BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) November 5-8, 2019 Salta, ARGENTINA 1 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) Cover page: The Synthetic Lethal Rosette Aberrant mitotic phenotype found in BRCA1-deficient cells treated with the PLK1 inhibitor Volasertib. Cells become giant and multinucleated and acquire a flower shape, with nuclei arranging in a circular disposition around a cluster of centrosomes. Blue (DAPI: nuclei), Green (FITC-phalloidin: actin cytoskeleton), Red (γ-Tubulin: centrosomes). Author: María Laura Guantay (CONICET fellow; Director: Gaston Soria) Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI- CONICET), Facultad de Ciencias Químicas (Universidad Nacional de Córdoba). 2 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) MEMBERS OF THE SAIB BOARD Silvia Moreno President IQUIBICEN CONICET Facultad de Cs Exactas y Naturales Universidad de Buenos Aires María Isabel Colombo Vicepresident IHEM CONICET Facultad de Ciencias Médicas Universidad Nacional de Cuyo – Mendoza José Luis Bocco Past President CIBICI CONICET Facultad de Ciencias Químicas-Universidad Nacional de Córdoba Silvia Rossi Secretary IQUIBICEN CONICET Facultad de Cs Exactas y Naturales-Universidad de Buenos Aires Sandra Ruzal Treasurer IQUIBICEN CONICET Facultad de Cs Exactas y Naturales-Universidad de Buenos Aires Gabriela Salvador Prosecretary INIBIBB CONICET Universidad Nacional del Sur Eleonora García Véscovi Protreasurer IBR CONICET Facultad de Ciencias Bioquímicas y Farmacéuticas Universidad Nacional de Rosario 3 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) Silvia Belmonte Auditor IHEM CONICET Facultad de Ciencias Médicas Universidad Nacional de Cuyo - Mendoza Romina Uranga Auditor INIBIBB CONICET Universidad Nacional del Sur DELEGATES OF SCIENTIFIC SESSIONS Cell Biology Javier Valdez Taubas CIQUIBIC CONICET Facultad de Ciencias Químicas Universidad Nacional de Córdoba Lipids Nicolas Favale IQUIFIB Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Plants José M Estevez FIL-IIBBA CONICET Microbiology Augusto Bellomio INSIBIO-CONICET Facultad de Bioquímica, Química y Farmacia. Universidad Nacional de Tucumán Signal Transduction Vanesa Gottifredi FIL-IIBBA CONICET 4 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) PABMB EXECUTIVE COMMITTEE Sergio Grinstein Chairman Program in Cell Biology, Hospital of Sick Children, Toronto, Canada Bianca Zingales Vice Chairman Institute of Chemistry, University of São Paulo, São Paulo, Brazil Hugo JF Maccioni Past Chairman CIQUIBIC-CONICET, Dpt of Biological Chemistry, Universidad Nacional de Córdoba, Córdoba, Argentina Claudio R. Aguilar Treasurer Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA José Sotelo Silveira Secretary General Department of Genomics Instituto de Investigaciones Biológicas “Clemente Estable”, Montevideo, Uruguay 5 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) IN MEMORIAM HORACIO G. PONTIS (1928–2019) (1947), G. Cori (1947), F. Lynen (1964), L. F. Leloir (1970)). However, his “mi mejor experimento y experiencia de formación” came to a halt-in when the Bariloche lab was closed (1977). In 1979, Dr. Pontis moved to Mar del Plata where over time his outstanding capacity for innovation launched Instituto de Investigaciones Biológicas (IIB) – U. N. Mar del Plata, Fundación de Investigaciones Científicas (FIBA) and Centro de Investigaciones Biológicas (CIB). Horacio Guillermo Pontis, born in Mendoza In any site, Dr. Pontis maintained active (1928), graduated in chemistry and obtained the research groups that trained graduate and post- Ph.D. (1953; Dir.: V. Deulofeu) from the graduate students generating a steady flow of University of Buenos Aires. After working for important contributions to plant biochemistry. three years with Dr Luis F. Leloir—where he The research international community approached to carbohydrate metabolism—he acknowledged these accomplishments, such as stayed successively at King College (UK), American Society of Plant Biologists that named Durham University (UK) and finally at him Correspondent Member. In his scientific Karolinska Institutet and University of activities, Dr. Pontis has been member of the Stockholm—where his attention turned to National Research Council of Argentina (1961; enzymology studies. After returning to Leloir´s CONICET), and Biochemistry Professor –at the lab (1960), he embarked on plant biochemistry UBA and at Universidad Nacional de Mar del studies. In his search for clues about fructans, Dr. Plata. The former and the later institutions Pontis´ lab synthesized not only UDP-fructose recognized his academic performance but also fructose-2-phosphate, which two designating him Emeritus Investigator and