2019 FOCIS Abstract Supplement 1 Federation of Clincial Immunology Societies June 18 – 21, 2019 Boston, Massachusetts FOCIS 2019 Abstract Supplement Table of Contents Abstracts by Subject Area ............................................................................................................................. 4 Allergy/Asthma .......................................................................................................................................... 4 Autoimmune Neurologic Diseases .......................................................................................................... 18 Autoimmune Rheumatologic Diseases .................................................................................................... 35 Bone Marrow or Stem Cell Transplantation ............................................................................................. 63 Cytokines/Chemokines ............................................................................................................................ 75 Diabetes and Other Autoimmune Endocrine Diseases ........................................................................... 83 General Autoimmunity ........................................................................................................................... 104 Genetics ................................................................................................................................................ 117 Immune Monitoring ................................................................................................................................ 121 Immunity & Infection .............................................................................................................................. 133 Immunodeficiency: Primary or Acquired ................................................................................................ 155 Immuno-dermatology ............................................................................................................................ 166 Immunology of the Eye .......................................................................................................................... 168 Immuno-oncology .................................................................................................................................. 171 Inflammatory Bowel Diseases ............................................................................................................... 194 Innate Immunity ..................................................................................................................................... 201 Organ Transplantation ........................................................................................................................... 209 Other ..................................................................................................................................................... 217 Autoimmunity in Cardiovascular Disease .......................................................................................... 217 B cells, Immunology .......................................................................................................................... 218 Bioinformatics ................................................................................................................................... 219 Data Analysis; Bioinformatics ............................................................................................................ 220 Developmental Immunology.............................................................................................................. 220 Eosinophilic Esophagitis Pathology .................................................................................................. 221 Food Allergy ...................................................................................................................................... 221 Gene-Therapy / Immunity ................................................................................................................. 224 2 Immune Aberrations in Human Disease............................................................................................ 224 Immune Development ....................................................................................................................... 225 Immune System Development in Toddlers ....................................................................................... 226 Immunogenicity Screening ................................................................................................................ 226 Immunology ...................................................................................................................................... 227 Immunology and Inflammation .......................................................................................................... 228 Immunology and Metabolism ............................................................................................................ 228 Immunoregulation ............................................................................................................................. 229 Immunosenescence .......................................................................................................................... 229 Mathematical Modeling of Immune System Activity .......................................................................... 230 Micrbiota and Auto-Inflammatory Diseases ....................................................................................... 231 Neuroimmunology ............................................................................................................................. 232 Pediatric Systemic Lupus Erythematosus ......................................................................................... 232 Skin Cancer ...................................................................................................................................... 233 Theoretical Model of the Immune System ......................................................................................... 233 Reproductive Immunology ..................................................................................................................... 234 Therapeutics/Pharmacology .................................................................................................................. 235 Transplantation...................................................................................................................................... 246 Abstract Index by Subject Area ................................................................................................................. 258 Abstract Index by Author ........................................................................................................................... 260 3 Abstracts by Subject Area Allergy/Asthma T. 13. Towards a data-driven approach to dissect interactions between diet and autoimmunity Leonardo Ferreira and Iosif Gershteyn UCSF, San Francisco, CA Autoimmunity is on the rise around the globe. An estimated 70% of autoimmune disease cases are due to environmental factors. Diet has been proposed as a risk factor for autoimmunity and shown to modulate the severity of several autoimmune disorders. Yet, the interactions between diet and autoimmunity in humans remains largely unstudied. Here, we systematically interrogated commonly consumed animals and plants for peptide epitopes previously implicated in seventy seven human autoimmune diseases. A total of fourteen species could be divided into three broad categories regarding their content in human autoimmune epitopes. Strikingly, however, pig contains a disproportionately high number of autoimmune epitopes not found in any of the other species analyzed. Importantly, these epitopes were found to be expressed across all tissues collectively. Ongoing analyses focus on mapping autoimmune epitopes present in food onto specific HLA alleles and inspecting epidemiological data on diet and autoimmune disease incidence. This work sheds light on potential new links between diet and autoimmunity in humans and lays the foundation for future mechanistic studies on the impact of diet on the pathogenesis and progression of autoimmune disorders. H. 1. Natural Tr1-like Cells Do Not Confer Long-Term Tolerogenic Memory Paul Bollyky1, Carlos Medina1, Koshika Yadava1, Heather Ishak1, Irina Gurevich1, Hedwich Kuipers1, Elya Shamskhou1, Ievgen Koliesnik1, James Moon2, Casey Weaver3 and Kari Nadeau4 1Stanford University School of Medicine, Stanford, CA, 2Harvard University, Boston, MA, 3University of Alabama School of Medicine, Birmingham, AL, 4Stanford University, Department of Medicine - Sean N Parker Center for Allergy and Asthma Research, Stanford, CA IL-10-producing Tr1 cells promote tolerance but their contributions to tolerogenic memory are unclear. Using 10BiT mice that carry a Foxp3-eGFP reporter and stably express CD90.1 following IL-10 production, we characterized the spatiotemporal dynamics of Tr1 cells in a house dust mite model of allergic airway inflammation. CD90.1+Foxp3-IL-10+ Tr1- like cells arise from memory cells and rejoin the tissue-resident memory T-cell pool after cessation of IL-10 production. Persistent antigenic stimulation is necessary to sustain IL-10 production and Irf1 and Batf expression distinguishes CD90.1+Foxp3-IL-10+ Tr1-like cells from CD90.1+Foxp3-IL-10- “former” Tr1. Depletion of Tr1-like