Welcome to Stockholm and Advances in Neuroblastoma Research! Dear all, We are so happy that you all finally made it here, to ANR 2010, to Scandinavia, and most of all, to our beautiful capital of Sweden, Stockholm! We are excited to have received more than 400 abstracts which is the basis of our scientific programme. We are therefore confident that this year’s programme will satisfy every single participant, being a researcher, a clinician, a nurse, a student or a parent. Numerous sessions are prepared, spanning all aspects of neuroblastoma from bench to bedside. We are thrilled to have such excellent invited lecturers including four Nobel laureates visiting us, together with several future ones, we are sure! We are grateful to our sponsors and all others who have contributed to make the meeting possible. Please enjoy the multitude of oral and poster presentations. Discuss and interact! Enjoy the social programme, explore the light summer in the beautiful city of Stockholm. After the meeting you should go home exhausted with important experiences, new ideas and friends. On behalf of the local organising committee, Per Kogner CONTENTS General Information 2Abstract Book Contents Abstract Book 77 Programme Author Index 218 Monday June 21st 7 Keyword Index 233 Tuesday June 22nd 14 Poster session 29 Wednesday June 23rd 53 Poster session 29 Thursday June 24th 70 Committees* ANRA, Advances in Neuroblastoma Research Association ANRA President: Susan L. Cohn ANRA Past President: Frank Berthold ANRA Incoming President: Michelle Haber ANRA Steering Committee ANRA Advisory Board (North/South America) Frank Berthold Rochelle Bagatell Garrett M. Brodeur Sylvain Baruchel General Information General Susan L. Cohn Garrett M. Brodeur Audrey E. Evans Susan L. Cohn Michelle Haber Michael Hogarty Per Kogner Wendy London Akira Nakagawara John M. Maris Patrick C. Reynolds Katherine K. Matthay Manfred Schwab Julie Park Frank Speleman Patrick C. Reynolds Carol J. Thiele Carol J. Thiele Darell Yamashiro ANRA Advisory Board (Russia/Europe) ANRA Advisory Board (Asia/Australia/Africa) Klaus Beiske Chan C.F. Godfrey Bruno De Bernardi Michelle Haber Huib Caron Hitoshi Ikeda Angelika Eggert Kenji Kadomatsu Ruth Ladenstein Purna Kurkure Geneviéve Laureys Glenn Marshall Jean Michon Akira Nakagawara Andrew Pearson Murray D. Norris Gudrun Schleiermacher Nili Peylan-Ramu Dominique Valteau-Couanet Cai Weisong Rogier Versteeg Frank Westermann ANR2010 Local Organising Committee ANR2010 Scientific Committee President: Per Kogner Per Kogner Ninib Baryawno Marie Arsenian Henriksson Birgitta de Verdier John Inge Johnsen Ann-Mari Dumanski Bertil Kågedal Lotta Elfman Tommy Martinsson Helena Gleissman Sven Påhlman John Inge Johnsen Ingrid Öra Catharina Karlsson Lova Segerström Malin Wickström ANR2010 Nurses Committee Lisa Burström Karin Enskär Pernilla Pergert Eva Turup * as before election spring 2010. Please see www.anrmeeting.org for updates and contact details. 2 ANR 2010, June 21–24 2010 Acknowledgements and Sponsors The Advances in Neuroblastoma Research Conference would like to thank the following sponsors for their generous support and contributions Co-organisers and main contributors Swedish Childhood Cancer Foundation/Barncancerfonden Karolinska Institutet ANRA Swedish Cancer Society/Cancerfonden Swedish Institute/Svenska Institutet Information General Silver sponsorship Mary Béve Foundation Bronze Sponsorship Pierre Fabre Oncology Visual Sonics Exhibiting Organisations The Advances in Neuroblastoma Research Conference would like to thank the following exhibiting organisations for their contribution and participation. Exhibiting organisations are listed in alphabetical order. ACGT Advancing Clinico Genomic Trials on Cancer ANR2012 Covidien Hospira Pierre Fabre Oncology Ridgeview Instruments AB Swedish Childhood Cancer Foundation/Barncancerfonden Visual Sonics Additional contributors Amgen Oncology Medac Scandinavian Airlines SAS The Vasa Museum Waldemarsudde Social Programme The Social Programme is open to all registered participants and accompanying persons, and must be pre-booked. Additional tickets may be booked and/or purchased at the Registration desk, should space be available. Welcome Programme (Welcome to Stockholm and Welcome to Sweden) The Welcome Programme will take place at the Stockholm City Conference Centre Monday June 21st at 16:30. The programme includes an introduction to Stockholm, Karolinska Institutet and the Nobel Prize, followed by a lecture by the Swedish Nobel Laureate, Professor Bengt Samuelsson. This will be followed by traditional Swedish music and performances by various artists, and you will get to know Sweden culturally and historically. The Welcome Programme is followed by a Welcome Reception at the Stockholm City