<p>Dear Colleagues, </p><p>MRC SUPREMO – a Phase III randomised trial to assess the role of adjuvant chest wall irradiation in intermediate risk breast cancer after mastectomy.</p><p>SUPREMO welcomes the Olympics to London. In line with this occasion we are also celebrating the highest recruiting month the trial has seen this year with a total of 36 patients recruited in July. This is a fantastic accomplishment, well done to all centre’s who entered patients last month. Please keep up this hard work as we approach the finish line to recruitment.</p><p>We would like to take this opportunity to thank all our top recruiting sites. </p><p>Dr Loncaster and colleagues at The Christie Hospital, Manchester (59 pts)</p><p>Dr Hatton and colleagues at Weston Park Hospital, Sheffield (53 pts)</p><p>Dr Westenberg and colleagues at Arnhems Radiotherapeutisch Instituut (49 pts)</p><p>Quality of Life and Health Economics sub-study As detailed in a previous edition we have recently received approvals to continue recruitment into the QoL sub-study past the initial accrual target. We have now attached the MREC approval for this non-substantial amendment. Please forward a copy of this to your local R&D office for their information.</p><p>Please could you ensure that any patients taking part in the HE sub-study complete their patient diaries based on any visits to a health professional after the completion of any post-operative chemotherapy (if received) or after the patient’s last definitive surgery (in those patients not receiving post-operative chemotherapy). We have had a few cases where patients have completed their diaries retrospectively including visits to a health professional which occurred prior to these dates.</p><p>If you have any questions relating to the HE or Quality of Life sub-study please can you direct them to Linda Williams ([email protected]) or Susan Hermiston ([email protected]) who will both be available to answer these queries.</p><p>The SUPREMO team would like to welcome the following new sites who recently completed all the necessary approvals to open to recruitment:</p><p> Dr Chaudhuri & colleagues at Lincoln County Hospital, UK.  Associate Professor Christie & Colleagues at Premion Centres in Tugun, Southport, Wesley, Chermside & Nambour, Australia.</p><p>We look forward to randomising the 1st patient from these sites. </p><p>In addition we would like to congratulate the research teams at the following sites for randomising their first subject(s) to the trial in July:  Dr Julia Hall and site staff at Kent and Canterbury Hospital  Dr Bishop and colleagues at Peter MacCallum Cancer Centre – Bendigo, Australia</p><p>Thanks are also due to the research teams at the following centres who have randomised patients to SUPREMO in July [patients in July / total patients recruited to date by site]:</p><p>Dr Jackie Clarke, Belfast City Hospital (3/39) Dr Charles Lowdell, Charing Cross Hospital (3/23) Dr Pamela Woodings, Derbyshire Royal Infirmary (2/33) Dr Blanca Farrus, Clinico Y Provincial De Barcelona (2/24) Dr Sunil Upadhyay, Castle Hill Hospital Hull (2/23) Dr Mathew Hatton, Weston Park Hospital, Sheffield (1/53) Dr Nicola Russell, Antoni Van Leeuwenhoekziekenhuis (1/46) Dr Adrian Harnett, Norfolk & Norwich University Hospital (1/32) Dr Chris Cottrill, Barts Health NHS Trust (1/31) Dr Lisa Barraclough, Macclesfield District General Hospital (1/27) Dr Martin Rolles, Singleton Hospital, Swansea (1/21) Dr Neil Bayman, Wigan Royal Albert Edward Infirmary (1/20) Dr Anne Robinson, Southend Hospital (1/17) Dr Elzbieta Senkus-Konefka, Medical University of Gdansk (1/16) Dr Mohini Varughese, Taunton and Somerset NHS Foundation Trust (1/15) Dr Mary Quigley, Barking, Havering & Redbridge Hospitals NHS Trust (1/15) Dr Douglas Adamson, Ninewells Hospital, Dundee (1/13) Dr Fuh Yong Wong, National Cancer Centre Singapore (1/13) Dr Carla Rodenhuis, UMC Utrecht (1/13) Dr M Stenfert-Kroese, Stedendriehoek en Omstreken (1/11) Dr Peter Barrett-Lee, Velindre Cancer Centre (1/11) Dr JJ Jager, Maastro (1/10) Dr Geoffrey Sparrow, Yeovil Hospital (1/9) Dr Nicola Storey, University Hospital of North Tees and Hartlepool (1/8) Dr Diana Ritchie, Victoria ACH, Glasgow (1/5) Dr Sri Kumar, Leeds Teaching Hospitals NHS Trust (1/3) Dr Marjorie Tomlinson, Weston General Hospital, Weston-Super-Mare (1/3) Dr Julia Hall, Kent and Canterbury Hospital (1/1) Dr Michelle Bishop, Peter MacCallum Cancer Centre – Bendigo (1/1)</p><p>188 patients have been recruited into SUPREMO in 2012 so far. There are only 5 months of recruitment left on the trial so we require 25 patients each month to meet our accrual target of 1600 patients. </p><p>With kind regards, Professor Ian Kunkler Chief Investigator, MRC/EORTC SUPREMO trial </p>