<p> Cytochrome P450 Drug Metabolism/Inhibition Table A For a complete list see: http://medicine.iupui.edu/clinpharm/ddis/ Adapted from Indiana University Department of Medicine Division of Clinical Pharmacology website.</p><p>CY1A2 Substrates Significant enzyme inducers Significant enzyme inhibitors Amitriptyline Carbamazepine (strong) Amiodarone Asenapine Insulin Cimetidine Caffeine Modafinil Ciprofloxacin (strong) Clomipramine Omeprazole Fluoroquinolones Clozapine Tobacco Fluvoxamine (strong) Duloxetine Estradiol Fluvoxamine Haloperidol Mirtazapine Olanzapine Ondansetron Propranolol Theophylline Thiothixene Tizanidine Trifluoperazine Verapamil Warfarin</p><p>CYP2C9 Substrates Significant enzyme inducers Significant enzyme inhibitors Amitriptyline Carbamazepine (strong) Amiodarone (moderate) Fluoxetine Rifampin Fenofibrate Glipizide Fluconazole (strong) Glyburide Fluvastatin (moderate) Ibuprofen Indomethacin (strong) Irbesartan Isoniazid Losartan Lovastatin Sertraline Sulfamethoxazole (moderate) Zafirlukast (moderate)</p><p>Revised 04-2012 CYP2C19 Substrates Significant enzyme inducers Significant enzyme inhibitors Amitriptyline Carbamazepine (strong) Cimetidine Carisoprodol Prednisone Fluoxetine Citalopram Rifampin Fluvoxamine Clomipramine Ketoconazole Clopidogrel Lansoprazole Diazepam Modafinil Imipramine Omeprazole Lansoprazole Oxcarbazepine Omeprazole Pantoprazole Pantoprazole Probenecid Propranolol Topiramate Warfarin</p><p>Revised 04-2012 CYP2D6 Substrates Significant enzyme inducers Significant enzyme inhibitors Amitriptyline Dexamethasone Amiodarone Amphetamine Rifampin (weak) Bupropion (strong) Aripiprazole Chlorpromazine (strong) Atomoxetine Cimetidine Carvedilol Citalopram Chlorpheniramine Clomipramine Chlorpromazine Clozapine (moderate) Clomipramine Duloxetine (moderate) Clonidine Escitalopram Codeine Fluoxetine (strong) Desipramine Haloperidol (moderate) Dextromethorphan Methadone Donepezil Paroxetine (strong) Duloxetine Quinidine (strong) Fluoxetine Ritonavir Fluphenazine Sertraline (moderate) Fluvoxamine Terbinafine (moderate) Haloperidol Iloperidone Imipramine Metoclopramide Mirtazapine Nortriptyline Ondansetron Oxycodone Paroxetine Perphenazine Promethazine Propranolol Risperidone Tamoxifen Thioridazine Timolol Tramadol Venlafaxine</p><p>Revised 04-2012 CYP3A4, 5, 7 Substrates Significant enzyme inducers Significant enzyme inhibitors Alprazolam Barbiturates Amiodarone Amlodipine Carbamazepine (strong) Cimetidine Aripiprazole Efavirenz Ciprofloxacin Atorvastatin Glucocorticoids Clarithromycin (strong) Buspirone Modafinil Diltiazem (moderate) Chlorpheniramine Nevirapine Erythromycin (moderate) Clarithromycin Oxcarbazepine (strong) Fluconazole (moderate) Dapsone Phenobarbital Fluvoxamine Dexamethasone Phenytoin Grapefruit juice (moderate) Diazepam Pioglitazone Haloperidol (moderate) Diltiazem Rifabutin Indinavir (strong) Erythromycin (not 3A5) Rifampin Itraconazole (strong) Estradiol St. John’s wort Ketoconazole (strong) Fentanyl Troglitazone Nefazodone (strong) Finasteride Nelfinavir (strong) Haloperidol Norfloxacin (weak) Iloperidone Ritonavir (strong) Indinavir Saquinavir (strong) Lidocaine Verapamil (moderate) Lovastatin Lurasidone Methadone Midazolam Nelfinavir Nifedipine Ondansetron Pimozide Propranolol Quetiapine Quinidine (not 3A5) Risperidone Ritonavir Saquinavir Simvastatin Tamoxifen Triazolam Venlafaxine Verapamil Zaleplon Ziprasidone Zolpidem </p><p>Revised 04-2012</p>