochoenterostomy and duodenojejunostomy (pylorus-sparing, whipple-type procedure); with pancreatojejunostomy 48154 Pancreatectomy, proximal subtotal with near-total duodenectomy, choledochoenterostomy and duodenojejunostomy (pylorus-sparing, whipple-type procedure); without pancreatojejunostomy 48155 Pancreatectomy, total 48160 Pancreatectomy, total or subtotal, with autologous transplantation of pancreas or pancreatic islet cells 48400 Injection procedure for intraoperative pancreatography (list separately in addition to code for primary procedure) 48500 Marsupialization of pancreatic cyst 48510 External drainage, pseudocyst of pancreas; open 48511 External drainage, pseudocyst of pancreas; percutaneous 48520 Internal anastomosis of pancreatic cyst to gastrointestinal tract; direct 48540 Internal anastomosis of pancreatic cyst to gastrointestinal tract; Roux-en- Y 48545 Pancreatorrhaphy for injury 48547 Duodenal exclusion with gastrojejunostomy for pancreatic injury 48548 Pancreaticojejunostomy, side-to-side anastomosis (Puestow-type operation) 48550 Donor pancreatectomy (including cold preservation), with or without duodenal segment for transplantation 48552 Backbench reconstruction of cadaver donor pancreas allograft prior to transplantation, venous anastomosis, each 48554 Transplantation of pancreatic allograft 48556 Removal of transplanted pancreatic allograft 48999 Unlisted procedure, pancreas</p><p>16 CPT codes according to surgical procedure 32100 Thoracotomy, major; with exploration and biopsy 32110 Thoracotomy, major; with control of traumatic hemorrhage and/or repair of lung tear 32120 Thoracotomy, major; for postoperative complications 32124 Thoracotomy, major; with open intrapleural pneumonolysis 32140 Thoracotomy, major; with cyst(s) removal, with or without a pleural procedure 32141 Thoracotomy, major; with excision-plication of bullae, with or without any pleural procedure 32150 Thoracotomy, major; with removal of intrapleural foreign body or fibrin deposit 32151 Thoracotomy, major; with removal of intrapulmonary foreign body 32160 Thoracotomy, major; with cardiac massage 33140 Transmyocardial laser revascularization, by thoracotomy; (separate procedure) 33141 Transmyocardial laser revascularization, by thoracotomy; performed at the time of other open cardiac procedure(s) (List separately in addition to code for primary procedure) 33202 Insertion of epicardial electrode(s); open incision (e.g. thoracotomy, median sternotomy, subxiphoid approach) 33236 Removal of permanent epicardial pacemaker and electrodes by thoracotomy; single lead system, atrial or ventricular 33237 Removal of permanent epicardial pacemaker and electrodes by thoracotomy; dual lead system 33238 Removal of permanent transvenous electrode(s) by thoracotomy 33243 Removal of single or dual chamber pacing cardioverter-defibrillator electrode(s); by thoracotomy 43117 Partial esophagectomy, distal two-thirds, with thoracotomy and separate abdominal incision, with or without proximal gastrectomy; with thoracic esophagogastrostomy, with or without pyloroplasty (ivor lewis) 43118 Partial esophagectomy, distal two-thirds, with thoracotomy and separate abdominal incision, with or without proximal gastrectomy; with colon interposition or small intestine reconstruction, including intestine mobilization, preparation, and anastomosis(es) 43121 Partial esophagectomy, distal two-thirds, with thoracotomy only, with or without proximal gastrectomy, with thoracic esophagogastrostomy, with or without pyloroplasty 43328 Esophagogastric fundoplasty partial or complete; thoracotomy 43334 Repair, paraesophageal hiatal hernia (including fundoplication), via thoracotomy, except neonatal; without implantation of mesh or other prosthesis 43335 Repair, paraesophageal hiatal hernia (including fundoplication), via thoracotomy, except neonatal; with implantation of mesh or other prosthesis 0157T Laparotomy, implantation or replacement of gastric stimulation electrodes, lesser curvature (i.e. morbid obesity) 0158T Laparotomy, revision or removal of gastric stimulation electrodes, lesser </p><p>17 curvature (i.e. morbid obesity) 43332 Repair, paraesophageal hiatal hernia (including fundoplication), via laparotomy, except neonatal; without implantation of mesh or other prosthesis 43333 