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Vicenzini E, Ricciardi MC, Puccinelli F, Guidetti G, Delfini R, Lenzi GL (2007) </p><p>Common carotid artery intima-media thickness determinants in a population study. J </p><p>Ultrsound Med 26: 427-432</p><p>25. World Health Organization. BMI-for-age (5-19 years). </p><p> http://www.who.int/growthref/who2007_bmi_for_age/en/print.html. Assessed May 2, </p><p>2008</p><p>26. Wunsch R, de Souza G, Toschke AM, Reinehr T (2006) Intima-media thickness in obese </p><p> children before and after weight loss. Pediatrics 118: 2334-2340 5</p><p>TABLES</p><p>Table 1: Anthropometric, clinical and laboratory characteristics of the study population. Normal weight Overweight and Variable Total (n=93) (n=52) obese (n=41) Age (months): mean (±SD) 106 (±29) 104 (±28) 109 (±30) Caucasian: n (%) 78 (84) 43 (83) 35 (85) Male: n (%) 49 (53) 27 (52) 22 (54) BMI (kg/m2): mean (±SD) 18.9 (±5.1) 15.6 (±1.7)* 22.7 (±5.1)* Family history of CHD: n (%) 55 (60) 29 (56) 26 (63) DBP (mm Hg): mean (±SD) 68 (±10) 66 (±10) 70 (±10) SBP (mm Hg): mean (±SD) 109 (±14) 107 (±15) 109 (±12) Composite cIMT (mm): mean (±SD) 0.44 (±0.07) 0.43 (±0.06)** 0.46 (±0.08)** Fibrinogen (mol/l): mean (±SD) 8.40 (±2.06) 7.97 (±2.03) 8.76 (±2.03) Glucose (mmol/l): mean (±SD) 4.61 (±0.40) 4.60 (±0.37) 4.62 (±0.45) HDL (mmol/l): mean (±SD) 1.37 (±0.40) 1.42 (±0.34) 1.29 (±0.26) LDL (mmol/l): mean (±SD) 2.32 (±0.74) 2.28 (±0.83) 2.56 (±0.67) T-CHOL (mmol/l): mean (±SD) 4.11 (±1.16) 4.09 (±1.14) 4.22 (±0.78) Triglycerides (mmol/l): median (IQR) 0.76 (0.55–1.03) 0.67 (0.47-0.87)# 0.89 (0.80-1.02)# SD: standard deviation; BMI: body mass index; CHD: cardiovascular heart disease; DBP: diastolic blood pressure; SBP: systolic blood pressure; HDL: high-density lipoprotein cholesterol;</p><p>LDL: low-density lipoprotein cholesterol; T-CHOL: total cholesterol; IQR: interquartile range; cIMT: carotid intima-media thickness; * and **: Student’s t test - P<0.001 and P=0.023, respectively; #: Mann-Whitney test; P=0.010. 6</p><p>Table 2: Pearson’s correlation coefficients for normally distributed variables (P value); n=93. Age Glucose Fibrinogen DBP SBP BMI z-score Composite cIMT Age 1.0 0.200 - 0.102 - 0.020 - 0.014 0.001 0.132 (0.054) (0.331) (0.850) (0.895) (0.995) (0.206)</p><p>Glucose 0.200 1.0 0.051 0.001 0.126 0.151 0.113 (0.054) (0.150) (0.999) (0.227) (0.150) (0.279)</p><p>Fibrinogen - 0.102 0.051 1.0 0.008 0.092 0.254 0.082 (0.331) (0.150) (0.938) (0.383) (0.014) (0.433)</p><p>DBP - 0.020 0.001 0.008 1.0 0.772 0.301 0.107 (0.850) (0.999) (0.938) (<0.001) (0.003) (0.307)</p><p>SBP - 0.014 0.126 0.092 0.772 1.0 0.296 0.256 (0.895) (0.227) (0.383) (<0.001) (0.004) (0.013)</p><p>BMI z-score 0.001 0.151 0.254 0.301 0.296 1.0 0.259 (0.995) (0.150) (0.014) (0.003) (0.004) (0.012) 0.259 Composite cIMT 0.132 0.113 0.082 0.107 0.256 1.0 (0.206) (0.279) (0.433 (0.307 (0.013) (0.012) DBP: diastolic blood pressure; SBP: systolic blood pressure. 7</p><p>Table 3: Spearman’s correlation coefficients for categorical of skewed variables (P value); n=93. Gender CHD CRP T-CHOL HDL TGL Overweight Composite Obesity cIMT 0.045 - 0.062 -0.129 -0.129 - 0.059 Gender 1.0 0.047 0.193 (0.670) (0.554) (0.226) (0.219) (0.572) (0.655) (0.063) 0.045 0.231 - 0.135 - 0.068 - 0.141 0.082 - 0.043 CHD 1.0 (0.670) (0.026) (0.206) (0.521) (0.178) (0.435) (0.681) - 0.062 0.231 0.098 - 0.094 - 0.068 0.027 0.113 CRP 1.0 (0.554) (0.023) (0.360) (0.371) (0.519) (0.800) (0.280) -0.129 - 0.135 0.098 0.251 0.468 0.087 0.060 T-CHOL* 1.0 (0.226) (0.206)) (0.360) (0.018) (<0.001) (0.414) (0.573) -0.129 - 0.068 - 0.094 0.251 - 0.010 - 0.249 - 0.029 HDL* 1.0 (0.219) (0.521)) (0.371) (0.018) (0.927) (0.017) (0.784) - 0.059 - 0.141 - 0.068 0.468 - 0.010 0.297 0.043 TGL 1.0 (0.572) (0.178) (0.519) (<0.001) (0.927) (0.004) (0.682) Overweight/ 0.047 0.082 0.027 0.087 - 0.249 0.297 0.230 1.0 obesity (0.655) (0.435)) (0.800) (0.414) (0.017) (0.004) (0.027) Composite 0.193 - 0.043 0.113 0.060 - 0.029 0.043 0.230 1.0 cIMT (0.063) (0.681)) (0.280) (0.573) (0.784) (0.682) (0.027)</p><p>CHD: coronary heart disease; CRP: C-reactive protein; T-CHOL: total cholesterol;</p><p>HDL: high-density lipoprotein cholesterol; TGL: triglycerides.</p>