<p> 1</p><p>Journal Name: Drug Safety Article Title: Cancer chemotherapy and cardiac arrhythmias: a review Author names: Tamargo J, Caballero R, Delpón E Author Affiliations: Department of Pharmacology, School of Medicine, University Complutense, Madrid. </p><p>Electronic Supplementary Table 1. Classification, mechanism of action and representative chemotherapy drugs</p><p>Class Mechanism of action Representative drugs Alkylating Bind covalently to DNA and  Busulfan, Carmustine agents promotes cross-linking of DNA, Cyclophosphamide, abnormal base pairing, or DNA Ifosphamide, Melphalan strand breaks and blockade of  Platinum drugs: DNA replication carboplatin, cisplatin, oxaliplatin Angiogenesis Slow/stop the growth of new Lenalidomide, Thalidomide inhibitors blood vessels which tumour needs to grow and survive Anthracycline Intercale into DNA, inhibits Daunorubicin, Doxorubicin, s topoisomerase II, and prevent Epirubicin, Idarubicin, Antraquinones DNA and RNA synthesis Mitoxantrone</p><p>Antimetabolit Block the synthesis of nucleic Capecitabine, Cytarabine, 5- es (Pyrimidine acids required for DNA replication fluorouracil, Fludarabine, analogues) Gemcitabine, Methotrexate, Pentostatin Antitumor Cause DNA alkylation and cross- Bleomycin, Mitomycin, antibiotics linking Cytokines Necessary for the growth, Interleukin-2 proliferation, and differentiation T cells Histone Removal of acetyl groups by Dacinostat, Panibinostat, deacetylase HDAC stabilizes the interaction Romidepsin, Vorinostat (HDAC) between DNA and histones, inhibitors repressing transcription. Microtubule Block cell division by stabilizing  Taxanes: docetacel, targeting GDP-bound tubulin in the paclitaxel agents microtubules. Vinca alkaloids  Vinca alkaloids: destroy mitotic spindles vinblastine, vincristine, vinorelbine  Eribulin mesylate, Ixapepilone Non-specific Interferon, Interleukin-2 immunothera 2 pies Proteasome Binds the catalytic site of the 26S Bortezomib, Carfilzomib inhibitors proteasome Protein kinase Impairs VEGF activity and tumor Enzastaurin Cβ inhibitors angiogenesis Protein kinase  Small molecules interfering  Afatinib, Axitinib, inhibitors with intracellular downstream Bosutinib, Crizotinib, (PKIs) signaling pathways of protein Dasatinib, Erlotinib, Gefitinib, kinase-linked receptors Imatinib, Lapatinib, Nilotinib, Ponatinib, regorafenib, Ruloxitinib, Sorafenib,  Monoclonal antibodies Sunitinib, Vandetanib, directed against specific Vemurafenib membrane bound components  Alemtuzumab, of receptor tyrosine kinases Bevacizumab, Cetuximab, Gentuzumab, Pertuzumab, Rituximab, Trastuzumab Topoisomeras Prevent religation of DNA strands, Amsacrine, Etoposide, e II inhibitors cause DNA strand breaks, and Mitoxantrone lead to apoptosis. Other drugs Causes degradation of the PML- Arsenic trioxide RARα fusion protein in leukemic cells Abbreviations: GDP: guanosine diphosphate. HDAC: histone deacetilase inhibitors. PML/RARα: promyelocytic leukemia/Retinoic acid receptor α. VEGF: vascular endothelial growth factor.</p>