<p> 1</p><p>Electronic Supplementary Material: Figures</p><p>Figure S1. Heat map of 104 C. elegans genes that are equally regulated in 5-7 microarray studies assaying DR versus AL conditions. Colour code; magenta: high upregulated, red: upregulated, dark green: high downregulated, green: downregulated. Black numbers indicate fold differential regulation DR/AL. DR1,5 ad; livelong exposure to mild DR conditions, harvested as 3 days old adults; DR0,7 ad; livelong exposure to severe DR conditions, harvested as 3 days old adults; . DR1,5 L4; livelong exposure to mild DR conditions, harvested at larval stage 4 (46h); DR0,7 L4; livelong exposure to severe DR conditions, harvested at larval stage 4 (46h); DR0,7 L4e; livelong exposure to severe DR conditions, harvested at early larval stage 4 (42h); GSE9682: worms were exposed to intermittent fasting (IF) or ad libitum food intake (Honjoh et al., 2009); GSE6057: worms were grown in liquid minimal axcenic medium versus worms grown on full medium (Szewczyk et al.2009). </p><p>Figure S2. Functional orthologs. The upmost panel in each sub figure displays the mouse protein and its functional domains (adapted from http://blast.ncbi.nlm.nih.gov/), each middle panel shows stretches of homology within the closest C. elegans orthologs (blue bars), the length of the C. elegans protein in amino acid (aa) is indicated to the left and the degree of homology (BLAST; e-value) to the right. The lower panel shows the x -fold change in transcriptional expression of putative C. elegans functional orthologs in microarray approaches assaying DR versus AL conditions; red- upregulated, green-downregulated, yellow- no regulation. </p><p>Figure S3. Interconection networks of DR regulated genes; A) MUP-4 muscle positioning network. B) Lysosomal network.</p><p>1 2</p><p>2 3</p><p>3 4</p><p>Figure S1)</p><p>4 5</p><p>5 6</p><p>6 7</p><p>7 8</p><p>Figure S2) Functional orthologs</p><p>8 9</p><p>Figure S3)</p><p>9</p>