Royal Postgraduate Medical School/Hammersmith, Queen Charlotte S & Chelsea and Acton Hospitals

HAMMERSMITH AND QUEEN CHARLOTTE’S & CHELSEA HOSPITALS research ethics committee annual report 2001/2002Report for period 1 April 2001 – 31 March 2002  INTRODUCTIONThe Research Ethics Committee is responsible for protecting the rights of research participants and ensuring that all research involving human subjects carried out within the Imperial College School of Medicine (Hammersmith Campus), the Hammersmith Hospitals NHS Trust and its immediate geographical area conforms to the highest ethical standards.All research projects involving human subjects at any of the hospitals of the Hammersmith Hospitals NHS Trust must be approved by a Research Ethics Committee. Currently, protocols undertaken at either Hammersmith, Queen Charlotte's and Chelsea or Acton hospitals are considered by the Hammersmith, Queen Charlotte's and Chelsea and Acton hospitals (HQC & AH) Research Ethics Committee. Applications for projects to be carried out at Charing Cross Hospital are considered by the Riverside Research Ethics Committee based at Chelsea and Westminster Hospital. Professor John CalamThe former Research Ethics Committee Chairman Professor John Calam died on 9 July 2001. The Chairman and the Secretary along with several members of the committee attended the memorial service celebrating John's life. The Committee’s sincere sympathies were forwarded to John's wife Joyce and his family. MEMBERSHIPThe Committee currently has 19 members (as of 31st March 2002), including the Chair and Vice Chair. The full membership is listed at annex 1. DEPARTURES:May 2001:Mr Jim Jeffs, Statistician, ICSMAugust 2001:Professor T R Rogers MSc, FRCPath, FRCPI, Infectious Diseases, ICSMNEW MEMBERS:The Committee welcomed the following new members during 2001/2002:April 2001: Mr Jim Jeffs, Statistician, ICSM (resigned May 2001)September 2001: Dr J Apperley, Reader in Haematology, ICSM; Dr Piers Benn, Lecturer in Medical ethics & Law, ICSM (lay member)October 2001: Ms Alison Forrester, Trials Co-ordinator, ICRF Dept. of Viral & Gene Therapy, Hammersmith HospitalDecember 2001: Ms D O'Dell-Athill, BSc Lecturer (lay member)January 2002: Ms S Strickland, BSc, Clinical Nurse Specialist in Gestational Trophoblastic Disease, Charing X HospitalOBSERVERS:July 2001: Dr Piers Benn, Lecturer in Medical ethics & Law, ICSM (Prospective Lay Member)September 2001: Ms A Forrester, BSc, Research Nurse/Trials Co-ordinator, Viral & Gene Therapy Dept., ICRF - (Prospective Lay Member)November 2001: Dr S Coates, General PractitionerMarch 2002: Dr Charles Mackworth-Young (Chair) and Ms Katherine Bolton (Administrator) from the Riverside Research Ethics Committee. REPORTS/GUIDELINES DISCUSSED Draft guidelines regarding student research produced by AREC for comment. The Nuffield Council of Bioethics consultation document “Genetics And Human Behaviour: The Ethical Context”2 The committee felt that the Nuffield Council's should be contacted to indicate our general support for research into the genetic basis of human behaviour. The Chairman and the Secretary would compose a brief communication. MRC Human & Biological Samples: Use In Research – Final Guidelines  The RCP Transitional Guidelines To Facilitate Changes In Procedures For Handling ‘Surplus’ And Archival Material From Human Biological SamplesIt was noted that the general tone of the RCP's guidance was somewhat at variance with the MRC guidelines, specifically the recommendation by the MRC that tissue samples should be regarded as a "gift". It was also noted that the RCP guidelines did not address the use of paediatric samples.However, the MRC guidelines were felt to be more likely to be those followed by the research community and were the guidelines that the committee expected all research using human tissue to be conducted by. It was felt that the Trust, ICSM and the MRC needed to disseminate the MRC guidelines to all research active staff. Dr Rodney Gale in the trust's R&D office would be approached to disseminate the document to Trust staff. Dr Charles Mackworth-Young would also be approached to ascertain whether the Riverside REC also require investigators to follow the MRC guidelines for research performed at Charing Cross. The Secretary would also disseminate the document to ICSM divisional heads informing them the committee required all research using human tissue to be conducted in accordance with the MRC guidelines. Governance Arrangements for NHS Research Ethics Committees (Draft) (New “Red Book”)  AREC meeting: “Protecting Patients Better: Recent Advances in Research Regulation” - Information and application form. The draft national LREC application form from COREC for comments. COMMITTEE PROCEDURESICSM "no fault" scheme - standard paragraph in the information sheet:The committee decided that the wording of the standard phrase regarding compensation through the Imperial College School of Medicine "no fault" scheme should be revised. Old paragraph: “In the event of your suffering any adverse effects as a consequence of your participation in this study, you will be compensated through the Imperial College School of Medicine’s “No Fault” Compensation Scheme.”Revised paragraph: “If you are harmed by taking part in this research project, you will be compensated through the Imperial College School of Medicine’s “No Fault” Compensation Scheme.” OTHER ISSUES DISCUSSED AND DECISIONS REACHED 3REGISTER OF TISSUE SAMPLES:It was felt that a letter should be written to the trust R&D department to encourage it to set up and maintain a register of all tissue samples taken from patients within the hospital. This register should be publicly available.POLKINGHORNE GUIDELINESThe Committee discussed the relevance of the Polkinghorne guidelines to the provision of research information to women undergoing termination of pregnancy. It was felt that if the information regarding the research was given after the decision to terminate was made that this would not unduly influence or compromise the initial decision to undergo the termination.  WORKLOADThe Committee met on eleven occasions in 2001/2002. No. of applications reviewed by Full Committee 124 No. of applications “approved” by Full Committee (as of 31-3-01) 96No. of applications “approved” by Full Committee without amendment 1 No. of applications “approved” by Full Committee following amendment 95 (as of 31-3-01)No. of applications “approved in principle” or “not approved” by Full Committee 28 awaiting final approval (at 31-3-01)No. of applications reviewed by MREC Sub-Committee 29 No. of applications “noted” by MREC Sub-Committee (at 31-3-01) 27 No. of MREC applications pending (at 31-3-03) 2No. of applications reviewed by Chairman’s action 85 No. of applications “approved” by Chairman’s action 85Total new applications considered: 238No. of applications for amendments reviewed by Chairman’s action 105No. of applications “reviewed” in previous year finally given approval by Chairman’s action 23A full list of protocols considered/approved during 2001/2002 is at annex 2. APPENDICES 4 1. Committee Membership 2(a). Studies “approved in principle” in previous financial year given final approval in 2001/2002 2(b). Studies approved by Full Committee without amendment 2(c). Studies approved by full committee after amendment 2(d). Studies approved by ‘Chairman's Action’ 2(e). Studies considered by Full Committee - Still pending (i.e. Approved in Principle/Not Approved) 2(f) MREC approved studies approved by sub-committeeAppendix 1 MEMBERSHIP OF HAMMERSMITH, QUEEN CHARLOTTE'S & CHELSEA AND ACTON HOSPITALS RESEARCH ETHICS COMMITTEE 5 Dr A George MA, PhD, MRCPath, Reader in Molecular Immunology, ICSM, (Chairman)Dr J Apperley, Reader in Haematology, ICSMProfessor P Bennett BSc, Phd, MD, MRCOG, Professor in Obstetrics & Gynaecology, ICSMDr S Brett MB. MD, ChB, FRCA, Consultant in Intensive Care Medicine and Anaesthesia, HHTMiss J Butler-Barnes, Imaging Research Nurse, Hammersmith Hospitals TrustDr S Coates, G.P.Professor A D Edwards MA, MB, BS, FRCP, Weston Professor of Neonatal Medicine, ICSMDr D N F Harris MD, DA, FRCA, Senior Lecturer of Anaesthesia, ICSMMs A Jacklin Chief Pharmacist, Hammersmith Hospitals TrustMr P Jankowiak Head of Information, Hammersmith Hospitals TrustProf El-Nasir Lalani MBChB, B.Sc.(Hons), MRCPath, Ph.D. , Reader in Cellular and Molecular Pathology, ICSMDr M J Myers BSc, PhD, ARCS, FInstPSM, Honorary Lecturer Medical Physics and Radiation Protection Advisor, Hammersmith Hospitals TrustDr S Shaunak PhD, FRCP, FRCPE, Infectious diseases, ICSMMs S Strickland BSc, Clinical Nurse Specialist in Gestational Trophoblastic Disease, Charing X Hospital Lay RepresentativesLady Riddell (Vice-Chair) Dr P BennMs F Freedland, BAMrs J Lundie BAMs D O'Dell-Athill, BScSecretaryMr Clive Collett, BSc., PGDip., MA Appendix 2(a)Studies “approved in principle/not approved” in previous year given final approval in 2001/20026 LREC Ref 2000/5942Study Title Assessment of Ventilation-Perfusion abnormalities in patients with asthma and chronic obstructive pulmonary disease during acute exacerbations and recovery. Title Dr.First Name PhilipLast Name IndLREC Ref 2000/5973Study Title Aortic Stentless Versus Stented Echocardiography Randomised Trial - A randomized comparison of the FreestyleTM valve and the MosaicTM valve in the Title Mr.First Name JLast Name AndersonLREC Ref 2000/5974Study Title The effect of cytokines on renal transplant outcome. Title Dr.First Name ArleneLast Name Rodrigues-NaimLREC Ref 2000/5989Study Title A study of the anti-leukaemic activity of cytotoxic T lymphocytes specific for haemopoietic antigens in acute and chronic myeloid leukaemia. Title Dr.First Name PersisLast Name AmroliaLREC Ref 2001/6011Study Title (BY9010 FK1 116 EXAC Trial) Comparative study of inhaled ciclesonide (800 µg bd) versus oral prednisolone (40 mg od) in patients with an asthma exacerbation. A randomized, double-blind, double dummy, parallel group study Title Dr.First Name PhilipLast Name IndLREC Ref 2001/6012Study Title Understanding pathophysiological mechanisms in sporadic and familial cases of motor neurone disease Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6027 7 Study Title In Vitro Studies of Endothelial Cells Derived from HHT Patients Title Dr.First Name ClaireLast Name ShovlinLREC Ref 2001/6028Study Title Investigation of the genetic aetiology of intrauterine growth (blood and fetal tissues at termination) Title Dr.First Name GudrunLast Name MooreLREC Ref 2001/6029Study Title Investigation of the genetic aetiology of intrauterine growth (blood and placenta at Title Dr.First Name GudrunLast Name MooreLREC Ref 2001/6032Study Title Awareness of memory functioning in cognitive impairment: an empirical evaluation of the reformulated DICE model. Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6034Study Title The effect of continuous combined oestrogen and progesteron on arterial compliance, left ventricular function and cognition in elderly women Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6037Study Title Role of high-resolution ultrasound in the diagnosis and assessment of soft-tissue rheumatic complaints Title DrFirst Name MichaelLast Name NaughtonLREC Ref 2001/6042Study Title Placental pathophysiology of intertwin transfusion syndromes in monochorionic multiple pregnancy 8 Title Prof.First Name NMLast Name FiskLREC Ref 2001/6053Study Title Non-invasive determination of macrophage behaviour in scleroderma (SSc) patients at risk of fibrosing alveolitis (FA) Title Dr.First Name PhilipLast Name IndLREC Ref 2001/6054Study Title Bio-feedback for the active second stage of labour - does it facilitate spontaneous vaginal delivery? Title Dr.First Name SaraLast Name Paterson-BrownLREC Ref 2001/6055Study Title An open-label, single-center, pilot study to assess the ovarian response and technically correct injections using the needle-free J-Tip to administer Puregon to subjects undergoing controlled ovarian hyperstimulation for IVF or ICSI Title Mr.First Name GLast Name TrewLREC Ref 2001/6056Study Title A positron emission tomography study to investigate the effect of globus pallidum deep brain stimulation on patients with primary torsion dystonia. Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6058Study Title Expression of a novel human apical membrane calcium transporter and intestinal calcium absorption (Protocol B) Title Dr.First Name JulianLast Name WaltersLREC Ref 2001/6059Study Title Expression of a novel human apical membrane calcium transporter and intestinal calcium absorption (Protocol C) Title Dr. 9 First Name JulianLast Name WaltersLREC Ref 2001/6060Study Title The relationship of cognitive measures of memory and personality traits to serotonin 1A receptor binding in the human brain Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6061Study Title Brain 5-HT2A receptors in healthy volunteers and depressed patients: An [11C]MDL-100907 PET study Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6062Study Title A Medium Term Follow-up Study of Women who took part in the Hammersmith Hospital Cervical Screening Study Title Dr.First Name AnneLast Name SzarewskiLREC Ref 2001/6063Study Title Evaluation of the HemoCue for measuring haemoglobin in the peripartum population. Title Dr.First Name GaryLast Name StocksAppendix 2(b)Studies Approved by Full Committee without AmendmentLREC Ref 2001/6082Study Title Zinc in tuberculosis skin testing Title Dr.First Name CarltonLast Name Evans10 Appendix 2(c)Studies approved by full committee after amendmentLREC Ref 1993/3995Study Title Clinical Evaluation of magnetic resonance imaging (MRI). (Extension of protocol Title Prof.First Name GraemeLast Name BydderLREC Ref 1993/4047Study Title Clinical evaluation of magnetic resonance spectroscopy (MRS). (Extension of protocol 93/4047)Title Prof.First Name GraemeLast Name BydderLREC Ref 2001/6026Study Title Protocol No CSTI571B2225. An open label, pilot phase 11 study of STI571 in patients with life threatening diseases known to be associated with one or more STI571-sensitive tyrosine Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6035Study Title Can a percentage change in the fractional retention of 2-(11C) thymidine at 1 hour be used to measure fractional cell kill and assess ultimate tumour response following anti cancer treatment ? (RREC 2761)Title Prof.First Name CharlesLast Name Coombes11 LREC Ref 2001/6038Study Title Glucose-Insulin-Potassium (GIK) Treatment In Non-Diabetic Females Undergoing Cardiac Surgery TrialTitle Prof.First Name KLast Name TaylorLREC Ref 2001/6039Study Title Androgens and endometrial receptivityTitle Mr.First Name GLast Name TrewLREC Ref 2001/6052Study Title A Phase 2, Multi-center, Double-blinded, Placebo-controlled, Dose-finding Study of ZYC101a in the Treatment of High-Grade Squamous Intra-epithelial Lesions of the Uterine Cervix.Title Mr.First Name PatLast Name SoutterLREC Ref 2001/6057Study Title Pharmacogenomics of Essential HypertensionTitle Prof.First Name MartinLast Name WilkinsLREC Ref 2001/6076Study Title Development of methods to assess sensory function in spinal cord injuryTitle Prof.First Name PraveenLast Name Anand12 LREC Ref 2001/6077Study Title The Diagnostic Utility of Fluorescence Lifetime Imaging Microscopy (FLIM), Optical Coherence Tomography (OCT) and Magnetic Resonance Microscopy (MRM) in Human Female Breast CancerTitle Dr.First Name PaulLast Name TadrousLREC Ref 2001/6078Study Title In-vitro magnetic resonance spectroscopy of liver biopsies in viral hepatitis and steatohepatitisTitle Dr.First Name SimonLast Name Taylor-RobinsonLREC Ref 2001/6079Study Title Microglial activation in patients taking neuroleptic therapy with/without tardive dyskinesia: A PET StudyTitle Prof.First Name DavidLast Name BrooksLREC Ref 2001/6080Study Title Investigation of the effects of repetitive Transcranial Magnetic Stimulation of the Anterior Cingulate on blood flow using Positron Emission TomographyTitle Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6091Study Title Investigation of the abnormal response to monosodium urate crystals in Behçet’s syndromeTitle Prof.First Name DorianLast Name Haskard13 LREC Ref 2001/6092Study Title A study investigating whether progesterone suppositories (Cyclogest®) provide adequate luteal support / result in sufficient progesterone levels during IVF cyclesTitle Mr.First Name GLast Name TrewLREC Ref 2001/6093Study Title A phase II, multi-centre, double-blind, placebo-controlled, parallel group study to assess the safety and efficacy of a single intravenous dose of the humanised anti-TNF PEG conjugate, CDP870 (1.25, 5 20mg/kg) in patients with active Crohn's Title Dr.First Name JulianLast Name WaltersLREC Ref 2001/6094Study Title Investigation Of The Effects Of Peptide YY On Appetite.Title Prof.First Name SLast Name BloomLREC Ref 2001/6096Study Title A novel human cell culture model of prion disease to study the pathophysiology of prion infectionTitle Dr.First Name SarahLast Name TabriziLREC Ref 2001/6097Study Title Anti-cytokine therapy with Infliximab for vasculitisTitle Prof.First Name CharlesLast Name Pusey14 LREC Ref 2001/6098Study Title A study to measure the occupancy of ziprasidone at the 5-HT1A receptor using PET scanningTitle Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6099Study Title Genetic determinants of plasma factor VIII concentrationTitle Dr.First Name MikeLast Name LaffanLREC Ref 2001/6108Study Title Brain receptor occupancy and pharmacokinetics of Ro 67-5930 after oral administration of multiple doses (MD PET Scan Study) version B dated 19th July Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6111Study Title The effect of low glycaemic diet on weight maintenance following a three-months weight reduction program using formula meal replacement in obese patients with late-onset diabetes mellitus (NIDDM).Title Dr.First Name GaryLast Name FrostLREC Ref 2001/6112Study Title Evaluation of sexual satisfaction after dilator therapy for absent vagina in patients with Rokitansky syndromeTitle Dr.First Name SadhanaLast Name Nadarajah15 LREC Ref 2001/6113Study Title A multicentre, randomised, double-blind, placebo controlled, dose response study to evaluate the efficacy and safety of Ad5FGF-4 in patients with stable anginaTitle Dr.First Name KevinLast Name BeattLREC Ref 2001/6114Study Title Myocardial Stunning in Type II Diabetes MellitusTitle Prof.First Name RogerLast Name HallLREC Ref 2001/6115Study Title A randomised prospective phase I/II study comparing HLA-A2+ autologous dendritic cells with HLA-A2+ haplotype mismatched dendritic cells pulsed with autologous tumour cells in CEA positive patients with advanced colorectal liver metastases.Title Prof.First Name RobertLast Name LechlerLREC Ref 2001/6116Study Title Effects of delivery on the infant’s hypothalamic-pituitary-adrenal responseTitle Prof.First Name VivetteLast Name GloverLREC Ref 2001/6129Study Title Treatment of leukaemic relapse after allogeneic stem cell transplantation by HSV-tk genetically modified donor lymphocyte transfusionsTitle Dr.First Name JaneLast Name Apperley16 LREC Ref 2001/6130Study Title Informed consent (IC) for medicines – An exploratory trialTitle Dr.First Name BryonyLast Name DeanLREC Ref 2001/6131Study Title Differential occupancy of brain 5HT1A receptors by agonists: Positron Emission Tomography (PET) study using 11C-WAY 100635Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6132Study Title Differential occupancy of 5-HT1A receptors by pindolol in depression: Positron Emission Tomography (PET) study using 11C-WAY 100635Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6133Study Title PET measurement of the displaceability of [11C]FLB 457 from extra-striatal dopamine D2 receptors in man.Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6135Study Title A positron emission tomography study to investigate the distribution of opioid receptors in patients with restless legs syndrome.Title Prof.First Name DavidLast Name Brooks17 LREC Ref 2001/6152Study Title Pilot trial of Salbutamol in Minicore diseaseTitle Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6153Study Title Pilot trial of Salbutamol in Nemaline MyopathyTitle Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6154Study Title Pilot trial of Salbutamol in Central Core diseaseTitle Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6155Study Title Pilot trial of Salbutamol in Myotubular MyopathyTitle Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6158Study Title 15O PET investigations of tumour perfusion in patients with metastatic renal cell carcinoma receiving thalidomide and/or interferon-alphaTitle Prof.First Name CharlesLast Name Coombes18 LREC Ref 2001/6159Study Title 15O PET investigations of tumour perfusion in patients with epithelial cell malignancies receiving platinum based chemotherapyTitle Prof.First Name CharlesLast Name CoombesLREC Ref 2001/6160Study Title Euro Heart Survey on Coronary RevascularizationTitle Prof.First Name DavidLast Name WoodLREC Ref 2001/6161Study Title An Open, Comparative, Within Patient, Controlled Phase III, Multicentre Study Of Hexvix Fluorescence Cystoscopy And Standard Cystoscopy In The Detection Of Carcinoma In Situ In Patients With Bladder CancerTitle Mr.First Name GordonLast Name WilliamsLREC Ref 2001/6162Study Title Use of bovine colostrum to reduce dyspepsia in patients taking non-steroidal anti-inflammatory drugs (NSAIDS).Title Prof.First Name RaymondLast Name PlayfordLREC Ref 2001/6163Study Title Localization of brain regions involved in the processing of perceptual information obtained from observing human vs. robotic systems: A PET activation study.Title Prof.First Name DavidLast Name Brooks19 LREC Ref 2001/6164Study Title Investigation of the Effect of Oxyntomodulin on AppetiteTitle Prof.First Name StephenLast Name BloomLREC Ref 2001/6165Study Title The relationship between D2 receptor occupancy by sulpiride and neuropsychological function: an [11C] raclopride PET studyTitle Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6166Study Title Significance of Serum Bactericidal Activity (SBA) test in ICU patients treated empirically for sepsisTitle Dr.First Name PanagiotisLast Name KaltsasLREC Ref 2001/6167Study Title Investigation into the use of sucrose in the treatment of moderate Title Dr.First Name AudreyLast Name BrynesLREC Ref 2001/6168Study Title The glycaemic index of malt containing products and their effects on cognitive Title Dr.First Name GaryLast Name Frost20 LREC Ref 2001/6169Study Title The possible use of Human Chorionic Gonadotrophin in prevention of preterm Title Prof.First Name PhillipLast Name BennettLREC Ref 2001/6170Study Title To examine the effect that sexual activity may have on pregnancy outcome, in particular onset of natural labourTitle Dr.First Name PhilipLast Name RahmanouLREC Ref 2001/6186Study Title A clinical trial to assess the intracerebral transplantation of carotid body aggregates for Parkinson's Disease.Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6187Study Title Development of PET procedures for assessment of functional recovery following spinal cord injury in manTitle Prof.First Name DavidLast Name BrooksLREC Ref 2001/6188Study Title Effects of the PPAR-gamma agonist Pioglitazone in the treatment of symptomatic peripheral arterial diseaseTitle Prof.First Name MartinLast Name Wilkins21 LREC Ref 2001/6189Study Title The use of flow cytometry to compare the dendritic cell population in induced sputum of normal healthy volunteers, atopic healthy volunteers and patients with mildTitle Dr.First Name PhilipLast Name IndLREC Ref 2001/6192Study Title A clinical and laboratory evaluation of topical micronutrient supplementation to improve the diagnosis of latent TB infection in haemodialysis patients.Title Dr.First Name CarltonLast Name EvansLREC Ref 2001/6193Study Title Mirtazapine and 5-HT2A binding: The use of the cerebellum as a reference tissue to model the 5-HT2A PET ligand [11C] MDL 100907Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6194Study Title Development of laboratory methods for non invasive prenatal genetic diagnosis in fetal cells in maternal blood.Title Prof.First Name Nicholas MLast Name FiskLREC Ref 2001/6195Study Title Study of a Red Clover Food Supplement (P-07) versus Placebo for Premenstrual SyndromeTitle Mr.First Name NicholasLast Name Panay22 LREC Ref 2001/6196Study Title 11C-raclopride PET studies of endogenous dopamine release during performance of rewarded and unrewarded visual memory tasks by Parkinson’s disease patients and healthy volunteersTitle Prof.First Name DavidLast Name BrooksLREC Ref 2001/6197Study Title Links between maternal and fetal stress hormone levelsTitle Prof.First Name VivetteLast Name GloverLREC Ref 2001/6198Study Title Investigation of the efficacy in safety profile of the Nlite Laser for Treatment of Acne VulgarisTitle Dr.First Name AnthonyLast Name ChuLREC Ref 2001/6214Study Title The Effect of Medical Therapy on Cognitive Function and Cerebral Blood Flow in Patients Requiring Intensive Treatment for Heart FailureTitle Prof.First Name CJLast Name BulpittLREC Ref 2001/6215Study Title The effects of the D1-agonist prodrug DAS-431 on cognitive and language functions in healthy volunteersTitle Prof.First Name PaulLast Name Grasby23 LREC Ref 2001/6216Study Title Mannose Binding Lectin (MBL) mutations and their association with infections in the Title Dr.First Name StephenLast Name BrettLREC Ref 2001/6217Study Title A multi-centre, randomised, double-blind, parallel groups, placebo-controlled trial on efficacy and safety of activated recombinant factor VII (rFVIIa/NovoSeven) in treatment of bleeding in patients following allogeneic stem cell transplantation (F7BMT1360)Title Dr.First Name MLast Name LaffanLREC Ref 2001/6218Study Title 1. Validation of measurement of cerebrovascular compliance. 2. The association between cerebral vascular compliance and cognitive function in the elderly.Title Dr.First Name CLast Name RajkumarLREC Ref 2001/6222Study Title Comparison between early and late immunization with three doses of an heptavalant pneumococcal conjugate vaccine in allogeneic stem cell transplant recipientsTitle Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6224Study Title [11C]raclopride PET measurement of nicotine induced dopamine releaseTitle Prof.First Name PaulLast Name Grasby24 LREC Ref 2001/6225Study Title First Administration To Man Of An Oncolytic Herpesvirus-1 Vector Containing A Transgene For Granulocyte Macrophage Colony Stimulating Factor (Oncovex gm-csf) - A Study Of Its Safety, Biodistribution And Biological ActivityTitle Prof.First Name CharlesLast Name CoombesLREC Ref 2001/6226Study Title Cross-cultural study of early infant crying and parental careTitle Dr.First Name IanLast Name St. James-RobertsLREC Ref 2001/6227Study Title Study of Arterial Compliance in Women With the Syndrome of Polycystic OvariesTitle Prof.First Name CJLast Name BulpittLREC Ref 2001/6228Study Title Dynamic Spectral Imaging of the CervixTitle Mr.First Name PatLast Name SoutterLREC Ref 2001/6229Study Title Expectations and experiences of hospital-based postnatal care: a preliminary study of women’s and midwives’ perspectives.Title Dr.First Name JaneLast Name Weaver25 LREC Ref 2001/6230Study Title Does improvement of coronary vasodilator reserve after aortic valve replacement reflect left ventricular decompression or regression of left ventricular hypertrophy?Title Prof.First Name DJLast Name SheridanLREC Ref 2001/6231Study Title Fetal cystoscopy to evaluate lower urinary tract obstruction in uteroTitle Dr.First Name SaileshLast Name KumarLREC Ref 2001/6232Study Title The development of a consumer friendly system to enable older people to express their health care wishes. (initial stage: interviews with elderly patients and design of proforma). (full study NOT APPROVED) first stage of the study alone approved i.e. the investigation of the opinions of elderly people as to the type of health care subjects they wish to discuss and their views on the type of language they understand. The use of this information to design a proforma along with "expert" input including the Trust's legal advisor. The use of this proforma will need to be submitted to the REC for review by the full committee before approval for the full Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6233Study Title Pilot study of allogeneic peripheral stem cell transplantation and donor lymphocyte infusion following non-myeloablative conditioning in patients with metastatic breast Title Dr.First Name DMLast Name Vigushin26 LREC Ref 2001/6234Study Title Characterisation, differentiation, transduction, engraftment and reparative potential of fetal mesenchymal stem/progenitor cells.Title Prof.First Name NMLast Name FiskLREC Ref 2001/6235Study Title Can novel Ultrasound and CT methods show early responses to chemotherapy of liver metastases?Title Dr.First Name ThomasLast Name BryantLREC Ref 2001/6242Study Title In normal development, does the attainment of motor skills have an effect on the rate of development of cognitive skills? A comparison of intellectual development in children with type II and type III spinal muscular atrophyTitle MissFirst Name EmmaLast Name SalesLREC Ref 2002/6254Study Title Investigation of neutrophil abnormalities in Inflammatory Bowel Disease and Behçet’s Syndrome using a skin blister techniqueTitle Prof.First Name DorianLast Name HaskardLREC Ref 2002/6255Study Title Monocyte intracellular interleukin-1Beta (IL-1 Beta) for the early detection of infections and necrotizing enterocolitis (NEC) in preterm infantsTitle Dr.First Name NeilLast Name Murray27 LREC Ref 2002/6256Study Title Optimizing platelet transfusion therapy in preterm neonates with severe Title Dr.First Name NeilLast Name MurrayLREC Ref 2002/6258Study Title The effects