RIKEN IM S Annual RIKEN Center for Repo Integrative Medical Sciences http://www.ims.riken.jp/english/ r t RIKEN Yokohama Campus 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan RIKEN Center for Integrative Medical Sciences Integrative Medical for Center RIKEN Tel : 045-503-9111 Fax : 045-503-9113 Email : [email protected] RIKEN IMS Annual Report RIKEN IMS Annual Report RIKEN Center for Integrative Medical Sciences RIKEN - RIKEN Center for Integrative Medical Sciences Access to RIKEN Yokohama Campus Organization Chart Local Access RIKEN President By Bus Take the #08 bus from Platform 8 at the East Exit of Hiroshi Matsumoto Tsurumi Station (also accessible from the West Exit of Keikyu Tsurumi Station) and get off at the RIKEN Shidai Daigakuin Mae bus stop. The institute is across the street. All buses from this platform are bound for Fureyu. Director Buses depart Tsurumi every 5–15 minutes. It takes about 15 minutes to arrive at RIKEN Yokohama. The Tadashi Yamamoto fare is 220 yen. By Train A 15-minute walk from JR Tsurumi-Ono Station (JR Tsurumi Line), which is directly accessible by transfer Integrative Senior Advisor from JR Tsurumi Station. Medical Sciences rains run about every 10 minutes during morning and Planning Oce Masaru Taniguchi evening rush hour, but less frequently at other times. Shizuo Akira Searchable train timetables in English are available at http://www.hyperdia.com/en/ By Taxi Use the taxi stand at the East Exit of JR Tsurumi Station or the West Exit of Keikyu Tsurumi Station. The trip takes about 10 minutes and costs around 1,200 yen. RIKEN Center for Integrative From the Airport Medical Sciences Advisory Council From Haneda Airport From Narita Airport Max Cooper (chair) Route 1 From Narita Airport Station take the JR Sobu Line Deputy Director Take the Keikyu Railways Airport Express* (blue kanji (Rapid Express), Airport Limousine Bus or JR Narita Mark Lathrop (vice chair) sign) for Yokohama and get off at Keikyu Tsurumi Express to JR Shinagawa Station. (JR Sobu Line is the Hiroyuki Aburatani Station (27–29 minutes). Airport Express trains run most inexpensive option and takes about 1 hour and 15 Michiaki Kubo every 10–15 minutes between 9:30 a.m. and 9:30 p.m. minutes). From JR Shinagawa Station take the JR Keihin Rudi Balling Next, follow the Local Access directions above to get to Tohoku Line (Yokohama direction) to JR Tsurumi Station Haruhiko Koseki Riccardo Dalla-Favera RIKEN Yokohama. (18 minutes). Next, follow the Local Access directions Kazuhiko Yamamoto Michel Georges above to get to RIKEN Yokohama. Ronald N. Germain Route 2 * A reserved seat express that requires payment of a Hajime Karasuyama Take any train marked with a green (express), red or surcharge in addition to train fare. Yutaka Kawakami dark grey kanji sign to Keikyu Kamata Station. Transfer to the Keikyu Main Line and take a local train* toward Searchable train timetables in English are available at Paul W. Kincade Yokohama until Keikyu Tsurumi Station* (12 minutes). http://www.hyperdia.com/en/ Bernard Malissen *Only Airport Express (blue kanji sign) and local trains John O’Shea (dark grey kanji sign) stop at Keikyu Tsurumi Station. Fiona Powrie Note that Keikyu Tsurumi Station and JR Tsurumi Station Peter Sorger are two different railway stations and are separated by a bus rotary (the stations are about 150 meters apart). Kiyoshi Takatsu Katsushi Tokunaga Dale Umetsu Arthur Weiss Core for Homeostatic Regulation Lab. for Cell Signaling: Takashi Saito Lab. for Immune Homeostasis: Taishin Akiyama Lab. for Lymphocyte Dierentiation: Tomohiro Kurosaki Lab. for Skin Homeostasis: Masayuki Amagai Lab. for Transcriptional Regulation: Ichiro Taniuchi Lab. for Metabolic Homeostasis: Naoto Kubota Lab. for Immune Cell Systems: Shigeo Koyasu Lab. for Immune Crosstalk: Hilde Cheroutre Lab. for Human Disease Models: Fumihiko Ishikawa Lab. for Inammatory Regulation: Takashi Tanaka Lab. for Intestinal Ecosystem: Hiroshi Ohno Lab. for Cytokine Regulation: Masato Kubo Lab. for Mucosal Immunity: Sidonia Fagarasan Lab. for Innate Immune Systems: Kazuyo Moro Lab. for Gut Homeostasis: Kenya Honda Core for Precise Measuring and Modeling Lab. for Developmental Genetics: Haruhiko Koseki Lab. for Integrated Bioinformatics: Todd Duane Taylor Lab. for Integrative Genomics: Osamu Ohara Lab. for Tissue Dynamics: Takaharu Okada Lab. for Disease Systems Modeling: Hiroaki Kitano Lab. for Integrated Cellular Systems: Mariko Okada Lab. for Medical Science Mathematics: Tatsuhiko Tsunoda Lab. for Metabolomics: Makoto Arita Lab. for Immunogenetics: Tadashi Yamamoto Lab. for Microbiome Sciences: Masahira Hattori Core for Genomic Medicine Lab. for Genotyping Development: Yukihide Momozawa Lab. for Autoimmune Diseases: Kazuhiko Yamamoto Lab. for Genome Sequencing Analysis: Hidewaki Nakagawa Lab. for Digestive Diseases: Kazuaki Chayama Lab. for Statistical Analysis: Yoichiro Kamatani Lab. for Bone and Joint Diseases: Shiro Ikegawa Lab. for Pharmacogenomics: Taisei Mushiroda Lab. for Endocrinology, Metabolism and Kidney Diseases: Lab. for International Alliance on Genomic Research: Momoko Horikoshi Taisei Mushiroda Lab. for Respiratory and Allergic Diseases: Mayumi Tamari Lab. for Cardiovascular Diseases: Kaoru Ito Program for Medical Innovations Lab. for Immune Regulation: Masaru Taniguchi Drug Discovery Antibody Platform Unit: Toshitada Takemori Lab. for Immunotherapy: Shin-ichiro Fujii Young Chief Investigator Program YCI Laboratory for Immune Regeneration: Tomokatsu Ikawa YCI Laboratory for Trans-omics: Katsuyuki Yugi YCI Laboratory for Cellular Bioenergetic Network: YCI Laboratory for Immunological Transcriptomics: Toshimori Kitami Hideyuki Yoshida YCI Laboratory for Next-Generation Proteomics: Yibo Wu Contents Organization .......................................................................... Director’s Report ................................................................... Contents ................................................................................. Part 1 Research Highlights Alternative pathway for NKT cell development ................ Genome-wide association study reveals the Six new genetic loci associated with atrial brillation involvement of B lymphocytes in obesity .................... are identied in the Japanese population ..................... Ectopically colonized oral bacteria may induce Mast cells are crucial for induction of group 2 inammatory bowel disease. ......................................... innate lymphoid cells and clearance of helminth Activation of immune T cells leads to behavioral infections ......................................................................... changes ............................................................................. Mapping disease genes to immune cells ............................ Blocking key pathways is a way to defeat cancer cells ..... New link between Polycomb and Xist RNA for X New asthma risk loci have been identied and chromosome inactivation .............................................. found to colocalize with immune cell cis-acting BATF is a critical regulator of regulatory T cells regulatory elements ........................................................ in peripheral tissues ........................................................ Part 2 Lab Activities Core for Homeostatic Regulation ........................... Laboratory for Medical Science Mathematics ............. Laboratory for Cell Signaling ........................................ Laboratory for Immunogenetics ................................... Laboratory for Lymphocyte Dierentiation ................ Laboratory for Integrated Bioinformatics .................... Laboratory for Transcriptional Regulation .................. Laboratory for Tissue Dynamics .................................. Laboratory for Immune Cell Systems .......................... Laboratory for Integrated Cellular Systems ................. Laboratory for Human Disease Models ....................... Laboratory for Metabolomics ....................................... Laboratory for Intestinal Ecosystem ............................ Core for Genomic Medicine ....................................... Laboratory for Mucosal Immunity ............................... Laboratory for Genotyping Development ................... Laboratory for Gut Homeostasis .................................. Laboratory for Genome Sequencing Analysis ............. Laboratory for Immune Homeostasis .......................... Laboratory for Statistical Analysis ................................ Laboratory for Skin Homeostasis ................................. Laboratory for Pharmacogenomics .............................. Laboratory for Metabolic Homeostasis ........................ Laboratory for Cardiovascular Diseases ...................... Laboratory for Immune Crosstalk ................................ Laboratory for Autoimmune Diseases ......................... Laboratory for Inammatory Regulation .................... Laboratory for Digestive Diseases ................................ Laboratory for Cytokine Regulation ............................ Laboratory for Bone and Joint Diseases ....................... Laboratory for Innate Immune Systems ...................... Laboratory for Endocrinology, Metabolism and Core for Precise Measuring and Modeling ......... Kidney Diseases ........................................................ Laboratory for Developmental Genetics ...................... Laboratory