<p>Table S1 Summary of discussed bacteria surface glycoproteins systemsa) Organism surface Linkage Glycan transferred Gtfs References glycoprot ein Oral microbes Streptococcus Fap1 O Rha1-3Glc1-(Glc1- Gtf1,2,3,DUF1972,GalT1, (Wu et al., 2010; parasanguinis FW213 3GlcNAc1-)2,6Glc1- GalT2, Gly Zhang et al., 6GlcNAc 2014; Zhou et al., 2010; Zhu et al., 2015b) Streptococcus gordonii GspB, O GtfA,GtfB (Bensing et al., Hsa 2004; Takamatsu et al., 2004a, b) Streptococcus mutans Cnm O GlcNAc Pgfs (Aviles-Reyes et al., 2014; Miller et al., 2015) Streptococcus sanguinis SrpA N rhamnose N/D (Erickson and Herzberg, 1993) Porphyromonas Mfa1 N and O fucose, mannose, N/D (Zeituni et al., gingivalis GlcNAc, 2010) and GalNAc RgpA and N and O Ara, Rha, Fuc, Man, VimF (Curtis et al., RgpB Gal, Glc, GalNAc, 1999) GlcNAc Aggregatibacter EmaA O fucose, rhamnose, N/D (Tang and Mintz, actinomycetemcomitans and GalNAc 2010; Tang et al., 2012) T. forsythia TfsA and O 4-Me-β- N/D (Posch et al., TfsB ManpNAcCONH2- 2011) (1→3)- [Pse5Am7Gc- (2→4)-]-β- ManpNAcA-(1→4)- [4-Me-α-Galp- (1→2)-]-α-Fucp- (1→4)-[-α-Xylp- (1→3)-]-β-GlcpA- (1→3)-[-β-Digp- (1→2)-]-α-Galp Gut microbes diffusely adhering AIDA-I O Heptose AAH and AAH2 (Benz and Escherichia Schmidt, 2001; coli Lindenthal and Elsinghorst, 1999) enterotoxigenic TibA O Heptose TibC (Lu et al., 2014) E. coli E.coli Ag43 O Heptose N/D (Sherlock et al., 2006) Campylobacter jejuni PEB3 N GalNAc N/D (Linton et al., 2002) CgpA N GalNAc N/D (Linton et al., 2002) MOMP O Gal(β1-3)- N/D (Mahdavi et al., GalNAc(β1-4)- 2014) GalNAc(β1-4)- GalNAcα1 Streptococcus PsrP O GlcNAc and Glc GtfA,B,C (Shi et al., 2014; pneumonia Wu et al., 2010; Zhu et al., 2015a) Streptococcus agalactiae Srr1 O GlcNAc and Glc GtfA,B,C (Chaze et al., 2014) Srr2 O GlcNAc and Glc GtfA,B,C (Seifert et al., 2006; Zhu et al., 2015a) Skin microbes Staphylococcus aureus SraP O GlcNAc GtfA,GtfB (Li et al., 2014) Staphylococcus Sdr O GlcNAc N/D (Hazenbos et al., epidermidis 2013)</p><p> a) N/D, not determined. </p><p>References Aviles-Reyes, A., Miller, J.H., Simpson-Haidaris, P.J., Lemos, J.A., and Abranches, J. (2014). Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus. Molecular oral microbiology 29, 11-23. Bensing, B.A., Lopez, J.A., and Sullam, P.M. (2004). The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha. Infection and immunity 72, 6528-6537. Benz, I., and Schmidt, M.A. (2001). Glycosylation with heptose residues mediated by the aah gene product is essential for adherence of the AIDA-I adhesin. Molecular microbiology 40, 1403-1413. Chaze, T., Guillot, A., Valot, B., Langella, O., Chamot-Rooke, J., Di Guilmi, A.M., Trieu-Cuot, P., Dramsi, S., and Mistou, M.Y. (2014). O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry. Molecular & cellular proteomics : MCP 13, 2168-2182. Curtis, M.A., Thickett, A., Slaney, J.M., Rangarajan, M., Aduse-Opoku, J., Shepherd, P., Paramonov, N., and Hounsell, E.F. (1999). Variable carbohydrate modifications to the catalytic chains of the RgpA and RgpB proteases of Porphyromonas gingivalis W50. Infection and immunity 67, 3816-3823. Erickson, P.R., and Herzberg, M.C. (1993). Evidence for the covalent linkage of carbohydrate polymers to a glycoprotein from Streptococcus sanguis. The Journal of biological chemistry 268, 23780-23783. Hazenbos, W.L., Kajihara, K.K., Vandlen, R., Morisaki, J.H., Lehar, S.M., Kwakkenbos, M.J., Beaumont, T., Bakker, A.Q., Phung, Q., Swem, L.R., Ramakrishnan, S., Kim, J., Xu, M., Shah, I.M., Diep, B.A., Sai, T., Sebrell, A., Khalfin, Y., Oh, A., Koth, C., Lin, S.J., Lee, B.C., Strandh, M., Koefoed, K., Andersen, P.S., Spits, H., Brown, E.J., Tan, M.W., and Mariathasan, S. (2013). Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS pathogens 9, e1003653. Li, Y., Huang, X., Li, J., Zeng, J., Zhu, F., Fan, W., and Hu, L. (2014). Both GtfA and GtfB are required for SraP glycosylation in Staphylococcus aureus. Current microbiology 69, 121-126. Lindenthal, C., and Elsinghorst, E.A. (1999). Identification of a glycoprotein produced by enterotoxigenic Escherichia coli. Infection and immunity 67, 4084-4091. Linton, D., Allan, E., Karlyshev, A.V., Cronshaw, A.D., and Wren, B.W. (2002). Identification of N-acetylgalactosamine- containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Molecular microbiology 43, 497-508. Lu, Q., Yao, Q., Xu, Y., Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G., Zamyatina, A., Liu, X., Chen, S., and Shao, F. (2014). An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell host & microbe 16, 351-363. Mahdavi, J., Pirinccioglu, N., Oldfield, N.J., Carlsohn, E., Stoof, J., Aslam, A., Self, T., Cawthraw, S.A., Petrovska, L., Colborne, N., Sihlbom, C., Boren, T., Wooldridge, K.G., and Ala'Aldeen, D.A. (2014). A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and </p>