<p> UCSF Lab Standard Operating Procedure</p><p>Chemical Process, Name or Hazard Class: Diazoxide</p><p>Please fill out the form completely. Insure all users have access to this SOP. Refer to instructions for assistance. Department: Enter text. Date SOP was written: Enter date. This lab specific SOP has been reviewed and approved by: Principal Investigator Name: Enter text. Principal Investigator Signature Lab Manager/Supervisor: Enter text.</p><p>Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class</p><p>Purpose</p><p>Diazoxide is a drug used as a vasodilator in the treatment of hypertension, and can also be used to counter hypoglycemia. Its brand name is Proglycem, and is also known as 7-chloro-3-methyl-2H-1,2,4- benzothiadiazine and 1,1- dioxide. It is listed in Prop 65 as a reproductive toxin </p><p>Physical & Chemical Properties/Definition of Chemical Group</p><p>CAS#: 364-98-7</p><p>Class: Toxic and Reproductive Toxin</p><p>Molecular Formula: C8H7ClN2O2S</p><p>Form (physical state): solid</p><p>Color: White</p><p>Melting point: >310 oC</p><p>Potential Hazards/Toxicity</p><p>Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin contact Harmful if absorbed through skin. Causes skin irritation. Eye contact Cause eye irritation.</p><p>Diazoxide 1 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Ingestion Harmful if swallowed.</p><p>Engineering Controls</p><p>Work with this chemical in a certified ducted fume hood. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.</p><p>Personal Protective Equipment (PPE)</p><p>Respirator Protection If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/) </p><p>Hand Protection Wear nitrile gloves.</p><p>NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with diazoxide.</p><p>Refer to glove selection chart from the links below: http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf OR http://www.allsafetyproducts.biz/page/74172 OR http://www.showabestglove.com/site/default.aspx OR http://www.mapaglove.com/</p><p>Eye Protection ANSI approved safety glasses or goggles. </p><p>Skin and Body Protection Lab coats should be worn. These laboratory coats must be appropriately sized for the individual and be buttoned to their full length. Laboratory coat sleeves must be of a sufficient length to prevent skin exposure while wearing gloves. Full length pants and close-toed shoes must be worn at all times by all individuals that are occupying the laboratory area. The area of skin between the shoe and ankle should not be exposed.</p><p>Hygiene Measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.</p><p>First Aid Procedures</p><p>If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.</p><p>In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.</p><p>In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes (using emergency eyewash) and consult a physician. Continue rinsing eyes during transport to hospital.</p><p>Diazoxide 2 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician</p><p>Special Handling and Storage Requirements</p><p>Precautions for safe handling Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Avoid oxidizing agents. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Place in secondary containment. Label container, secondary containment, and storage location as “Reproductive Toxicant”. </p><p>Spill and Accident Procedure Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206- 8522 (SFGH only)</p><p>Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.). </p><p>Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up. </p><p>Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206- 8522 (SFGH only) for assistance. </p><p>Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800- 222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415- 476-1300 during work hours, or 9-911 during non-working hours and weekends. </p><p>Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends. </p><p>Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)</p><p>Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.</p><p>Diazoxide 3 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885- 7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays). </p><p>Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.</p><p>Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).</p><p>Decontamination/Waste Disposal Procedure</p><p>Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste. </p><p>Safety Data Sheet (SDS) Location</p><p>Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html</p><p>Protocol/Procedure</p><p>Quantities covered by this SOP: ______(g , ml) to ______(g, ml) </p><p>Temperature range covered by this SOP: __ °C – __ °C </p><p>General Overview and Purpose: Enter the experimental purpose </p><p>Procedure: Enter experimental procedure. You can copy procedure from your lab notebook or from literature. </p><p>NOTE</p><p>Any deviation from this SOP requires approval from the Principal Investigator.</p><p>Diazoxide 4 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)</p>