<p>Table 1 Characteristics of the participants. Children with juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and healthy controls were enrolled in the study on high mobility group box-1 (HMGB1) and soluble receptor for advanced glycation endproducts (sRAGE).</p><p>The data are summarized as median and range.</p><p>Juvenile idiopathic arthritis SLE Healthy controls Characteristic p-value Systemic Oligoarticular Polyarticular (n = 19) (n = 28) (n = 27) (n = 34) (n = 35) No. girls/ - 7/20 27/7 27/8 14/5 20/8 boys Age, years - 9.9* (5.3-12.2) 2.9* (0.4-8.2) 6.4 (7.2-12.3) 14.4* (10.6-15.9) 6.2 (0.9-11.9) 17402.50* 3551.97* 4374.04* 8523.92* HMGB1 1149.70 (10.89- < 0.001 (6400.57- (108.89- (273.50- (3639.35- (pg/ml) 1976.47) 80844.98) 10713.20) 93493.88) 98296.88) 2269.84 1757.76 sRAGE 1237.53* 924.45* (118.08- 2275.80 (162.37- 0.006 (225.60- (230.40- (pg/ml) (46.42-6634.4) 10569.20) 9206.38) 5137.92) 4730.88) ESR (mm/h) < 0.001 86* (34-139) 17* (5-41) 40* (5-140) 57* (10-113) 7 (2-36) 145.0* (6.9- 23.5* (0.1- CRP (mg/l) < 0.001 2.6 (0.2-25.7) 3.0 (0.6-25.0) 2.0 (0.1-6.8) 264.0) 156.0) Hb (g/l) < 0.001 111* (80-128) 123 (99-144) 115* (75-140) 119 (78-140) 124 (110-145) 0.34* (0.23- Hct (%) < 0.001 0.37 (0.29-0.43) 0.35 (0.24-0.43) 0.36 (0.22-0.42) 0.37 (0.32-0.52) 0.56) PLT, < 0.001 397* (125-563) 391 (180-651) 363 (131-1038) 222 (122-568) 322 (176-414) ×10^9/l RBC, 4.17* (3.30- 4.26* (3.60- < 0.001 4.51 (3.54-5.31) 4.13* (2.88-5.09) 4.63 (4.10-5.17) ×10^12/l 4.96) 5.88) WBC, < 0.001 9.0* (6.4-29.9) 8.7* (4.0-17.1) 8.5* (3.5-27.0) 4.3 (2.0-19.4) 7.4 (2.5-9.7) ×10^9/l γ-globulin 21.8* (10.0- < 0.001 17.0* (7.8-39.0) 14.2 (7.9-21.5) 22.2* (12.0-38.2) 13.9 (6.8-19.2) (%) 32.1) α2-globulin 15.3* (11.2- 13.5* (12.9- < 0.001 9.9* (5.2-16.7) 10.3* (8.0-17.7) 7.2 (4.9-14.3) (%) 26.3) 19.2) ANA - 640 (100-10242) (RU/ml) anti-dsDNA - 285 (68-2480) (RU/ml) C3 (mg/l) - 0.87 (0.32-1.74) C4 (mg/l) - 0.13 (0.03-0.32) *Significantly different from the healthy controls (Kruskal-Wallis test followed by a post-hoc test). ESR =erythrocyte sedimentation rate; CRP=C-reactive protein; Hb=hemoglobin; Hct=haematocrit; PLT=platelets; RBC = red blood cells; WBC= white blood cells; ANA=antinuclear antibody; anti-dsDNA=double stranded DNA antibodies; C3,C4= complement components.</p>