1 FC & BC focus sym covers_Layout 1 9/19/12 3:30 PM Page 2 Current and Future Applications of Focused Ultrasound 2012 3rd International Symposium Program & Abstract Book October 14–17, 2012 Bethesda North Marriott Hotel & Conference Center Focused Ultrasound Foundation www.fusfoundation.org | Charlottesville, VA | T 434.220.4993 Washington, DC Metro Area, USA 2 IFC 9x11 acknowledgment12rev_Layout 1 10/1/12 7:36 AM Page 2 Sponsor Acknowledgements GE Healthcare Platinum InSightec Platinum Philips Platinum Varian Platinum Elekta Gold FUS Instruments Supersonic Image Bronze Bronze Alpinion EDAP Image Guided Therapy Imasonic ISTU Friend Friend Friend Friend Friend Contents Welcome Messages 1 Symposium Organizer 3 Maps 5 General Information 6 Program at a Glance 8 Detailed Program 11 Poster Session Overview 16 Invited Speakers and Moderators 20 Abstracts 21 Oral Abstracts 22 Poster Abstracts 105 Author Indexes By Name 209 By Organization 213 Young Investigator Awards 219 Sponsors 225 Focused Ultrasound 2012 3rd International Symposium i ii Focused Ultrasound 2012 3rd International Symposium Welcome Messages From the Honorary President Dear Colleagues: Everyone working in the field of focused ultrasound has been intrigued and inspired by the therapeutic potential and promise of this exciting technology. While still at an early stage, our push to develop focused ultrasound applications is increasing in scope and intensity. To me, the best gauge of our progress is the 3rd International Symposium on Focused Ultrasound. What makes this year’s symposium different from its predecessors is the inclusion of more presentations, more indications and more advances in R&D and commercialization. All signal that the pace of progress in our field is escalating. I hope that clinicians attending this year’s symposium gain meaningful insight into the full range of applications that focused ultrasound can provide to them and, therefore, to their patients. After all, having patients live longer, healthier lives is the driving force in all of our work. Sincerely, Professor Wladyslaw M. Gedroyc Director and Consultant Radiologist St. Mary’s Hospital, Imperial College Honorary Symposium President Focused Ultrasound 2012 3rd International Symposium 1 Welcome Messages (continued) From the Foundation Chairman Dear Colleagues: Welcome to the 3rd International Symposium on Focused Ultrasound. You are participating in the most extensive program we have hosted to date featuring more than 170 oral and poster presentations spotlighting the latest developments in our field. This represents more than a 50% increase compared to the 2010 symposium and reflects the accelerating progress being achieved by the focused ultrasound community. In keeping with the Foundation’s intense patient-centric orientation, the program emphasizes the translational and clinical research that is moving focused ultrasound into the realm of patient care. The potential focused ultrasound to improve the quality of life and longevity for millions of people around the world with serious medical disorders has never been more apparent. Effective therapies to decrease death, disability and suffering are now on the horizon, no longer beyond it. But we still need to shorten the distance. We will do that through capital – financial and, more importantly, human capital. The number of focused ultrasound investigators is continuing to grow as evidenced by the applications received for the Young Investigator Travel Awards. In 2010, there were 11 applications; this year, there were 44. But in order to move focused ultrasound forward more rapidly, we need more human capital. The most expeditious way to achieve this is to leverage the people who are currently engaged. The symposium is an important vehicle for disseminating knowledge and sharing ideas, the most important role is to serve as an incubator to foster collaboration – collaboration being the ultimate force multiplier for human capital. Please take advantage of the opportunities to establish new partnerships and collaborations, particularly during the Tuesday evening poster session. Several special events are planned during the symposium, including keynote talks by Dean Kamen, one of the international leaders in medical device innovation and inventor of the Segway, at Sunday’s opening reception and by John Grisham, best-selling author and Foundation board member, on Tuesday morning. The Focused Ultrasound Foundation is proud to serve as the nexus for the global focused ultrasound ecosystem. We are deeply appreciative of your participation in the symposium and of your ongoing and steadfast commitment to advancing focused ultrasound. I am confident that this event will inspire and facilitate your continued contributions to the growing