TH 25 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY WOLFVILLE NOVA SCOTIA JUNE 28 - JULY 3, 2015 TH 25 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY WOLFVILLE JUNE 28 – JULY 3, 2015 Symposium Programming by Cortical Systematics LLC Copyright © 2015 International Cannabinoid Research Society Research Triangle Park, NC USA ISBN: 978-0-9892885-2-1 These abstracts may be cited in the scientific literature as follows: Author(s), Abstract Title (2015) 25th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, Research Triangle Park, NC, USA, Page #. Funding for this conference was made possible in part by grant 5R13DA016280-13 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Sponsors ICRS Government Sponsors National Institute on Drug Abuse Non- Profit Organization Sponsors Kang Tsou Memorial Fund 2015 ICRS Board of Directors Executive Director Cecilia Hillard, Ph.D. President Stephen Alexander, Ph.D. President- Elect Michelle Glass, Ph.D. Past President Ethan Russo, M.D. Secretary Steve Kinsey, Ph.D. Treasurer Mary Abood, Ph.D. International Secretary Roger Pertwee, D . Phil. , D . S c. Student Representative Tiffany Lee, Ph.D. Grant PI Jenny Wiley, Ph.D. Managing Director Jason Schechter, Ph.D. 2015 Symposium on the Cannabinoids Conference Coordinators Steve Alexander, Ph.D. Cecilia Hillard, Ph.D. Mary Lynch, M.D. Jason Schechter, Ph.D. Sara Whynot Myrna Yazer Programme Committee Mary Abood, Ph.D. Steve Alexander, Ph.D. Heather B Bradshaw, Ph.D. Michelle Glass, Ph.D. Matthew Hill, Ph.D Melanie Kelly, Ph.D. Steve Kinsey, Ph.D., Mary Lynch, M.D. Mauro Maccarrone, Ph.D. Sachin Patel, M.D., Ph.D. Roger Pertwee, D.Phil., D.Sc. Ethan Russo, M.D. Kasia Starowicz, Ph.D. Jenny Wiley, Ph.D. Committee on Awards Steve Kinsey, Ph.D., Chair Sachin Patel, M.D., Ph.D. Student Award Committee Chairs Eliot Gardner, Ph.D. Melanie Kelly, Ph.D. Mechoulam Award Committee Francis Barth, Ph.D. Benjamin Cravatt, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D. George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Beat Lutz, Ph.D. Ken Mackie, M.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil., D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D th Registration: June 28 , 2015, 16.00 – 18.00 Festival Theatre - Lobby Welcome Reception: 18.30 – 20.00 KC Irving Centre Day 1 Monday, June 29th 7.30 Breakfast Welcome and Opening Remarks 8.30 Festival Theatre Oral Session 1. Novel chemical entities MODERATORS: ROGER PERTWEE, D.PHIL, D.SC. AND YOSSI TAM, D.M.D, PH.D. Resat Cinar, Malliga Iyer, Ziyi Liu, Tony PERIPHERALLY RESTRICTED, DUAL Jourdan, Katalin Erdelyi, TARGET CB1R ANTAGONISTS WITH 9.00 Grzegorz Godlewski, 1 IMPROVED SAFETY AND ANTI- Gergo Szanda, Jie Liu, FIBROTIC EFFICACY Pal Pacher, Kenner Rice and George Kunos Brian F. Thomas, Gregory W. Endres, Jenny L. Wiley, Gerald CHEMICAL EXPOSURES AND RISKS T. Pollard, Ann M. ASSOCIATED WITH VAPORIZATION 9.15 2 Decker, Elaine A. Gay, AND INHALATION OF SYNTHETIC Purvi R. Patel, Alexander CANNABINOIDS L. Kovach and Megan Grabenauer Jenny L. Wiley, HIGH