<p> Spring 2016 BBS504 ………… revised 3.07.16</p><p>Feb. 2 & 4, 2016 – Dr. Yosten: Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors; Kristen L. Pierce et al, PNAS, February 15, 2000, vol. 97, no. 4, 1489–1494. </p><p>Feb. 9, 2016 – Dr. Burris: Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading; Bokai Zhu et al, Molecular Cell 60, 769–783, December 3, 2015, http://dx.doi.org/10.1016/j.molcel.2015.10.024</p><p>Feb. 11, 2016 – NO CLASS due to 503 Study Day</p><p>Feb. 16 & Feb. 18, 2016 - Dr. Flaveny: ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis, Juan R. Cubillos-Ruiz et al, Cell 161, 1527–1538, June 18, 2015, http://dx.doi.org/10.1016/j.cell.2015.05.025</p><p>Feb. 23 & Feb. 25, 2016 - Dr. Flaveny: Identification and Specification of the Mouse Skeletal Stem Cell, Charles K.F. Chan et al, Cell 160, 285–298, January 15, 2015, http://dx.doi.org/10.1016/j.cell.2014.12.002</p><p>Mar. 1 & Mar. 3, 2016 - Dr. Salvemini: Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy, Zheng et al, Experimental Neurology 238 (2012) 225–234. http://dx.doi.org/10.1016/j.expneurol.2012.08.023</p><p>Mar. 15 & Mar. 17, 2016 - Dr. Salvemini: Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia, Xu et al, The Journal of Clinical Investigation, Volume 124, Number 2, February 2014. doi:10.1172/JCI70236</p><p>Apr. 5 & 7, 2016 - Dr. Butler: Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice, Robert A. Koza et al, PLoS Genetics | May 2006 | Volume 2 | Issue 5 | e81, DOI: 10.1371/journal.pgen.0020081</p><p>Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity, Kevin Dalgaard et al, Cell 164, 353–364, January 28, 2016, http://dx.doi.org/10.1016/j.cell.2015.12.025</p><p>Apr. 12, 2016 – NO CLASS due to 503 double lecture Apr. 14, 2016 - Dr. Knuepfer: A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice, Eric M. Green et al, Science 351, 617 (2016), DOI: 10.1126/science.aad3456</p><p>Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy; John T. Hinson et al, 8 Science 349, 982 (2015), DOI: 10.1126/science.aaa5458</p><p>Apr. 19, 2016 - Dr. Sprague: Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin, Jennifer P. Richards et al, Am J Physiol Regul Integr Comp Physiol 307: R862–R868, 2014. First published July 30, 2014; doi:10.1152/ajpregu.00206.2014.</p><p>Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes, Jennifer P. Richards et al, Am J Physiol Regul Integr Comp Physiol 305: R1331– R1336, 2013. First published 2, 2013; doi:10.1152/ajpregu.00341.2013.</p><p>Mechanisms of C-peptide-mediated rescue of low O2-induced ATP release from erythrocytes of humans with Type 2 diabetes, Jennifer P. Richards et al, Am J Physiol Regul Integr Comp Physiol 308: R411–R418, 2015. First published December 31, 2014; doi:10.1152/ajpregu.00420.2014.</p><p>Apr. 21, 2016 – Dr. Samson: (final exam paper distributed)</p><p>Apr. 28, 2016 – In class Final Exam</p>