decades later cleared the way for the chemical Emeritus Professor, respectively. synthesis of fructose-2,6-bisphosphate (a key Dr. Pontis’ story rose from limited glycolysis modulator). beginnings—in Deulofeu´s and Leloir´s labs— From 1968 to1977, he was the director of to international scientific prestige. In this Dept. of Biology – Fundación Bariloche. In Nov. context, the challenge to overcome adversity 1971, Bariloche hosted the SAIB Annual during shameful periods in Argentine history Meeting, being elected Dr. Pontis the President honors not only his willingness but also his of SAIB (1972). enthusiasm. This reunion was followed by the Symposium “Biochemistry of the glycosidic linkage” with the presence of four Nobel Prizes (C. Cori Ricardo Wolosiuk 6 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) Schedule Tuesday Wednesday Thursday Friday November 5 November 6 November 7 November 8 8:30-9:00 WORKSHOPS Workshop Accreditation 9:00- Oral Oral 11:00 Communications Conferences Communications Biochemistry 1st Workshop Room Jacaranda Room Lapacho Room Jacaranda PL-C01, PL-C02, PL-C04 PL-C03, PL-C07, PL- to PL-C06, PL-C09, PL- C08, PL-C10, PL-C11, PL- Education On Robert Gennis C12, ST-02, BT-C02 C13, PL-C14, PL-C15 Francisco Barrantes Room Los Ceibos Room Los Ceibos MI-C01 a MI-C06, BT- CB-C01 to CB-C04, C01, CB-C06 Workshop Drug Discovery CB-C07 to CB-C10, Room Lapacho ST-C01 LI-C01 to LI-C05, ST- C03, CB-C11, CB-C05 11:00-11:30 COFFEE-BREAK 11:30-12:30 Plenary lecture IUBMB Jubilee Lecture “Hector Torres” Plenary Lecture Bruno Amati Philip D. Stahl Alejandro Colman Lerner Room Lapacho Room Lapacho Room Lapacho 12:30-14:30 LUNCH TIME 14:30-16:30 Symposia Symposia Symposia Lipids Cell Biology Microbiology Room Jacaranda Room Jacaranda Room Los Ceibos Plants RNA PABMB Congress Room Los Ceibos Room Los Ceibos Young Investigators Room Jacaramda Accreditation Signal Transduction Room Lapacho 16:30-17:00 COFFEE –BREAK 16:30-18:30 POSTERS POSTERS POSTERS Opening BT-P01 to BT-P06 BT-P07 to BT-P12 BT-P13 to BT-P19 Ceremony CB-P01 to CB-P15 CB-P16 to CB-P31 CB-P32 to CB-P47 Room Lapacho MI-P01 to MI-P18 EN-P01 to EN-P11 LI-P01 to LI-P15 In memoriam of PL-P01 to PL-P15 MI-P19 to MI-P37 MI-P38 to MI-P49 Horacio Pontis ST-P01 to ST-P13 PL-P16 to PL-P32 PL-P33 to PL-P48 Room Lapacho 18:30-19:30 “Alberto Sols” Plenary Lecture EMBO Keynote “Ranwel Caputto” Lecture Plenary Lecture Closing Ceremony Room Lapacho Encarnación F. Gisou van der Maria Elena Alvarez Martinez Salas Goot Room Lapacho Room Lapacho Room Lapacho SAIB Assembly Cocktail 20:00 hs 19:45 hs Dinner 20:00 hs 7 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) SAIB 2019 TUESDAY November 5 2019 WORKSHOPS WORKSHOP ON DRUG DISCOVERY 08:30-09:00 REGISTRATION 09:00-11:00 ORAL COMMUNICATIONS 1 Room Jacaranda 9:00-9:20 WELCOME BY ORGANIZERS Ricardo Biondi Instituto de Investigacion En Biomedicina de Buenos Aires - Instituto Partner De La Sociedad Max Planck (IBIOBA), Buenos Aires, Argentina Hugo Gramajo Instituto de Biologia Molecular y Celular de Rosario (IBR), Rosario, Argentina Gaston Soria Centro de Investigacion En Bioquimica Clinica e Inmunologia (CIBICI), Córdoba, Argentina 9:20 – 9:35 WS-C05 USE OF IN VIVO IMAGING SYSTEM FOR PRECLINICAL EVALUATION: EXAMPLES OF ITS APPLICATION IN DRUG DEVELOPMENT Salinas FJ, Berengeno AL, Santiago G, Marelli BE, Baravalle ME, Salvetti NR, Ortega HH. Centro de Medicina Comparada, ICiVet-Litoral (UNL-CONICET), Esperanza, Santa Fe, Argentina. Facultad de Ciencias Veterinarias – Universidad Nacional del Litoral, Esperanza, Santa Fe, Argentina. E-mail: [email protected] 9:40 - 9:55 WS-C07 HYDROXYLAMINE CHEMICALLY ENGINEERED EXTRACTS AS SOURCE OF ANTIMYCOBACTERIAL COMPOUNDS Ramallo IA1, Parés VS1, Gago G2, Gramajo H2, Furlan RLE1. 1Fac. de Ciencias. Bioquímicas y Farmacéuticas, UNR-CONICET. 2IBR-CONICET, Rosario. E-mail: [email protected] 8 BIOCELL 43 (suppl.5), 2019 ISSN 1667-5746 (online version) 10:00 – 10:15 WS-C06 VINARDO2: A NEW SCORING FUNCTION FOR MOLECULAR DOCKING WITH IMPROVED VIRTUAL SCREENING Quiroga R, Villarreal MA. INFIQC-CONICET, Departamento de Química Teórica y Computacional - Facultad de Ciencias Químicas – UNC E-mail: [email protected] 10:20-10:35 WS-C01 DRUG DISCOVERY OF TLS INHIBITORS TO SELECTIVELY TARGET CANCER CELLS WITH HOMOLOGOUS RECOMBINATION REPAIR DEFICIENCIES García IA1*, Villafañez F1*, Quiroga R2*, Bocco JL1, Villareal M2, Soria G1. *These authors contributed equally to this work. 1CIBICI-CONICET, 2INFIQC-CONICET. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. E-mail: [email protected] 10:40-10:55 WS-C03 EXPLORATION OF VITAMIN D RECEPTOR PHARMACODYNAMIC FEATURES UNDER TUMORAL AND NORMAL CELLS MICROENVIROMENTS: A MOLECULAR MODELING