<p> Supplementary data</p><p>Postdiagnosis Body Mass Index and Risk of Mortality in Colorectal Cancer Survivors –</p><p> a Prospective Study and Meta-Analysis</p><p>Authors: Sabrina Schlesinger, Sabine Siegert, Manja Koch, Jessica Walter, Nils Heits, </p><p>Sebastian Hinz, Gunnar Jacobs, Jochen Hampe, Clemens Schafmayer, Ute Nöthlings</p><p>Supplementary table 1: Self-reported characteristics among responders and non-responders of the total PopGen colorectal cancer survivor cohort (N = 2,733)</p><p>Responders Non-Responders p</p><p>Numbers 2,263 470 Age at BMI assessment, years 65.8 68.9 <0.0001 Age at diagnosis, years 62.0 65.0 <0.0001 Time since diagnosis 3.0 3.0 0.38 BMI, kg/m² 26.3 26.3 0.87 Men, % 48.5 56.4 <0.01 Cancer site, % Colon 50.4 52.2 0.41 Rectum 44.7 41.8 Colon & Rectum 4.9 6.0 Family history of CRC, % 21.8 19.7 0.60 Other cancer, % 16.7 19.8 0.10 Metastases, % 16.7 16.4 0.88 Values are medians or percentages. a not included due to missing values in variables of interest.</p><p>Age at diagnosis on 2,706, time since diagnosis on 2683, BMI 2687, cancer site on 2,504, family history on CRC on 2,531, other cancer on 2,683 and metastases on 2,625.</p><p>Supplementary table 2: Relative risks (RR) and 95% confidence intervals (95% CI) of mortality in participants with colorectal cancer according to body mass index (BMI) (N = 2,071) after excluding first 12 months after baseline No. of Model 1a Model 2b deaths RR (95% CI) RR (95% CI) (277) 1 BMI, kg/m²</p><p>< 18.5 7 2.89 (1.31-6.37) 1.87 (0.84-4.19)</p><p>18.5 - < 25 103 1 1</p><p>25 - < 30 115 0.86 (0.65-1.13) 0.81 (0.62-1.07)</p><p>≥ 30 52 0.91 (0.64-1.27) 0.82 (0.58-1.15) p-Trend 0.17 0.08</p><p>Per 5 kg/m² 0.91 (0.79-1.05) 0.89 (0.77-1.03) a adjusted for age and sex. b Model 2 based on Model 1 with additional adjustment for alcohol consumption, smoking status, tumour location, family history of CRC, metastases and other cancer.</p><p>Supplementary table 3: Relative risks (RR) and 95% confidence intervals (95% CI) of mortality in participants with colorectal cancer according to body mass index (BMI) (N = 2,119) after excluding not verified deaths No. of Model 1a Model 2b deaths RR (95% CI) RR (95% CI) (325) BMI, kg/m²</p><p>< 18.5 7 2.61 (1.20-5.68) 1.59 (0.72-3.50)</p><p>18.5 - < 25 121 1 1</p><p>25 - < 30 134 0.83 (0.64-1.07) 0.80 (0.62-1.03)</p><p>≥ 30 63 0.95 (0.70-1.30) 0.86 (0.63-1.18) p-Trend 0.26 0.14</p><p>Per 5 kg/m² 0.92 (0.80-1.05) 0.90 (0.79-1.03) a adjusted for age and sex. b Model 2 based on Model 1 with additional adjustment for alcohol consumption, smoking status, tumour location, family history of CRC, metastases and other cancer. 3 Supplementary Figure 1: Kaplan-Meier estimates of survival for participants of the PopGen colorectal cancer survivor cohort (n=2,143). The p value was derived from log-rank test and was p=0.13.</p><p>BMI: Body mass Index</p><p>4 Supplementary</p><p>Figure 2:</p><p>Adjusted hazard</p><p> rate ratios of all-</p><p> cause mortality</p><p> among 2,143</p><p> participants of</p><p> the PopGen</p><p> colorectal cancer</p><p> survivor cohort</p><p> according to</p><p> body mass index derived from restricted cubic spline regression. The solid line indicates hazard rate ratios, the black dashed lines are the 95% confidence intervals and the red points indicate the knots placed at the 5th, 25th, 75th and 95th percentiles. The reference category was chosen at the midpoint of the category for normal body mass index (=21.7 kg/m²). The model was adjusted for age, sex, alcohol consumption, smoking status, tumour location, family history of CRC, metastases and other cancer. The p value for nonlinearity was derived from Wald chi-square test and was p=0.10.</p><p>5</p>