<p>Supplemental Table 1: RT2 Profiler Angiogenesis Array on 2B Teratoma Panel - All Genes Samples: Three representative sets of teratomas in three independent experiments performed on 5/29/2008 (Set #1), 5/30/08 (Set #2), and 6/2/2008 (Set #3) Calculations: All cycle thresholds were normalized to 18S and averaged across sample sets (Nml Avg), followed by calculation of fold-induction relative to the normalized average for J1 (Avg J1 Fold). Key: red indicates >2-fold over-expression relative to J1 or significant p-value (p<0.05), blue indicates <0.03-fold expression (under-expression) relative to J1, and orange indicates near- significant p-value (0.05<p<0.07) J1 Null Avg J1 Avg J1 Gene Nml Avg Fold SD Gene Nml Avg Fold SD p-value Angpt1 6.434114 1 0.451234 Angpt1 7.910941 0.36 0.501338 0.0012 Angpt2 5.772214 1 0.622179 Angpt2 5.67933 1.07 1.017639 0.8569 Anpep 5.877128 1 0.385855 Anpep 5.817978 1.04 0.702875 0.8951 Bai1 6.748335 1 1.046361 Bai1 7.226236 0.72 1.328039 0.6157 Ccl11 5.117926 1 1.51719 Ccl11 4.807911 1.24 0.561076 0.7707 Ccl2 5.590166 1 1.575292 Ccl2 5.055138 1.45 0.502313 0.5530 Cdh5 5.019307 1 0.477573 Cdh5 4.23642 1.72 0.638376 0.0618 Col18a1 3.184106 1 0.712986 Col18a1 3.794576 0.65 0.873939 0.1402 Col4a3 11.48803 1 0.664585 Col4a3 12.26903 0.58 1.857247 0.5188 Csf3 11.14549 1 0.657417 Csf3 12.65882 0.35 1.434698 0.1863 Ctgf 2.476044 1 0.989385 Ctgf 2.3773 1.07 0.501717 0.7470 Cxcl1 11.61576 1 1.77294 Cxcl1 10.5866 2.04 0.282456 0.3056 Cxcl2 9.408056 1 0.111585 Cxcl2 8.775359 1.55 1.050754 0.3693 Cxcl5 10.0549 1 1.684045 Cxcl5 9.132086 1.90 0.66222 0.5040 Tymp 9.517695 1 1.202701 Tymp 10.31985 0.57 1.225479 0.4049 Edg1 5.478806 1 0.76692 Edg1 5.749897 0.83 0.403819 0.6253 Efna1 6.9263 1 0.334228 Efna1 6.841083 1.06 1.461589 0.9144 Efnb2 3.920274 1 0.641945 Efnb2 4.087624 0.89 1.182939 0.7342 Egf 8.684996 1 0.296779 Egf 9.54521 0.55 0.265573 0.2633 Eng 5.23952 1 0.989748 Eng 4.213836 2.04 0.84256 0.0286 Epas1 4.479136 1 0.617185 Epas1 4.901507 0.75 1.438081 0.6399 Ephb4 4.376732 1 0.515557 Ephb4 4.544264 0.89 0.740544 0.6012 Ereg 12.38722 1 0.725565 Ereg 11.60747 1.72 2.372841 0.5321 F2 9.151703 1 1.097171 F2 7.999107 2.22 1.651635 0.3308 Fgf1 6.576941 1 0.539932 Fgf1 7.161911 0.67 0.80734 0.1967 Fgf2 7.773667 1 1.173199 Fgf2 9.109308 0.40 0.992367 0.1396 Fgf6 12.64087 1 1.509354 Fgf6 13.85415 0.43 0.348743 0.1144 