UvA-DARE (Digital Academic Repository) The transcription factor KLF2 in vascular biology Boon, R.A. Publication date 2008 Link to publication Citation for published version (APA): Boon, R. A. (2008). The transcription factor KLF2 in vascular biology. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. 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LocusLink Accession Gene Sequence Description Fold p-value ID number symbol change (FDR) 6654 AK022099 SOS1 cDNA FLJ12037 fis, clone HEMBB1001921. 100.00 5.9E-09 56999 AF086069 ADAMTS9 full length insert cDNA clone YZ35C05. 100.00 1.2E-09 6672 AF085934 SP100 full length insert cDNA clone YR57D07. 100.00 6.7E-13 9031 AF132602 BAZ1B Williams Syndrome critical region WS25 mRNA, partial sequence. 43.78 2.9E-05 64919 AJ404614 BCL11B mRNA for B-cell lymphoma/leukaemia 11B (BCL11B gene). 37.11 9.2E-04 AF095854 asthmatic clone 2 mRNA, 3' UTR. 24.88 1.9E-03 3489 M62402 IGFBP6 insulin-like growth factor binding protein 6 (IGFBP6) mRNA, complete cds. 15.06 2.1E-07 8692 NM_003773 HYAL2 hyaluronoglucosaminidase 2 (HYAL2), transcript variant 1 . 12.67 6.7E-42 2199 NM_001998 FBLN2 fibulin 2 (FBLN2) . 10.90 6.7E-42 492304 AK025719 LOC492304 cDNA: FLJ22066 fis, clone HEP10611. 9.60 2.5E-41 1382 NM_001878 CRABP2 cellular retinoic acid binding protein 2 (CRABP2) . 9.12 2.0E-06 10365 NM_016270 KLF2 Kruppel-like factor 2 (lung) (KLF2) . 8.73 6.7E-42 22808 NM_012219 MRAS muscle RAS oncogene homolog (MRAS) . 8.32 6.7E-42 90809 AL137727 C14orf9 mRNA; cDNA DKFZp434M0519 (from clone DKFZp434M0519); partial cds. 7.62 1.9E-28 1514 NM_001912 CTSL cathepsin L (CTSL), transcript variant 1 . 7.58 6.7E-42 3554 NM_000877 IL1R1 interleukin 1 receptor, type I (IL1R1) . 7.56 7.7E-15 55600 NM_017625 ITLN1 intelectin 1 (galactofuranose binding) (ITLN1) . 7.53 6.7E-42 5744 NM_002820 PTHLH parathyroid hormone-like hormone (PTHLH) . 7.48 6.7E-42 5239 AL137698 PGM5 mRNA; cDNA DKFZp434C1915 (from clone DKFZp434C1915); partial cds. 6.83 1.5E-37 7148 Y17867 TNXB mRNA for tenascin-X (partial), fibronectin type III repeats h13-h16 and h13a. 6.78 2.1E-17 10100 AK022144 TSPAN2 cDNA FLJ12082 fis, clone HEMBB1002492. 6.61 2.2E-26 6405 NM_004186 SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F (SEMA3F) . 6.56 6.7E-42 10716 NM_006593 TBR1 T-box, brain, 1 (TBR1) . 6.48 5.8E-32 3783 NM_002250 KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4) . 6.38 6.7E-42 2006 NM_000501 ELN elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) (ELN) . 6.12 1.5E-07 7056 NM_000361 THBD thrombomodulin (THBD) . 6.06 6.7E-42 10397 NM_006096 NDRG1 N-myc downstream regulated gene 1 (NDRG1) . 5.89 2.4E-27 79148 AF315683 MMP28 matrix metalloproteinase 28 (MMP28) mRNA, complete cds. 5.82 6.7E-42 6441 NM_003019 SFTPD surfactant, pulmonary-associated protein D (SFTPD) . 