<p>SUPPLEMENTARY TABLE IV. Risks of paternal age at childbearing on schizophrenia in offspring from studies employing 5-year age categories. Age category (years) Psych iatric 2 Study N Outcome measure disord 5- 40- 45- < 20 20-24 30-34 35-39 50-54 ≥ 55 er 2 44 49 9 Cases: 43 7,641 Brown et al. SCZ individual Rate ratio 1.00 2.7 (0.6-4.1) 3.6 (0.4-33.9) [2002]** s were followed Cases: Buizer- 1.47 1.05 2,564 1. 1.24 (1.07- Voskamp et SSD OR (0.98- (0.91- 1.04 (0.94-1.17) 1.27 (1.05-1.53) Controls: 00 1.42) al. [2011] 2.21) 1.22) 10,256 SCZ, SAD, STPD, acute polymo rphic psychot ic 1. Cases: disorder 0.98 03 1.25 1.50 1.95 Frans et al. 20,582 1.16 (1.08- 1.59 (1.37- with OR (0.85- 1.00 (0. 1.09 (1.03-1.16) (1.16- (1.35- (1.58- [2011] Controls: 1.24) 1.85) sympto 1.12) 97- 1.36) 1.66) 2.40) 100,176 1.0 ms of 8) SCZ, acute SCZ- like psychot ic disorder 0. 94 Cases: 5 0.871 1.223 Lehrer et al. SCZ + 3942 (0. 1.005 (0.883- 1.038 RRR (0.711- 1.00 (1.022- 1.442 (1.172-1.773) [2015] SAD Controls: 83 1.144) (0.900-1.196) 1.066) 3- 1.462) 7,658 1.0 72 ) SCZ and Cases: 638 1. other 87,907 14 1.73 2.02 Malaspina et non- 1.64 (1.13- individual RR X 1.00 (.8 1.42 (1.03-1.93) (1.11- (1.17- 2.96 (1.60-5.47) al. [2001]** affectiv 2.38) s were 4- 2.70) 3.51) e 1.5 followed psychos 3) is Cases: 12,594 1.12 1.07 1.40 McGrath et 2,894,688 1. 1.21 (1.13- SCZ IRR (0.97- (1.01- 1.08 (1.03-1.13) (1.28- 1.47 (1.29-1.67) 1.30) al. [2014] individual 1.28) 1.13) 00 1.54) s were followed Cases: 129 10,224 Miller et al. NAP individual RR 1.02 (0.59–1.76) 1.00 1.23 (0.64–2.37) 0.79 (0.32–1.91) [2011b] s were followed Cases: 639 1. 712,014 1.31 26 2.08 1.30 Sipos et al. 2.32 (1.56- SCZ individual HR (0.73- 1.00 (0. 1.66 (1.18-2.34) (1.25- (0.56- 4.62 (2.28-9.36) 3.44) [2004]** 2.36) 93- 3.46) 3.06) s were 1.6 followed 9) Cases: 351 Wu et al. SCZ Controls: OR 0.628 (0.350–1.127) 1.00 10.183 (4.772–21.729) [2012] 238 Zammit et al. Cases: 337 3.8 (1.3- [2003]** SCZ Controls: OR 1.00 1.2 (0.8-1.8) 1.6 (0.8-3.1) 11.8) ♂ 46,956 The values represent (95% CI) the estimated risks of the most adjusted model of the studies. Bold risk values indicate significant adjusted risks. Reference age categories are 1.00. ** Indicates that the corresponding study is included in the meta-analysis of Miller et al. [2011a]. Abbreviations: SCZ, schizophrenia; SSD; Schizophrenia Spectrum Disorders; SAD, schizoaffective disorders; STPD, schizotypal personality disorder; NAP, non-affective psychosis; OR, Odds Ratio; RRR, Relative Risk Ratio; RR, Relative Risk; IRR, Incidence Rate Ratio; HR, Hazard Ratio.</p>