<p>Table S5: Strict Antibiotic resistance analysis of Proteus mirabilis SCDR1 </p><p>Bes t Best Hit e-value Best Hit ARO Ide ARO name SNP Best Hit ARO category AR0 category ntit ies efflux pump conferring antibiotic aminocoumarin resistance gene; aminoglycoside resistance; aminocoumarin resistance gene; efflux pump conferring 1.19E-135 cpxR 86 cpxR n/a resistance gene; aminoglycoside antibiotic resistance; gene modulating antibiotic resistance gene; gene modulating efflux antibiotic efflux Bifidobacteria Bifidobacteria intrinsic ileS intrinsic ileS 5.26E-60 conferring resistance to 25 conferring n/a mupirocin resistance gene mupirocin resistance gene mupirocin resistance to mupirocin aminocoumarin resistance gene; aminoglycoside mtrD, adeB, resistance gene; antibiotic resistance gene ceoB, mdsB, cluster, cassette, or operon; beta-lactam smeE, mexY, resistance gene; chloramphenicol resistance smeB, amrB, efflux pump conferring antibiotic gene; efflux pump conferring antibiotic mexQ, acrB, resistance; tetracycline resistance 0 adeG 61 n/a resistance; erythromycin resistance efflux pump; adeG, acrF, gene; fluoroquinolone resistance fluoroquinolone resistance gene; lincosamide mdtF, acrD, gene resistance gene; macrolide resistance gene; mexF, mexD, polymyxin resistance gene; rifampin resistance mexB, cmeB, gene; tetracycline resistance gene; trimethoprim adeJ resistance gene efflux pump conferring antibiotic beta-lactam resistance gene; chloramphenicol resistance; chloramphenicol mdsB, mexW, resistance gene; efflux pump conferring 0 mexW 77 n/a resistance gene; tetracycline mexI antibiotic resistance; fluoroquinolone resistance resistance gene; fluoroquinolone gene; tetracycline resistance gene resistance gene Escherichia coli Escherichia coli mutant mutant GlpT fosfomycin resistance gene; antibiotic resistant gene variant or mutant; 0 GlpT conferring resistance 87 conferring E448K antibiotic resistant gene variant or fosfomycin resistance gene to fosfomycin resistance to mutant fosfomycin efflux pump conferring antibiotic aminocoumarin resistance gene; aminoglycoside resistance; aminocoumarin resistance gene; efflux pump conferring 6.84E-161 baeS 53 baeS n/a resistance gene; aminoglycoside antibiotic resistance; gene modulating antibiotic resistance gene; gene modulating efflux antibiotic efflux polymyxin resistance gene; gene gene altering cell wall charge conferring 0 PmrF 72 PmrF n/a altering cell wall charge conferring antibiotic resistance; polymyxin resistance gene antibiotic resistance 3.14E-131 Streptomyces cinnamoneus 71 Streptomyces n/a gene involved in self-resistance to antibiotic resistant gene variant or mutant; EF-Tu mutants conferring cinnamoneus antibiotic; antibiotic resistant gene elfamycin resistance gene; gene involved in self- resistance to elfamycin EF-Tu mutants variant or mutant; elfamycin resistance to antibiotic conferring resistance gene resistance to elfamycin efflux pump conferring antibiotic beta-lactam resistance gene; efflux pump resistance; macrolide resistance conferring antibiotic resistance; fluoroquinolone 1.33E-154 CRP 98 CRP n/a gene; beta-lactam resistance gene; resistance gene; gene modulating antibiotic gene modulating antibiotic efflux; efflux; macrolide resistance gene fluoroquinolone resistance gene efflux pump conferring antibiotic aminocoumarin resistance gene; aminoglycoside resistance; aminocoumarin resistance gene; beta-lactam resistance gene; 2.45E-107 baeR 66 smeR, baeR n/a resistance gene; aminoglycoside efflux pump conferring antibiotic resistance; resistance gene; gene modulating fluoroquinolone resistance gene; gene antibiotic efflux modulating antibiotic efflux efflux pump conferring antibiotic efflux pump conferring antibiotic resistance; 0 tetJ 94 tetJ n/a resistance; tetracycline resistance tetracycline resistance gene gene chloramphenicol resistance gene; antibiotic inactivation enzyme; chloramphenicol 1.35E-147 cat 91 catI, cat n/a antibiotic inactivation enzyme resistance gene aminocoumarin resistance gene; aminoglycoside mtrD, adeB, resistance gene; antibiotic resistance gene ceoB, mdsB, cluster, cassette, or operon; beta-lactam smeE, mexY, resistance gene; chloramphenicol resistance smeB, amrB, efflux pump conferring antibiotic gene; efflux pump conferring antibiotic mexQ, acrB, resistance; tetracycline resistance 0 adeG 76 n/a resistance; erythromycin resistance efflux pump; adeG, acrF, gene; fluoroquinolone resistance fluoroquinolone resistance gene; lincosamide mdtF, acrD, gene resistance gene; macrolide resistance gene; mexF, mexD, polymyxin resistance gene; rifampin resistance mexB, cmeB, gene; tetracycline resistance