<p> OIE Reference Laboratory Reports Activities in 2011</p><p>Name of disease (or topic) for Echinococcosis/Hydatidosis which you are a designated OIE Reference Laboratory:</p><p>Address of laboratory: Cestode Zoonoses Research Group Parasitology and Disease Research Centre School of Environment and Life Sciences University of Salford Salford M54WT, UNITED KINDGOM</p><p>Tel.: (44)161 295 5488</p><p>Fax: (44 )161 295 521</p><p> e-mail address: [email protected]</p><p> website: (44 )161 295 521</p><p>Name (including Title and Professor Judith Smith Position) of Head of Laboratory (Responsible Official):</p><p>Name(including Title and Professor Philip Craig Position) of OIE Reference Expert:</p><p>Name (including Title and Position) of writer of this report</p><p>(if different from above):</p><p>Annual reports of OIE Reference Centres, 2011 1 Echinococcosis/hydatidosis</p><p>Part I: Summary of general activities related to the disease</p><p>Testing and screening dogs or other carnivores for echinococcosis using ELISA and PCR; livestock and wild or captive mammals for echinococcosis by DNA analysis/sequencing</p><p>1. Test(s) in use/or available for the specified disease/topic at your laboratory</p><p>Test For Specificity Total</p><p>ELISA coproantigen Echinococcus spp. 600</p><p>PCR coproDNA (dogs) Echinococcus granulosus 40</p><p>PCR coproDNA (dogs, foxes) E. multilocularis 20</p><p>PCR Tissue DNA Echinococcus /Taenia spp. 10</p><p>2. Production and distribution of diagnostic reagents </p><p>Diagnostic antibodies and primers, and/or coprotests for canine echinococcosis, hydatidosis and Taenia spp.</p><p>Part II: Activities specifically related to the mandate of OIE Reference Laboratories</p><p>3. International harmonisation and standardisation of methods for diagnostic testing or the production and testing of vaccines</p><p> a) Establishment and maintenance of a network with other OIE Reference Laboratories designated for the same pathogen or disease and organisation of regular inter-laboratory proficiency testing to ensure comparability of results</p><p>None.</p><p> b) Organisation of inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results</p><p>None.</p><p>4. Preparation and supply of international reference standards for diagnostic tests or vaccines</p><p>None.</p><p>5. Research and development of new procedures for diagnosis and control </p><p>None.</p><p>6. Collection, analysis and dissemination of epizootiological data relevant to international disease control</p><p>None.</p><p>2 Annual reports of OIE Reference Centres, 2011 Echinococcosis/hydatidosis</p><p>7. Maintenance of a system of quality assurance, biosafety and biosecurity relevant to the pathogen and the disease concerned</p><p>Biosafety laboratory at University of Salford to handle Hazard Group 3 agents (UK Health and Safety executive) cestode zoonoses: E.granulosus, E.multilocularis and Taenia solium. </p><p>UK licence: Specified Animal Pathogens Order UK Government licence # BAU639/PATH/52.2009.3 Period 2010-2015.</p><p>The laboratory operates under a strict Standard Operating Procedures (SOP) for these parasites. The SOP meets both UK HSE/ DEFRA and OIE guidelines for containment, operation and quality assurance regarding human and animal health.</p><p>8. Provision of consultant expertise to OIE or to OIE Member Countries</p><p>Seminar for the OIE National Focal points for Animal Production Food Safety. Invited participant and speaker. Role of an OIE Reference Laboratory: standards for echinococcosis. Brescia, Italy, 8–10 November 2011.</p><p>9. Provision of scientific and technical training to personnel from other OIE Member Countries</p><p>None.</p><p>10. Provision of diagnostic testing facilities to other OIE Member Countries</p><p>None.</p><p>11. Organisation of international scientific meetings on behalf of OIE or other international bodies</p><p> 2011 WHO Consultation on Cystic and Alveolar Echinococcosis surveillance, prevention and control. Invited organiser, consultant and speaker. Geneva, 22–23 June.</p><p> 2011 24th International Congress of Hydatidology: Scientific Committee Member and invited Chair/Speaker. Emergence and re-emergence of echinococcosis: is it out of control? Urumqi, China, 14-18 September </p><p>12. Participation in international scientific collaborative studies</p><p>Wellcome Trust funded Project 2011-14- Multispecies transmission of Echinococcus on the Tibetan Plateau (and Central Asia).- University of Salford, Sichuan CDC, University of Zurich, Universite de Franche Comte, Asahikawa Medical college</p><p>13. Publication and dissemination of information relevant to the work of OIE (including list of scientific publications, internet publishing activities, presentations at international conferences) </p><p> Presentations at international conferences and meetings</p><p> Rogan MT, Bodell A, Okiti E, Zeyhle E and Craig PS. (2011). Natural history and development of Echinococcus granulosus cysts and associated immune responses. XXIV World Congress of Hydatidology, Urumqi, China, 14-18th September.</p><p> Giraudoux P, Raoul F, li T, Han X, Pleydell D, Xie Y, Qiu J, Wang H, Ito A and Craig PS. (2011). Landscape, biodiversity and human AE distribution: can ecological theory predict disease hotspots in China? XXIV World Congress of Hydatidology, Urumqi, China, 14-18th September.</p><p>Annual reports of OIE Reference Centres, 2011 3 Echinococcosis/hydatidosis</p><p> Feng XH, Wen H, Duan X, Qi X, Zhang J and Craig PS. (2011). Epidemiological analysis of Echinococcus infections in three Mongolian communities of Xinjiang, PR China. XXIV World Congress of Hydatidology, Urumqi, China, 14-18th September.</p><p> Li T, Ito A, Sako Y, Chen X, Qiu D, Ning X and Craig PS. (2011). Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan province, China. XXIV World Congress of Hydatidology, Urumqi, China, 14-18th September.</p><p> Seminar for the OIE National Focal points for Animal Production Food Safety. Invited participant and speaker. Role of an OIE Reference Laboratory: standards for echinococcosis. Brescia, Italy, 8-10th November 2011.</p><p> Scientific publications in peer-reviewed journals</p><p> Vaniscotte A, Raoul F, Poulle ML, Romig T, Dinkel A, Takahashi K, Guislain MH, Moss J, Li T, Wang Q, Qiu J, Craig PS and Giraudoux P. (2011). Role of dog behaviour and environmental faecal contamination in transmission of Echinococcus multilocularis in Tibetan communities. Parasitology, 138, 1316-1329.</p><p> Mastin A, Brouwer A, Fox M, Li W, Godfrey D and Craig PS. (2011). Spatial and temporal investigation of Echinococcus granulosus coproantigen prevalence in farm dogs in South Powys, Wales. Veterinary Parasitology. 178, 100-107.</p><p> Li T, Ito A, Pengcuo R, sato Y, Chen X, Qiu D, Xiao N and Craig PS. (2011). Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan Province, China. PLoS Neglected Tropical Diseases, 5 (10), e 1364.</p><p>______</p><p>4 Annual reports of OIE Reference Centres, 2011</p>