<p>Supplemental Tables Supplemental Table 1. Baseline Patient Characteristics of the Entire Study Population Comparing Patients With or Without Diabetes Mellitus.</p><p>Non-DM DM Variable P value (N = 3507) (N = 2924) Age, years 69.6±1 68.6±9.4 <0.001 Age ≥75 years, n (%) 1223 (35) 824 (28) <0.001 Male gender, n (%) 2691 (77) 2261 (77) 0.57 Body mass index 23.8±3.4 24.7±3.7 <0.001 Hemoglobin A1c, % 5.4±0.4 6.9±1.2 <0.001 Coexisting condition, n (%) Hypertension 2416 (83) 2782 (79) <0.001 Diabetes mellitus Insulin-treated diabetes - 676 (23) - Treated with oral medication only - 1575 (54) - Treated with diet therapy only - 422 (14) - Dyslipidemia 2623 (75) 2297 (79) <0.001 ESRD (eGFR <30 mL/min per 1.73m2) not on hemodialysis 61 (1.8) 93 (3.2) <0.001 Hemodialysis 128 (3.7) 234 (8.0) <0.001 Atrial fibrillation 257 (7.3) 190 (6.5) 0.19 Anemia (hemoglobin <11.0 g/dl) 449 (15) 351 (10) <0.0001 Chronic obstructive pulmonary disease 58 (2.0) 87 (2.5) 0.18 Malignancy 243 (6.9) 209 (7.2) 0.73 Cardiac risk factor, n (%) Current smoker 566 (19) 686 (20) 0.84 Family history of coronary artery disease 454 (17) 547 (17) 0.81 Previous myocardial infarction 897 (31) 983 (28) 0.02 Previous stroke 324 (9.2) 364 (12) <0.001 Heart failure 340 (9.7) 460 (16) <0.001 Peripheral vascular disease 268 (7.6) 353 (12) <0.001 Previous percutaneous coronary intervention 1636 (47) 1567 (54) <0.001 Previous coronary artery bypass grafting 144 (4.1) 179 (6.1) <0.001 Clinical characteristics, n (%) Clinical presentation Stable coronary artery disease 2883 (82) 2446 (84) 0.21 Unstable angina 424 (12) 337 (12) Acute myocardial infarction 200 (5.7) 141 (4.8) Left ventricular ejection fraction <30% 47 (1.6) 66 (2.6) 0.006 Multivessel disease 1569 (45) 1631 (56) <0.001 Target-vessel location, n (%) Left main coronary artery 84 (2.4) 95 (3.3) 0.04 Left anterior descending coronary artery 1390 (48) 1727 (49) 0.17 Left circumflex coronary artery 870 (25) 787 (27) 0.05 Right coronary artery 1138 (32) 949 (32) 0.996 Bypass graft 17 (0.5) 26 (0.9) 0.048 Complexity of coronary artery disease Number of treated lesions per patient 1.23±0.5 1.26±0.54 0.002 SYNTAX score Number of patients analyzed 3102 2535 Median (interquartile range) 9 (5.5-15) 11 (7-17) Tertiles, n (%) Low (<23) 2853 (92) 2225 (88) <0.001 Intermediate (≥23 to <33) 210 (6.8) 241 (9.5) High (≥33) 39 (1.3) 69 (2.7) Medications, n (%) Aspirin 3494 (99.6) 2913 (99.6) 0.97 Thienopyridines 3489 (99.5) 2901 (99.2) 0.17 Clopidogrel 3027 (87) 2466 (85) 0.03 Ticlopidine 440 (13) 421 (15) 0.03 1 Statins 2694 (77) 2236 (2924) 0.74 β-blockers 1278 (36) 1131 (39) 0.06 ACE-I/ARB 2043 (58) 1906 (65) <0.001 Calcium-channel blockers 1559 (44) 1309 (45) 0.80 Nitrates 972 (28) 731 (25) 0.01 Warfarin 280 (8.0) 224 (7.7) 0.63 Pioglitazone - 404 (14) - Data are presented as number (%) or mean ± SD, unless otherwise specified. ACE-I indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blockers; DM, diabetes mellitus; ESRD, end-stage renal disease; eGFR, estimated glomerular filtration rate; G1-DES, first-generation drug-eluting stents; G2-DES, second-generation drug-eluting stents; and SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery.</p><p>2 Supplemental Table 2. Lesion and Procedural Characteristics of the Entire Study Population Comparing Patients With or Without Diabetes Mellitus.</p><p>Non-DM DM Variable P value (N = 3507) (N = 2924) Number of lesions treated 4297 3698 Before index procedure Lesion length, mm 17.7±11.6 (3821) 18.9±12.8 (3216) <0.001 Reference vessel diameter, mm 2.64±0.61 (4028) 2.54±0.6 (3388) <0.001 Minimum lumen diameter, mm 0.8±0.45 (4036) 0.77±0.44 (3398) 0.006 Diameter stenosis, % 70±15.4 (4035) 70.2±15.4 (3398) 0.70 Thrombus 147/4036 (3.6) 76/3398 (2.2) <0.001 Chronic total occlusion 254/4297 (5.9) 244/3698 (6.6) 0.21 In-stent restenosis 442/4297 (10) 447/3698 (12) 0.01 Culprit for STEMI 147/4297 (3.4) 91/3698 (2.5) 0.01 Bifurcation 1695/4114 (41) 1418/3482 (41) 0.67 Moderate or heavy calcification 740/4036 (18) 740/3399 (22) <0.001 Small vessel (reference vessel diameter ≤2.75mm) 2440/4028 (61) 2229/3388 (66) <0.001 Long lesion (lesion length >18mm) 1384/3821 (36) 1316/3216 (41) <0.001 After index procedure Number of stents used Per patient 1.51±0.77 (387) 1.59±0.82 (2913) <0.001 Per lesion 1.26±0.55 (4169) 1.3±0.58 (3564) 0.001 Total stent length, mm Per patient 