Fgfr3 3.44048 1 0.397906 Fgfr3 4.611767 0.44 1.263798 0.1197 Figf 9.917381 1 1.089028 Figf 9.602814 1.24 1.020165 0.6243 Flt1 7.707836 1 0.437642 Flt1 7.021857 1.61 0.893927 0.2303 Fzd5 5.755382 1 0.903563 Fzd5 5.534873 1.17 0.621145 0.2300 Gna13 3.218829 1 0.98142 Gna13 3.40588 0.88 0.810162 0.6307 Hand2 9.684724 1 1.33829 Hand2 11.98528 0.20 3.290685 0.3473 Hgf 7.956648 1 0.342224 Hgf 8.549372 0.66 0.705796 0.3530 Hif1a 2.75455 1 0.70592 Hif1a 3.621638 0.55 0.883708 0.0569 Ifng 11.88905 1 1.267791 Ifng 11.94387 0.96 3.657435 0.9831 Igf1 5.058941 1 0.173842 Igf1 5.520377 0.73 0.274384 0.2586 Il1b 7.907807 1 0.994436 Il1b 6.711673 2.29 0.266488 0.0840 Il6 12.13291 1 1.782952 Il6 11.85515 1.21 0.958829 0.8285 Itgav 4.072633 1 0.897254 Itgav 4.752383 0.62 0.923504 0.0672 Itgb3 6.320996 1 0.790384 Itgb3 6.072421 1.19 0.505008 0.1372 Jag1 4.941572 1 0.676675 Jag1 5.258532 0.80 1.047666 0.5485 Kdr 5.763716 1 0.327408 Kdr 5.128825 1.55 1.06777 0.2494 Lama5 6.482599 1 0.426165 Lama5 5.745811 1.67 0.840625 0.1067 Lect1 9.453821 1 0.258973 Lect1 10.40011 0.52 1.16337 0.2468 Lep 12.05316 1 2.857765 Lep 11.97588 1.06 1.801002 0.9752 Mapk14 4.251126 1 0.698375 Mapk14 4.553224 0.81 0.322931 0.3829 Mdk 0.153627 1 0.642874 Mdk 0.907283 0.59 1.130169 0.1755 Mmp19 7.975779 1 0.509334 Mmp19 8.448741 0.72 0.440768 0.4172 Mmp2 3.663357 1 0.562778 Mmp2 4.109663 0.73 1.095251 0.5534 Mmp9 7.032294 1 0.772086 Mmp9 7.808187 0.58 1.012868 0.3704 Npr1 8.318668 1 0.024614 Npr1 8.889494 0.67 0.81785 0.3705 Nrp1 4.279229 1 0.29579 Nrp1 4.40228 0.92 0.549678 0.6916 Nrp2 4.654636 1 0.523887 Nrp2 4.524591 1.09 1.00531 0.7696 Pdgfa 6.069525 1 0.586321 Pdgfa 6.066538 1.00 0.824076 0.9902 Pecam1 6.183117 1 0.787638 Pecam1 5.801016 1.30 0.202981 0.3118 Pgf 6.917237 1 0.832599 Pgf 7.055822 0.91 0.591254 0.5860 Plau 6.977048 1 0.599853 Plau 6.686967 1.22 0.305325 0.3578 Plg 13.50415 1 0.418629 Plg 12.77287 1.66 1.899037 0.4983 Plxdc1 7.767838 1 0.69613 Plxdc1 8.149974 0.77 0.363913 0.4123 Ptgs1 6.206223 1 0.431158 Ptgs1 6.073136 1.10 0.456533 0.7486 Serpinf1 3.728753 1 0.326149 Serpinf1 4.723555 0.50 0.254429 0.0684 Smad5 3.935498 1 0.708832 Smad5 4.368678 0.74 0.714331 0.2679 Sphk1 9.153774 1 0.381523 Sphk1 10.18396 0.49 0.721804 0.0747 Stab1 5.756362 1 0.299084 Stab1 5.748497 1.01 0.626081 0.9866 Tbx1 7.219448 1 0.410245 Tbx1 7.249866 0.98 0.753206 0.9518 Tbx4 