Hall. The Welcome Programme is open to all participants and registered accompanying guests. Welcome Reception at Stockholm City Hall The Welcome Reception, Monday June 21st, at 19:00, is hosted by the City of Stockholm and the County Council at Stockholm City Hall, the venue for the Nobel Prize dinner. A buffet dinner will be served followed by a guided tour of the building. Please note: The reception is open to participants and registered accompanying guests, only if marked on the registration form. Please bring your ticket. Programme 3 Opening Ceremony All participants and registered accompanying guest are invited to attend the Opening Ceremony on June 22nd at 08:00 in the Stockholm City Conference Centre where ANR 2010 officially will be opened. Archipelago Boat Tour The Archipelago Boat Tour, Tuesday June 22nd, will depart from, and return to Nybrokajen, in Stockholm. The duration of the Tour is approximately three and a half hours and you will be given the opportunity to see some of the most beautiful scenery of Stockholm. A light dinner, including a glass of wine or non-alcoholic beverage and coffee, will be served on-board. A cash bar will be open, at own expense, during the Tour. Please note: The Archipelago Boat Tour is open for participants and registered accompanying guests. The boat will General Information General depart at 19:00 sharp. Please bring your ticket. A light jacket and/or scarf is recommended. Gala Dinner The Gala Dinner will take place at Solliden, a classic restaurant with beautiful decor and a stunning view of Stockholm and south inlet heights. The Gala Dinner will be held on Wednesday June 23rd, at 19:00 and buses will depart from City Conference Centre/Norra Bantorget from 18:45. Buses will return to Norra Bantorget from 22:45. Solliden is located at Skansen, Sweden’s largest outdoor museum, where there is always something happening. Every season has its own charm. Summer and winter, every day, all year round, there are lots to see and experience. Skansen is known for its wild animals and culture and out-door exhibitions of Sweden’s cultural heritage. It is also the stage from where entertainment programmes are often shown live on TV. Registered Accompanying Guests The registration fee for accompanying guests includes admission to the Welcome Programme at the City Conference Centre and Welcome Reception at the City Hall on Monday June 21st, as well as the Opening Ceremony on Tuesday June 22nd. Registered accompanying guests are also invited to listen to the lectures “The Road to Stockholm and Beyond” 1 and 2 in conjunction with the above mentioned events. In addition it gives accompanying guests the possibility to attend the Archipelago Boat Tour and the Gala Dinner for an additional fee. Please note that the fee for accompanying guests does not include admission to the scientific sessions, the commercial- or the poster exhibitions nor does it entitle them to any Conference documentation or meals during breaks. Exhibitor Registration Fee The registration fee for exhibitors includes daily tea/coffee and lunch as well as the Welcome Reception at Stockholm City Hall. Please note that the fee for exhibitors and sponsors does not include admission to the scientific sessions. General Information Badges Each participant will receive a name badge upon registration at the Conference venue. For security reasons all participants are requested to wear their badge during all the Conference activities and social events. The cost for replacing a lost badge is SEK 100. Banks, Credit Cards and Currency Exchange Banks are open between 09:30/10:00 and 15:00 on weekdays. Some banks in central Stockholm are open from 09:00 to 17:00. Major credit cards are accepted in hotels, restaurants, taxis and shops. It is advisable to carry an identity card or some form of photo identification. The official currency is Swedish Krona (SEK). USD 1 = SEK 7.75, EUR 1 = SEK 10.00 (May, 2010). For money exchange, the companies Forex and X-change have offices at the airports and in the city. Opening hours and other information about exchange can be found at www.forex.se and www.x-change.se. Certificate of Attendance A certificate of attendance will be given to registered participants upon request. 4 ANR 2010, June 21–24 2010 Climate and Dress The weather in Stockholm at this time of the year is usually warm and sunny with temperatures of approximately 15–20 degrees Celsius; showers may occur. Informal dress is recommended for the Conference sessions and smart casual is recommended for the Welcome Reception and the Gala Dinner. A light jacket and/or scarf is recommended for the Archipelago Boat Tour. Commercial Exhibition A commercial exhibition will be arranged in the Conference Hall Foyer in conjunction with the Conference.