30.9±18.9 (3487) 33.6±20.6 (2912) <0.001 Per lesion 25.9±14.9 (4169) 27.5±16.3 (3563) <0.001 Stent diameter, mm 2.94±0.53 (4236) 2.9±0.55 (3634) 0.001 Multivessel treatment 364/3507 (10) 373/2924 (13) 0.003 Direct stenting 1047/4169 (25) 802/3564 (23) 0.007 Maximum stent inflation pressure, atmosphere 17.0±4.4 (4169) 17.3±4.4 (3564) 0.02 Postdilatation 3028/4236 (71) 2658/3634 (73) 0.10 Bifurcation 2-stent approach 49/2587 (1.9) 35/2153 (1.6) 0.49 Intravascular ultrasound use 2975/3507 (85) 2505/2924 (86) 0.34 Received study stent only 4114/4297 (96) 3518/3698 (95) 0.19 Minimum Lumen diameter, mm In-stent 2.51±0.47 (4008) 2.43±0.47 (3381) <0.001 In-segment 2.11±0.55 (4014) 2.01±0.54 (3387) <0.001 Diameter stenosis, % In-stent 10.2±8.1 (4007) 10.3±8.3 (3379) 0.51 In-segment 21.6±11.7 (4013) 22.8±12 (3385) <0.001 Acute gain, mm In-stent 1.71±0.52 (4008) 1.66±0.51 (3380) <0.001 In-segment 1.31±0.56 (4014) 1.24±0.53 (3386) <0.001 Duration of procedure, min 69.1±42.6 (3507) 71.7±43.8 (2924) 0.02 Successful outcome Lesion success by any treatment modalities 4273/4297 (99.4) 3672/3698 (99.3) 0.41 Lesion success by study stents (acute device success) 4124/4212 (97.9) 3528/3620 (97.5) 0.18 Procedural success (patient level) 3402/3507 (97.0) 2835/2924 (97.0) 0.91 Staged PCI procedures 863/3507 (25) 776/2924 (27) 0.08 Data are presented as number (%) or mean ± SD. PCI indicates percutaneous coronary intervention; and STEMI, ST-segment elevation myocardial infarction. Other abbreviations are same as in Supplemental Table 1.</p><p>3 Supplemental Table 3. Baseline Patient Characteristics of the Entire Study Population; Insulin-Treated Versus Non-Insulin-Treated Diabetes Mellitus.</p><p>Insulin-Treated DM Non-Insulin-Treated DM Variable P value (n = 676) (n = 2248) Age, years 67.4±9.9 68.9±9.2 <0.001 Age ≥75 years, n (%) 164 (24) 660 (29) 0.01 Male gender, n (%) 480 (71) 1781 (79) <0.001 Body mass index 24.9±4 24.6±3.6 0.053 Hemoglobin A1c, % 7.4±1.4 6.7±1.1 <0.001 Coexisting condition, n (%) Hypertension 570 (84) 2248 (82) 0.19 Dyslipidemia 506 (75) 1791 (80) 0.007 ESRD (eGFR <30 mL/min per 1.73m2) not 36 (5.3) 57 (2.5) <0.001 on hemodialysis Hemodialysis 115 (17) 119 (5.3) <0.0001 Atrial fibrillation 46 (6.8) 144 (6.4) 0.71 Anemia (hemoglobin <11.0 g/dl) 168 (25) 281 (13) <0.001 Chronic obstructive pulmonary disease 11 (1.6) 47 (2.1) 0.45 Malignancy 40 (5.9) 169 (7.5) 0.16 Cardiac risk factor, n (%) Current smoker 120 (18) 446 (20) 0.23 Family history of coronary artery disease 112 (18) 342 (17) 0.35 Previous myocardial infarction 193 (29) 704 (31) 0.17 Previous stroke 86 (13) 278 (12) 0.81 Heart failure 145 (21) 315 (14) <0.001 Peripheral vascular disease 114 (17) 239 (11) <0.001 Previous percutaneous coronary intervention 375 (55) 1192 (53) 0.26 Previous coronary artery bypass grafting 62 (9.2) 117 (5.2) <0.001 Clinical characteristics, n (%) Clinical presentation Stable coronary artery disease 578 (86) 1868 (83) 0.32 Unstable angina 70 (10) 267 (12) Acute myocardial infarction 28 (4.1) 113 (5.0) Left ventricular ejection fraction <30% 17 (2.9) 49 (2.5) 0.57 Multivessel disease 387 (57) 1244 (55) 0.38 Target-vessel location, n (%) Left main coronary artery 26 (3.9) 69 (3.1) 0.32 Left anterior descending coronary artery 313 (46) 1077 (48) 0.46 Left circumflex coronary artery 178 (26) 609 (27) 0.70 Right coronary artery 224 (33) 725 (32) 0.67 Bypass graft 11 (1.6) 15 (0.7) 0.02 Complexity of coronary artery disease Number of treated lesions per patient 1.28±0.56 1.26±0.53 0.38 SYNTAX score Number of patients analyzed 566 1969 Median (interquartile range) 12 (7-17.5) 11 (6.75-17) 0.07 Tertiles, n (%) Low (<23) 487 (86) 1738 (88) 0.13 Intermediate (≥23 to <33) 57 (10) 184 (9.3) High (≥33) 22 (3.9) 47 (2.4) Medications, n (%) Aspirin 671 (99.3) 2242 (99.7) 0.08 Thienopyridines 670 (99.1) 2231 (99.2) 0.73 Clopidogrel 558 (83) 1908 (86) 0.09 Ticlopidine 111 (17) 310 (14) Statins 501 (74) 1735 (77) 0.10 β-blockers 268 (40) 863 (38) 0.56 ACE-I/ARB 456 (67) 1450 (65) 0.17 Calcium-channel blockers 307 (45) 1002 (45) 0.70</p><p>4 Nitrates 159 (676) 572 (25) 0.31 Warfarin 59 (8.7) 165 (7.3) 0.23 Pioglitazone 40 (5.9) 364 (16) <0.001 Data are presented as number (%) or mean ± SD, unless otherwise specified. Data are presented as number (%) or mean ± SD. ACE-I indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blockers; DM, diabetes mellitus; ESRD, end-stage renal disease; eGFR, estimated glomerular filtration rate; G1-DES, first-generation drug-eluting stents; G2-DES, second-generation drug- eluting stents; and SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery.</p><p>5 Supplemental Table 4. Lesion and Procedural Characteristics of the Entire Study Population; Insulin-Treated Versus Non-Insulin- Treated Diabetes Mellitus.</p><p>Insulin-Treated DM Non-Insulin-treated DM Variable P value (n = 676) (n = 2248) Number of lesions treated 866 2832 Before index procedure Lesion length, mm 18.7±13.3 (757) 18.9±12.6 (2459) 0.69 Reference vessel diameter, mm 2.47±0.59 (788) 2.56±0.6 (2600) <0.001 Minimum lumen diameter, mm 0.77±0.44 (791) 0.77±0.45 (2607) 0.87 Diameter stenosis, % 69.0±15.7 (791) 70.5±15.3 (2607) 0.02 Thrombus 17/791 (0.85) 59/2607 (2.3) 0.85 Chronic total occlusion 60/866 (6.9) 184/2832 (6.5) 0.65 In-stent restenosis 121/866 (14) 326/2832 (12) 0.052 Culprit for STEMI 18/866 (2.1) 73/2832 (2.6) 0.41 Bifurcation 322/808 (40) 1096/2674 (41) 0.56 Moderate or heavy calcification 195/792 (25) 545/2607 (21) 0.03 Small vessel (reference vessel diameter ≤2.75mm) 546/788 (69) 1683/2600 (65) 0.02 Long lesion (lesion length >18mm) 294/757 (39) 1022/2459 (42) 0.18 After index procedure Number of stents used Per patient 1.64±0.87 (674) 1.58±0.81 (2239) 0.12 Per lesion 1.33±0.62 (833) 1.29±0.57 (2731) 0.20 Total stent length, mm Per patient 34.8±21.7 (674) 33.2±20.3 (2238) 0.09 Per lesion 28.2±17 (833) 27.2±16 (2730) 0.16 Stent diameter, mm 2.87±0.51 (846) 2.90±0.56 (2788) 0.16 Multivessel treatment 87/676 (13) 286/2248 (13) 0.92 Direct stenting 150/833 (18) 652/2731 (24) <0.001 Maximum stent inflation pressure, atmosphere 17.4±4.5 (833) 17.2±4.3 (2731) 0.46 Postdilatation 626/846 (74) 2032/2788 (73) 0.52 Bifurcation 2-stent approach 8/511 (1.6) 27/1642 (1.6) 0.90 Intravascular ultrasound use 566/676 (84) 1939/2248 (86) 0.10 Received study stent only 825/866 (95.3) 2693/2832 (95.1) 0.84 Minimum Lumen diameter, mm In-stent 2.38±0.45 (788) 2.45±0.47 (2593) <0.001 In-segment 1.95±0.52 (790) 2.03±0.54 (2597) <0.001 Diameter stenosis, % In-stent 10.6±8.9 (788) 10.2±8.2 (2591) 0.20 In-segment 23.2±11.8 (790) 22.7±12 (2595) 0.28 Acute gain, mm In-stent 1.6±0.51 (787) 1.67±0.51 (2593) <0.001 In-segment 1.17±0.52 (789) 1.25±0.54 (2597) <0.001 Duration of procedure, min 72.1±2.6 (676) 71.6±44.2 (2248) 0.78 Successful outcome Lesion success by any treatment modalities 860/866 (99.3) 2812/2832 (99.3) 0.97 Lesion success by study stents (acute device 827/852 (97.1) 2701/2768 (97.6) 0.40 success) Procedural success (patient level) 654/676 (96.8) 2181/2248 (97.0) 0.72 Staged PCI procedures 172/676 (25) 604/2248 (27) 0.46 Data are presented as number (%) or mean ± SD. PCI indicates percutaneous coronary intervention; and STEMI, ST-segment elevation myocardial infarction. Other abbreviations are same as in Supplemental Table 1.</p><p>6 Supplemental Table 5. Baseline Patient Characteristics in Insulin-Treated and Non-Insulin-Treated Diabetes Mellitus: G1-DES Versus G2-DES.</p><p>Insulin-Treated DM Non-Insulin-Treated DM G1-DES G2-DES P G1-DES G2-DES P</p><p>(N = 163) (N = 513) value (N = 550) (N = 1698) value Age, years 67.6±10 67.3±9.9 0.80 69±9.4 68.9±9.1 0.79 Age ≥75 years, n (%) 37 (23) 127 (25) 0.59 492 (29) 168 (31) 0.48 Male gender, n (%) 114 (70) 366 (71) 0.73 431 (78) 1350 (80) 0.57 Body mass index 24.8±3.7 25±4.1 0.49 24.7±3.7 24.6±3.6 0.47 Hemoglobin A1c, % 7.5±1.3 7.4±1.4 0.48 6.7±1.1 6.7±1.1 0.67 Coexisting condition, n (%) Hypertension 139 (85) 431 (84) 0.70 450 (82) 1396 (82) 0.83 Dyslipidemia 113 (69) 393 (77) 0.06 430 (78) 1361 (80) 0.32 ESRD (eGFR <30 mL/min per 1.73m2) not on 7 (4.3) 29 (5.7) 0.69 15 (2.7) 42 (2.5) 0.76 hemodialysis Hemodialysis 30 (18) 85 (17) 0.59 23 (4.2) 96 (5.7) 0.18 Atrial fibrillation 11 (6.8) 35 (6.8) 0.97 39 (7.1) 105 (6.2) 0.45 Anemia (hemoglobin <11.0 g/dl) 40 (25) 128 (25) 0.91 73 (13) 208 (12) 0.52 Chronic obstructive pulmonary disease 4 (2.5) 7 (1.4) 0.31 8 (1.5) 39 (2.3) 0.30 Malignancy 12 (7.4) 28 (5.5) 0.37 42 (7.6) 127 (7.5) 0.90 Cardiac risk factor, n (%) Current smoker 26 (16) 94 (18) 0.49 108 (20) 338 (20) 0.89 Family history of coronary artery disease 31 (24) 81 (17) 0.07 91 (19) 251 (16) 0.08 Previous myocardial infarction 54 (33) 139 (27) 0.14 196 (36) 508 (30) 0.01 Previous stroke 