<p>Additional file 1 – Summary of primary and additional outcomes of all included studies CS = cross-sectional study; LT = longitudinal study; CO = cohort study; VA = validation. 1, 2 same numbers indicate same sample. First author, Population/sample Subject of the study Main outcomes concerning Other outcomes/conclusions year n (% females) missing teeth</p><p>OHIP-49 (Oral Health Impact Profile)</p><p>Bae, 2007VA Korean elderly OHIP validation for Number of missing teeth Perceived treatment need also [22] elderly associated with OHRQoL associated with OHRQoL n =128 (51) impairment. impairment.</p><p>Hassel, German Dental and non-dental No difference in OHRQoL Fewer teeth in static occlusion 2006CS [23] institutionalized factors on OHRQoL between dentate and associated with OHRQoL impairment elderly of institutionalized edentulous subject.s (bivariate analysis). elderly n = 159 (81) Non-dental factors had a striking effect on OHRQoL. The model with variables education, general pain status, denture retention, age of denture and kind of denture, explained 34% of the variance in OHIP total scores.</p><p>Ide, 2004VA Japanese employees OHIP validation for Number of missing teeth Outcome independent of gender, age, [12] young and middle- associated with OHRQoL and denture wearing. n = 6079 (25) aged adults impairment. </p><p>Locker, Canadian older Clinical and Number of missing teeth Non-dental factors (general health, 1994LT [29] adults subjective indicators associated with OHRQoL life stress, dental insurance, of oral health status impairment. household income and age) explained n = 312 (54) and OHRQoL almost as much variance in OHIP scores as the number of missing teeth (14, respectively 18%).</p><p>Mason, British middle aged Risk factors, Number of retained teeth OHRQoL in men mostly explained 2006CO [30] adults lifecourse and more impact on OHRQoL in by ‘early-life’ factors. OHRQoL woman; impact for men n = 281 (57) almost absent.</p><p>Walter, Canadian rural Clinical and socio- Number of present natural Missing anterior teeth associated with 2007CS [48] adults demographic variables teeth was not a significant OHRQoL impairment. and OHRQoL variable in OHRQoL. n = 140 (64) OHRQoL positively related to molar pairs occluding, anterior pairs occluding, premolar pairs occluding and total number of occluding pairs.</p><p>Gender and normative endodontic treatment need also effected OHRQoL.</p><p>OHIP-14 (Oral Health Impact Profile short version) de Oliveira, Brazilian Validation of the Tooth loss associated with Perceived and normative dental 2005VA [39] postpartum women Brazilian OHIP-14 OHRQoL impairmen.t treatment needs, self-rating oral health, pattern of dental attendance n = 504 (100) and untreated dental caries also associated with OHRQoL impairment.</p><p>Ekanayake, Sinhalese elderly Oral health status and Weak association between Wearing dentures and halitosis were 2004CS [10] oral impacts in elderly number of missing teeth and significant predictors of OHRQoL n = 235 (60) OHRQoL impairment. impairment.</p><p>Lahti, 2008CS Finish adults aged Prevalence and Subjects with more missing Subjects with 20 or more teeth [25] over 30 yrs severity of oral health teeth have higher prevalence wearing RPD more likely to report impacts of, and more severe impact oral impacts than those with 20 or n = 5897 (53) on OHRQoL. more teeth without RPD. Young subjects with low educational level had higher and more impacts.</p><p>Lawrence, 32-year old New Dental and non-dental Tooth loss associated with Clinical oral health status indicators 2008CO [26] Zealanders factors on OHRQoL OHRQoL impairment. associated with OHRQoL in a birth cohort impairment, independent of gender n = 924 (49) and SES.</p><p>Mariño, Australian older Self-reported and Number of missing teeth Male subjects, subjects with fewer 2008CS [4] adult migrants clinically determined associated with OHRQoL reported oral health treatment need oral health status impairment. and subjects that did not need to sip n = 603 (64) aspredictors of liquid to swallow food had less OHRQoL OHRQoL impairment.</p><p>Pallegredara, Sinhalese elderly Tooth loss, denture Number of missing teeth Anterior spaces more impact on 2008CS [40] status and OHRQoL most significant predictor of OHRQoL than posterior spaces. n = 630 (54) OHRQoL.</p>