Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis - Schreiber - Acta Paediatrica - Wiley Online Library Forgotten Password? Register Institutional Login Remember Me Home > Pediatrics > Pediatrics > Acta Paediatrica > Accepted Articles > Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Regular Article SEARCH Recommend to Your Nasal irrigation with saline solution significantly improves oxygen In this issue Librarian saturation in infants with bronchiolitis JOURNAL MENU Silvana Schreiber1, Luca Ronfani1, Sergio Issue Advanced > Saved Searches > Journal Home Ghirardo2, Federico Minen3,*, Andrea Acta Paediatrica SEARCH BY CITATION Taddio1,2, Mohamad Jaber2, Elisa FIND ISSUES Accepted Article (Accepted, Volume: Issue: Page: Rizzello2 and Egidio Barbi1 Current Issue unedited articles published All Issues DOI: 10.1111/apa.13282 online and citable. 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Early View Get PDF (163K) Accepted Articles Save to My Profile Most Cited E-mail Link to this Article Editors' Choice Export Citation for this Article GET ACCESS Get Citation Alerts Subscribe / Renew Additional Information(Show All) Request Permissions Author InformationPublication History FOR CONTRIBUTORS Author Information | OnlineOpen Share Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy Author Guidelines 1 University of Trieste, Trieste, Italy Submit an Article 2 3 Struttura Operativa Complessa di Pediatria, Azienda Ospedaliera Santa Maria degli Angeli, ABOUT THIS JOURNAL Pordenone, Italy News * Corresponding author: Overview Federico MinenStruttura Operativa Complessa di Pediatria, Azienda Ospedaliera Santa Maria degli Editorial Board Angeli Permissions via Montereale 24 Advertise e-mail: [email protected]: +39 0434399785 Contact This article has been accepted for publication and undergone full peer review but has not been SPECIAL FEATURES through the copyediting, typesetting, pagination and proofreading process, which may lead to Acta Paediatrica Young differences between this version and the Version of Record. Please cite this article as doi: Investigator Award 10.1111/apa.13282 APA iPad/iPhone apps Publication History Press Releases Accepted manuscript online: 26 NOV 2015 02:05AM EST Wiley Job Network Manuscript Accepted: 18 NOV 2015 Wiley's Pediatrics Collection Manuscript Revised: 13 SEP 2015 Jobs Manuscript Received: 16 MAR 2015 Abstract Cited By Get PDF (163K) Keywords: Bronchiolitis; nasal irrigation; oxygen saturation; respiratory distress; sodium chloride Abstract Aim Published guidelines do not recommend nasal irrigation in bronchiolitis, but it is common practice in Italy, despite a lack of data on its benefits or adverse effects. This single-blind, multicentre, randomised controlled trial compared nasal irrigation using either isotonic 0.9% sodium chloride or hypertonic 3% sodium chloride with simple supportive care in infants with bronchiolitis. Method We randomly assigned 133 Infants up one year of age, who were admitted to the emergency department with bronchiolitis and an oxygen saturation (SpO2) of between 88-94%, to the isotonic (n=47), hypertonic (n=44) or standard care (n=42) groups. Variations in SpO2 and the wheeze, air exchange, respiratory rate, muscle use (WARM) respiratory distress score were recorded at zero, five, 15, 20 and 50 minutes. Results http://onlinelibrary.wiley.com/doi/10.1111/apa.13282/abstract;jsessionid=F7A4CBAC22205E53019357F2C57A0DB8.f04t01[2015/12/05 23:09:52] Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis - Schreiber - Acta Paediatrica - Wiley Online Library Five minutes after the intervention, the median SpO2 value (95%) in the isotonic group was higher than both the hypertonic (94%) and the standard care (93%) groups. The differences between the isotonic and standard treatment groups were statistically significant at each time point, while the hypertonic group only reached significantly higher values after 50 minutes. However, the WARM score did not improve. Conclusion A single nasal irrigation with saline solution significantly improved oxygen saturation in infants with bronchiolitis. This article is protected by copyright. All rights reserved. Get PDF (163K) More content like this Find more content: like this article Find more content written by: Silvana Schreiber Luca Ronfani Sergio Ghirardo Federico Minen Andrea Taddio Mohamad Jaber Elisa Rizzello Egidio Barbi All Authors Publications Browse by Subject Resources About Us Help Contact Us Agents Advertisers Media Privacy Cookies Terms & Conditions Site Map Copyright © 1999-2015 John Wiley & Sons, Inc. All Rights Reserved. About Wiley Wiley.com Wiley Job Network http://onlinelibrary.wiley.com/doi/10.1111/apa.13282/abstract;jsessionid=F7A4CBAC22205E53019357F2C57A0DB8.f04t01[2015/12/05 23:09:52].