<p> ISF Workshop on MITOCHONDRIA: FUNCTION AND DYSFUNCTION February 13-15, 2008, Kibbutz Ein Gedi, Dead Sea, Israel SCIENTIFIC PROGRAM</p><p>Wednesday, February 13, 2008</p><p>12:00-13:00 REGISTRATION AND DISTRIBUTION OF MEETING MATERIAL </p><p>Opening Keynote lecture </p><p>Chair: O. Pines, Jerusalem</p><p>13:00-13:40 Walter Neupert, Munich BIOGENESIS OF MITOCHONDRIA</p><p>Session I – Protein targeting and fate</p><p>Chair: J. Orly, Jerusalem</p><p>14:00- 14:25 Doron Rapaport, Tuebingen BIOGENESIS OF MITOCHONDRIAL OUTER MEMBRANE COM- PLEXES.</p><p>14:25- 14:50 Abdussalam Azem, Tel Aviv CHAPERONES AND THE DYNAMICS OF THE MITOCHONDRIAL IMPORT MOTOR.</p><p>14:50- 15:15 Dejana Mokranjac, Munich STRUCTURE AND FUNCTION OF TIM14 AND TIM16.</p><p>15:15- 15:40 Ophry Pines, Jerusalem DUAL AND ECLIPSED DISTRIBUTION OF MITOCHONDRIAL PROTEINS.</p><p>15:40- 16:20 LIGHT LUNCH </p><p>16:20- 16:45 Johannes Herrmann, Kaiserslautern THE MITOCHONDRIAL TRANSLATION MACHINERY: FROM PROTEIN SYNTHESIS TO MEMBRANE INTEGRATION. 16:45- 17:00 Nils Wiedemann, Freiburg MECHANISM OF PROTEIN SORTING INTO THE OUTER MITOCHONDRIAL MEMBRANE.</p><p>17:00- 17:25 Thomas Langer, Cologne PROTEOLYTIC CONTROL OF MITOCHONDRIAL BIOGENESIS.</p><p>17:25- 17:50 Elzbieta Glaser, Stockholm A NOVEL ORGANELLAR PEPTIDASOME, PREP: A JOURNEY FROM ARABIDOPSIS TO ALZHEIMER DISEASE.</p><p>17:50- 19:30 POSTER SESSION</p><p>20:00 MIDDLE EASTERN HAFLA</p><p>Thursday, February 14, 2006</p><p>7:00-8:30 BREAKFAST</p><p>Session II – Stress and cell death</p><p>Chair: N. Nelson, Tel Aviv</p><p>08:45- 09:10 Roland Lill, Marburg THE ROLE OF MITOCHONDRIA IN THE MATURATION OF CYTOSOLIC IRON-SULFUR PROTEINS.</p><p>09:10- 09:25 Patricia Jennings, San Diego MITONEET IS A UNIQUELY FOLDED 2FE-2S OUTER MITOCHONDRIAL MEMBRANE PROTEIN.</p><p>09:25- 09:50 Ioav Cabantchik, Jerusalem WHY ARE MITOCHONDRIA THE TARGETS OF SYSTEMIC AND REGIONAL IRON ACCUMULATION?</p><p>09:50- 10:20 COFFEE BREAK </p><p>10:20- 10:45 Varda Shoshan-Barmatz, Beer Sheba THE HUMAN MITOCHONDRIAL VDAC AND APOPTOSIS.</p><p>10:45- 11:10 Atan Gross, Rehovot NEW INSIGHTS INTO THE ROLE AND FUNCTION OF MITOCHONDRIAL MTCH2. 11:10- 11:35 Adi Kimchi, Rehovot A SHORT MITOCHONDRIAL FORM OF P19ARF INDUCES AUTOPHAGY AND CELL DEATH.</p><p>11:35- 12:00 Haim Breitbart. Ramat Gan SPERM TRANSLATE NUCLEAR-ENCODED PROTEINS BY MITOCHONDRIAL-TYPE RIBOSOMES.</p><p>12:00- 14:00 POSTER SESSION AND LIGHT LUNCH IN THE POSTER AREA</p><p>Session III – Disorders in human </p><p>Chair: A. Munnich, Paris</p><p>14:00- 14:25 Luigi Palmieri, Bari MITOCHONDRIAL TRANSPORTERS.</p><p>14:25- 14:50 Haya Lorberboum-Galski, Jerusalem REPLACEMENT THERAPY: TARGETING PROTEINS TO THE MITOCHONDRIA.</p><p>14:50- 15:15 Orly Elpeleg, Jerusalem NOVEL GENES INVOLVED IN RESPIRATORY CHAIN DEFECTS.</p><p>15:15- 15:40 Ann Saada-Reisch, Jerusalem THE HUMAN MITOCHONDRIAL RIBOSOME.</p><p>15:40-16:10 COFFEE BREAK</p><p>16:10-16:35 Massimo Zeviani, Milano DISORDERS OF mtDNA MAINTENANCE AND INTEGRITY.</p><p>16:35- 17:00 Agnes Rotig, Paris NOVEL MECHANISMS IN MITOCHONDRIAL DNA REPLICATION.</p><p>17:00- 17:25 Leo G. Nijtmans, Nijmegen HUMAN COMPLEX I ASSEMBLY</p><p>17:25- 17:50 Carla Koehler, Los Angeles TAFAZZIN AND ITS FUNCTION IN BARTH SYNDROME.</p><p>DINNER AND EIN GEDI SPRINGS Friday, February 15, 2008</p><p>Closing keynote lecture </p><p>Chair: A. Azem, Tel-Aviv</p><p>09:00-09:30 Gottfried Schatz, Basel A LIFE IN MITOCHONDRIAL RESEARCH - WHAT IT MEANS IN RETROSPECT.</p><p>Session IV – Morphology, inheritance and nucleic acids </p><p>Chair: M. Glickman, Haifa</p><p>09:30-09:55 Rob Jensen, Baltimore FUSION AND FISSION. </p><p>09:55-10:20 Joseph Shlomai, Jerusalem REPLICATION ORIGINS OF THE MITOCHONDRIAL GENOME.</p><p>10:20-10:45 Chris Meisinger, Freiburg THE MITOCHONDRIAL PROTEOME: NOVEL INSIGHTS INTO MITOCHONDRIAL FUNCTIONS.</p><p>10:45-11:15 COFFEE BREAK</p><p>11:15-11:40 Nils-Goran Larsson, Stockholm mtDNA MUTATIONS AND AGEING.</p><p>11:40-12:05 Gadi Schuster, Haifa PolyA MODIFICATION AND DEGRADATION OF mRNA.</p><p>12:05-12:30 Karl Skorecki, Haifa THE DRUZE mtDNA - A POPULATION GENETIC SNAPSHOT OF THE NEAR EAST IN ANTIQUITY</p><p>FAREWELL WORDS Orly Elpeleg, Jerusalem</p><p>13:00 DEPARTURE </p>