19 (12) 67 (13) 0.64 62 (11) 216 (13) 0.37 Heart failure 33 (20) 112 (22) 0.67 83 (15) 232 (14) 0.40 Peripheral vascular disease 29 (18) 85 (17) 0.72 44 (8.0) 195 (11) 0.02 Previous percutaneous coronary intervention 94 (58) 281 (55) 0.52 308 (56) 884 (52) 0.11 Previous coronary artery bypass grafting 15 (9.2) 47 (9.2) 0.99 45 (8.2) 72 (4.2) <0.001 Clinical characteristics, n (%) Clinical presentation Stable coronary artery disease 141 (87) 437 (85) 0.91 450 (82) 1418 (84) 0.006 Unstable angina 16 (9.8) 54 (11) 82 (15) 185 (11) Acute myocardial infarction 6 (3.7) 22 (4.3) 18 (3.3) 95 (5.6) Left ventricular ejection fraction <30% 7 (5.0) 10 (2.3) 0.09 15 (3.1) 34 (2.3) 0.34 Multivessel disease 95 (58) 292 (57) 0.76 293 (53) 951 (56) 0.26 Target-vessel location, n (%) Left main coronary artery 4 (2.5) 22 (4.3) 0.36 16 (2.9) 53 (3.1) 0.89 Left anterior descending coronary artery 79 (48) 234 (46) 0.52 264 (48) 813 (48) 0.96 Left circumflex coronary artery 44 (27) 134 (26) 0.83 141 (26) 468 (28) 0.38 Right coronary artery 51 (31) 173 (34) 0.57 171 (31) 554 (33) 0.50 Bypass graft 4 (2.5) 7 (1.4) 0.34 4 (0.7) 11 (0.7) 0.84 Complexity of coronary artery disease No. of treated lesions per patient 1.31±0.56 1.27±0.56 0.50 1.23±0.48 1.27±0.55 0.06 SYNTAX score No. of patients analyzed 130 436 444 1525 Median (interquartile range) 11.5 (7.75-16.5) 7 (7-18) 0.90 10 (6-16) 11 (7-17.25) 0.02 Tertiles, n (%) Low (<23) 117 (90) 370 (85) 0.03 404 (91) 1334 (87) 0.13 Intermediate (≥23 to <33) 13 (10) 44 (10) 32 (7.2) 152 (10) High (≥33) 0 22 (5.1) 8 (1.8) 39 (2.6) Medications, n (%) Aspirin 161 (98.8) 510 (99.4) 0.40 547 (99.5) 1695 (99.8) 0.15 Thienopyridines 161 (98.8) 509 (99.2) 0.60 542 (98.6) 1689 (99.5) 0.03 Clopidogrel 134 (83) 424 (83) 0.94 468 (86) 1440 (86) 0.80 Ticlopidine 27 (17) 84 (17) 74 (14) 236 (14) Statins 117 (72) 384 (75) 0.44 433 (79) 1302 (77) 0.32 β-blockers 59 (36) 209 (41) 0.30 210 (38) 653 (38) 0.91 ACE-I/ARB 111 (68) 345 (67) 0.84 348 (63) 1102 (65) 0.47 7 Calcium-channel blockers 77 (47) 230 (45) 0.59 248 (45) 754 (44) 0.78 Nitrates 50 (31) 109 (21) 0.01 161 (29) 411 (24) 0.02 Warfarin 16 (9.8) 43 (8.4) 0.57 46 (8.4) 119 (7.0) 0.29 Pioglitazone 6 (3.7) 34 (6.6) 0.16 114 (21) 250 (15) <0.001 Data are presented as number (%) or mean ± SD, unless otherwise specified. ACE-I indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blockers; DM, diabetes mellitus; ESRD, end-stage renal disease; eGFR, estimated glomerular filtration rate; G1-DES, first-generation drug-eluting stents; G2-DES, second-generation drug-eluting stents; and SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery.</p><p>8 Supplemental Table 6. Lesion and Procedural Characteristics in Insulin-Treated and Non-Insulin-Treated Diabetes Mellitus: G1- DES Versus G2-DES.</p><p>Insulin-Treated DM Non- Insulin-Treated DM P G1-DES G2-DES G1-DES G2-DES P valu (N = 163) (N = 513) (N = 550) (N = 1698) value e Number of lesions treated 213 653 674 2158 Before index procedure 19.2±13.9 16.6±10.5 Lesion length, mm 17±10.9 (178) 0.02 18±11.9 (2888) <0.001 (579) (933) Reference vessel diameter, mm 2.44±0.56 (187) 2.48±0.6 (601) 0.37 2.6±0.65 (985) 2.65±0.59 (3043) 0.04 0.76±0.43 0.81±0.46 Minimum lumen diameter, mm 0.81±0.45 (189) 0.19 0.8±0.45 (3050) 0.41 (602) (986) 69.8±15.3 69.2±16.1 Diameter stenosis, % 66.7±16.8 (189) 0.03 70.3±15.1 (3049) 0.049 (602) (986) Thrombus 15/602 (2.5) 2/189 (1.1) 0.39 102/3050 (3.3) 45/986 (4.6) 0.08 Chronic total occlusion 17/213 (8.0) 43/653 (6.6) 0.49 43/674 (6.4) 141/2158 (6.5) 0.89 In-stent restenosis 26/213 (12) 95/653 (15) 0.39 90/674 (13) 236/2158 (11) 0.09 Culprit for STEMI 3/213 (1.4) 15/653 (2.3) 0.58 9/674 (1.3) 64/2158 (3.0) 0.02 Bifurcation 245/619 (40) 77/189 (41) 0.78 390/986 (40) 1305/3128 (42) 0.23 Moderate or heavy calcification 39/189 (21) 156/603 (26) 0.14 119/608 (20) 426/1999 (21) 0.36 Small vessel (reference vessel diameter ≤2.75mm) 137/187 (73) 409/601 (68) 0.18 622/985 (63) 1818/3043 (60) 0.06 Long lesion (lesion length >18mm) 231/579 (40) 63/178 (35) 0.28 296/933 (32) 1088/2888 (38) 0.001 After index procedure Number of stents used 1.66±0.89 1.49±0.69 Per patient 1.56±0.76 (162) 0.13 1.61±0.84 (1693) 0.002 (512) (546) 1.35±0.65 1.25±0.51 Per lesion 1.24±0.49 (204) 0.006 1.31±0.59 (2078) 0.01 (629) (653) Total stent length, mm 31.8±18.2 Per patient 34.2±20.1 (162) 35±22.2 (512) 