of methylphenidate on cognitive and language functions in healthy elderly volunteers and patients suffering aphasic strokeTitle Dr.First Name DavidLast Name SharpLREC Ref 2002/6259Study Title A randomized, double-blind, vehicle controlled phase I/II study to evaluate the safety, tolerability and efficacy of a histamine dihydrochloride-containing gel versus a gel vehicle in the treatment of radiotherapy-induced dermatitis in patients with head and neck squamous cell carcinomaTitle Dr.First Name J SimonLast Name StewartLREC Ref 2002/6260Study Title Quantifying the 24 hour glycaemic response of a low glycaemic index diet in free living people with type 2 diabetes treated with insulin: A pilot studyTitle Dr.First Name AudreyLast Name BrynesLREC Ref 2002/6261Study Title Investigation of The Effects Of Glucagon-Like-Peptide-1 and Peptide YY On AppetiteTitle Prof.First Name SRLast Name Bloom28 LREC Ref 2002/6262Study Title Randomised double blind study to determine the effect of epidural volume extension on intrathecal dose requirements for Caesarean sectionTitle Dr.First Name GaryLast Name StocksLREC Ref 2002/6263Study Title MRI Investigations of the Subgenual Prefrontal Cortex in Patients with Familial Bipolar DisorderTitle Prof.First Name PaulLast Name GrasbyLREC Ref 2002/6271Study Title Comparison of hepatic vein transit times of Levovist and SonoVue in normal Title Dr.First Name AdrianLast Name LimLREC Ref 2002/6273Study Title A pilot study to determine the feasibility and reproducibility of kinetic 11C-choline PET imaging as an index of signal transduction in tumours and normal tissuesTitle Prof.First Name CharlesLast Name CoombesLREC Ref 2002/6274Study Title Investigation of the effects of the pancreatic polypeptide on appetiteTitle Prof.First Name SRLast Name Bloom29 LREC Ref 2002/6276Study Title Investigation of the effect on tidal breathing of negative pressure applied at the mouth during normal expiration in normal volunteers and patients with chronic obstructive pulmonary disease (COPD)Title Dr.First Name PWLast Name IndLREC Ref 2002/6277Study Title A study to assess the inter- and intra-subject variability of lung 18FDG uptake by Positron Emission Tomography in stable COPD patients in comparison with normal Title Dr.First Name PhilipLast Name Ind30 Appendix 2(d) Studies Approved by Chairman's ActionNB – These include studies that have been approved by other LRECs with whom we operate a reciprocal approval agreement as well as exten- sions to studies that have been previously reviewed by the full committee.LREC Ref 1998/5310Study Title In vitro maturation of ovarian follicles and oocytes. (reapproval of study) Title Dr.First Name KateLast Name Hardy Comments: reapproval of study - Co-investigator Dr S Buxani-RiceLREC Ref 2001/6084Study Title Musculoskeletal pain in patients with painful and with silent ischaemic heart disease. Title Dr.First Name Jens PederLast Name Bagger Comments:LREC Ref 2001/6086Study Title Genetic Manipulation of Vascular Endothelium; modulation of adhesion molecule expression. Title Dr.First Name Peng HongLast Name Tan Comments: Approved by Vice Chair - Sarah RiddellLREC Ref 2001/6087Study Title The release of VEGF and aggregation of platelets from patients with malignancy compared to controls upon endostatin treatment Title Mr.First Name GuyLast Name Nash Comments:31 LREC Ref 2001/6088Study Title Serum levels of Granulocyte Colony Stimulating Factor following abdominal and cardiothoracic surgery Title Dr.First Name MahdadLast Name Noursadeghi Comments:LREC Ref 2001/6089Study Title Preventing medication administration errors - Bridging the knowledge gap Title Ms.First Name RaliatLast Name Onatade Comments:LREC Ref 2001/6090Study Title A Study of blood levels of markers for the prediction of Ovarian Hyperstimulation Syndrome in patients undergoing IVF treatment Title Dr.First Name NLast Name Reddy Comments:LREC Ref 2001/6100Study Title Familial Prostate Cancer Screening Study (MREC 00/1/72) Title Dr.First Name DPLast Name Dearnaley Comments: limited contact of local clininician within LREC Ref 2001/6102Study Title Study of the comparative incidences of pre-eclampsia in monochorionic and diochorionic twin pregnancies Title Prof.First Name Nicholas MLast Name Fisk Comments:LREC Ref 2001/6103Study Title Preliminary study on the presence of MUC-1 protein in bone marrow plasma cells and multiple myeloma Title Dr.First Name IALast Name Lampert Comments:32 LREC Ref 2001/6104Study Title Study on the follicular dendritic cells in the germinal centres Title Dr.First Name IALast Name Lampert Comments:LREC Ref 2001/6105Study Title Characterisation of two new antibodies to class II phosphatidylinositol 3 kinase enzymes C2 alpha and beta Title Dr.First Name SohaLast Name El-Sheikh Comments: tissue studyLREC Ref 2001/6106Study Title Understanding the influences or variables which affect pain outcome in the immediate post-operative period Title Ms.First Name AngelaLast Name Eccles Comments: BSc projectLREC Ref 2001/6118Study Title Development of the Barnes Language Assessment Title Mrs.First Name SLast Name Stevens Comments:LREC Ref 2001/6119Study Title Analysis of genetic predisposition to brain injury in preterm infants by anonymous studies of umbilical cord blood Title Prof.First Name DavidLast Name Edwards Comments:LREC Ref 2001/6120Study Title Investigation of the effects of manual assist, cough in-exsufflation device and non-invasive ventilation on cough efficacy in adults and children with spinal muscular atrophy (SMA) and other neuromuscular disease Title Ms.First Name MichelleLast Name Chatwin Comments: Royal Brompton Registration No. 01-00933 LREC Ref 2001/6121Study Title Identification of genetic loci linked to systemic hypertension in the Kyrgyz Title Prof.First Name MartinLast Name Wilkins Comments: Study taking place in KyrgyzLREC Ref 2001/6122-MStudy Title The role of diet, environment and genotype in the development of breast cancer (MREC 01/1/07) Title Dr.First Name CatherineLast Name Duggan Comments:LREC Ref 2001/6123Study Title Clinical isolates of S. epidermidis from patients with a prosthesis/venous Title Dr.First Name RobertLast Name Feldman Comments: isolates from catheter lines only - no other patient involvementLREC Ref 2001/6125Study Title Assessment of cardiac sympathetic function in hibernating myocardium: correlation between CMR & PET in vivo and histopathological and molecular studies in vitro Title Prof.First Name PaoloLast Name Camici Comments: Brompton approval: 00-225;Co-investigators: Dr O Rimoldi; Dr M Khan and Dr A JohnLREC Ref 2001/6126-MStudy Title Millenium Cohort Study (MREC /01/6/19) Title Prof.First Name HeatherLast Name Joshi Comments:LREC Ref 2001/6127Study Title The role of nitric oxide in renal tubule cell injury Title Dr.First Name Thomas JohnLast Name Evans Comments:34 LREC Ref 2001/6128-MStudy Title The genetic analysis of multiple sclerosis Title Prof.First Name DASLast Name Compston Comments:LREC Ref 2001/6138Study Title The effects of immunosuppresive treatment - questionnaire study Title Dr.First Name JeremyLast Name Levy Comments: MSc audit studyLREC Ref 2001/6139Study Title Expression of CD80 in atherosclerotic plaques Title Dr.First Name JosephLast Name Boyle Comments: archive tissue samplesLREC Ref 2001/6140-MStudy Title London Managed Clinical Networks: Evaluation (MREC/00/8/81) Title Prof.First Name EwanLast Name Ferlie Comments:LREC Ref 2001/6141Study Title Evaluation of a bioelectrical impedance device (Bodystat 1500) Title Dr.First Name NeenaLast Name Modi Comments:LREC Ref 2001/6143Study Title Testing the power and utility of SCI45 in selection and assessment of doctors in training Title Dr.First Name RodneyLast Name Gale Comments:LREC Ref 2001/614635 Study Title Is the Wilms tumour antigen 1 a target for immunotherapy of malignancies? Title Dr.First Name HansLast Name Stauss Comments:LREC Ref 2001/6147Study Title Measuring the amount of oxygen in leg muscles Title Dr.First Name DavidLast Name Harris Comments:LREC Ref 2001/6148Study Title Ex vivo testing of surgically resected tissue from cancer patients for efficacy of genetic treatments Title Dr.First Name Nicholas RLast Name Lemoine Comments: Dr D Kirn (Original PI) left IC 12-4- 2002LREC Ref 2001/6149-MStudy Title Isolation of purified, sterile and viable islets from human pancreases (MREC/01/2/20) Title Dr.First Name VassiliosLast Name Papalois Comments:LREC Ref 2001/6151Study Title Are the needs of the physically disabled catered for in radiography Title Ms.First Name KarenLast Name Cole Comments: BSc studyLREC Ref 2001/6172Study Title A phase I, double-blind, placebo-controlled, dose escalating study of recombinant human interleukin-11 (rhIL-11) in patients with ankylosing spondylitis (RREC 2608) Title Prof.First Name RNLast Name Maini Comments: RREC approved study - recruitment from HH36 LREC Ref 2001/6173Study Title A randomised, double-blind trial of anti-TNF alpha chimeric monoclonal antibody (infliximab) in combination with methotrexate compared with methotrexate alone, for the treatment of patients with early RA (Centocor - ASPIRE study) (RREC 2448) Title Prof.First Name RNLast Name Maini Comments: RREC approved study - recruitment from HHLREC Ref 2001/6174-MStudy Title A double-blind, randomised, parallel group, controlled, dose ranging study of the safety, tolerability, pharmocokinetics and efficacy of repeat doses of MRA given alone or in combination with methotrexate in patients with rheumatoid arthritis (RREC 2724) Title Prof.First Name RNLast Name Maini Comments: RREC approved study - recruitment from HHLREC Ref 2001/6175-MStudy Title Morbidity of pneumococcal meningitis in UK 1996-1999 (MREC/01/2/12) Title Dr.First Name MLast Name Hussain Comments: no local researcherLREC Ref 2001/6176Study Title Randomised, placebo-controlled study of the effect of sildenafil on hypoxia induced pulmonary hypertension Title Prof.First Name MartinLast Name Wilkins Comments: Study