<p>ESM - Soares et al. Prognostic Scores in Cancer Patients 1</p><p>Validation of Four Prognostic Scores in Patients with Cancer Admitted to </p><p>Brazilian Intensive Care Units: Results from a Prospective Multicenter Study</p><p>Type of manuscript: Original research.</p><p>Electronic Supplementary Material</p><p>Corresponding author:</p><p>Márcio Soares MD PhD; Instituto Nacional de Câncer; Centro de Tratamento Intensivo </p><p>– 10o Andar; Pça. Cruz Vermelha, 23; Rio de Janeiro – RJ; Brazil; CEP: 20230-130</p><p>Phone: +55 21 2506 6120; Fax: +55 21 2294 8620</p><p>E-mail: [email protected] ESM - Soares et al. Prognostic Scores in Cancer Patients 2</p><p>Table 1– Missing Laboratory Variables (n=717)</p><p>Variables n (%) Hematocrit 2 (0.3%) Hemoglobin 7 (1.0%) Platelets count 3 (0.4%) Leukocyte count 8 (1.2%) Creatinine 4 (0.6%) Urea / Blood urea nitrogen 16 (2.3%) Sodium 4 (0.6%) Potassium 7 (1.0%) Blood gas analyses 75 (10.5%) Bilirubin 342 (47.7%) Prothrombin time 110 (15.3%) Albumin 376 (52.4%) ICU=intensive care unit; IQR=25%-75% interquartile range ESM - Soares et al. Prognostic Scores in Cancer Patients 3</p><p>Table 2. Hosmer-Lemeshow goodness-of-fit C-statistics, predicted mortality rates and standardized mortality ratios for the different customized equations of the SAPS 3 prognostic model.</p><p>Prognostic model Goodness-of-fit C-test Predicted Mortality SMR (95% CI) 2 p-value (Mean  SD) All patients admitted to ICU (n = 717; observed hospital mortality = 30.4%) General quation 15.804 0.045 23.6 ± 26.3 1.29 (1.09 – 1.53) Central and South America 12.608 0.126 29.8 ± 30.5 1.02 (0.87 – 1.19) Australasia 15.950 0.043 21.8 ± 24.8 1.40 (1.17 – 1.67) Central and Western Europe 21.079 0.007 20.8 ± 25.5 1.46 (1.22 – 1.75) Eastern Europe 18.508 0.018 25.9 ± 30.5 1.17 (0.99 – 1.38) Northern Europe 17.602 0.024 22.5 ± 26.5 1.35 (1.14 – 1.61) Southern and Mediterranean Europe 13.571 0.094 23.9 ± 25.7 1.27 (1.07 – 1.51) North America 12.858 0.117 20.8 ± 21.4 1.46 (1.22 – 1.75) AROC = area under receiver operating characteristic curve; CI = confidence interval, SD = standard deviation; SMR = standardized mortality rate, SAPS=Simplified Acute Physiology Score</p><p>. ESM - Soares et al. Prognostic Scores in Cancer Patients 4</p><p>Figure Legends</p><p>Figure 1 Receiver operating characteristic curves for the different prognostic scores in medical and emergency surgical patients with cancer admitted to the intensive care units</p><p>(n=336). Figure 2a: MPM0-III (solid black line) and CMM (gray solid line). Figure 2b: </p><p>SAPS II solid black line and SAPS 3 (gray solid line). The diagonal dotted line represents reference line.</p><p>Figure 2. Calibration curves for the different prognostic scores in medical and emergency surgical patients with cancer admitted to the intensive care units (n=336). </p><p>Figure 2a: MPM0-III (dotted black line) and CMM (black solid line). Figure 2b: SAPS </p><p>II (solid black line), SAPS 3 (dotted black line) and SAPS 3 customized for Central and </p><p>South America (CSA) (solid gray lines). The diagonal dotted line represents the line of ideal prediction. Columns represent the number of patients in each stratum (10% of probability). ESM - Soares et al. Prognostic Scores in Cancer Patients 5</p><p>Figure 1 ESM - Soares et al. Prognostic Scores in Cancer Patients 6</p><p>Figure 2.</p>