0.67 33.7±20.9 (1692) 0.04 (546) 28.5±17.6 26.6±15.4 Per lesion 27.2±14.9 (204) 0.29 27.5±16.2 (2077) 0.20 (629) (653) 2.95±0.37 Stent diameter, mm 2.9±0.37 (204) 2.87±0.55 0.26 2.89±0.61 (2135) <0.001 (653) Multivessel treatment 21/163 (13) 66/513 (13) 0.995 60/550 (11) 226/1698 (13) 0.14 Direct stenting 42/204 (21) 108/629 (17) 0.27 149/653 (23) 503/2078 (24) 0.47 Maximum stent inflation pressure, atmosphere 18.1±4.2 (204) 17.1±4.6 (629) 0.005 18.1±3.8 (653) 17.0±4.4 (2078) <0.001 Postdilatation 151/204 (74) 475/642 (74) 0.99 487/653 (75) 1545/2135 (72) 0.27 Bifurcation 2-stent approach 1/213 (0.5) 7/298 (2.4) 0.15 5/674 (0.7) 22/968 (2.3) 0.02 Intravascular ultrasound use 131/163 (80) 435/513 (85) 0.18 459/550 (83) 1480/1698 (87) 0.03 Received study stent only 201/213 (94) 624/653 (96) 0.48 637/674 (95) 2056/2158 (95) 0.42 Minimum Lumen diameter, mm 2.38±0.45 2.48±0.46 In-stent 2.35±0.48 (188) 0.42 2.52±0.48 (3031) 0.03 (600) (977) 1.95±0.52 2.08±0.54 In-segment 1.95±0.51 (188) 0.96 2.12±0.55 (3037) 0.10 (602) (977) Diameter stenosis, % In-stent 11.2±8.9 (188) 10.5±8.8 (600) 0.34 10.6±8.2 (977) 10±8.1 (3030) 0.049 23.1±12.2 In-segment 23.6±10.6 (188) 0.53 22.6±11.6 (977) 21.3±11.7 (3036) 0.003 (602) Acute gain, mm 1.62±0.48 1.67±0.52 In-stent 1.54±0.59 (188) 0.09 1.72±0.53 (3031) 0.007 (599) (977) 1.27±0.57 In-segment 1.13±0.56 (188) 1.19±0.5 (601) 0.25 1.32±0.56 (3037) 0.02 (977) 71.1±42.7 70.1±44.1 Duration of procedure, min 75.4±42.4 (163) 0.26 72.1±44.3 (1698) 0.34 (513) (550) Successful outcome Lesion success by any treatment modalities 211/213 (99.1) 649/653 (99.4) 0.62 666/674 (98.8) 2146/2158 (99.4) 0.11 Lesion success by study stents (acute device 201/213 (94) 623/639 (98.0) 0.007 640/674 (95) 2061/2094 (98.4) <0.001 success) Procedural success (patient level) 158/163 (96.9) 496/513 (96.7) 0.88 533/550 (96.9) 1648/1698 (97.1) 0.86</p><p>9 Staged PCI procedures 40/163 (25) 132/513 (26) 0.76 143/550 (26) 461/1698 (27) 0.60 Data are presented as number (%) or mean ± SD. Stent implantation was not attempted in 17 patients (G1-DES: 9 patients and G2-DES: 8 patients) because of guidewire failure, undilatable lesions, or complications. Non-study stents were attempted without attempt of the study stent in 19 patients (G1-DES: 7 patients and G2-DES: 12 patients; protocol violation). PCI indicates percutaneous coronary intervention; and STEMI, ST-segment elevation myocardial infarction. Other abbreviations are same as in Table 1.</p><p>10 Supplemental Table 7. Angiographic Results at 8-month in Patients Enrolled in the Angiographic Substudy: G1-DES versus G2-DES.</p><p>Non-DM DM G1-DES G2-DES P G1-DES G2-DES P</p><p>145 411 103 285 Number of patients 165 505 120 362 Number of lesions</p><p>8-month 280±51 (165) 268±54 (503) 0.01 278±58 (120) 271±57 (361) 0.28 Study interval, days 2.7±0.43 (165) 2.66±0.5 (503) 0.25 2.66±0.24 (118) 2.59±0.53 (360) 0.24 Reference vessel diameter, mm</p><p>Minimum lumen diameter, mm 2.39±0.44 (165) 2.36±0.5 (502) 0.43 2.26±0.57 (118) 2.27±0.55 (360) 0.92 In-stent 2.08±0.46 (165) 2.04±0.54 (503) 0.31 1.97±0.56 (118) 1.94±0.57 (361) 0.57 In-segment</p><p>Percent diameter stenosis, % 13.6±10.6 (165) 14±12 (502) 0.63 17.1±16.1 (118) 14.9±13.8 (360) 0.19 In-stent 23±11.8 (165) 23.3±14.4 (503) 0.80 25.4±16.8 (118) 25.3±16.9 (361) 0.95 In-segment</p><p>Late loss, mm 0.11±0.33 (165) 0.14±0.35 (501) 0.37 0.17±0.45 (118) 0.18±0.38 (360) 0.81 In-stent 0.04±0.5 (118) 0.06±0.44 (503) 0.27 0.04±0.5 (118) 0.06±0.44 (361) 0.80 In-segment Data are presented as number (%) or mean ± SD, unless otherwise specified. DM indicates diabetes mellitus; G1-DES, first-generation drug-eluting stents; and G2-DES, second-generation drug-eluting stents.</p><p>11 Supplementary Figure legend</p><p>Supplemantary Figure 1. Cumulative 3-year incidences of TLR in the non-DM and DM strata and in the ITDM and non-ITDM patients: SES versus EES versus BES.