taking place in KyrgyzLREC Ref 2001/6177Study Title Study to compare the results of different questionnaires in pregnancy Title Prof.First Name VivetteLast Name Glover Comments:LREC Ref 2001/6178Study Title The effect of vascular disease on the intravertebral disc and low back pain (RREC 1928) Title Prof.First Name SPFLast Name Hughes Comments: reciprocal approval37 LREC Ref 2001/6179Study Title The measurement of soluble DAF in order to assess of cellular cryoprotection and predict relative risk of long-term vascular injury Title Prof.First Name DorianLast Name Haskard Comments: Uses plasma from blood obtained under 99/5625LREC Ref 2001/6180-MStudy Title National comparative subarachnoid haemorrhage Audit (MREC/00/0/59) Title Mr.First Name JuliaLast Name Langham Comments: no local researcherLREC Ref 2001/6181Study Title Cardiac resynchronization in heart failure Title Prof.First Name PauloLast Name Camici Comments: St Marys Rec approved;Co-investigators: Dr O Rimoldi; Dr M Khan and Dr A JohnLREC Ref 2001/6183Study Title Household Survey to assess the impact of Single Regeneration Budget (SRB) expenditure on the Edward Woods Estate, Hammersmith and Fulham Title Dr.First Name GordanaLast Name Djuric Comments:LREC Ref 2001/6184-MStudy Title Randomised controlled trial of the effects of antioxidant and folinic acid supplementation on the mental development, growth and health of children with Down's syndrome Title Prof.First Name SallyLast Name Grantham-McGregor Comments:LREC Ref 2001/6200Study Title A prospective analysis of the cost benefit implications of introducing an orally active anti-gram positive agent at a London Hospital Trust Title Dr.First Name KathleenLast Name Bamford Comments: 38 LREC Ref 2001/6201Study Title Reducing the risk of overdose from take home methadone study of impact of community pharmacy leaflets Title Dr.First Name VinceLast Name Naik Comments: previously approved by maudsley LRECLREC Ref 2001/6202Study Title Pregnacy test result questionnaire Title SisterFirst Name CathyLast Name Turner Comments:LREC Ref 2001/6203Study Title Audit of provision of vaccinations for asplenic patients Title Dr.First Name AlisonLast Name Holmes Comments:LREC Ref 2001/6204-MStudy Title Prospective collaborative study of the aetiopathogenesis of Kawasaki disease (MREC 01/2/45) Title Dr.First Name AnuradhaLast Name Bose Comments:LREC Ref 2001/6206Study Title Should health professionals who perform 1st trimester ultrasound scans be involved in informing patients about those scans? Title Ms.First Name AngelaLast Name Smith Comments: MSc project - QuestionnaireLREC Ref 2001/6207Study Title Research Investigation of Perceptions, Management and Control of Type-2 Diabetes Title Dr.First Name TimothyLast Name Moor Comments:LREC Ref 2001/6209-M 39 Study Title A multicentre, randomised controlled trial of Pentacol - a new enteric copated tablet form of Mesalazine - in comparison to Asacol - Lagap study EC 2444 (MREC/1/3/26) (RREC 2738) Title Dr.First Name AndrewLast Name Thillainayagam Comments: Reciprocal approvalLREC Ref 2001/6210-MStudy Title children, families and services in communities (MREC/01/6/65) Title Prof.First Name EdwardLast Name Melhuish Comments:LREC Ref 2001/6212Study Title The distribution of gastrointestinal peptide receptors in human tissue Title Dr.First Name TomLast Name Evans Comments:LREC Ref 2001/6213Study Title Zinc cream in tuberculosis skin testing in Peru - a follow-up study to extend the positive results from the similar project 'zinc in TB skin testing' (Hammersmith Ethical approval #2001/6082). Title Dr.First Name CarltonLast Name Evans Comments: THIS PROJECT HAS LOCAL ETHICAL APPROVAL IN PERU - This document includes the results of study #2001/6082. The current protocol is the same as study #2001/6082 except that individuals are now asked to have unilateral single rather than simultaneous bilateral skin tests. This change is necessary to confirm and extend the results of study #2001/6082LREC Ref 2001/6219Study Title Epidural questionnaire Title Ms.First Name SarahLast Name Beake Comments: Audit/questionnaireLREC Ref 2001/6220Study Title Induced sputum as a surrogate for broncho-alveolar lavage in patients with fibrosing alveolitis secondary to systemic sclerosis Title Prof.40 First Name RLast Name du Bois Comments: Brompton approved 01-221 - reciprocal actionLREC Ref 2001/6221Study Title Hiatus hernia as a cause of gastrointestinal bleeding diagnosis on Title Dr.First Name VaishaliLast Name Gada Comments:LREC Ref 2001/6236Study Title Long term glial changes in the thalamus following limb amputation, brachial plexus injury and paraplegia (using material from the tissue collection of the German Spinal Cord Injury Foundation) Title Dr.First Name RichardLast Name Banati Comments: Tissue coming form GermanyLREC Ref 2001/6237Study Title Fluorescent in situ hybridisation to detect Helicobacter pylori in gastric antral biopsies Title Dr.First Name JulianLast Name Walters Comments:LREC Ref 2001/6238Study Title Study to establish whether variations in cortisol binding globulin (CBG) in normal volunteers affects their results to a short synacthen test (SST) (RREC Title Dr.First Name WSLast Name Dillo Comments: reciprocal action with RRECLREC Ref 2001/6239Study Title Components of spatial neglect following stroke (RREC 2677) Title Dr.First Name MasudLast Name Husain Comments:LREC Ref 2001/6240Study Title To develop a quality of life measure for Behçet’s disease Title Prof. 41 First Name DorianLast Name Haskard Comments: other investigator: Mrs G GilworthLREC Ref 2001/6241Study Title Determining tensile strength of human cardiac tissue Title Dr.First Name Maria-BenedictaLast Name Edwards Comments:LREC Ref 2001/6243-MStudy Title Waiting for drug treatment - effects on uptake and immediate outcome a.k.a. the outcome of waiting lists (OWL) project Title Ms.First Name AJLast Name Watson Comments:LREC Ref 2001/6244Study Title In vitro studies into the role of monocytes and platelets in inflammation and thrombosis Title Dr.First Name RCLast Name Landis Comments:LREC Ref 2002/6248Study Title Outcome data in diabetic patients with coronary disease. A retrospective Title Dr.First Name JulianLast Name Strange Comments:LREC Ref 2002/6249-MStudy Title Genetic factors in the development of insulin-dependant (type 1) diabetes: A study in UK patients diagnosed before age two (MREC/01/6/09) Title Dr.First Name PaulLast Name Lambert Comments: no local researcherLREC Ref 2002/6250Study Title Attitudes of sub-fertile women on the use of acupuncture to aid fertility - Questionnaire Title Ms.First Name Lyndsey 42 Last Name Taylor Comments: BSc StudyLREC Ref 2002/6251Study Title UK prevalence of patients with refractory angina pectoris study Title Dr.First Name JPLast Name Bagger Comments:LREC Ref 2002/6252Study Title Recording of heart sounds from patients - MSc project Title Dr.First Name TerryLast Name Gourlay Comments: MSc StudyLREC Ref 2002/6253Study Title An operational assessment of strategies to prevent airbourne TB transmission and to improve TB diagnosis and treatment Title Dr.First Name CarltonLast Name Evans Comments: Study taking place in Peru - has Peruvian REC approvalLREC Ref 2002/6270-MStudy Title Links between statutory and non-statutory agencies providing support and facilities for teenagers in sexual health promotion Title Dr.First Name MaryLast Name Cooke Comments: no local researcherLREC Ref 2002/6281Study Title Quantifying glomerular cytokine expression in glomerulonephritis using paraffin sections Title Prof.First Name HTLast Name Cook Comments: tissue studyLREC Ref 2002/6282Study Title Are epitope spread and the Th1 cytokine response essential for relapsing-remitting experimental allergic encephalomyelitis Title MissFirst Name Selina43 Last Name Davies Comments: 30mls blood from HV'sLREC Ref 2002/6283Study Title The biochemistry of term human placenta and membranes Title Prof.First Name PRLast Name Bennett Comments: Dr Cath WilliamsonLREC Ref 2002/6284Study Title Histological analyses and in vitro studies of endothelial cells derived from HHT patients Title Dr.First Name ClaireLast Name Shovlin Comments:LREC Ref 2002/6286Study Title In vivo hepatocyte transplant model for research into hepatitis viruses Title Mr.First Name NagyLast Name Habib Comments:LREC Ref 2002/6289Study Title Investigation of coagulation parameters in hereditary hemorrhagic telangiectasia - DNA Analysis (amendment to 00/5908) Title Dr.First Name ClaireLast Name Shovlin Comments:LREC Ref 2002/6290Study Title A prospective, randomised, controlled study of a rapid protocol for the prevention of contrast induced renal dysfunction (RAPPID) (ELCHA REC No. Title Dr.First Name SanjayLast Name Kumar Comments: Approved by St Bart's REC (study reviewed by Dr David Harris & Chairman)LREC Ref 2002/6291Study Title A prospective, randomised, controlled study of a rapid protocol for the prevention of contrast induced renal dysfunction Title Dr.First Name Sanjay44 Last Name Kumar Comments: Study approved by ELCHA RECLREC Ref 2002/6295Study Title Effect of preformed antibodies on renal transplant outcome Title Dr.First Name AnthonyLast Name Warrens Comments: Archived tissue studyLREC Ref 2002/6308Study Title Studies of white blood cells derived from HHT Patients Title Dr.First Name ClaireLast Name Shovlin Comments: extra blood sample taken at time of clinical LREC Ref 2002/6309Study Title Does 67gallium scanning still have a role in the diagnosis and management of pulmonary sarcoidosis Title Dr.First Name RobinaLast Name Coker Comments: Retrospective survey of case notesAppendix 2(e) Studies considered by Full Committee - Still Pending (i.e. Approved in Principle/Not approved)LREC Ref 1993/3995Study Title Clinical Evaluation of magnetic resonance imaging (MRI). (Extension of protocol Title Prof.First Name GraemeLast Name BydderLREC Ref 1993/4047Study Title Clinical evaluation of magnetic resonance spectroscopy (MRS). (Extension of protocol 93/4047) Title Prof.First Name GraemeLast Name BydderLREC Ref 2001/6026Study Title Protocol No CSTI571B2225. 