EFFICACY DEGRADANTS OF Brian F. Thomas, SYNTHETIC CANNABINOIDS EXHIBIT 9.30 Julie A. Marusich, 3 POTENT SUBSTITUTION IN JWH-018 Timothy W. Lefever DISCRIMINATION IN MICE and Gregory W. Endres Spyros P. Nikas, Shashank Kulkarni, Rishi Sharma, Carol A. Paronis, Shan Jiang, Jimit Girish Raghav, SAFER EFFECTIVE CANNABINOIDS 9.45 Chandrashekhar Honrao, THROUGH CONTROLLED 4 Srikrishnan Mallipeddi, DEACTIVATION Roger S. Gifford, Torbjörn U.C. Järbe, Jack Bergman and Alexandros Makriyannis CANNABIS-DERIVED COMPOUNDS AS CANNABINOID RECEPTOR Pankaj Pandey, MODULATORS: SYSTEMATIC 10.00 Kuldeep K. Roy 5 ANALYSIS USING MOLECULAR and Robert J. Doerksen DOCKING AND BINDING FREE-ENERGY STUDIES Dai Lu, Hamed I. Ali, DESIGN AND SYNTHESIS OF Changjiang Qiao, PHOTOACTIVATABLE AFFINITY 10.15 Kwang H. Ahn, 6 LIGANDS FOR THE CB1 ALLOSTERIC Leepakshi Khurana SITE and Debra A. Kendall 10.30 Break Oral Session 2. Plant Studies and Non-THC Cannabinoids MODERATORS: ETHAN RUSSO, M.D. AND RANGAN (RONNIE) MAITRA, PH.D. Kazuhito Watanabe, Satoshi Yamaori, Rongrong Jiang, INDUCIBILITY OF CYP ENZYMES 11.00 7 Yuka Kinugasa, BY CANNABIDIOL Yoshimi Okushima and Ikuo Yamamoto Justine Renard, CANNABIDIOL’S ANTIPSYCHOTIC Michael Loureiro, PROPERTIES IN THE MESOLIMBIC 11.15 Laura G. Rosen, 8 PATHWAY: ROLE OF MTORC/P70S6K Walter J. Rushlow SIGNALLING and Steven R. Laviolette CANNABIDIOL REDUCES THE Blathnaid Hughes ATTENUATION OF HIPPOCAMPAL 11.30 9 and Caroline E. Herron LONG-TERM POTENTIATION IN MODELS OF ALZHEIMER’S DISEASE Daniel I Brierley, CANNABIGEROL ATTENUATES Joe R Harman, Natasa MUSCLE CATABOLISM AND Giallourou, Jonathan R 11.45 ANOREXIA IN A PRE-CLINICAL 10 Swann, Ketan Patel, MODEL OF CHEMOTHERAPY- Benjamin J Whalley INDUCED CACHEXIA and Claire M Williams Jahan P. Marcu, IMPROVING QUALITY CONTROL James Neal-Kababick, 12.00 METHODS FOR CANNABIS USING 11 Melissa Wilcox FLASH CHROMATOGRAPHY and Mark Jacyno THE SEED PROJECT: DEVELOPMENT N. Rielle Capler, Kim OF STANDARDS AND CERTIFICATION 12.15 Crosby, Philippe Lucas 12 PROGRAM FOR MEDICAL CANNABIS and Zachary Walsh DISPENSARIES IN CANADA Kevin McKernan, SEQUENCING OF THREE MALE Vasisht Tadigotla, CANNABIS GENOMES AND 12.30 Yvonne Helbert, Jessica DEVELOPMENT OF MULTIPLEX 13 Spangler, Lei Zhang QPCR ASSAYS FOR RAPID MALE and Douglas Smith SEX DETERMINATION Kevin McKernan, Cameron Miller, Brad Douglass, Jessica GENOMIC, TERPENE Spangler, Braden Doane, AND CANNABINOID PROFILES 12.45 Vasisht Tadigotla, Colin 14 OF A PUTATIVELY Montgomery, Yvonne NOVEL CANNABIS SPECIES Helbert, Lei Zhang, Douglas Smith and Jeffrey Raber LUNCH 13.00 NIDA Lunch & Mentoring Wheelock Dining Hall Poster Session P1 14.00 - 16.00 Fountain Commons ODD Presidential Plenary Speaker FROM RECEPTORS TO PAIN: 16.00 THE MOLECULAR DYNAMICS OF PAIN Michael Salter, M.D., Ph.D. Hospital for Sick Children and University of Toronto Toronto, Canada 17.00 Break Oral Session 3. Animal Models MODERATORS: JENNY WILEY, PH.D. AND JAMES BURSTON, PH.D. Shiran Udi, Liad Hinden, ROLE OF PROXIMAL TUBULAR Adi Drori, Rivka Hadar, CANNABINOID-1 