Asplenioideae Species as a Reservoir of Volatile Organic Compounds with Potential Therapeutic Properties Didier Froissard, Sylvie Rapior, Jean-Marie Bessière, Bruno Buatois, Alain Fruchier, Vincent Sol, Françoise Fons To cite this version: Didier Froissard, Sylvie Rapior, Jean-Marie Bessière, Bruno Buatois, Alain Fruchier, et al.. As- plenioideae Species as a Reservoir of Volatile Organic Compounds with Potential Therapeutic Properties. Natural Product Communications , SAGE Publications, 2015, 10 (6), pp.1079-1083. 10.1177/1934578X1501000671. hal-01257591 HAL Id: hal-01257591 https://hal-unilim.archives-ouvertes.fr/hal-01257591 Submitted on 26 Jul 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. 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All issues are dispatched by airmail throughout the world, excluding the USA and Canada. 2015 NPC Natural Product Communications Vol. 10 No. 6 Asplenioideae Species as a Reservoir of Volatile Organic Compounds 1079 - 1083 with Potential Therapeutic Properties Didier Froissarda, Sylvie Rapiorb, Jean-Marie Bessièrec, Bruno Buatoisc, Alain Fruchierd, Vincent Sola and Françoise Fonsb* a Laboratoire de Chimie des Substances Naturelles, LCSN, EA 1069, Faculté de Pharmacie de Limoges, 2 rue du Docteur Marcland, F-87025 Limoges Cedex, France b Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175, CNRS - Université de Montpellier - Université Paul-Valéry Montpellier – EPHE, 15 avenue Charles Flahault, F-34093 Montpellier Cedex 5, France c Centre d'Ecologie Fonctionnelle et Evolutive – Plate-forme d’analyses chimiques en écologie, UMR 5175 CEFE, 1919 Route de Mende, F-34293 Montpellier Cedex 5, France d ENSCM, UMR 5253, 8 Rue de l’Ecole Normale, F-34296 Montpellier Cedex 5, France. [email protected] Received: September 17th, 2014; Accepted: November 14th, 2014 Twelve French Asplenioideae ferns (genera Asplenium and subgenera Ceterach and Phyllitis) were investigated for the first time for volatile organic compounds (VOC) using GC-MS. Sixty-two VOC biosynthesized from the lipidic, shikimic, terpenic and carotenoid pathways were identified. Several VOC profiles can be highlighted from Asplenium jahandiezii and A. ×alternifolium with exclusively lipidic derivatives to A. onopteris with an equal ratio of lipidic/shikimic compounds. Very few terpenes as caryophyllene derivatives were identified, but only in A. obovatum subsp. bilotii. The main odorous lipidic derivatives were (E)-2-decenal (waxy and fatty odor), nonanal (aldehydic and waxy odor with a fresh green nuance), (E)-2-heptenal (green odor with a fatty note) and 1-octen-3-ol (mushroom-like odor), reported for all species. A few VOC are present in several species in high content, i.e., 9-oxononanoic acid used as a precursor for biopolymers (19% in A. jahandiezii), 4-hydroxyacetophenone with a sweet and heavy floral odor (17.1% in A. onopteris), and 4-hydroxybenzoic acid used as a precursor in the synthesis of parabens (11.3% in A. foreziense). Most of the identified compounds have pharmacological activities, i.e., octanoic acid as antimicrobial, in particular against Salmonellas, with fatty and waxy odor (41.1% in A. petrarchae), tetradecanoic acid with trypanocidal activity (13.3% in A. obovatum subsp. bilotii), 4-hydroxybenzoic acid (8.7% in A. onopteris) with antimicrobial and anti-aging effects, 3,4-dihydroxybenzaldehyde as an inhibitor of growth of human cancer cells (6.7% in Ceterach officinarum), and phenylacetic acid with antifungal and antibacterial activities (5.8% in A. onopteris). Propionylfilicinic acid was identified in the twelve species. The broad spectrum of odorous and bioactive VOC identified from the Asplenium, Ceterach and Phyllitis species are indeed of great interest to the cosmetic and food industries. Keywords: Asplenium, Ceterach, Phyllitis, Volatile Organic Compounds, 9-Oxononanoic acid, 3,4-Dihydroxybenzaldehyde, Antimicrobial, Anti-aging. Asplenioideae