<p>eFigure2: Nomogram relating predictors to the hippocampal volume</p><p>Description:</p><p>Nomogram relating predictors to the hippocampal volume. This nomogram is not complete, “in that point scores are obtained for each predictor and the user must add the point scores manually before reading predicted values on the final axis of the nomogram.” (Harrell)</p><p>1 For example, a 35 years old man with a diastolic blood pressure of 70 mmHg gets 97 points for his age, 22 points for being male, and 20 points for his diastolic blood pressure. These 139 points correspond to a hippocampal volume of 3450 mm³, assuming that variables other than age, gender, and diastolic blood pressure contributes zero points (body height=160cm,</p><p>HbA1c=15% and so on).</p><p>Points per unit of linear predictor: 0.1072908 Linear predictor units per point : 9.320463 </p><p> age Points 20 100 25 99 30 98 35 97 40 95 45 92 50 88 55 83 60 76 65 67 70 54 75 41 80 27 85 14 90 0 </p><p> gender Points men 22 women 0 </p><p> body height Points 135 1 140 1 145 1 150 0 155 0 160 0 165 3 170 8 175 14 180 20 185 25 190 31 195 36 200 42 205 47 </p><p>2 diastolic blood pressure Points 40 15 50 17 60 18 70 19 80 19 90 16 100 12 110 8 120 4 130 0 antihypertensive medication Points no 3 yes 0 </p><p>HbA1c Points 2 11 3 16 4 20 5 24 6 21 7 19 8 16 9 14 10 12 11 9 12 7 13 5 14 2 15 0 antidiabetics Points no 4 yes 0 </p><p>HDL-cholesterol Points 0.0 0 0.2 0 0.4 0 0.6 0 0.8 0 1.0 0 1.2 0 1.4 0 1.6 1 3 1.8 3 2.0 4 2.2 6 2.4 7 2.6 9 2.8 10 3.0 12 </p><p>LDL-cholesterol Points 0.5 0 1.0 1 1.5 2 2.0 3 2.5 4 3.0 5 3.5 5 4.0 6 4.5 6 5.0 6 5.5 6 6.0 6 6.5 6 7.0 6 7.5 6 lipid lowering drugs Points no 2 yes 0 waist circumference Points 50 0 60 3 70 5 80 8 90 9 100 9 110 9 120 8 130 7 140 6 150 5 physical activity Points no 0 >0-2h per week 4 >2h per week 2 </p><p>4 education Points <10 years 0 10 years 2 >10 years 7 smoking-nicotine Points no 6 yes 0 alcohol consumption Points 0 12 20 10 40 9 60 8 80 7 100 6 120 4 140 3 160 2 180 1 200 0 lifetime depressive disorder Points no 0 yes 0 antidepressants Points no 7 yes 0 study Points TREND-0 0 SHIP-2 0 </p><p>5</p>