</p><p>BES, biolimus-eluting stent; DM, diabetes mellitus; EES, everolimus-eluting stent; PCI, percutaneous coronary intervention; SES, sirolimus-eluting stent: and TLR, target-lesion revascularization. </p><p>12 Supplementary Figure 1(A)</p><p>13 Supplementary Figure 1(B)</p><p>14 Supplementary Figure 1(C)</p><p>15 Supplementary Figure 1(D)</p><p>16 Supplemental Appendix</p><p>Supplemental Appendix A. List of the participating centers and the investigators of RESET trial</p><p>Caress Sappro Tokeidai Memorial Hospital: Kazushi Urasawa, Ryoji Koshida</p><p>Teine Keijinkai Hospital: Mitsugu Hirokami</p><p>Cardio-vascular Center Hokkaido Ohno Hospital: Takehiro Yamashita, Masato Nagashima</p><p>Caress Sappro Hokko Memorial Hospital: Yoichi Nozaki</p><p>Hokkaido Social Insurance Hospital: Keiichi Igarashi, Jungo Furuya</p><p>Aomori Prefectural Central Hospital: Fuminobu Yoshimachi, Yukinori Sakamoto</p><p>Iwate Prefectural Central Hospital: Akihiro Nakamura, Shigefumi Fukui</p><p>Iwate Medical University Hospital: Tomonori Itoh</p><p>Sendai Kosuei Hospital: Naoto Inoue, Kaname Takizawa</p><p>Tohoku Kousei Nenkin Hospital: Yoshiaki Katahira, Takao Nakano</p><p>Sendai Open Hospital: Atsushi Kato</p><p>Iwaki Kyoritsu General Hospital: Yoshito Yamamoto, Tomohiro Tada</p><p>Fukushima Medical University Hospital: Yasuchika Takeishi, Kazuhiko Nakazato</p><p>Hoshi General Hospital: Mikihiro Kijima, Yuichi Ujiie</p><p>Ohta Nishinouchi Hospital: Nobuo Komatsu, Goro Ishida</p><p>Saiseikai Kurihashi Hospital: Yoshimi Ota, Atsushi Honda</p><p>Saitama Cardiovascular And Respiratory Center: Makoto Muto, Tetsuya Ishikawa</p><p>Dokkyo Medical University Koshigaya Hospital: Takaaki Komatsu</p><p>Jikei University Kashiwa Hospital: Mitsuyuki Shimizu, Yoshiki Uehara</p><p>Juntendo University Hospital: Hiroyuki Daida, Katsumi Miyauchi</p><p>Sakakibara Memorial Hospital: Tetsuya Sumiyoshi, Ryuta Asano</p><p>NTT Medical Center Tokyo: Masao Yamasaki</p><p>The Cardiovascular Institute Hospital: Junji Yajima, Ryuichi Funada</p><p>Mitsui Memorial Hospital: Kengo Tanabe, Masanori Taniwaki</p><p>Tokyo Medical University Hospital: Nobuhiro Tanaka, Masashi Ogawa</p><p>Teikyo University Hospital: Akiyoshi Miyazawa, Ken Kozuma, Nobuaki Suzuki</p><p>Tokyo Women's Medical University Hospital: Nobuhisa Hagiwara, Fumiaki Mori</p><p>The Jikei University Hospital: Takayuki Ogawa, Kazuo Ogawa</p><p>Juntendo University Nerima Hospital: Masataka Sumiyoshi, Shinya Okazaki</p><p>Tokyo Metropolitan Hiroo General Hospital: Tamotsu Tejima, Yasuhiro Tanabe</p><p>St. Luke's International Hospital: Yutaro Nishi</p><p>Itabashi Chuo General Hospital: Hiroshi Ohta</p><p>Saiseikai Yokohama-city Eastern Hospital: Toshiya Muramatsu, Hiroshi Ishimori</p><p>Yokohama Rosai Hospital: Kenichi Kato, Kazuhiko Yumoto</p><p>17 Tokai University Hospital: Yoshihiro Morino</p><p>Yokohama City University Medical Center: Kazuo Kimura, Kiyoshi Hibi</p><p>Kitasato University Hospital: Taiki Tojo, Takao Shimohama</p><p>Kanazawa Cardiovascular Hospital: Masanobu Namura, Yuki Horita</p><p>University of Fukui Hospital: Jong-Dae Lee, Akira Nakano</p><p>Fukui Cardio Vascular Center: Sumio Mizuno, Katsushi Misawa</p><p>Juntendo University Shizuoka Hospital: Satoru Suwa</p><p>Shizuoka City Shizuoka Hospital: Tomoya Onodera, Ryosuke Takeuchi</p><p>Shizuoka General Hospital: Osamu Doi, Satoshi Kaburagi</p><p>Okamura Memorial Hospital: Yasuhiro Tarutani</p><p>Seirei Hamamatsu General Hospital: Hisayuki Okada</p><p>Hamamatsu Medical Center: Masakazu Kobayashi, Yohei Takayama</p><p>Toyohashi Heart Center: Takahiko Suzuki, Masashi Kimura</p><p>Aichi Medical University Hospital: Takayuki Ito, Hiroaki Takashima</p><p>Tosei General Hospital: Hiroshi Asano</p><p>Nagoya Daini Red Cross Hospital: Haruo Hirayama, Mamoru Nanasato, Yasushi Tatematsu</p><p>Toyota Memorial Hospital: Hisashi Umeda</p><p>Nagoya Kyoritsu Hospital: Toru Aoyama</p><p>Fujita Health University Hospital: Yukio Ozaki, Hiroyuki Naruse</p><p>Matsusaka Chuo General Hospital: Masatoshi Miyahara</p><p>Nagai Hospital: Kozo Hoshino</p><p>Mie University Hospital: Takashi Tanigawa</p><p>Mie Heart Center: Hideo Nishikawa, Hiroyuki Suzuki</p><p>Yokkaichi Social Insurance Hospital: Masaki Kawamura</p><p>Koto Memorial Hospital: Teruki Takeda</p><p>Shiga University of Medical Science Hospital: Takashi Yamamoto</p><p>Kyoto University Hospital: Takeshi Kimura, Hiroki Shiomi</p><p>Mitsubishi Kyoto Hospital: Shinji Miki, Tetsu Mizoguchi</p><p>National Hospital Organization Kyoto Medical Center: Mitsuru Abe</p><p>Kyoto Second Red Cross Hospital: Hiroshi Fujita</p><p>Sakurabashi Watanabe Hospital: Kenji Fujii</p><p>Osaka City General Hospital: Akira Itoh, Kazuhiro Osawa</p><p>Osaka Saiseikai Noe Hospital: Shunsuke Take, Shiho Koyama</p><p>Osaka City University Hospital: Minoru Yoshiyama, Satoshi Nishimura</p><p>Osaka