<p>Supplementary Table 3: List of signal transduction-associated genes up- and down- regulated upon treatment with ionizing radiation and PKC 412 or Ro 31-8220</p><p>Down-regulated genes upon treatment with IR+PKC 412 </p><p>MAS1 MAS1 oncogene KCNH8 Potassium voltage-gated channel, subfamily H member 8 WNT16 Wingless-type MMTV integration site family, member 16 RPIP8 RaP2 interacting protein 8 ADCYAP1 Adenylate cyclase activating polypeptide 1 (pituitary) NPAS2 Neuronal PAS domain protein 2 DKFZp686G1344 Signal-induced proliferation-associated 1 like 1 CRABP1 Cellular retinoic acid binding protein 1 PRKCA Protein kinase C, alpha NPHP1 Nephronophthisis 1 (juvenile) GNAL Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type RASAL2 RAS protein activator-like 2</p><p>Down-regulated genes upon treatment with IR+Ro 31-8220</p><p>TRIB1 Phosphoprotein regulated by mitogenic pathways ARF6 ADP-ribosylation factor 6 TRAF6 TNF receptor-associated factor 6 SPRY2 Sprouty homolog 2 (Drosophila) CXCL3 Chemokine (C-X-C motif) ligand 3 CASP8AP2 CASP8 associated protein 2 RHOH Ras homolog gene family, member H NR2F2 Nuclear receptor subfamily 2, group F, member 2 ADRB2 Adrenergic, beta-2-, receptor, surface FLJ12875 Hypothetical protein FLJ12875 P2RY6 Pyrimidinergic receptor P2Y, G-protein coupled, 6 C21orf107 Chromosome 21 open reading frame 107 FZD7 Frizzled homolog 7 (Drosophila) PXN Paxillin (PXN), mRNA PRKY Protein kinase, Y-linked FZD2 Frizzled homolog 2 (Drosophila) FGD2 FGD1 family, member 2 NR2F6 Nuclear receptor subfamily 2, group F, member 6 NR4A2 Nuclear receptor subfamily 4, group A, member 2 LU Lutheran blood group (Auberger b antigen included) ARHGAP6 Rho GTPase activating protein 6 NR4A2 Nuclear receptor subfamily 4, group A, member 2 NAB2 Signal transducer and activator of transcription 6, interleukin-4 induced ARHGAP11 A similar to human GTPase-activating protein RAB33A RAB33A, member RAS oncogene family BCAR1 Breast cancer anti-estrogen resistance 1 ADRBK1 Adrenergic beta-receptor kinase 1 Up-regulated genes upon treatment with IR+PKC 412 </p><p>NTS Neurotensin ARNT Homo sapiens mRNA; cDNA DKFZp434J1416 (from clone DKFZp434J1416) GULP1 GULP, Engulfment adaptor PTB domain containing 1 ITGB1BP2 Integrin beta 1 binding protein (melusin) 2 WNT7A Wingless-type MMTV integration site family, member 7A AMHR2 Anti-Mullerian hormone receptor, type II RAB33A RAB33A, member RAS oncogene family CLTCL1 Clathrin, heavy polypeptide-like 1 GPRC6A G protein-coupled receptor, family C, group 6, member A EFS Embryonal Fyn-associated substrate NPAS3 Neuronal PAS domain protein 3 MAPK8IP2 Mitogen-activated protein kinase 8 interacting protein 2 AKAP9 A Kinase (PRKA) anchor protein (yotiao) 9 ATM Ataxia telangiectasia mutated (includes complementation groups A, C and D)</p><p>Up-regulated genes upon treatment with IR+Ro 31-8220</p><p>TBC1D16 TBC1 domain family, member 16 DOCK5 Hypothetical protein LOC286061 (LOC286061), mRNA GNAL Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type TM4SF2 Transmembrane 4 superfamily member 2 TRHDE Thyrotropin-releasing hormone degrading ectoenzyme PRLR Prolactin receptor ARHI Ras homolog gene family, member I GNAO1 Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O PPP2R2C Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform GPR133 G protein-coupled receptor 133 HPCA Hippocalcin MS4A12 Membrane-spanning 4-domains, subfamily A, member 12</p>