Repair, paraesophageal hiatal hernia (including fundoplication), via laparotomy, except neonatal; with implantation of mesh or other prosthesis 44050 Reduction of volvulus, intussusception, internal hernia, by laparotomy 47015 Laparotomy, with aspiration and/or injection of hepatic parasitic (e.g. amoebic or echinococcal) cyst(s) or abscess(es) 49002 Reopening of recent laparotomy 49220 Staging laparotomy for Hodgkins disease or lymphoma (includes splenectomy, needle or open biopsies of both liver lobes, possibly also removal of abdominal nodes, abdominal node and/or bone marrow biopsies, ovarian repositioning) 58960 Laparotomy, for staging or restaging of ovarian, tubal, or primary peritoneal malignancy (second look), with or without omentectomy, peritoneal washing, biopsy of abdominal and pelvic peritoneum, diaphragmatic assessment with pelvic and limited para-aortic lymphadenectomy 44141 Colectomy, partial; with skin level cecostomy or colostomy 44143 Colectomy, partial; with end colostomy and closure of distal segment (hartmann type procedure) 44144 Colectomy, partial; with resection, with colostomy or ileostomy and creation of mucofistula 44146 Colectomy, partial; with coloproctostomy (low pelvic anastomosis), with colostomy 44188 Laparoscopy, surgical, colostomy or skin level cecostomy 44206 Laparoscopy, surgical; colectomy, partial, with end colostomy and closure of distal segment (Hartmann type procedure) 44208 Laparoscopy, surgical; colectomy, partial, with anastomosis, with coloproctostomy (low pelvic anastomosis) with colostomy 44320 Colostomy or skin level cecostomy; 44322 Colostomy or skin level cecostomy; with multiple biopsies (e.g. for congenital megacolon) (separate procedure) 44340 Revision of colostomy; simple (release of superficial scar) (separate procedure) 44345 Revision of colostomy; complicated (reconstruction in-depth) (separate procedure) 44346 Revision of colostomy; with repair of paracolostomy hernia (separate procedure) 44604 Suture of large intestine (colorrhaphy) for perforated ulcer, diverticulum, wound, injury or rupture (single or multiple perforations); without colostomy 44605 Suture of large intestine (colorrhaphy) for perforated ulcer, diverticulum, wound, injury or rupture (single or multiple perforations); with colostomy 45110 Proctectomy; complete, combined abdominoperineal, with colostomy</p><p>18 45126 Pelvic exenteration for colorectal malignancy, with proctectomy (with or without colostomy), with removal of bladder and ureteral transplantations, and/or hysterectomy, or cervicectomy, with or without removal of tube(s), with or without removal of ovary(s), or any combination thereof 45395 Laparoscopy, surgical; proctectomy, complete, combined abdominoperineal, with colostomy 45805 Closure of rectovesical fistula; with colostomy 45825 Closure of rectourethral fistula; with colostomy 50810 Ureterosigmoidostomy, with creation of sigmoid bladder and establishment of abdominal or perineal colostomy, including intestine anastomosis 51597 Pelvic exenteration, complete, for vesical, prostatic or urethral malignancy, with removal of bladder and ureteral transplantations, with or without hysterectomy and/or abdominoperineal resection of rectum and colon and colostomy, or any combination thereof 57307 Closure of rectovaginal fistula; abdominal approach, with concomitant colostomy 58240 Pelvic exenteration for gynecologic malignancy, with total abdominal hysterectomy or cervicectomy, with or without removal of tube(s), with or without removal of ovary(s), with removal of bladder and ureteral transplantations, and/or abdominoperineal resection of rectum and colon and colostomy, or any combination thereof 43644 Laparoscopy, surgical, gastric restrictive procedure; with gastric bypass and Roux-en-Y gastroenterostomy (roux limb 150 cm or less) 43846 Gastric restrictive procedure, with gastric bypass for morbid obesity; with short limb (150 cm or less) Roux-en-Y gastroenterostomy 43847 Gastric restrictive procedure, with gastric bypass for morbid obesity; with small intestine reconstruction to limit absorption 43848 Revision, open, of gastric restrictive procedure for morbid obesity, other than adjustable gastric restrictive device (separate procedure)</p><p>19 Table S2. Identification of major bleeding complications: