<p>STUDY GUIDE FOR QUIZ 4</p><p>1. The dangers (or lack thereof) associated with taking ecstasy (3,4 – methylenedioxymethamphetamine or MDMA) have been widely debated (Ecstasy on the brain by Claire Ainsworth) and evidence has been introduced to support both sides of the argument.</p><p>Name 1 side effect that has been both advanced AND rebutted by contradictory scientific evidence (evidence exists to support both sides).</p><p>OR Name 2 physiological (not at the neuronal level) side effects that have been associated with use of MDMA.</p><p>2. What are the mechanisms of action of MDMA (3,4 – methylenedioxymethamphetamine or ecstasy) in the brain? What role does it play in neurotransmission? </p><p>3. Name 2 hallucinogenic drugs and at least 1 therapeutic (legal) application proposed (in conjunction with supportive interventions like talk therapy).</p><p>4. What are some of the potential tradeoffs discussed between ibogaine therapy vs. just the psychoactive noribogaine metabolite?</p><p>5. Briefly describe the 'Eastern Triangular' trade that existed during Britain's Opium Wars: Which countries were involved, and what was transfered to/from each of them?</p><p>6. Briefly explain the endogenous DMT hypothesis of schizophrenia (ie the effects of DMT in psychosis and what modulates its levels), and an experiment that may suport it.</p><p>7. Describe some of the factors leading to cocaine's interference with neurodevelopment at the behavioral level, and cite evidence for effects at the cellular level </p><p>8. Which turns out to have a stronger effect on IQ in children: prenatal cocaine exposure, or situations where the mother is using cocain after birth. Which one has a stronger effect on behavioral problems such as agression or impulsivity?</p><p>9. What is the role of the D1 receptor during brain development and what happens during dendrite formation during prenatal cocaine exposure?</p>