5.74 8.9E-39 4207 NM_005919 MEF2B MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) (MEF2B) . 5.73 6.7E-42 54941 AK027134 RNF125 cDNA: FLJ23481 fis, clone KAIA03003. 5.65 6.3E-11 1240 NM_004072 CMKLR1 chemokine-like receptor 1 (CMKLR1) . 5.53 1.1E-19 AL133656 mRNA; cDNA DKFZp434O2017 (from clone DKFZp434O2017). 5.42 2.1E-06 51365 NM_015900 PLA1A phospholipase A1 member A (PLA1A) . 5.42 3.5E-24 5730 NM_000954 PTGDS prostaglandin D2 synthase 21kDa (brain) (PTGDS) . 5.32 2.9E-27 7078 NM_000362 TIMP3 tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3) . 5.27 1.2E-12 4056 NM_000897 LTC4S leukotriene C4 synthase (LTC4S), transcript variant 2 . 5.22 8.0E-08 6578 NM_005630 SLCO2A1 solute carrier family 21 (prostaglandin transporter), member 2 (SLC21A2) . 5.21 5.3E-37 Page 1 / 15 Supplementary data: Genes induced by KLF2 Dekker et al. 22997 AB028953 KIAA1030 mRNA for KIAA1030 protein, partial cds. 5.19 8.0E-04 57669 AK023922 EPB41L5 cDNA FLJ13860 fis, clone THYRO1001062. 4.95 3.9E-09 58494 AF255910 JAM2 vascular endothelial junction-associated molecule mRNA, complete cds. 4.88 1.3E-03 2169 NM_000134 FABP2 fatty acid binding protein 2, intestinal (FABP2) . 4.74 4.9E-07 1363 NM_001873 CPE carboxypeptidase E (CPE) . 4.55 1.2E-15 7761 NM_013249 ZNF214 zinc finger protein 214 (ZNF214) . 4.37 2.0E-26 S51971 insulin-like growinsulin-like growth factor-II {5' region} [, placenta, mRNA Partial, 100 nt]. 4.37 7.6E-32 55251 NM_018257 C20orf36 chromosome 20 open reading frame 36 (C20orf36) . 4.34 1.1E-25 10628 NM_006472 TXNIP thioredoxin interacting protein (TXNIP) . 4.32 6.7E-42 283174 AL133591 LOC283174 mRNA; cDNA DKFZp434N079 (from clone DKFZp434N079). 4.26 1.0E-03 1512 NM_004390 CTSH cathepsin H (CTSH), transcript variant 1 . 4.25 1.0E-21 10138 NM_005748 YAF2 YY1 associated factor 2 (YAF2) . 4.24 8.9E-15 23545 NM_012463 ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 (ATP6V0A2) . 4.22 5.0E-23 3481 NM_000612 IGF2 insulin-like growth factor 2 (somatomedin A) (IGF2) . 4.15 8.2E-08 79733 AK026964 FLJ23311 cDNA: FLJ23311 fis, clone HEP11681. 4.14 8.3E-16 994 NM_004358 CDC25B cell division cycle 25B (CDC25B), transcript variant 1 . 4.14 3.0E-05 8751 NM_003815 ADAM15 a disintegrin and metalloproteinase domain 15 (metargidin) (ADAM15) . 4.12 2.4E-10 25890 AL117664 ABI3BP mRNA; cDNA DKFZp586L2024 (from clone DKFZp586L2024); partial cds. 4.12 1.2E-12 7576 X52355 ZNF28 Kox24 mRNA for zinc finger protein, partial. 4.10 2.0E-32 10268 NM_005856 RAMP3 receptor (calcitonin) activity modifying protein 3 (RAMP3) . 4.08 7.5E-11 4798 NM_006165 NFRKB nuclear factor related to kappa B binding protein (NFRKB) . 4.00 1.5E-37 57178 AK025812 RAI17 cDNA: FLJ22159 fis, clone HRC00251. 