definitions used in the United States IMPACT database analysis</p><p>ICD-9 CM code Definition</p><p>ISTH definition 431 Intracerebral hemorrhage 432 Intracranial hemorrhage NOS 767 Subdural and cerebral hemorrhage 767.11 Epicranial subaponeurotic hemorrhage (massive) 362.81 Retinal hemorrhage 376.32 Orbital hemorrhage 377.42 Hemorrhage in optic nerve sheaths 430 Subarachnoid hemorrhage 719.1 Hemarthrosis-site unspecified 719.11 Hemarthrosis-shoulder region 719.12 Hemarthrosis-upper arm 719.13 Hemarthrosis-forearm 719.14 Hemarthrosis-hand 719.15 Hemarthrosis-pelvic region and thigh 719.16 Hemarthrosis-lower leg 719.17 Hemarthrosis-ankle 719.18 Hemarthrosis-other specified sites 719.19 Hemarthrosis-multiple sites</p><p>Expanded ISTH definition* 246.3 Hemorrhage and infarction of thyroid (other) 285.1 Acute post-hemorrhagic anemia (major) 287.9 Unspecified hemorrhage conditions (other) 360.43 Hemophthalmos, except current injury (major) 362.81 Retinal hemorrhage (major) 363.61-363.62 Choroidal hemorrhage (major) 364.41 Hyphema (major) 374.81 Hemorrhage of eyelid (other) 376.32 Orbital hemorrhage (other) 377.42 Hemorrhage in Optic Nerve Sheaths (major) 379.23 Vitreous hemorrhage (major) 423.0 Hemopericardium (major) 430 Subarachnoid hemorrhage (major) 431 Intracerebral hemorrhage (major) 432 Other unspecified intracranial hemorrhage (major) 432.0 Nontraumatic extradural hemorrhage (major) 432.1 Subdural hemorrhage (major) 432.9 Unspecified intracranial hemorrhage (major) 456.0 Esophageal varices with bleeding (other) 456.20 Esophageal varices in disease classified elsewhere with bleeding (other) 459.0 Other disorders of circulatory system: hemorrhage, unspecified (other) 511.8† Other specified forms of effusion, except tuberculous, including </p><p>20 hemothorax (major) 530.21 Ulcer of esophagus with bleeding (other) 530.7 Mallory-Weiss tear (other) 530.82 Esophageal hemorrhage (other) 531.0x Acute gastric ulcer with hemorrhage (other) 531.2x Acute gastric ulcer with hemorrhage and perforation (other) 531.4x Chronic or unspecified gastric ulcer with hemorrhage (other) 531.6x Chronic or unspecified gastric ulcer with hemorrhage and perforation (other) 532.0x Acute duodenal ulcer with hemorrhage (other) 532.2x Acute duodenal ulcer with hemorrhage and perforation (other) 532.4x Chronic or unspecified duodenal ulcer with hemorrhage (other) 532.6x Chronic or unspecified duodenal ulcer with hemorrhage and perforation (other) 533.0x Acute peptic ulcer, site unspecified, with hemorrhage (other) 533.2x Acute peptic ulcer, site unspecified, with hemorrhage and perforation (other) 533.4x Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage (other) 533.6x Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage and perforation (other) 534.0x Acute gastrojejunal ulcer with hemorrhage (other) 534.2x Acute gastrojejunal ulcer with hemorrhage and perforation (other) 534.4x Chronic or unspecified gastrojejunal ulcer with hemorrhage (other) 534.6x Chronic or unspecified gastrojejunal ulcer with hemorrhage and perforation (other) 535.01 Acute gastritis with hemorrhage (other) 535.11 Atrophic gastritis with hemorrhage (other) 535.41 Other specified gastritis with hemorrhage (other) 535.51 Unspecified gastritis and gastroduodenitis with hemorrhage (other) 535.61 Duodenitis with hemorrhage (other) 537.83 Angiodysplasia of stomach and duodenum with hemorrhage (other) 562.02 Diverticulosis of small intestine with hemorrhage (other) 562.03 Diverticulitis of small intestine with hemorrhage (other) 562.12 Diverticulosis of colon with hemorrhage (other) 562.13 Diverticulitis of colon with hemorrhage (other) 568.81 Hemoperitoneum, nontraumatic (major) 569.3 Hemorrhage of rectum and anus (other) 569.85 Angiodysplasia of intestine with hemorrhage (other) 578 Gastrointestinal hemorrhage (other) 578.0 Hematemesis (other) 578.1 Blood in stool (other) 578.9 Hemorrhage of gastrointestinal tract, unspecified (other) 596.7 Hemorrhage into bladder wall (other) 599.7 Hematuria (other) 602.1 Congestion or hemorrhage of prostate (other) 608.82 Hematospermia (other) 608.83‡ Vascular disorders, hematoma [nontraumatic], hemorrhage, thrombosis (other)</p><p>21 621.4 Hematometra (other) 626.2 Excessive/frequent menstruation (other) 626.9 Disorders of menstruation and other abnormal bleeding