10.42518 1 0.843014 Tbx4 10.25121 1.13 1.198449 0.7831 Tek 7.571119 1 0.233794 Tek 7.277439 1.23 0.772956 0.6264 Tgfa 8.688346 1 0.832353 Tgfa 10.12545 0.37 0.885965 0.0637 Tgfb1 6.4807 1 0.821849 Tgfb1 5.78004 1.63 0.673487 0.2999 Tgfb2 5.892791 1 0.49127 Tgfb2 5.837092 1.04 0.824983 0.8399 Tgfb3 6.937569 1 0.75856 Tgfb3 7.52804 0.66 0.61497 0.0540 Tgfbr1 3.80756 1 0.382591 Tgfbr1 4.266702 0.73 0.989785 0.3539 Thbs1 4.057596 1 1.041127 Thbs1 4.012378 1.03 0.64881 0.8932 Thbs2 4.347557 1 1.246283 Thbs2 5.844481 0.35 1.183383 0.0539 Timp1 11.37485 1 0.95546 Timp1 11.96755 0.66 1.178548 0.2903 Timp2 2.891087 1 0.142078 Timp2 3.512147 0.65 0.818829 0.3375 Tmprss6 9.97243 1 0.50631 Tmprss6 9.967839 1.00 0.5625 0.9906 Tnf 12.08665 1 0.826678 Tnf 11.09427 1.99 1.130565 0.3454 Tnfaip2 7.418263 1 1.011878 Tnfaip2 6.479063 1.92 0.375862 0.0999 Tnfsf12 5.587389 1 0.592878 Tnfsf12 6.201785 0.65 0.526298 0.0048 Vegfa 5.05007 1 1.107649 Vegfa 3.683176 2.58 0.766328 0.0280 Vegfb 4.46748 1 1.374286 Vegfb 4.631726 0.89 0.768022 0.7238 Vegfc 6.65734 1 0.290899 Vegfc 6.148401 1.42 1.034994 0.3674 2BHet 2B2B Avg J1 Avg J1 Gene Nml Avg Fold SD p-value Gene Nml Avg Fold SD p-value Angpt1 5.966198 1.38 0.317351 0.0737 Angpt1 6.722282 0.82 0.512764 0.2273 Angpt2 5.773085 1.00 0.476045 0.9978 Angpt2 5.917352 0.90 0.385512 0.6371 Anpep 5.566406 1.24 0.453081 0.3894 Anpep 6.217047 0.79 0.623169 0.5505 Bai1 7.135728 0.76 1.652403 0.7174 Bai1 6.558167 1.14 1.866415 0.8429 Ccl11 5.420315 0.81 0.871181 0.8008 Ccl11 6.713884 0.33 1.270741 0.2722 Ccl2 5.770543 0.88 0.431578 0.8085 Ccl2 6.15567 0.68 1.333451 0.6550 Cdh5 3.846009 2.26 0.552637 0.0052 Cdh5 3.734829 2.44 0.176637 0.0251 Col18a1 2.844788 1.27 0.5708 0.3736 Col18a1 3.179457 1.00 0.299382 0.9883 Col4a3 12.90625 0.37 0.689798 0.0409 Col4a3 12.33165 0.56 1.398302 0.2634 Csf3 11.43046 0.82 2.110483 0.8381 Csf3 12.5571 0.38 2.376886 0.3405 Ctgf 2.044464 1.35 0.24606 0.2792 Ctgf 2.895335 0.75 0.490301 0.4386 Cxcl1 12.0307 0.75 1.566358 0.7536 Cxcl1 13.00198 0.38 0.807928 0.2011 Cxcl2 10.67736 0.41 1.419108 0.1887 Cxcl2 10.26403 0.55 0.462385 0.2036 Cxcl5 11.66392 0.33 1.856556 0.3477 Cxcl5 9.967943 1.06 0.243075 0.9495 Tymp 10.00777 0.71 1.210353 0.5984 Tymp 10.74507 0.43 1.783064 0.2459 Edg1 5.960582 0.72 0.769869 0.2132 Edg1 4.783851 1.62 0.391499 0.0611 Efna1 6.381445 1.46 0.809994 0.2197 Efna1 6.336811 