<p> McDermott et al.</p><p>Supplementary Table 1: Synonymous and non-synonymous nucleotide substitutions in the sequenced Dpo genes. </p><p>The amino acid differences resulting from non-synonymous substitutions (relative to LpRpo) are indicated in the single letter format beside the relevant codon.</p><p>Codon No. LpDpo FNzDpo FIp4Dpo Dpo domain 13 GCC GCT 19 GAT(D) GAA(E) 25 GAA(E) GAT(D) 48 ATC(I) ACC(T) 51 TCC(S) TAC(Y) TAC(Y) 66 GAC GAT 71 CCA CCT 78 ACA ACT ACT 79 TCA TCT TCT 107 CTG(L) ATG(M) ATG(M) 116 ATG(M) ATA(I) ATA(I) 120 CAG(Q) CCG(P) ExoI 123 GCA(A) GAG(E) ExoI 125 CCT(P) CCG CAG(Q) ExoI 128 CAG(Q) CTG(L) 196 CTG(L) ATG(M) ATG(M) 210 CTG(L) CAG(Q) 216 GTC GTG 218 TTT(F) TTG(L) ExoII 238 AAT(N) ATT(I) 241 TAC TAT 339 CTA CTG 340 GGT GGA 341 GTC GTA 358 ATC ATA 375 GAA(E) CAA(Q) CAA(Q) 432 TAC(Y) TTC(F) Pol I 444 ACT(T) AGT(S) 485 ACT(T) CCT(P) CCT(P) TPR1 494 GAC(D) GAA(E) GAA(E) TPR1 502 GGG GGC GGC TPR1 529 AAA(K) GCA(A) Pol IIa 536 GCT GCA Pol IIa 541 GTA(V) ATT(I) GTT Pol IIa 594 ATA(I) GTA(V) GTA(V) 615 ACA ACT 629 ATC(I) ATG(M) ATG(M) Pol IIb 658 GAG(E) GAT(D) Pol III 662 ACA(T) ATA(I) Pol III 665 GGC GGA Pol III 672 GGA GGT Pol III 674 GTA(V) TTA(L) Pol III 676 ACC(T) AAC(N) AAC(N) Pol III 681 GTA(V) ATA(I) ATA(I) Pol III 690 CAA(Q) ATC(I) Pol III 692 AAG AAA Pol III 696 AAG(K) CAG(Q) CAG(Q) Pol III 698 TGT(C) AGT(S) Pol III 717 GAC(D) GAG(E) Pol III 720 ATC(I) ACA(T) Pol III 724 GAG(E) CAG(Q) 726 ATA(I) ACA(T) ACA(T) 741 TTC TTT 744 GTT(V) ATT(I) ATT(I) 758 AAA(K) AAT(N) 761 AAA(K) GTA(V) 762 GCA(A) CCA(P) 772 GAT(D) GGT(G) 781 AAT(N) AAG(K) 784 AGA(R) AGT(S) 795 GTC(V) GTG 798 CTG(L) ATG(M) 799 TCA(S) CAA(Q) 801 CTA(L) ATC(I) 802 AGT(S) AAA(K) 803 AGG(R) AAG(K) 822 GAT(D) TCA(S) 827 GAC(D) AAC(N)</p>