3.96 6.7E-42 4584 M55406 MUC3A intestinal mucin (MUC-3) mRNA, partial cds. 3.96 9.9E-17 3241 NM_002149 HPCAL1 hippocalcin-like 1 (HPCAL1), transcript variant 1 . 3.94 8.3E-20 7851 U17077 BENE BENE protein . 3.93 5.2E-17 26112 AK023767 DKFZP434C171cDNA FLJ13705 fis, clone PLACE2000302. 3.92 2.5E-35 54888 NM_017755 NSUN2 hypothetical protein FLJ20303 (FLJ20303) . 3.86 4.2E-11 4856 NM_002514 NOV nephroblastoma overexpressed gene (NOV) . 3.84 1.3E-31 23512 AK024514 SUZ12 cDNA: FLJ20861 fis, clone ADKA01761. 3.80 1.9E-16 79887 AK026315 FLJ22662 cDNA: FLJ22662 fis, clone HSI08080. 3.74 2.5E-21 U84516 velo-cardio-facial syndrome 22q11 region mRNA sequence. 3.73 1.6E-35 79939 AK024313 SLC35E1 cDNA FLJ14251 fis, clone OVARC1001329. 3.72 5.6E-04 51152 NM_016181 LOC51152 melanoma antigen (LOC51152) . 3.70 1.8E-07 3488 AF055033 IGFBP5 clone 24645 insulin-like growth factor binding protein 5 (IGFBP5) mRNA, complete cds. 3.68 3.1E-12 55705 AF070633 IPO9 clone 24672 mRNA sequence. 3.65 1.6E-18 57007 U67784 CMKOR1 orphan G protein-coupled receptor (RDC1) mRNA, partial cds. 3.62 5.4E-23 608 Z29572 TNFRSF17 H.sapiens antisense mRNA for BCMA peptide. 3.60 1.0E-05 7102 NM_004615 TM4SF2 transmembrane 4 superfamily member 2 (TM4SF2) . 3.59 1.4E-17 4254 NM_000899 KITLG KIT ligand (KITLG) . 3.54 5.9E-08 55001 NM_017904 FLJ20619 hypothetical protein FLJ20619 (FLJ20619) . 3.50 1.8E-16 10855 NM_006665 HPSE heparanase (HPSE) . 3.49 1.9E-27 Page 2 / 15 Supplementary data: Genes induced by KLF2 Dekker et al. 55679 NM_017980 LIMS2 LIM and senescent cell antigen-like domains 2 (LIMS2) . 3.49 4.5E-09 50937 AK022986 cDNA FLJ12924 fis, clone NT2RP2004709. 3.48 1.0E-03 25890 AK025204 ABI3BP cDNA: FLJ21551 fis, clone COL06266. 3.46 2.6E-06 358 NM_000385 AQP1 aquaporin 1 (channel-forming integral protein, 28kDa) (AQP1), transcript variant 2 . 3.44 1.1E-13 2078 AK026868 ERG cDNA: FLJ23215 fis, clone ADSU01729. 3.43 2.8E-13 968 NM_001251 CD68 CD68 antigen (CD68) . 3.42 7.4E-28 144438 AK002085 LOC144438 cDNA FLJ11223 fis, clone PLACE1008209. 3.40 3.7E-06 56479 NM_019842 KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5 (KCNQ5) . 3.40 5.6E-14 187 NM_005161 AGTRL1 angiotensin II receptor-like 1 (AGTRL1) . 3.40 8.0E-21 84859 AL137527 LRCH3 mRNA; cDNA DKFZp434P1018 (from clone DKFZp434P1018); partial cds. 3.40 4.7E-20 AK026826 cDNA: FLJ23173 fis, clone LNG10019. 3.37 2.8E-05 24138 NM_012420 IFIT5 retinoic acid- and interferon-inducible protein (58kD) (RI58) . 3.36 2.3E-15 10111 NM_005732 RAD50 RAD50 homolog (S. cerevisiae) (RAD50), transcript variant 1 . 3.34 1.4E-07 Z25424 H.sapiens protein-serine/threonine kinase gene, complete CDS. 3.33 7.7E-15 NM_005179 . 3.32 2.1E-10 57592 AB037862 KIAA1441 mRNA for KIAA1441 protein, partial cds. 3.32 9.4E-28 64073 AB038318 C19orf33 imup-2 mRNA for immortalization-upregulated protein 2, complete cds.