Red Cross Hospital: Tsukasa Inada, Fujio Hayashi</p><p>National Cerebral and Cardiovascular Center: Hiroshi Nonogi, Eiji Tada</p><p>18 Sumitomo Hospital: Yuji Yasuga, Nobuhiro Mitsusada</p><p>Higashisumiyoshi Morimoto Hospital: Yuji Sakanoue</p><p>Kansai Denryoku Hospital: Katsuhisa Ishii, Kazuaki Kataoka</p><p>Kobe City Medical Center General Hospital: Makoto Kinoshita</p><p>Kobe University Hospital: Junya Shite, Hirotoshi Hariki</p><p>Kansai Rosai Hospital: Masaaki Uematsu, Masaki Awata</p><p>Hyogo Prefectural Amagasaki Hospital: Yoshiki Takatsu, Ryoji Taniguchi</p><p>Hyogo College of Medicine Hospital: Motomaru Masutani</p><p>Tenri Hospital: Yoshihisa Nakagawa, Hirokazu Kondo</p><p>Nara Medical University Hospital: Shiro Uemura, Kenichi Ishigami</p><p>Japanese Red Cross Society Wakayama Medical Center: Takashi Tamura, Hiroki Sakamoto</p><p>Wakayama Medical University Hospital: Takashi Akasaka, Hironori Kitabata</p><p>Tottori University Hospital: Masahiko Kato, Yoshiyuki Furuse</p><p>Matsue Red Cross Hospital: Kinya Shirota, Asao Mimura</p><p>The Sakakibara Heart Institute of Okayama: Keizou Yamamoto, Hiroyuki Takinami</p><p>Kurashiki Central Hospital: Kazushige Kadota, Hiroyuki Tanaka</p><p>Kawasaki Medical School Hospital: Hiroyuki Okura, Yoji Neishi</p><p>Okayama University Hospital: Hiroshi Ito, Yoshiki Hata</p><p>Hiroshima City Hospital: Masaharu Ishihara, Kazuoki Dai</p><p>Fukuyama Cardiovascular Hospital: Seiichi Haruta, Hideo Takebayashi</p><p>Tsuchiya General Hospital: Mamoru Toyofuku</p><p>Chikamori Hospital: Kazuya Kawai, Shuichi Seki</p><p>University Of Occupational And Environmental Health Japan: Shinjo Sonoda, Yoshitaka Muraoka</p><p>Kurume University Hospital: Takafumi Ueno, Seiji Kanaya</p><p>Kokura Memorial Hospital: Masashi Iwabuchi, Shinichi Shirai</p><p>Kouseikai Hospital: Yoshihiro Iwasaki</p><p>Saiseikai Kumamoto Hospital: Koichi Nakao</p><p>Kumamoto Rousai Hospital: Toshiyuki Matsumura, Sei Nakata</p><p>Miyazaki Medical Association Hospital: Yoshisato Shibata, Nehiro Kuriyama</p><p>Kagoshima Medical Center: Hitoshi Nakashima, Yasuhisa Iriki</p><p>19 Supplemental Appendix B. List of the participating centers and the investigators of NEXT trial</p><p>Caress Sapporo Tokeidai Memorial Hospital: Kazushi Urasawa, Ryoji Koshida</p><p>Oji General Hospital: Katsuhisa Ishii, Nobuo Kato</p><p>Hokkaido Junkanki Hospital: Daisuke Hotta, Masaru Yamaki</p><p>Teine Keijinkai Hospital: Mitsugu Hirokami</p><p>Cardio-vascular Center Hokkaido Ohno Hospital: Takehiro Yamashita, Masato Nagashima</p><p>Caress Sapporo Hokko Memorial Hospital: Yoichi Nozaki</p><p>Hokkaido Social Insurance Hospital: Keiichi Igarashi, Jungo Furuya</p><p>Aomori Prefectural Central Hospital: Fuminobu Yoshimachi, Dai Miura, Yoshihisa Aida, Yukinori Sakamoto</p><p>Iwate Prefectural Central Hospital: Akihiro Nakamura, Shigefumi Fukui</p><p>Iwate Medical University Hospital: Tetsuya Fusazaki</p><p>Tohoku Kousei Nenkin Hospital: Yoshiaki Katahira, Takao Nakano</p><p>Sendai Open Hospital: Atsushi Kato, Toru Takii</p><p>Iwaki Kyoritsu General Hospital: Yoshito Yamamoto, Tomohiro Tada </p><p>Fukushima Medical University Hospital: Yasuchika Takeishi, Kazuhiko Nakazato</p><p>Saiseikai Kurihashi Hospital: Yoshimi Ota, Atsushi Honda</p><p>Saitama Cardiovascular and Respiratory Center: Tetsuya Ishikawa, Takuro Fujii</p><p>Dokkyo Medical University Koshigaya Hospital: Takaaki Komatsu</p><p>New Tokyo Hospital: Sunao Nakamura, Naoyuki Kurita</p><p>Juntendo University Hospital: Hiroyuki Daida, Katsumi Miyauchi</p><p>Sakakibara Memorial Hospital: Itaru Takamisawa</p><p>NTT Medical Center Tokyo: Masao Yamasaki</p><p>The Cardiovascular Institute Hospital: Junji Yajima, Shingo Tanaka, Ryuichi Funada</p><p>Mitsui Memorial Hospital: Kengo Tanabe, Yoshifumi Nakajima</p><p>Tokyo Medical University Hospital: Nobuhiro Tanaka, Masashi Ogawa</p><p>Teikyo University Hospital: Ken Kozuma, Nobuaki Suzuki</p><p>Tokyo Women's Medical University Hospital: Nobuhisa Hagiwara, Fumiaki Mori</p><p>Juntendo University Nerima Hospital: Masataka Sumiyoshi, Kenji Inoue, Shinya Okazaki</p><p>Itabashi Chuo Medical Center: Hiroshi Ohta</p><p>Saiseikai Yokohama-City Eastern Hospital: Toshiya Muramatsu, Hiroshi Ishimori</p><p>Kanto Rosai Hospital: Atsuo Namiki</p><p>Yokohama Rosai Hospital: Kenichi Kato, Kazuhiko Yumoto</p><p>Tokai University Hospital: Nobuhiko