45 An open label, pilot phase 11 study of STI571 in patients with life threatening diseases known to be associated with one or more STI571-sensitive tyrosine Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6035Study Title Can a percentage change in the fractional retention of 2-(11C) thymidine at 1 hour be used to measure fractional cell kill and assess ultimate tumour response following anti cancer treatment ? (RREC 2761) Title Prof.First Name CharlesLast Name Coombes46 LREC Ref 2001/6038Study Title Glucose-Insulin-Potassium (GIK) Treatment In Non-Diabetic Females Undergoing Cardiac Surgery Trial Title Prof.First Name KLast Name TaylorLREC Ref 2001/6039Study Title Androgens and endometrial receptivity Title Mr.First Name GLast Name TrewLREC Ref 2001/6052Study Title A Phase 2, Multi-center, Double-blinded, Placebo-controlled, Dose-finding Study of ZYC101a in the Treatment of High-Grade Squamous Intra-epithelial Lesions of the Uterine Cervix. Title Mr.First Name PatLast Name SoutterLREC Ref 2001/6057Study Title Pharmacogenomics of Essential Hypertension Title Prof.First Name MartinLast Name WilkinsLREC Ref 2001/6075Study Title A personal cervical sampler - assesment of the adequacy of cytology samples Title Mr.First Name PatLast Name Soutter47 LREC Ref 2001/6076Study Title Development of methods to assess sensory function in spinal cord injury Title Prof.First Name PraveenLast Name AnandLREC Ref 2001/6077Study Title The Diagnostic Utility of Fluorescence Lifetime Imaging Microscopy (FLIM), Optical Coherence Tomography (OCT) and Magnetic Resonance Microscopy (MRM) in Human Female Breast Cancer Title Dr.First Name PaulLast Name TadrousLREC Ref 2001/6078Study Title In-vitro magnetic resonance spectroscopy of liver biopsies in viral hepatitis and steatohepatitis Title Dr.First Name SimonLast Name Taylor-RobinsonLREC Ref 2001/6079Study Title Microglial activation in patients taking neuroleptic therapy with/without tardive dyskinesia: A PET Study Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6080Study Title Investigation of the effects of repetitive Transcranial Magnetic Stimulation of the Anterior Cingulate on blood flow using Positron Emission Tomography Title Prof.First Name PaulLast Name Grasby48 LREC Ref 2001/6081Study Title A study of platelet reactivity, its relationship to glycoprotein polymorphisms and its predictive value for major cardiovascular events Title Dr.First Name GrahamLast Name DaviesLREC Ref 2001/6082Study Title Zinc in tuberculosis skin testing Title Dr.First Name CarltonLast Name EvansLREC Ref 2001/6091Study Title Investigation of the abnormal response to monosodium urate crystals in Behçet’s syndrome Title Prof.First Name DorianLast Name HaskardLREC Ref 2001/6092Study Title A study investigating whether progesterone suppositories (Cyclogest®) provide adequate luteal support / result in sufficient progesterone levels during IVF cycles Title Mr.First Name GLast Name TrewLREC Ref 2001/6093Study Title A phase II, multi-centre, double-blind, placebo-controlled, parallel group study to assess the safety and efficacy of a single intravenous dose of the humanised anti-TNF PEG conjugate, CDP870 (1.25, 5 20mg/kg) in patients with active Crohn's Title Dr.First Name JulianLast Name Walters49 LREC Ref 2001/6094Study Title Investigation Of The Effects Of Peptide YY On Appetite. Title Prof.First Name SLast Name BloomLREC Ref 2001/6095Study Title Xenon as a neuroprotective agent during cardiopulmonary bypass – Pilot Feasibility and Safety Study Title Prof.First Name MervynLast Name MazeLREC Ref 2001/6096Study Title A novel human cell culture model of prion disease to study the pathophysiology of prion infection Title Dr.First Name SarahLast Name TabriziLREC Ref 2001/6097Study Title Anti-cytokine therapy with Infliximab for vasculitis Title Prof.First Name CharlesLast Name PuseyLREC Ref 2001/6098Study Title A study to measure the occupancy of ziprasidone at the 5-HT1A receptor using PET scanning Title Prof.First Name PaulLast Name Grasby50 LREC Ref 2001/6099Study Title Genetic determinants of plasma factor VIII concentration Title Dr.First Name MikeLast Name LaffanLREC Ref 2001/6108Study Title Brain receptor occupancy and pharmacokinetics of Ro 67-5930 after oral administration of multiple doses (MD PET Scan Study) version B dated 19th July Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6109Study Title Investigation of the biochemistry, cell and molecular biology of haematological Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6110Study Title Cellular and molecular biology of haematological disorders and their treatment Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6111Study Title The effect of low glycaemic diet on weight maintenance following a three-months weight reduction program using formula meal replacement in obese patients with late-onset diabetes mellitus (NIDDM). Title Dr.First Name GaryLast Name Frost51 LREC Ref 2001/6112Study Title Evaluation of sexual satisfaction after dilator therapy for absent vagina in patients with Rokitansky syndrome Title Dr.First Name SadhanaLast Name NadarajahLREC Ref 2001/6113Study Title A multicentre, randomised, double-blind, placebo controlled, dose response study to evaluate the efficacy and safety of Ad5FGF-4 in patients with stable angina Title Dr.First Name KevinLast Name BeattLREC Ref 2001/6114Study Title Myocardial Stunning in Type II Diabetes Mellitus Title Prof.First Name RogerLast Name HallLREC Ref 2001/6115Study Title A randomised prospective phase I/II study comparing HLA-A2+ autologous dendritic cells with HLA-A2+ haplotype mismatched dendritic cells pulsed with autologous tumour cells in CEA positive patients with advanced colorectal liver metastases. Title Prof.First Name RobertLast Name LechlerLREC Ref 2001/6116Study Title Effects of delivery on the infant’s hypothalamic-pituitary-adrenal response Title Prof.First Name VivetteLast Name Glover52 LREC Ref 2001/6129Study Title Treatment of leukaemic relapse after allogeneic stem cell transplantation by HSV-tk genetically modified donor lymphocyte transfusions Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6130Study Title Informed consent (IC) for medicines – An exploratory trial Title Dr.First Name BryonyLast Name DeanLREC Ref 2001/6131Study Title Differential occupancy of brain 5HT1A receptors by agonists: Positron Emission Tomography (PET) study using 11C-WAY 100635 Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6132Study Title Differential occupancy of 5-HT1A receptors by pindolol in depression: Positron Emission Tomography (PET) study using 11C-WAY 100635 Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6133Study Title PET measurement of the displaceability of [11C]FLB 457 from extra-striatal dopamine D2 receptors in man. Title Prof.First Name PaulLast Name Grasby53 LREC Ref 2001/6134Study Title Identification of cell populations and mediators in patients undergoing clinical bronchoscopy for diagnostic purposes Title Dr.First Name PhilipLast Name IndLREC Ref 2001/6135Study Title A positron emission tomography study to investigate the distribution of opioid receptors in patients with restless legs syndrome. Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6152Study Title Pilot trial of Salbutamol in Minicore disease Title Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6153Study Title Pilot trial of Salbutamol in Nemaline Myopathy Title Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6154Study Title Pilot trial of Salbutamol in Central Core disease Title Dr.First Name EugenioLast Name Mercuri54 LREC Ref 2001/6155Study Title Pilot trial of Salbutamol in Myotubular Myopathy Title Dr.First Name EugenioLast Name MercuriLREC Ref 2001/6156Study Title An Action Research Project to develop and evaluate an evidence-based model for HIV antenatal testing in primary care Title Dr.First Name ChrisLast Name McCourtLREC Ref 2001/6157Study Title Analysis of genetic mutations in pulmonary hypertension: a gene bank Title Prof.First Name MartinLast Name WilkinsLREC Ref 2001/6158Study Title 15O PET investigations of tumour perfusion in patients with metastatic renal cell carcinoma receiving thalidomide and/or interferon-alpha Title Prof.First Name CharlesLast Name CoombesLREC Ref 2001/6159Study Title 15O PET investigations of tumour perfusion in patients with epithelial cell malignancies receiving platinum based chemotherapy Title Prof.First Name CharlesLast Name Coombes55 LREC Ref 2001/6160Study Title Euro Heart Survey on Coronary Revascularization Title Prof.First Name DavidLast Name WoodLREC Ref 2001/6161Study Title An Open, Comparative, Within Patient, Controlled Phase III, Multicentre Study Of Hexvix Fluorescence Cystoscopy And Standard Cystoscopy In The Detection Of Carcinoma In Situ In Patients With Bladder Cancer Title Mr.First Name GordonLast Name WilliamsLREC Ref 2001/6162Study Title Use of bovine colostrum to reduce dyspepsia in patients taking non-steroidal anti-inflammatory drugs (NSAIDS). Title Prof.First Name RaymondLast Name PlayfordLREC Ref 2001/6163Study Title Localization of brain regions involved in the processing of perceptual information obtained from observing human vs. robotic systems: A PET activation study. Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6164Study Title Investigation of the Effect of Oxyntomodulin on Appetite Title Prof.First Name StephenLast Name Bloom56 LREC Ref 2001/6165Study Title The relationship between D2 receptor occupancy by sulpiride and neuropsychological function: an [11C] raclopride PET study Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6166Study Title Significance of Serum Bactericidal Activity (SBA) test in ICU patients treated empirically for sepsis Title Dr.First Name PanagiotisLast Name KaltsasLREC Ref 2001/6167Study Title Investigation into the use of sucrose in the treatment of moderate Title Dr.First Name AudreyLast Name BrynesLREC Ref 2001/6168Study Title The glycaemic index of malt containing products and their effects on cognitive Title Dr.First Name GaryLast Name FrostLREC Ref 2001/6169Study Title The possible use of Human Chorionic Gonadotrophin in prevention of preterm Title Prof.First Name PhillipLast Name Bennett57 LREC Ref 2001/6170Study Title To examine the effect that sexual activity may have on pregnancy outcome, in particular onset of natural labour Title Dr.First Name PhilipLast Name RahmanouLREC Ref 2001/6186Study Title A clinical trial to assess the intracerebral transplantation of carotid body aggregates for Parkinson's Disease. Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6187Study Title Development of PET procedures for assessment of functional recovery following spinal cord injury in man Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6188Study Title Effects of the PPAR-gamma agonist Pioglitazone in the treatment of symptomatic peripheral arterial disease Title Prof.First Name MartinLast Name WilkinsLREC Ref 2001/6189Study Title The use of flow cytometry to compare the dendritic cell population in induced sputum of normal healthy volunteers, atopic healthy volunteers and patients with mild Title Dr.First Name PhilipLast Name Ind58 LREC Ref 2001/6190Study Title Will new imaging techniques improve assessment and treatment of sarcoidosis? Title DrFirst Name RobinaLast Name CokerLREC Ref 2001/6191Study Title Does HLA polymorphism influence the incidence and severity of sarcoidosis? Title DrFirst Name RobinaLast Name CokerLREC Ref 2001/6192Study Title A clinical and laboratory evaluation of topical micronutrient supplementation to improve the diagnosis of latent TB infection in haemodialysis patients. Title Dr.First Name CarltonLast Name EvansLREC Ref 2001/6193Study Title Mirtazapine and 5-HT2A binding: The use of the cerebellum as a reference tissue to model the 5-HT2A PET ligand [11C] MDL 100907 Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6194Study Title Development of laboratory methods for non invasive prenatal genetic diagnosis in fetal cells in maternal blood. Title Prof.First Name Nicholas MLast Name Fisk59 LREC Ref 2001/6195Study Title Study of a Red Clover Food Supplement (P-07) versus Placebo for Premenstrual Syndrome Title Mr.First Name NicholasLast Name PanayLREC Ref 2001/6196Study Title 11C-raclopride PET studies of endogenous dopamine release during performance of rewarded and unrewarded visual memory tasks by Parkinson’s disease patients and healthy volunteers Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6197Study Title Links between maternal and fetal stress hormone levels Title Prof.First Name VivetteLast Name GloverLREC Ref 2001/6198Study Title Investigation of the efficacy in safety profile of the Nlite Laser for Treatment of Acne Vulgaris Title Dr.First Name AnthonyLast Name ChuLREC Ref 2001/6199Study Title VTP-1/01: A Phase I/II Trial of Intravenous vs. Hepatic Arterial Infusion of an E1A-CR2 Deleted Adenovirus (VTP-1) Alone and in Combination with Intravenous 5FU/Leucovorin for Patients with Inoperable, Metastatic Colorectal Carcinoma - Title Dr.First Name DavidLast Name Kirn60 LREC Ref 2001/6214Study Title The Effect of Medical Therapy on Cognitive Function and Cerebral Blood Flow in Patients Requiring Intensive Treatment for Heart Failure Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6215Study Title The effects of the D1-agonist prodrug DAS-431 on cognitive and language functions in healthy volunteers Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6216Study Title Mannose Binding Lectin (MBL) mutations and their association with infections in the Title Dr.First Name StephenLast Name BrettLREC Ref 2001/6217Study Title A multi-centre, randomised, double-blind, parallel groups, placebo-controlled trial on efficacy and safety of activated recombinant factor VII (rFVIIa/NovoSeven) in treatment of bleeding in patients following allogeneic stem cell transplantation (F7BMT1360) Title Dr.First Name MLast Name LaffanLREC Ref 2001/6218Study Title 1. Validation of measurement of cerebrovascular compliance. 2. The association between cerebral vascular compliance and cognitive function in the elderly. Title Dr.First Name CLast Name Rajkumar61 LREC Ref 2001/6222Study Title Comparison between early and late immunization with three doses of an heptavalant pneumococcal conjugate vaccine in allogeneic stem cell transplant recipients Title Dr.First Name JaneLast Name ApperleyLREC Ref 2001/6223Study Title An experimental therapeutic intervention in Huntington’s disease: pre-operative characterization and post-operative follow-up with PET of patients receiving foetal striatal cell implant. Title Prof.First Name DavidLast Name BrooksLREC Ref 2001/6224Study Title [11C]raclopride PET measurement of nicotine induced dopamine release Title Prof.First Name PaulLast Name GrasbyLREC Ref 2001/6225Study Title First Administration To Man Of An Oncolytic Herpesvirus-1 Vector Containing A Transgene For Granulocyte Macrophage Colony Stimulating Factor (Oncovex gm-csf) - A Study Of Its Safety, Biodistribution And Biological Activity Title Prof.First Name CharlesLast Name CoombesLREC Ref 2001/6226Study Title Cross-cultural study of early infant crying and parental care Title Dr.First Name IanLast Name St. James-Roberts62 LREC Ref 2001/6227Study Title Study of Arterial Compliance in Women With the Syndrome of Polycystic Ovaries Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6228Study Title Dynamic Spectral Imaging of the Cervix Title Mr.First Name PatLast Name SoutterLREC Ref 2001/6229Study Title Expectations and experiences of hospital-based postnatal care: a preliminary study of women’s and midwives’ perspectives. Title Dr.First Name JaneLast Name WeaverLREC Ref 2001/6230Study Title Does improvement of coronary vasodilator reserve after aortic valve replacement reflect left ventricular decompression or regression of left ventricular hypertrophy? Title Prof.First Name DJLast Name SheridanLREC Ref 2001/6231Study Title Fetal cystoscopy to evaluate lower urinary tract obstruction in utero Title Dr.First Name SaileshLast Name Kumar63 LREC Ref 2001/6232Study Title The development of a consumer friendly system to enable older people to express their health care wishes. (initial stage: interviews with elderly patients and design of proforma). (full study NOT APPROVED) first stage of the study alone approved i.e. the investigation of the opinions of elderly people as to the type of health care subjects they wish to discuss and their views on the type of language they understand. The use of this information to design a proforma along with "expert" input including the Trust's legal advisor. The use of this proforma will need to be submitted to the REC for review by the full committee before approval for the full Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6233Study Title Pilot study of allogeneic peripheral stem cell transplantation and donor lymphocyte infusion following non-myeloablative conditioning in patients with metastatic breast Title Dr.First Name DMLast Name VigushinLREC Ref 2001/6234Study Title Characterisation, differentiation, transduction, engraftment and reparative potential of fetal mesenchymal stem/progenitor cells. Title Prof.First Name NMLast Name FiskLREC Ref 2001/6235Study Title Can novel Ultrasound and CT methods show early responses to chemotherapy of liver metastases? Title Dr.First Name ThomasLast Name Bryant64 LREC Ref 2001/6242Study Title In normal development, does the attainment of motor skills have an effect on the rate of development of cognitive skills? A comparison of intellectual development in children with type II and type III spinal muscular atrophy Title MissFirst Name EmmaLast Name SalesLREC Ref 2001/6247Study Title High-resolution computed tomographic features of aging lung Title Dr.First Name SLast Name CopleyLREC Ref 2002/6254Study Title Investigation of neutrophil abnormalities in Inflammatory Bowel Disease and Behçet’s Syndrome using a skin blister technique Title Prof.First Name DorianLast Name HaskardLREC Ref 2002/6255Study Title Monocyte intracellular interleukin-1Beta (IL-1 Beta) for the early detection of infections and necrotizing enterocolitis (NEC) in preterm infants Title Dr.First Name NeilLast Name MurrayLREC Ref 2002/6256Study Title Optimizing platelet transfusion therapy in preterm neonates with severe Title Dr.First Name NeilLast Name Murray65 LREC Ref 2002/6257Study Title Assessment of changes in ventilation following induced broncho-constriction with inhaled histamine in normal subjects using 81Krypton ventilation scintigraphy Title Dr.First Name Philip WLast Name IndLREC Ref 2002/6258Study Title The effects of methylphenidate on cognitive and language functions in healthy elderly volunteers and patients suffering aphasic stroke Title Dr.First Name DavidLast Name SharpLREC Ref 2002/6259Study Title A randomized, double-blind, vehicle controlled phase I/II study to evaluate the safety, tolerability and efficacy of a histamine dihydrochloride-containing gel versus a gel vehicle in the treatment of radiotherapy-induced dermatitis in patients with head and neck squamous cell carcinoma Title Dr.First Name J SimonLast Name StewartLREC Ref 2002/6260Study Title Quantifying the 24 hour glycaemic response of a low glycaemic index diet in free living people with type 2 diabetes treated with insulin: A pilot study Title Dr.First Name AudreyLast Name BrynesLREC Ref 2002/6261Study Title Investigation of The Effects Of Glucagon-Like-Peptide-1 and Peptide YY On Appetite Title Prof.First Name SRLast Name Bloom66 LREC Ref 2002/6262Study Title Randomised double blind study to determine the effect of epidural volume extension on intrathecal dose requirements for Caesarean section Title Dr.First Name GaryLast Name StocksLREC Ref 2002/6263Study Title MRI Investigations of the Subgenual Prefrontal Cortex in Patients