<p> ADDITIONAL INFORMATION</p><p>The data for APTT in the tables for peptides with Val115 refer to values above Ref.t. 29.7 sec. Table 1. Data for anticoagulant activity of the compound H-Arg-Pro-Lys-</p><p>Arg-Lys-Leu-Val-Pro-NH2 Concentration (mol.10-9) APTT (sec) 200,50 10,0 260,70 29,9 300,80 45,0</p><p>Table 2. Data for anticoagulant activity of the compound H-Lys-Pro-Lys-</p><p>Arg-Lys-Leu-Val-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec) 211,00 8,9 646,61 28,9 1077,70 57,9</p><p>Table 3. Data for anticoagulant activity of the compound H-Orn-Pro-Lys-</p><p>Arg-Lys-Leu-Val-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec) 528,94 0,5 705,25 29,3 881,56 53,3</p><p>Table 4. Data for anticoagulant activity of the compound H-Pro-Lys-Arg-</p><p>Lys-Leu-Val-Pro-NH2 Concentration (mol.10-9) APTT (sec) 906,80 8,8 1813,59 18,6 2266,99 18,8 2720,39 25,5 2901,75 29,8 2992,43 32,4</p><p>Table 5. Data for anticoagulant activity of the compound H-Arg-Pro-Lys- Arg-Lys-Leu-Val-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec) 41,89 NA 272,29 3,8 418,91 5,5 523,64 15,6 802,24 62,4 NA-no activity Table 6. Data for anticoagulant activity of the compound H-Lys-Pro-Lys- Arg-Lys-Leu-Val-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec) 290,00 6,7 894,00 21,6 1043,42 24,1 1117,95 30,0 1192,00 50,9 2235,90 122,8</p><p>Table 7. Data for anticoagulant activity of the compound H-Orn-Pro-Lys- Arg-Lys-Leu-Val-Pro-OH Concentration (mol.10-9) APTT (sec) 771,00 22,2 1156,56 28,5</p><p>Table 8. Data for anticoagulant activity of the compound H-Pro-Lys-Arg- Lys-Leu-Val-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec) 1338,96 22,1 1562,12 31,0 1785,28 47,1</p><p>The data for APTT in the tables for peptides with Ile115 refer to values above Ref.t. 28.8 sec. Table 9. Anticoagulant activity of the compound H-Arg-Pro-Lys-Arg-Lys-</p><p>Leu-Ile-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec.) 19,88 NA 835,00 NA 1252,49 NA 1550,70 NA 1600,00 28,9±0,4</p><p>Table 10. Anticoagulant activity of the compound H-Lys-Pro-Lys-Arg-</p><p>Lys-Leu-Ile-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec.) 73,24 3,1±0,1 476,06 8,8±0,1 1025,36 16,6±0,4 1464,8 29,5±0,3</p><p>Table 11. Anticoagulant activity of the compound H-Orn-Pro-Lys-Arg-</p><p>Lys-Leu-Ile-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec.) 790,90 14,8±0,4 1224,30 28,5±0,4 2902,61 Out of range</p><p>Table 12. Anticoagulant activity of the compound H-Pro-Lys-Arg-Lys-</p><p>Leu-Ile-Pro-OH</p><p>Concentration (mol.10-9) APTT (sec.) 1134,52 24,0±0,4 3857,40 29,1±0,2 6807,12 Out of range</p><p>Table 13. Anticoagulant activity of the compound H-Arg-Pro-Lys-Arg-</p><p>Lys-Leu-Ile-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec.) 2535,60 27,9±0,3 3480,19 30,6±0,5</p><p>Table 14. Anticoagulant activity of the compound H-Lys-Pro-Lys-Arg-</p><p>Lys-Leu-Ile-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec.) 413,33 19,1±0,4 448,57 27,9±0,2 516,67 54,0±0,2</p><p>Table 15. Anticoagulant activity of the compound H-Orn-Pro-Lys-Arg-</p><p>Lys-Leu-Ile-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec.) 3748,3 28,8±0,5 4150.40 33.2±0,5 4669.2 35.7±0,5</p><p>Table 16. Anticoagulant activity of the compound H-Pro-Lys-Arg-Lys-</p><p>Leu-Ile-Pro-NH2</p><p>Concentration (mol.10-9) APTT (sec.) 4708.00 20.8±0,2 5002.30 29.2±0,2 7062.00 Out of range</p><p>Table 17. ESI-MS data for newly synthesized compounds Compound MS data Mass exact [M+H] found calculated Arg-Pro-Lys-Arg-Lys-Leu-Val-Pro-OH 992,6607 993,84</p><p>Arg-Pro-Lys-Arg-Lys-Leu-Val-Pro-NH2 991,6767 992,80 Lys-Pro-Lys-Arg-Lys-Leu-Val-Pro-OH 964,6546 965,44</p><p>Lys-Pro-Lys-Arg-Lys-Leu-Val-Pro-NH2 963,6706 964,68 Orn-Pro-Lys-Arg-Lys-Leu-Val-Pro-OH 950,6389 951,80</p><p>Orn-Pro-Lys-Arg-Lys-Leu-Val-Pro-NH2 949,6549 950,80 Pro-Lys-Arg-Lys-Leu-Val-Pro-OH 836,5596 837,66</p><p>Pro-Lys-Arg-Lys-Leu-Val-Pro-NH2 835,5756 836,60 Arg-Pro-Lys-Arg-Lys-Leu-Ile-Pro-OH 1006,6764 1007,40 Arg-Pro-Lys-Arg-Lys-Leu-Ile-Pro-NH2 1005,6924 1006,44 Lys-Pro-Lys-Arg-Lys-Leu-Ile-Pro-OH 978,6702 979,40</p><p>Lys-Pro-Lys-Arg-Lys-Leu-Ile-Pro-NH2 977,6862 978,40 Orn-Pro-Lys-Arg-Lys-Leu-Ile-Pro-OH 964,6546 965,37</p><p>Orn-Pro-Lys-Arg-Lys-Leu-Ile-Pro-NH2 963,6706 964,40 Pro-Lys-Arg-Lys-Leu-Ile-Pro-OH 850,5753 851,30</p><p>Pro-Lys-Arg-Lys-Leu-Ile-Pro-NH2 849,5912 850,31</p>