7. Literaturverzeichnis

7. Literaturverzeichnis

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Arselin,G.,Giraud,M.F.,Dautant,A.,Vaillier,J.,Brethes,D.,Coulary-Salin,B.,Schaeffer, J.andVelours,J.(200)TheGxxxGmotifofthetransmembranedomainof subuniteisinvolvedinthedimerization/oligomerizationoftheyeastATPsynthase complexinthemitochondrialmembrane.EurJBiochem,270,875-884. Bayer,T.A.,Schafer,S.,Simons,A.,Kemmling,A.,Kamer,T.,Tepest,R.,Eckert,A., Schussel,K.,Eikenberg,O.,Sturchler-Pierrat,C.,Abramowski,D.,Staufenbiel, M.andMulthaup,G.(200)DietaryCustabilizesbrainsuperoxidedismutase activityandreducesamyloidAbetaproductioninAPP2transgenicmice.ProcNatl AcadSciUSA,00,487-492. Bedouelle,H.andDuplay,P.(988)ProductioninEscherichiacoliandone-step purification of bifunctional hybrid proteins which bind maltose. Export of the Klenow polymeraseintotheperiplasmicspace.EurJBiochem,7,54-549. Beher,D.,Hesse,L.,Masters,C.L.andMulthaup,G.(996)Regulationofamyloidprotein precursor(APP)bindingtocollagenandmappingofthebindingsitesonAPPand collagentypeI.JBiolChem,27,6-620. Beyreuther,K.,Multhaup,G.andMasters,C.L.(996)Alzheimer‘sdisease:genesisof amyloid.CibaFoundSymp,99, 119-27;discussion27-. Borchardt,T.,Camakaris,J.,Cappai,R.,Masters,C.L.,Beyreuther,K.andMulthaup, G.(999)Copperinhibitsbeta-amyloidproductionandstimulatesthenon- amyloidogenicpathwayofamyloid-precursor-proteinsecretion.BiochemJ,44Pt 2,46-467. Borchelt,D.R.,Thinakaran,G.,Eckman,C.B.,Lee,M.K.,Davenport,F.,Ratovitsky,T., Prada,C.M.,Kim,G.,Seekins,S.,Yager,D.,Slunt,H.H.,Wang,R.,Seeger,M., Levey,A.I.,Gandy,S.E.,Copeland,N.G.,Jenkins,N.A.,Price,D.L.,Younkin,S.G. andSisodia,S.S.(996)FamilialAlzheimer‘sdisease-linkedpresenilinvariants elevateAbeta-42/-40ratioinvitroandinvivo.Neuron,7,005-0. Brown,M.S.,Ye,J.,Rawson,R.B.andGoldstein,J.L.(2000)Regulatedintramembrane proteolysis:acontrolmechanismconservedfrombacteriatohumans.Cell,00, 9-98. 82 Literatur Brunkan,A.L.andGoate,A.M.(2005)Presenilinfunctionandgamma-secretaseactivity.J Neurochem,9,769-792. Bush,A.I.,Beyreuther,K.andMasters,C.L.(992)BetaA4amyloidproteinandits precursorinAlzheimer‘sdisease.PharmacolTher,56,97-117. Bush,A.I.,Multhaup,G.,Moir,R.D.,Williamson,T.G.,Small,D.H.,Rumble,B.,Pollwein, P.,Beyreuther,K.andMasters,C.L.(99)Anovelzinc(II)bindingsitemodulates thefunctionofthebetaA4amyloidproteinprecursorofAlzheimer‘sdisease.JBiol Chem,268,609-6112. Buxbaum,J.D.,Gandy,S.E.,Cicchetti,P.,Ehrlich,M.E.,Czernik,A.J.,Fracasso,R.P., Ramabhadran,T.V.,Unterbeck,A.J.andGreengard,P.