<p>SUPPLEMENTARY INFORMATION In format provided by Wu et al. (doi:10.1038/nrneurol.2017.63)</p><p>Supplementary information S2 | Incidence studies: estimates by 10-year age group</p><p>Incidence Cohort (yr.) N Person-year Overall 60–69 years 70–79 years 80–89 years Ratio (95% CI) Rotterdam study1* Total II (1990) 5727 25696 6.6 1.3 9.7 31.5 (reference) (per 1000 person-years) (5.6, 7.7) (0.7, 2.2) (7.9, 11.8) (26.6, 37.3) II (2000) 1769 8384 4.9 1.1 6.4 26.4 0.8 (0.6, 1.0) (3.7, 6.6) (0.4, 2.4) (3.9, 10.3) (18.1, 38.7) Men II (1990) 2313 10297 6.3 1.8 9.8 30.9 (reference) (4.8, 8.1) (0.9, 3.6) (7.1, 13.5) (22.9, 42.3) II (2000) 777 3643 4.5 1.4 4.7 30.4 0.7 (0.4, 1.2) (2.8, 7.1) (0.4, 4.6) (2.1, 10.6) (16.6, 55.6) Women II (1990) 3414 15399 6.8 0.9 9.5 31.8 (reference) (5.5, 8.4) (0.4, 2.2) (7.3, 12.3) (26.0, 38.8) II (2000) 992 4741 5.2 0.8 7.8 24.2 0.8 (0.5, 1.1) (3.6, 7.6) (0.2, 3.5) (4.3, 14.3) (14.8, 39.6) Framingham Heart Study2‡ Total II (1977) 2457 11379 3.6 1.2 5.3 23.1 (reference) (per 100 persons over 5 years) (2.9, 4.4) (0.7, 1.9) (3.8, 7.4) (16.8, 31.6) II (1986) 2135 9769 2.8 0.5 4.9 17.9 0.8 (0.6, 1.0) (2.2, 3.5) (0.2, 1.1) (3.6, 6.6) (12.8, 25.1) III (1992) 2333 10506 2.2 0.4 3.6 17.3 0.6 (0.5, 0.8) (1.8, 2.8) (0.2, 1.0) (2.5, 5.0) (13.2, 22.7) IV (2004) 2090 8548 2.0 0.5 3.4 15.8 0.6 (0.4, 0.8) (1.5, 2.6) (0.2, 1.1) (2.1, 5.3) (11.4, 21.9) Men II (1977) 999 4574 2.6 1.3 4.4 15.1 (reference) (1.8, 3.8) (0.6, 2.6) (2.4, 7.8) (7.5, 30.3) II (1986) 914 4117 2.5 0.9 4.4 17.7 1.0 (0.6, 1.6) (1.7, 3.6) (0.3, 2.4) (2.6, 7.4) (10.1, 30.9) III (1992) 1000 4456 2.3 0.5 4.1 14.2 0.9 (0.6, 1.4)</p><p>NATURE REVIEWS | NEUROLOGY www.nature.com/nrneurol SUPPLEMENTARY INFORMATION In format provided by Wu et al. (doi:10.1038/nrneurol.2017.63)</p><p>(1.6, 3.3) (0.2, 1.7) (2.5, 6.8) (8.5, 23.8) IV (2004) 929 3807 1.7 0.2 3.1 18.0 0.6 (0.4, 1.1) (1.1, 2.6) (0.0, 1.3) (1.6, 6.2) (11.0, 29.4) Women II (1977) 1458 6796 4.3 1.1 5.9 26.8 (reference) (3.3, 5.5) (0.6, 2.2) (3.9, 8.9) (18.8, 38.2) II (1986) 1221 5651 3.0 0.2 5.2 17.1 0.7 (0.5, 1.0) (2.2, 4.0) (0.1, 1.0) (3.5, 7.6) (11.1, 26.3) III (1992) 1333 6049 2.2 0.4 3.0 18.6 0.5 (0.4, 0.7) (1.6, 3.0) (0.1, 1.3) (1.8, 5.0) (13.5, 25.7) IV (2004) 1161 4740 2.3 0.7 3.5 13.9 0.5 (0.4, 0.8) (1.6, 3.2) (0.2, 1.7) (1.9, 6.6) (8.8, 21.8)</p><p>*Rotterdam study: All incidence rate estimates and ratios were adjusted for age. ‡Framingham Heart study: All incidence estimates and ratios were adjusted for age and gender.</p><p>1. Schrijvers, E. M. et al. Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology 78, 1456–1463 (2012). 2. Satizabal, C. L. et al. Incidence of dementia over three decades in the Framingham Heart Study. N. Engl. J. Med. 374, 523–532 (2016).</p><p>NATURE REVIEWS | NEUROLOGY www.nature.com/nrneurol</p>