from female genital tract (other) 626.6 Metrorrhagia (other) 627.1 Postmenopausal bleeding (other) 629.0 Hematocele, female, not elsewhere classified (other) 719.1x Hemarthrosis (major) 729.92 Nontraumatic hematoma of soft tissue (other) 782.7 Spontaneous ecchymoses (other) 784.7 Epistaxis (other) 784.8 Hemorrhage from throat (other) 786.3 Hemoptysis (other) 998.1 Hemorrhage or hematoma or seroma complicating a procedure (other) 998.11 Hemorrhage complicating a procedure (other) 998.12 Hematoma complicating a procedure (other) *In the expanded ISTH definition, major bleeding was defined as having at least one of the ICD-9-CM codes with bleeding definition category of ‘major’ or having at least one of the ICD-9-CM codes with bleeding definition category of ‘other’ but also requiring a blood transfusion (ICD-9-CM procedure code 99.0 or Current Procedural Terminology [CPT] code 36430) within 7 days of the bleeding diagnosis or requiring hospitalization. †To identify hemothorax in the expanded ISTH definition ICD-9-CM code 511.8 (other specified forms of effusion, except tuberculous, including hemothorax) was linked with CPT code 32020 (tube thoracostomy with or without water seal); depending on whether fluoroscopy was used during the procedure, CPT code 76003 (fluoroscopic guidance for needle placement) was also linked. ‡In the expanded ISTH definition ICD-9-CM code 608.83 it was ensured that patients did not have an associated code for myocardial infarction, stroke, or ischemic event to exclude arterial thrombosis.</p><p>Analyses of VTE incidence were performed using three different definitions: - Definition A, was an ‘all inclusive’ analysis comprising all individuals with an ICD-9-CM code relating to VTE who met the inclusion and exclusion criteria for the study (i.e. study period, tumor location). This definition considered a VTE case as a patient who had at least 1 VTE claim. - Definition B considered a VTE case as only patients who had 2 or more outpatient claims at least 30 days apart, or one inpatient claim, or a single outpatient claim in which an anticoagulation drug was disbursed within 90 days, and excluded the ICD-9-CM code 997.2 (peripheral vascular complications not elsewhere classified). - Definition C, the most stringent definition, further excluded from definition B any VTE events within 90 days of any major or invasive surgery. Codes relating to esophageal, kidney, and uterine cancer were not included.</p><p>22 Figure S1. Study cohort selection.</p><p>23 Figure S2. Cumulative risk of VTE in cancer patients undergoing chemotherapy according to: (a) definition B; (b) definition C; and (c) definition A, B, and C. </p><p>Number of patients at risk Days 0 30 60 90 120 150 180 210 240 270 300 330 360 Lung 10,422 10,191 9963 9773 9388 8759 8161 7622 7082 6595 6172 5801 5452 Colon/rectum 9615 9442 9296 9191 8974 8663 8371 8060 7777 7536 7294 7047 6850 Ovary 2209 2164 2135 2108 2056 1988 1923 1856 1799 1745 1696 1648 1592 Bladder 2393 2369 2344 2325 2259 2181 2097 2009 1954 1886 1819 1751 1707 Stomach 928 910 883 868 830 785 722 667 624 584 552 507 475 Pancreas 1912 1850 1791 1753 1636 1470 1360 1231 1114 1017 938 869 800 All cancers 27,479 26,926 26,412 26,018 25,143 23,846 22,634 21,445 20,350 19,363 18,471 17,623 16,876</p><p>24 Number of patients at risk Days 0 30 60 90 120 150 180 210 240 270 300 330 360 Lung 10,422 10,206 9989 9809 9428 8800 8201 7661 7120 6630 6202 5827 5474 Colon/rectum 9615 9530 9400 9284 9076 8784 8483 8170 7883 7636 7390 7144 6942 Ovary 2209 2180 2162 2133 2081 2012 1947 1878 1820 1762 1711 1663 1607 Bladder 2393 2371 2346 2329 2263 2185 2100 2014 1959 1890 1823 1755 1714 Stomach 928 915 891 877 841 797 734 680 637 595 562 518 484 Pancreas 1912 1859 1803 1766 1654 1490 1375 1244 1128 1028 948 878 809 All cancers 27,479 27,061 26,591 26,198 25,343 24,068 22,840 21,647 20,547 19,541 18,636 17,785 17,030</p><p>25 Number of patients at risk Days 0 30 60 90 120 150 180 210 240 270 300 330 360 Definition A 27,479 26,795 26,183 25,706 24,773 23,448 22,219 20,992 19,920 18,936 18,048 17,206 16,456 Definition B 27,479 26,926 26,412 26,018 25,143 23,846 22,634 21,445 20,350 19,363 18,471 17,623 16,876 Definition C 27,479 27,061 26,591 26,198 25,343 24,068 22,840 21,647 20,547 19,541 18,636 17,785 17,030</p><p>26</p>