with Familial Bipolar Disorder Title Prof.First Name PaulLast Name GrasbyLREC Ref 2002/6271Study Title Comparison of hepatic vein transit times of Levovist and SonoVue in normal Title Dr.First Name AdrianLast Name LimLREC Ref 2002/6272Study Title Phase 1/2 Study Of The Adjunctive Use Of Glivec (STI-571) In Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation For Chronic Myeloid Title Dr.First Name EduardoLast Name OlavarriaLREC Ref 2002/6273Study Title A pilot study to determine the feasibility and reproducibility of kinetic 11C-choline PET imaging as an index of signal transduction in tumours and normal tissues Title Prof.First Name CharlesLast Name Coombes67 LREC Ref 2002/6274Study Title Investigation of the effects of the pancreatic polypeptide on appetite Title Prof.First Name SRLast Name BloomLREC Ref 2002/6275Study Title A multinational, multicentre, randomised, double-blind, parallel group, active controlled, comparative trial, to assess the endometrial histological profile following treatment with tibolone (Org OD 14) versus conjugated oestrogen (CE) plus medroxyprogesterone acetate (MPA) in postmenopausal women. Title Mr.First Name NLast Name PanayLREC Ref 2002/6276Study Title Investigation of the effect on tidal breathing of negative pressure applied at the mouth during normal expiration in normal volunteers and patients with chronic obstructive pulmonary disease (COPD) Title Dr.First Name PWLast Name IndLREC Ref 2002/6277Study Title A study to assess the inter- and intra-subject variability of lung 18FDG uptake by Positron Emission Tomography in stable COPD patients in comparison with normal Title Dr.First Name PhilipLast Name IndLREC Ref 2002/6278Study Title A randomized placebo-controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy Title Mr.First Name NicholasLast Name Panay68 LREC Ref 2002/6279Study Title Distribution of Opioid Receptors Measured with Positron Emission Tomography in Parkinsonian Patients Experiencing Pain Title Prof.First Name DJLast Name BrooksLREC Ref 2002/6280Study Title An investigation in to the use of hospital services by refugees and asylum seekers in West London Title Dr.First Name PhilipLast Name GothardLREC Ref 2002/6296Study Title Contribution of PET imaging with [F-18] FLT to the evaluation of patients with non-small cell lung cancer Title Dr.First Name PhilipLast Name IndLREC Ref 2002/6297Study Title To evaluate the feasibility and reproducibility of the combination of an automatic border delineation technique for assessment of systolic cardiac function with an algorithm for qualitative and quantitative assessment of myocardial perfusion during SonoVue®-enhanced echocardiography. Title Dr.First Name PetrosLast Name NihoyannopoulosLREC Ref 2002/6298Study Title A multicentre, Double blind, Randomised, Placebo controlled study to evaluate the effects of Simvastatin on clinical endpoints in patients with degenerative aortic Title Dr.First Name PetrosLast Name Nihoyannopoulos69 LREC Ref 2002/6299Study Title Autologous stem cell transplant followed by imatinib mesylate as therapy for patients cytogenetically resistant to imatinib mesylate Title Dr.First Name DavidLast Name MarinLREC Ref 2002/6300Study Title Calcium blockade and Pulmonary AVMs Title Dr.First Name ClaireLast Name ShovlinLREC Ref 2002/6301Study Title A prospective randomised pilot study to compare the absorption of Adept versus ringers lactate solution from the pelvis following laparoscopic gynaecological surgery using a semi-quantitative ultrasound scoring system. Title Mr.First Name GLast Name TrewLREC Ref 2002/6302Study Title Effects of dapsone on microglia activation in early Alzheimer’s disease: A positron emission tomography study. Title Prof.First Name DavidLast Name BrooksLREC Ref 2002/6303Study Title Longitudinal changes of microglial activation and dopaminergic function in patients with idiopathic and atypical parkinson's disease: a pet study Title Prof.First Name DavidLast Name Brooks70 LREC Ref 2002/6305Study Title The effects of methylphenidate on acute stress-responsivity and working memory Title Prof.First Name PaulLast Name GrasbyLREC Ref 2002/6306Study Title The effects of withdrawal from dopamine medication on cognitive function in Parkinson’s disease Title Prof.First Name DavidLast Name BrooksLREC Ref 2002/6307Study Title Assessing the dopaminergic function of the globus pallidus internus in Parkinson's disease complicated by motor fluctuations. Title Prof.First Name DavidLast Name BrooksAppendix 2(f) 71 MREC approved studies approved by sub-committeeLREC Ref 2001/6047-MStudy Title A study comparing the costs and efficacy of on demand treatment with esomeprazole 20mg and continuous treatment with esomeprazole 20mg in long term management of patients with symptomatic gastro-oesophageal reflux disease (GORD). A six month, open, randomised multi centre study - Title Dr.First Name Navin ALast Name ThakrarLREC Ref 2001/6066-MStudy Title European Heart Survey for Valvular Heart Disease Title Prof.First Name DavidLast Name WoodLREC Ref 2001/6074-MStudy Title A national DNA Bank for Glomerulonephritis (MREC00/5/42) Title Prof.First Name CharlesLast Name PuseyLREC Ref 2001/6083-MStudy Title A study of the time lag between a move of address and subsequent GP registration (MREC/1/3/5) Title Mr.First Name ChristopherLast Name Millett72 LREC Ref 2001/6085-MStudy Title An open label study of recombinant human activated protein C in severe sepsis A phase 3b clinical trial Title Dr.First Name StephenLast Name BrettLREC Ref 2001/6107-MStudy Title Phase II study of low intensity non-myeloablative allografts following high-dose melphalan with autologous stem cell support in myeloma patients with sibling donors (MREC 01/8/4) Title Dr.First Name DianaLast Name SamsonLREC Ref 2001/6117-MStudy Title DNA Repository for characterisation of the inherited abnormalities in combined hyperlipidaemia Title Prof.First Name JamesLast Name ScottLREC Ref 2001/6136-MStudy Title Non-neutropenic candida infection treatment study (MREC(1) 99/46) Title Dr.First Name StephenLast Name BrettLREC Ref 2001/6137-MStudy Title Risk factors for group B streptococcal (GBS) disease in infants <90 days of Title Dr.First Name NeenaLast Name Modi73 LREC Ref 2001/6142-MStudy Title Randomised trial evaluating Elotaxin (Oxaliplatin) combined with two different 5-Fluorouracil regimens in patients with previously untreated advanced colorectal cancer. Title Dr.First Name HarpreetLast Name WasanLREC Ref 2001/6144-MStudy Title A randomised double blind, placebo controlled, parallel group, multi-centre, phase II study to assess the efficacy and tolerability of ME3301 in patients with moderate asthma Title Dr.First Name PhilipLast Name IndLREC Ref 2001/6145-MStudy Title Omalizumab in patients with co-morbid allergic asthma and perennial allergic rhinitis (MREC 01/1/42) Title Dr.First Name PhilipLast Name IndLREC Ref 2001/6150-MStudy Title Five year follow up of children who suffered from meningitis during neonatal Title Prof.First Name DavidLast Name HarveyLREC Ref 2001/6171-MStudy Title The coronary artery revascularisation in diabetics (CARDia) trial Title Dr.First Name AkhilLast Name Kapur74 LREC Ref 2001/6182-MStudy Title Heart failure revascularisation trial - UK Title Dr.First Name PetrosLast Name NihoyannopoulosLREC Ref 2001/6185-MStudy Title Optimising the use of Azathioprine in inflammatory bowel disease: a study to investigate the influence of Thiopurine methyl transferase genotype and phenotype and the role of 6-thioguanine nucleotides (Azathioprine in inflammatory bowel disease: the role of measuring TPMT and 6-TGN) Title Dr.First Name AndrewLast Name ThillainayagamLREC Ref 2001/6205-MStudy Title Carriage of hypervirulent meningococci before and after the introduction of serogroup C conjugate polysaccharide vaccine in the UK (MREC/99/4/036) Title Dr.First Name Yuen kaiLast Name LauLREC Ref 2001/6208-MStudy Title Diabetes in the very elderly pilot trial (DIVET) Title Prof.First Name CJLast Name BulpittLREC Ref 2001/6245-MStudy Title Efficacy of Probiotics in the prevention of Antibiotic-associated Diarrhoea Title Prof.First Name CJLast Name Bulpitt75 LREC Ref 2001/6246-MStudy Title A randomised trial of hormone therapy alone versus hormone therapy plus radical radiotherapy in non-metastatic prostate cancer (PRO7) Title Dr.First Name SimonLast Name StewartLREC Ref 2002/6265-MStudy Title Genetic study of multiple leiomyomas of the skin (amendment #1 - 8-11-01) (MREC 99/2/13) Title Dr.First Name IanLast Name TomlinsonLREC Ref 2002/6268-MStudy Title Thalidomide maintainance following high dose therapy in multiple myeloma: phase 2 study (MREC/01/7/19) Title Dr.First Name AminLast Name RahemtullaLREC Ref 2002/6269-MStudy Title MREC/99/2/4 An international, multi-centre observational registry of patients with haemoglobinopathies Title Dr.First Name DMLast Name LaytonLREC Ref 2002/6285-MStudy Title Whole body hypothermia for the treatment of perinatal asphyxia encephalopathy (MREC 00/2/73) Title Dr.First Name DenisLast Name Azzopardi76 LREC Ref 2002/6288-MStudy Title A randomized, double-blind study of GT160-246 versus vancomycin in patients with c.difficile associated diarrhoea Title Prof.First Name CJLast Name BulpittLREC Ref 2002/6292-MStudy Title A multi-centre randomised double-blind placebo-controlled parallel-group study to evaluate the safety and efficacy of CDC-501 in the treatment of adults with moderately severe Crohn's disease (MREC 01/4/075) Title Prof.First Name SubrataLast Name GhoshLREC Ref 2002/6293-MStudy Title A multicentre, double blind, randomised, placebo controlled, phase 2 study of prophylactic administration of recombinant human lactoferrin in patients receiving autologous peripheral stem cell transplants (MREC/01/9/50) Title Dr.First Name JaneLast Name Apperley77

Royal Postgraduate Medical School/Hammersmith, Queen Charlotte S & Chelsea and Acton Hospitals

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