<p>Supplemental Data Table 1: represents the distribution of the APOE genotypes with lipids in the British Women Heart & Health Study participants (women aged 60-79 year described as white by the examining nurse).</p><p>Means (SD) mmol/l by genotype 2/2 3/2 3/3 3/4 4/4 4/2 F-statistic & p-</p><p>N = 19 N = 419 N = 1988 N = 682 N = 72 N = 91 value* Total 5.71 (0.80) 6.25 (1.15) 6.67 (1.16) 6.77 (1.17) 7.19 (1.24) 6.24 (1.17) F = 18.9 cholesterol < 0.0001 LDLc 3.07 (0.90) 3.61 (0.94) 4.20 (1.06) 4.32 (1.07) 4.63 (1.20) 3.66 (0.98) F = 36.0</p><p>< 0.0001 HDLc 1.77 (0.57) 1.73 (0.46) 1.66 (0.46) 1.60 (0.44) 1.63 (0.45) 1.65 (0.43) F = 4.9</p><p>= 0.0002 Triglycerides$ 1.83 1.72 1.65 1.70 2.07 1.71 F = 39.4</p><p>(1.51, 2.21) (1.64, 1.80) (1.61, 1.67) (1.64, 1.76) (1.84, 2.30) (1.51, 1.93) < 0.0001</p><p>* all based on anova with 5df i.e. test for heterogeneity between the genotype categories $ geometric means and 95% confidence interval of arithmetic mean (SD) for all other lipids arithmetic means (SD) presented.</p>