<p>Supplemental material</p><p>Figure 3.</p><p>Effect of age and gender on cortical atrophy. Upper row denote significance map of diagnosis on gray matter atrophy controlled by age and lower row significance map of diagnosis on gray matter atrophy controlled by gender for the three comparisons (controls vs iAD, iAD vs miAD and miAD vs moAD). Altough less marked, the BA found atrophic are basically unchanged respect to the main analysis for the three comparisons, indicating that age and gender are not confounders of the findings of this study. Figure 4.</p><p>Incremental gray matter loss from incipient through mild and moderate AD after excluding 3 miAD and 3 moAD patients from the starting samples. The results are unchanged, although less powerful </p><p>(p = 0.0001 on permutation testing for both left and right hemispheres in iAD vs miAD comparison; p = 0.06 for the left and p = 0.05 for the right hemispheres in miAD vs moAD comparison).</p>