gene; trimethoprim adeJ resistance gene sulfonamide resistance gene; gene gene modulating antibiotic efflux; sulfonamide 3.39E-128 leuO 58 leuO n/a modulating antibiotic efflux resistance gene efflux pump conferring antibiotic efflux pump conferring antibiotic resistance; 0 emrB 72 emrY, emrB n/a resistance; fluoroquinolone fluoroquinolone resistance gene; tetracycline resistance gene resistance gene polymyxin resistance gene; gene gene altering cell wall charge conferring 0 arnA 68 arnA n/a altering cell wall charge conferring antibiotic resistance; polymyxin resistance gene antibiotic resistance efflux pump conferring antibiotic 0 mdtH 73 mdtH n/a efflux pump conferring antibiotic resistance resistance efflux pump conferring antibiotic aminocoumarin resistance gene; aminoglycoside resistance; aminocoumarin resistance gene; efflux pump conferring 0 cpxA 79 cpxA n/a resistance gene; aminoglycoside antibiotic resistance; gene modulating antibiotic resistance gene; gene modulating efflux antibiotic efflux 0 tolC 67 tolC n/a chloramphenicol resistance gene; aminocoumarin resistance gene; beta-lactam macrolide resistance gene; resistance gene; chloramphenicol resistance fluoroquinolone resistance gene; gene; efflux pump conferring antibiotic efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; resistance; aminocoumarin macrolide resistance gene; rifampin resistance resistance gene; tetracycline gene; tetracycline resistance gene resistance gene; rifampin resistance gene; beta-lactam resistance gene efflux pump conferring antibiotic aminocoumarin resistance gene; efflux pump 8.52E-155 mdtA 61 mdtA n/a resistance; aminocoumarin conferring antibiotic resistance resistance gene efflux pump conferring antibiotic aminocoumarin resistance gene; mdtC, mdtB, 0 mdtC 75 n/a resistance; aminocoumarin chloramphenicol resistance gene; efflux pump mexN resistance gene conferring antibiotic resistance efflux pump conferring antibiotic efflux pump conferring antibiotic resistance; 0 rosB 66 rosB n/a resistance; polymyxin resistance polymyxin resistance gene gene efflux pump conferring antibiotic 2.39E-166 emrD 65 emrD n/a efflux pump conferring antibiotic resistance resistance aminoglycoside resistance gene; antibiotic efflux pump conferring antibiotic resistance gene cluster, cassette, or operon; beta- resistance; antibiotic resistance gene lactam resistance gene; chloramphenicol smeA, mexC, cluster, cassette, or operon; beta- 4.97E-134 mdtE 51 n/a resistance gene; efflux pump conferring mdtE, adeA lactam resistance gene; macrolide antibiotic resistance; fluoroquinolone resistance resistance gene; fluoroquinolone gene; macrolide resistance gene; tetracycline resistance gene resistance gene; trimethoprim resistance gene efflux pump conferring antibiotic efflux pump conferring antibiotic resistance; 0 macB 49 macB n/a resistance; macrolide resistance macrolide resistance gene gene efflux pump conferring antibiotic chloramphenicol resistance gene; efflux pump 2.38E-123 mexH 54 mexV, mexH n/a resistance; fluoroquinolone conferring antibiotic resistance; fluoroquinolone resistance gene resistance gene; tetracycline resistance gene aminocoumarin resistant aminocoumarin 4.03E-105 47 n/a aminocoumarin resistance gene aminocoumarin resistance gene cysB resistant cysB efflux pump conferring antibiotic aminocoumarin resistance gene; mdtC, mdtB, 0 mdtC 72 n/a resistance; aminocoumarin chloramphenicol resistance gene; efflux pump mexN resistance gene conferring antibiotic resistance polymyxin resistance gene; gene gene altering cell wall charge conferring 1.52E-166 PmrE 78 PmrE n/a altering cell wall charge conferring antibiotic resistance; polymyxin resistance gene antibiotic resistance aminocoumarin resistant aminocoumarin 0 77 n/a aminocoumarin resistance gene aminocoumarin resistance gene alaS resistant alaS antibiotic target protection protein; antibiotic target protection protein; 0 mfd 76 mfd n/a fluoroquinolone resistance gene fluoroquinolone resistance gene Mycobacterium Mycobacterium tuberculosis antibiotic resistant gene variant or tuberculosis gyrA antibiotic resistant gene variant or mutant; 0 43 gyrA conferring S95T mutant; fluoroquinolone resistance conferring resistance to fluoroquinolone resistance gene resistance to gene fluoroquinolones fluoroquinolones efflux pump conferring antibiotic 4.31E-72 bcr-1 38 bcr-1 n/a efflux pump conferring antibiotic resistance resistance aminocoumarin resistant aminocoumarin 0 76 n/a aminocoumarin resistance gene aminocoumarin resistance gene cysB resistant cysB</p><p>ARO: Antibiotic Resistance Ontology Model_type used is protein homolog model or protein variant model</p>