1.50 0.131445 0.1807 Efnb2 3.159079 1.69 0.65406 0.0694 Efnb2 3.52839 1.31 0.711655 0.2090 Egf 8.54916 1.10 0.115753 0.8406 Egf 8.478333 1.15 0.783983 0.7691 Eng 4.576137 1.58 0.520782 0.0352 Eng 4.206016 2.05 0.168391 0.0321 Epas1 4.654902 0.89 0.658837 0.7047 Epas1 4.517656 0.97 0.781479 0.9381 Ephb4 4.387388 0.99 0.291826 0.9710 Ephb4 4.275967 1.07 0.229358 0.7876 Ereg 13.28936 0.54 0.688854 0.2564 Ereg 12.88471 0.71 0.915209 0.4236 F2 9.231095 0.95 0.505492 0.8393 F2 10.36445 0.43 0.194579 0.0519 Fgf1 7.078278 0.71 0.87954 0.5104 Fgf1 7.266941 0.62 1.648304 0.3890 Fgf2 9.229978 0.36 0.079399 0.0259 Fgf2 8.241691 0.72 0.761357 0.3058 Fgf6 13.61152 0.51 0.075859 0.1603 Fgf6 13.9294 0.41 0 0.1014 Fgfr3 3.478868 0.97 0.532532 0.8907 Fgfr3 3.559153 0.92 1.046 0.7988 Figf 8.931669 1.98 0.726286 0.0791 Figf 9.298153 1.54 0.739309 0.3407 Flt1 7.423777 1.22 0.534761 0.2944 Flt1 7.43312 1.21 0.599732 0.3283 Fzd5 5.902588 0.90 0.591178 0.4965 Fzd5 5.594025 1.12 2.396692 0.9079 Gna13 3.517983 0.81 0.835835 0.4848 Gna13 3.164348 1.04 0.765367 0.8526 Hand2 9.504172 1.13 1.028851 0.9031 Hand2 10.86041 0.44 2.330052 0.5597 Hgf 8.027054 0.95 0.243172 0.8645 Hgf 9.193561 0.42 1.245912 0.2467 Hif1a 2.894455 0.91 0.506078 0.3390 Hif1a 2.601275 1.11 0.296229 0.3587 Ifng 13.68707 0.29 0 0.0127 Ifng 12.02288 0.91 1.905659 0.9157 Igf1 4.735786 1.25 0.415106 0.5286 Igf1 5.057223 1.00 0.646522 0.9979 Il1b 7.946175 0.97 0.932244 0.9356 Il1b 8.050387 0.91 0.676012 0.7652 Il6 11.70367 1.35 2.063865 0.7826 Il6 10.71469 2.67 0.667133 0.2638 Itgav 4.497918 0.74 0.420829 0.1181 Itgav 4.675661 0.66 0.69269 0.0177 Itgb3 6.628442 0.81 0.74855 0.4023 Itgb3 6.938241 0.65 0.342196 0.0590 Jag1 4.41936 1.44 0.907514 0.3448 Jag1 4.460112 1.40 0.322515 0.4037 Kdr 5.698448 1.05 0.614949 0.8674 Kdr 4.612858 2.22 0.199102 0.0513 Lama5 6.037891 1.36 0.75044 0.3777 Lama5 6.755365 0.83 1.534326 0.6971 Lect1 9.444469 1.01 0.326198 0.9877 Lect1 9.366619 1.06 2.740648 0.9596 Lep 12.84703 0.58 1.289415 0.7294 Lep 11.88454 1.12 2.731245 0.9533 Mapk14 4.415535 0.89 0.227819 0.4878 Mapk14 4.472958 0.86 0.533991 0.3246 Mdk -0.07781 1.17 0.502369 0.4400 Mdk -0.24451 1.32 0.117752 0.3024 Mmp19 7.916133 1.04 0.460218 0.8761 Mmp19 7.848335 1.09 0.863835 0.8785 Mmp2 2.684393 1.97 0.453662 0.0885 Mmp2 3.691001 0.98 0.6018 0.9649 Mmp9 6.832465 1.15 1.59206 0.8521 Mmp9 6.541343 1.41 