(990)Processingof Alzheimerbeta/A4amyloidprecursorprotein:modulationbyagentsthatregulate proteinphosphorylation.ProcNatlAcadSciUSA,87,600-6006. Campion,D.,Dumanchin,C.,Hannequin,D.,Dubois,B.,Belliard,S.,Puel,M.,Thomas- Anterion,C.,Michon,A.,Martin,C.,Charbonnier,F.,Raux,G.,Camuzat,A.,Penet, C.,Mesnage,V.,Martinez,M.,Clerget-Darpoux,F.,Brice,A.andFrebourg,T. (999)Early-onsetautosomaldominantAlzheimerdisease:prevalence,genetic heterogeneity,andmutationspectrum.AmJHumGenet,65,664-670. Cao,X.andSudhof,T.C.(2004)Dissectionofamyloid-betaprecursorprotein-dependent transcriptionaltransactivation.JBiolChem,279,2460-24611. Cervantes,S.,Gonzalez-Duarte,R.andMarfany,G.(200)Homodimerizationof presenilinN-terminalfragmentsisaffectedbymutationslinkedtoAlzheimer‘s disease.FEBSLett,505,8-86. Cervantes,S.,Saura,C.A.,Pomares,E.,Gonzalez-Duarte,R.andMarfany,G.(2004) Functionalimplicationsofthepresenilindimerization:reconstitutionofgamma- secretaseactivitybyassemblyofacatalyticsiteatthedimerinterfaceoftwo catalyticallyinactivepresenilins.JBiolChem,279,659-6529. Chandu,D.,Huppert,S.S.andKopan,R.(2006)Analysisoftransmembranedomain mutantsisconsistentwithsequentialcleavageofNotchbygamma-secretase.J Neurochem,96,228-25. Chyung,J.H.,Raper,D.M.andSelkoe,D.J.(2005)Gamma-secretaseexistsonthe plasmamembraneasanintactcomplexthatacceptssubstratesandeffects intramembranecleavage.JBiolChem,280,48-492. Citron,M.,Oltersdorf,T.,Haass,C.,McConlogue,L.,Hung,A.Y.,Seubert,P.,Vigo-Pelfrey, C.,Lieberburg,I.andSelkoe,D.J.(992)Mutationofthebeta-amyloidprecursor proteininfamilialAlzheimer‘sdiseaseincreasesbeta-proteinproduction.Nature, 60,672-674. Citron,M.,Vigo-Pelfrey,C.,Teplow,D.B.,Miller,C.,Schenk,D.,Johnston,J.,Winblad,B., Venizelos,N.,Lannfelt,L.andSelkoe,D.J.(994)Excessiveproductionofamyloid beta-proteinbyperipheralcellsofsymptomaticandpresymptomaticpatients carryingtheSwedishfamilialAlzheimerdiseasemutation.ProcNatlAcadSciUS A,9, 1199-11997. Cordy,J.M.,Hussain,I.,Dingwall,C.,Hooper,N.M.andTurner,A.J.(200)Exclusively targetingbeta-secretasetolipidraftsbyGPI-anchoradditionup-regulatesbeta-site processingoftheamyloidprecursorprotein.ProcNatlAcadSciUSA,00, 1175- 11740. Coulson,E.J.,Paliga,K.,Beyreuther,K.andMasters,C.L.(2000)Whattheevolution 8 Literatur oftheamyloidproteinprecursorsupergenefamilytellsusaboutitsfunction. NeurochemInt,6,75-84. Cruts,M.,Backhovens,H.,Wang,S.Y.,VanGassen,G.,Theuns,J.,DeJonghe,C.D., Wehnert,A.,DeVoecht,J.,DeWinter,G.,Cras,P.andetal.(995)Molecular geneticanalysisoffamilialearly-onsetAlzheimer‘sdiseaselinkedtochromosome 4q24..HumMolGenet,4,26-27. Curtain,C.C.,Ali,F.,Volitakis,I.,Cherny,R.A.,Norton,R.S.,Beyreuther,K.,Barrow,C.J., Masters,C.L.,Bush,A.I.andBarnham,K.J.