RECEPTOR IN 17.30 Brian Earley, 15 OBESITY-INDUCED RENAL Resat Cinar, Ken Mackie DYSFUNCTION and Joseph Tam SEXUALLY DIMORPHIC EFFECTS Angela M. Williams, OF ALCOHOL WITHDRAWAL ON 17.45 Anthony L. Berger ENDOCANNABINOID GENE 16 and Ryan J. McLaughlin EXPRESSION AND ANXIETY-LIKE BEHAVIOR Sara Peñasco, Nagore Puente, Almudena Ramos, Naiara Royo, Ana Gutiérrez, Itziar ALTERATION OF THE Bonilla, Leire Reguero, ENDOCANNABINOID-DEPENDENT Miren-Josune Canduela, 18.00 SYNAPTIC PLASTICITY IN ADULT 17 Juan Mendizabal- BRAIN AFTER ETHANOL EXPOSURE Zubiaga, Fernando OF MICE DURING ADOLESCENCE Rodríguez de Fonseca, Juan Suárez, Izaskun Elezgarai and Pedro Grandes Zheng-Xiong Xi, Hai- COCAINE SELF-ADMINISTRATION Ying Zhang, Qing-Rong 18.15 UP-REGULATES CANNABINOID CB2 18 Liu, Guo-Hua Bi GENE EXPRESSION IN MOUSE BRAIN and Eliot L. Gardner Jayme R McReynolds, GLUCOCORTIOID- Elizabeth M Doncheck, ENDOCANNABINOID INTERACTIONS Oliver Vranjkovic, Evan IN THE PRELIMBIC CORTEX 18.30 19 N Graf, Qing-song Liu, MEDIATE STRESS-POTENTIATED Cecilia J Hillard REINSTATEMENT OF and John R Mantsch COCAINE SEEKING EFFECT OF CHRONIC CANNABINOID Sara Jane Ward, AGONIST TREATMENT ALONE OR IN 18.45 Patrick Siegele COMBINATION WITH CANNABIDIOL 20 and Ronald Tuma ON WITHDRAWAL BEHAVIORS IN MICE Martin A. Sticht, Cheryl L. Limebeer, Rehab A. Abdullah, 2-ARACHIDONOYLGLYCEROL Justin L. Poklis, Winnie MEDIATES THE ANTI-NAUSEA 19.00 Ho, Micah J. Niphakis, EFFECTS OF THE VISCERAL INSULAR 21 Keith A. Sharkey, CORTEX ENDOCANNABINOID Benjamin F. Cravatt, SYSTEM IN RATS Aron H. Lichtman and Linda A. Parker Carol A. Paronis, Girish R. Chopda, SPONTANEOUS CANNABINOID 19.15 Spyros P. Nikas, WITHDRAWAL IN MICE: EVIDENCE 22 Vidyanand G. Shukla FROM THREE BEHAVIORAL ASSAYS and Alex Makriyannis Dinner 19.30 Wheelock Dining Hall Day 2 Tuesday, June 30th 7.30 Breakfast Oral Session 4. CB2 Receptors MODERATORS: ANDREA HOHMANN, PH.D. AND JAYME MCREYNOLDS, PH.D. Tomohiro Kimura, Krishna Vukoti, Diane L. GLOBAL FOLD OF HUMAN Lynch, Dow P. Hurst, CANNABINOID TYPE 2 RECEPTOR 8.30 Alan Grossfield, Michael PROBED BY SOLID-STATE NMR 23 C. Pitman, Patricia H. AND MOLECULAR DYNAMICS Reggio, Alexei Yeliseev SIMULATIONS and Klaus Gawrisch Uwe Grether, Jean-Michel Adam, Christian M. Apfel, Stefanie Bendels, Caterina Bissantz, Jürgen Fingerle, Ivan Formentini, Jürgen Funk, 2,4,5-TRISUBSTITUTED PYRIDINES – Sabine Grüner, A NOVEL CLASS OF HIGHLY POTENT, 8.45 Atsushi Kimbara, 24 HIGHLY SELECTIVE AND IN VIVO Matthias Nettekoven, ACTIVE CB2 AGONISTS Giorgio Ottaviani, Camille Perret, Mark Rogers-Evans, Benno Rothenhäusler, Stephan Röver, Franz Schuler, Tanja Schulz-Gasch and Christoph Ullmer Natalia Malek, Magdalena Kostrzewa, TARGETING PERIPHERAL Michal Korostynski, CANNABINOID RECEPTORS CB2 9.00 Julia Borowczyk, 25 AS A NOVEL THERAPY TO TREAT Zbigniew Madeja, OSTEOARTHRITIS Justyna Drukala and Katarzyna Starowicz Dan Ting Kho, DO CIRCULATING MONOCYTES Kristina Burkert, IN HUMANS REPRESENT A 9.15 Michelle Glass, THERAPEUTIC TARGET FOR CB2- 26 Kate Angel MIMETIC DRUGS OR IS IT THEIR