1.12841 0.6924 Npr1 8.336921 0.99 0.958004 0.9808 Npr1 8.465966 0.90 0.265147 0.7585 Nrp1 3.260052 2.03 0.599929 0.0484 Nrp1 3.195364 2.12 0.247782 0.0535 Nrp2 4.444093 1.16 0.408542 0.4750 Nrp2 3.670846 1.98 0.68202 0.0348 Pdgfa 6.177096 0.93 0.559965 0.7753 Pdgfa 6.370769 0.81 0.77814 0.1999 Pecam1 6.637423 0.73 0.590546 0.0636 Pecam1 6.230921 0.97 0.081146 0.8740 Pgf 7.19205 0.83 0.328285 0.0149 Pgf 6.053818 1.82 0.792604 0.0893 Plau 7.145641 0.89 0.484128 0.4140 Plau 7.439593 0.73 0.200178 0.1458 Plg 11.54941 3.88 0.90197 0.0547 Plg 12.59271 1.88 0.615971 0.0707 Plxdc1 7.968949 0.87 0.918915 0.7278 Plxdc1 7.697438 1.05 0.772402 0.7579 Ptgs1 6.177745 1.02 0.700395 0.9666 Ptgs1 6.120711 1.06 0.437838 0.8718 Serpinf1 3.083577 1.56 0.45435 0.0730 Serpinf1 3.838057 0.93 0.995722 0.8982 Smad5 3.727441 1.16 0.1163 0.5613 Smad5 3.496515 1.36 0.213025 0.2953 Sphk1 8.838081 1.24 0.710788 0.5867 Sphk1 9.216848 0.96 0.53326 0.8890 Stab1 5.405658 1.28 0.796725 0.5241 Stab1 5.06669 1.61 0.860243 0.2070 Tbx1 5.693266 2.88 0.569346 0.0281 Tbx1 6.801985 1.34 0.612779 0.3653 Tbx4 11.65079 0.43 0.589608 0.0715 Tbx4 12.34363 0.26 1.560695 0.0558 Tek 7.207706 1.29 0.574607 0.4393 Tek 7.027863 1.46 0.40028 0.3632 Tgfa 8.847628 0.90 2.028542 0.9017 Tgfa 8.339184 1.27 1.948689 0.7340 Tgfb1 6.026503 1.37 0.240488 0.0408 Tgfb1 5.747674 1.66 0.389373 0.1608 Tgfb2 6.005011 0.93 0.806086 0.7970 Tgfb2 5.582868 1.24 0.897569 0.2902 Tgfb3 6.284431 1.57 0.837592 0.1657 Tgfb3 6.538266 1.32 0.539636 0.5010 Tgfbr1 3.487171 1.25 0.58529 0.4278 Tgfbr1 3.488384 1.25 0.586586 0.4477 Thbs1 3.590739 1.38 0.518623 0.1540 Thbs1 3.509498 1.46 0.543244 0.2380 Thbs2 3.539181 1.75 0.910723 0.1867 Thbs2 4.399377 0.96 0.129693 0.9242 Timp1 11.03276 1.27 0.633684 0.3545 Timp1 11.65821 0.82 1.755425 0.7225 Timp2 3.020104 0.91 0.385007 0.7664 Timp2 2.497818 1.31 0.76246 0.4205 Tmprss6 8.896126 2.11 0.786689 0.0893 Tmprss6 9.765787 1.15 0.66363 0.6083 Tnf 12.42562 0.79 1.133177 0.6131 Tnf 12.55068 0.72 0.92685 0.6363 Tnfaip2 6.702556 1.64 0.327986 0.0294 Tnfaip2 7.164243 1.19 0.293006 0.6491 Tnfsf12 5.816544 0.85 0.454257 0.1720 Tnfsf12 5.865007 0.82 0.746357 0.2894 Vegfa 4.434416 1.53 1.062701 0.2769 Vegfa 3.536165 2.86 0.592497 0.0053 Vegfb 4.643169 0.89 0.85428 0.7564 Vegfb 4.460553 1.00 0.777707 0.9879 Vegfc 6.312826 1.27 0.159712 0.3762 Vegfc 5.671077 1.98 0.379963 0.0557</p>