(200)Alzheimer‘sdiseaseamyloid- betabindscopperandzinctogenerateanallostericallyorderedmembrane- penetratingstructurecontainingsuperoxidedismutase-likesubunits.JBiolChem, 276,20466-2047. DeStrooper,B.(2007)Loss-of-functionpresenilinmutationsinAlzheimerdisease.Talking PointontheroleofpresenilinmutationsinAlzheimerdisease.EMBORep,8,4- 46. DeStrooper,B.,Saftig,P.,Craessaerts,K.,Vanderstichele,H.,Guhde,G.,Annaert,W., Von Figura, K. and Van Leuven, F. (1998) Deficiency of presenilin-1 inhibits the normalcleavageofamyloidprecursorprotein.Nature,9,87-90. Deibel,M.A.,Ehmann,W.D.andMarkesbery,W.R.(996)Copper,iron,andzinc imbalancesinseverelydegeneratedbrainregionsinAlzheimer‘sdisease:possible relationtooxidativestress.JNeurolSci,4,7-42. Dovey,H.F.,Suomensaari-Chrysler,S.,Lieberburg,I.,Sinha,S.andKeim,P.S.(99) CellswithafamilialAlzheimer‘sdiseasemutationproduceauthenticbeta-peptide. Neuroreport,4,09-042. Dyrks,T.,Dyrks,E.,Masters,C.andBeyreuther,K.(992)MembraneinsertedAPP fragmentscontainingthebetaA4sequenceofAlzheimer‘sdiseasedonot aggregate.FEBSLett,09,20-24. Edbauer,D.,Winkler,E.,Regula,J.T.,Pesold,B.,Steiner,H.andHaass,C.(200) Reconstitutionofgamma-secretaseactivity.NatCellBiol,5,486-488. Eggert,S.,Paliga,K.,Soba,P.,Evin,G.,Masters,C.L.,Weidemann,A.andBeyreuther, K.(2004)Theproteolyticprocessingoftheamyloidprecursorproteingenefamily membersAPLP-andAPLP-2involvesalpha-,beta-,gamma-,andepsilon-like cleavages:modulationofAPLP-processingbyn-glycosylation.JBiolChem,279, 846-856. Ehehalt,R.,Keller,P.,Haass,C.,Thiele,C.andSimons,K.(200)Amyloidogenic processingoftheAlzheimerbeta-amyloidprecursorproteindependsonlipidrafts. JCellBiol,60, 113-2. Eriksen,J.L.,Sagi,S.A.,Smith,T.E.,Weggen,S.,Das,P.,McLendon,D.C.,Ozols, V.V.,Jessing,K.W.,Zavitz,K.H.,Koo,E.H.andGolde,T.E.(200)NSAIDsand enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J ClinInvest, 112,440-449. Esch,F.S.,Keim,P.S.,Beattie,E.C.,Blacher,R.W.,Culwell,A.R.,Oltersdorf,T.,McClure, D.andWard,P.J.(990)Cleavageofamyloidbetapeptideduringconstitutive processingofitsprecursor.Science,248, 1122-1124. Esler,W.P.,Kimberly,W.T.,Ostaszewski,B.L.,Diehl,T.S.,Moore,C.L.,Tsai,J.Y., Rahmati,T.,Xia,W.,Selkoe,D.J.andWolfe,M.S.(2000)Transition-state 84 Literatur analogueinhibitorsofgamma-secretasebinddirectlytopresenilin-.NatCellBiol, 2,428-44. Ferguson,K.M.,Darling,P.J.,Mohan,M.J.,Macatee,T.L.andLemmon,M.A.(2000) Extracellulardomainsdrivehomo-butnothetero-dimerizationoferbBreceptors. 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(1987) CharacterizationandchromosomallocalizationofacDNAencodingbrainamyloid ofAlzheimer‘sdisease.Science,25,877-880. Goutte,C.,Tsunozaki,M.,Hale,V.A.andPriess,J.R.(2002)APH-isamultipass

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