<p>SBI3U A Decade of the Human Genome</p><p>BBC Documentary “A Decade of the Human Genome” on YouTube</p><p>Background Information The human genome project involved sequencing an entire human genome (the genetic code contained in all 46 chromosomes). It began in 1990 and was completed in 2003.</p><p>1. What is Sophie’s genetic disorder? Cystic Fibrosis</p><p>2. What is the regime that keeps Sophie alive? A combination of physiotherapy and drugs</p><p>3. What is the average life expectancy of a person with Cystic Fibrosis? 38 years</p><p>4. What is the breast cancer gene called? BRCA1</p><p>5. What do Sophie, Emma and Tom hope for? That the human genome project will help doctors to find cures or better treatments for their diseases.</p><p>6. The human genome has been printed and put into a series of books. How many volumes are there and how many pages in each volume? More than 100 volumes and each has 1000’s of pages</p><p>7. How many genes are in the human genome? 28000</p><p>8. Which gene causes Cystic Fibrosis? How many nitrogenous bases (letters) are in this gene? The CFTR gene which contains 4 nitrogenous bases</p><p>9. What is the idea behind gene therapy? 1) Identify a single mutated gene 2) Insert a healthy gene</p><p>10. How was Reese treated? His bone marrow was mixed with copies of the healthy gene</p><p>11. Scientists are at work sequencing genes from cancer cells. How can this help to find a cure? The genome from a cancer cell and a healthy cell from the same person can be compared and the differences can be identified which can lead to determining a cure.</p><p>12. How long did the human genome project take? About 10 years SBI3U 13. How long does it take to sequence a human genome now? 3 weeks</p><p>14. What does Tom order from the internet? A kit for testing for the alcoholism gene</p><p>15. What does Tom have to put in the vial to be tested? Saliva</p><p>16. What is the goal for gene therapy? To treat fetuses in utero so they never develop disease.</p><p>17. How can the scientist tell if the gene transfer into the mouse has been a success? The fluorescence gene from a jellyfish was also inserted to make the mouse glow if the gene has been transferred successfully.</p><p>18. How is the human genome project helping doctors to determine a cure for cancer? It can help create a targeted cure based on the individual’s specific cancer and genetics.</p><p>19. What percent of alcoholism is controlled by an individual’s genes? 50%</p><p>20. How long does it take for a treatment to go from an idea to a trial to a doctor’s cabinet?</p><p>21. Why are lungs resistant to gene therapy? Because lungs have a very large surface area and they have evolved to keep out contaminants</p><p>22. How does chemotherapy work? It kills cells that are growing fast such as hair, in the gut and blood. SBI3U A Decade of the Human Genome</p><p>BBC Documentary “A Decade of the Human Genome” on YouTube</p><p>Background Information The human genome project involved sequencing an entire human genome (the genetic code contained in all 46 chromosomes). It began in 1990 and was completed in 2003.</p><p>1. What is Sophie’s genetic disorder?</p><p>2. What is the regime that keeps Sophie alive?</p><p>3. What is the average life expectancy of a person with Cystic Fibrosis?</p><p>4. What is the breast cancer gene called?</p><p>5. What do Sophie, Emma and Tom hope for?</p><p>6. The human genome has been printed and put into a series of books. How many volumes are there and how many pages in each volume?</p><p>7. How many genes are in the human genome?</p><p>8. Which gene causes Cystic Fibrosis? How many nitrogenous bases (letters) are in this gene?</p><p>9. What is the idea behind gene therapy?</p><p>10. How was Reese treated?</p><p>11. Scientists are at work sequencing genes from cancer cells. How can this help to find a cure?</p><p>12. How long did the human genome project take?</p><p>13. How long does it take to sequence a human genome now? SBI3U</p><p>14. What does Tom order from the internet?</p><p>15. What does Tom have to put in the vial to be tested?</p><p>16. What is the goal for gene therapy?</p><p>17. How can the scientist tell if the gene transfer into the mouse has been a success?</p><p>18. How is the human genome project helping doctors to determine a cure for cancer?</p><p>19. What percent of alcoholism is controlled by an individual’s genes?</p><p>20. How long does it take for a treatment to go from an idea to a trial to a doctor’s cabinet?</p><p>21. Why are lungs resistant to gene therapy?</p><p>22. How does chemotherapy work?</p>