<p>Supplementary Table 1: Overview of clinical trials of imaging-guided treatment strategies for rheumatoid arthritis</p><p>Study Location ClinicalTrials.gov identifier Target Primary endpoint(s) Targeting Synovitis in Scotland NCT00920478 Ultrasonography-based (PDUS MRI RAMRIS erosion score and Early Rheumatoid Arthritis signal in ≤1 joint) DAS44 (TaSER)S1 Aiming for Remission in Norway NCT01205854 Ultrasonography-based (no Clinical remission Rheumatoid Arthritis (RA) PDUS signal) - the ARCTIC TrialS2 An MRI-guided Treatment Denmark NCT01656278 MRI-based (no bone oedema) Clinical remission and no Strategy to Prevent radiographic progression Disease Progression in Patients With Rheumatoid Arthritis (IMAGINE-RA)S3 Targeted Ultrasound in Europe NCT02056184 PDUS-based (no PDUS signal) PDUS (decrease in PDUS signal) Rheumatoid Arthritis (TURA)S4 Abbreviations: DAS44, 44-joint disease activity score; PDUS, power Doppler ultrasonography; RAMRIS, rheumatoid arthritis MRI scoring system.</p><p>References</p><p>S1. US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT00920478 (2009).</p><p>S2. US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01205854 (2013).</p><p>S3. US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01656278 (2014).</p><p>S4. US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT02056184 (2014).</p>