body of focused ultrasound research and knowledge. In closing, I would like to acknowledge the generosity of our donors and the support of our sponsors – they have made this meeting possible. I thank both groups, and encourage all attendees to visit the exhibit area and meet with our sponsoring organizations. Sincerely, Neal F. Kassell, MD Chairman, Focused Ultrasound Foundation 2 Focused Ultrasound 2012 3rd International Symposium Symposium Organizer About the Focused Ultrasound Foundation The Focused Ultrasound Foundation is a medical technology research, education and advocacy organization dedicated to improving the lives of millions of people with serious medical disorders by accelerating the development and adoption of focused ultrasound. The Foundation is unique in that it supports development of improved treatment for a wide variety of diseases utilizing a platform technology that exerts multiple mechanisms of action. Positioned at the nexus of the large, diverse group of stakeholders comprising the ultrasound community, the Foundation functions as an independent, trusted and unbiased third-party, aligning organizations into a cohesive ecosystem with a single goal: To make focused ultrasound technology available to patients in the shortest time possible. The Foundation works to establish a patient centric culture, instill a sense of urgency in all stakeholders, and alleviate barriers to progress. The Foundation catalyzes collaboration and partnerships, organizes and funds research, spearheads advocacy and patient support initiatives, and sponsors meetings, symposia and workshops to create and disseminate knowledge and increase awareness of focused ultrasound. Early-stage research funded by the Foundation “de-risks” subsequent investment, thus encouraging other funding sources such as disease specific foundations, the National Institutes of Health (NIH), and industry to become more involved. The Foundation is on the leading edge of the venture philanthropy and social entrepreneurship movements and is a model of how private philanthropy can work in concert with academia, industry and government to bridge the gap between research and commercialization of a high impact medical technology. To learn more about focused ultrasound and the Focused Ultrasound Foundation, visit the Foundation’s website: www.fusfoundation.org Organizing Committee Neal Kassell, MD, Chair Focused Ultrasound Foundation; University of Virginia Arik Hananel, MD, MBA, Vice Chair Focused Ultrasound Foundation Robin Jones, Project Lead Focused Ultrasound Foundation Focused Ultrasound 2012 3rd International Symposium 3 Symposium Organizer (continued) Board of Directors Scientific Program Committee Dorothy Batten Jean-Francois Aubry, PhD Former Director, Landmark Communications University of Virginia S Morry Blumenfeld, PhD Kim Butts Pauly, PhD Founding Partner, Meditech Advisors Management Stanford University Eugene V Fife Matthew Dreher, PhD Founding Principle, Vawter Capital, LLC National Institute of Health John Grisham Keyvan Farahani, PhD Author National Cancer Institute Daniel P Jordan, PhD Arik Hananel, MD President Emeritus, Thomas Jefferson Foundation Focused Ultrasound Foundation Neal F Kassell, MD Joo Ha Hwang, MD, PhD Chairman, Focused Ultrasound Foundation; University of Washington Professor, Department of Neurosurgery, University of Virginia Kullervo Hynynen, PhD Sunnybrook Health Sciences Centre Edward D Miller, MD Former CEO, Johns Hopkins Medicine Young-Sun Kim, MD Samsung Medical Center Frederic H Moll, MD Co-founder and Executive Chairman, Nathan McDannold, PhD Hansen Medical, Inc. Harvard Medical School Steve Rusckowski Chrit Moonen, PhD CEO, Quest Diagnostics University Medical Center Utrecht Former CEO, Philips Healthcare Dennis Parker, PhD Lodewijk JR de Vink University of Utah Founding Partner, Blackstone Health Care Partners Richard Price, PhD Andrew von Eschenbach, MD University of Virginia President, Samaritan Health Initiatives Gail ter Haar, PhD (Chair) Kobi Vortman, PhD Joint Department of Physics, Founder, President and CEO, InSightec Ltd. Institute of Cancer Research, Royal Marsden Hospital 4 Focused Ultrasound 2012 3rd International Symposium Map Main Level — Grand Ballroom Welcome Reception Sunday 14 October 2012 18:00 – 20:00 Posters Symposium Sessions Salon A - C Salon D Salon E - H Daily Food & Beverage Salon A - C Sponsors Registration Lower Level Lunch Discussion Sessions Linden Oak Brookside Monday: Payer Seneca Environment Tuesday: Prostate Glen Echo White Oak Vendor Monday: Brain Forest Glen Regulatory Focused Ultrasound 2012 3rd International Symposium 5 General Information Registration & Information Hours Sunday 16:00 – 20:00 Monday 7:00 – 18:00 Tuesday 7:00 – 18:00 Wednesday 7:00 – 18:00 Special Events