Ogata, Shou Torii</p><p>Yokohama City University Medical Center: Kazuo Kimura, Kiyoshi Hibi</p><p>Kitasato University Hospital: Taiki Tojo, Takao Shimohama</p><p>Kanazawa Cardiovascular Hospital: Masanobu Namura, Yuki Horita</p><p>20 University of Fukui Hospital: Jong-Dae Lee, Hiroyasu Uzui, Akira Nakano</p><p>Fukui Cardiovascular Center: Sumio Mizuno, Katsushi Misawa</p><p>Ogaki Municipal Hospital: Hiroaki Mukawa, Yohei Shibata</p><p>Juntendo University Shizuoka Hospital: Satoru Suwa</p><p>Shizuoka General Hospital: Osamu Doi, Hideaki Moriwaki</p><p>Okamura Memorial Hospital: Yasuhiro Tarutani</p><p>Seirei Hamamatsu General Hospital: Hisayuki Okada</p><p>Hamamatsu Medical Center: Masakazu Kobayashi, Terumori Sato, Yohei Takayama</p><p>Aichi Medical University Hospital: Hiroaki Takashima, Takayuki Ito</p><p>Tosei General Hospital: Masayoshi Ajioka, Yosuke Murase</p><p>Toyota Memorial Hospital: Hisashi Umeda, Kazutaka Hayashi</p><p>Fujita Health University Hospital: Yukio Ozaki, Hiroyuki Naruse</p><p>Japanese Red Cross Nagoya Daini Hospital: Haruo Hirayama, Yasushi Tatematsu</p><p>Chubu Rosai Hospital: Tetsuya Amano, Tomohiro Yoshida</p><p>Nagai Hospital: Kozo Hoshino</p><p>Mie University Hospital: Takashi Tanigawa</p><p>Mie Heart Center: Hideo Nishikawa, Hiroyuki Suzuki</p><p>Yokkaichi Social Insurance Hospital: Masaki Kawamura, Takashi Yamanaka</p><p>Koto Memorial Hospital: Teruki Takeda</p><p>Shiga University of Medical Science Hospital: Takashi Yamamoto</p><p>Kyoto University Hospital: Takeshi Kimura, Masahiro Natsuaki</p><p>Mitsubishi Kyoto Hospital: Shinji Miki, Tetsu Mizoguchi</p><p>National Hospital Organization Kyoto Medical Center: Masaharu Akao, Mitsuru Abe</p><p>Kyoto Second Red Cross Hospital: Hiroshi Fujita</p><p>Osaka University Hospital: Shinsuke Nanto, Masahiro Kumada</p><p>Sakurabashi Watanabe Hospital: Kenji Fujii</p><p>Osaka City General Hospital: Akira Itoh</p><p>Osaka Saiseikai Noe Hospital: Shunsuke Take, Yoshihiro Kato, Shiho Koyama</p><p>Osaka City University Hospital: Takao Hasegawa, Tomokazu Iguchi</p><p>Osaka Red Cross Hospital: Tsukasa Inada, Fujio Hayashi</p><p>National Cerebral and Cardiovascular Center: Hiroki Sakamoto</p><p>Sumitomo Hospital: Yuji Yasuga, Nobuhiro Mitsusada</p><p>Higashisumiyoshi Morimoto Hospital: Yuji Sakanoue</p><p>Kobe City Medical Center General Hospital: Natsuhiko Ehara</p><p>Kobe University Hospital: Toshihiro Shinke, Takumi Inoue, Junya Shite</p><p>Kansai Rosai Hospital: Masaki Awata</p><p>21 Hyogo Prefectural Amagasaki Hospital: Yoshiki Takatsu, Ryoji Taniguchi</p><p>Hyogo College of Medicine Hospital: Motomaru Masutani</p><p>Tenri Hospital: Yoshihisa Nakagawa, Toshihiro Tamura</p><p>Japanese Red Cross Society Wakayama Medical Center: Takashi Tamura, Yuichi Kawase</p><p>Wakayama Medical University Hospital: Takashi Akasaka, Yasushi Ino, Hironori Kitabata</p><p>Tottori University Hospital: Masahiko Kato, Yoshiyuki Furuse</p><p>Matsue Red Cross Hospital: Kinya Shirota</p><p>The Sakakibara Heart Institute of Okayama: Atsushi Hirohata, Eiki Hirose</p><p>Kurashiki Central Hospital: Kazushige Kadota, Seiji Habara</p><p>Kawasaki Medical School Hospital: Hiroyuki Okura, Yoji Neishi</p><p>Hiroshima City Hospital: Masaharu Ishihara, Yasuharu Nakama</p><p>Fukuyama Cardiovascular Hospital: Hideo Takebayashi, Kenji Goto</p><p>Tsuchiya General Hospital: Nobuo Shiode, Masaya Otsuka, Mamoru Toyofuku</p><p>Iwakuni Clinical Center: Satoru Sakuragi</p><p>Chikamori Hospital: Kazuya Kawai, Shuichi Seki</p><p>University of Occupational and Environmental Health Japan: Shinjo Sonoda </p><p>Fukuoka Wajiro Hospital: Taro Saito, Yoritaka Otsuka</p><p>Kurume University Hospital: Takafumi Ueno, Yoshiaki Mitsutake</p><p>Kokura Memorial Hospital: Masashi Iwabuchi, Shinichi Shirai</p><p>Kouseikai Hospital: Yoshihiro Iwasaki</p><p>Saiseikai Kumamoto Hospital: Koichi Nakao, Shinzo Miyamoto</p><p>National Hospital Organization Kumamoto Medical Center: Kazuteru Fujimoto</p><p>Kumamoto Rousai Hospital: Toshiyuki Matsumura, Takuo Tsurugi</p><p>Miyazaki Medical Association Hospital: Yoshisato Shibata, Nehiro Kuriyama</p><p>Tenyokai Central Hospital: Hiroshi Yamaguchi, Junichiro Takaoka</p><p>National Hospital Organization Kagoshima Medical Center: Hitoshi Nakashima, Tetsuro Kataoka</p><p>Bell Land General Hospital: Toru Kataoka</p><p>Sponsor: Abbott Vascular and Terumo.</p><p>22</p>