Emtree Terms Added and Changed (January 2017) This is an overview of new terms added and changes made in the first Emtree release in 2017. Overall, Emtree has grown by 782 preferred terms (269 drug terms and 513 non-drug terms) compared with the previous version released in September 2016. In total Emtree now counts 75,488 preferred terms. Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept. The terms added and changed are summarized below and specified in detail on the following pages. Emtree Terms Added in January 2017 930 new terms (including 148 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version January 2017 (compared to September 2016): 308 drug terms (terms assigned to the Chemicals and Drugs facet). 622 non-drug terms (terms not assigned as Chemicals and Drugs). The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2017 (typically as candidate terms), sometimes for several years, before they were added to Emtree. Emtree Terms Changed in January 2017 148 terms (39 drug terms and 109 non-drug terms) from Emtree September 2016 have been replaced by 148 different terms in January 2017 (39 drug terms and 109 non-drug terms). Of these, 129 terms (34 drug terms and 95 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2017; the remaining 19 replacement terms (5 drug terms and 14 non-drug terms) were already present in Emtree. No drug terms were replaced by a non-drug term, no non-drug terms were replaced by a drug term. No preferred terms were deleted. Changes are presented in alphabetical order of the new terms. Emtree Terms Added in January 2017 2 Drug terms 1,7 bis(3,4 dimethoxyphenyl) 4 cyclobutylmethyl atuveciclib 1,6 heptadiene 3,5 dione audencel 2 acetylamino 2 deoxy mannopyranose autophagy related protein 3 (5 amino 2 methyl 4 oxoquinazolin 3(4h) autophagy related protein 12 yl)piperidine 2,6 dione autophagy related protein 5 3 [4 (1h imidazol 1 ylmethyl)phenyl] 5 (2 autophagy related protein 7 methylpropyl)thiophene 2 [(n autophagy related protein 8 family butyloxylcarbamate) sulphonamide] sodium baclofen plus naltrexone plus sorbitol 6' methyl 5 ortho (5 amino 5,6 dideoxy alpha baliforsen talofuranosyl) paromamine sulfate baltaleucel T abbv 8e12 bivalirudin ABC transporter subfamily G bmn 270 acetylsalicylic acid plus omeprazole bps 804 acp 501 bpx 501 adalimumab atto branaplam ADAM12 protein bridged bicyclo compounds ADAMTS protein brilanestrant ADAMTS7 protein butyrophilin ADAMTS9 protein cab1803 adeno associated virus vector cadherin related protein aerase calcium release activated calcium channel 2 afm13 caly 002 agerafenib camrelizumab agil as canine adenovirus plus canine distemper virus plus alicapistat canine parainfluenza virus plus canine alidornase alfa parvovirus vaccine alkB protein casimersen alkylated DNA repair protein alkB homolog 1 cavosonstat alkylated DNA repair protein alkB homolog 4 cenegermin alkylated DNA repair protein alkB homolog 5 cergutuzumab alkylated DNA repair protein alkB homolog 8 chitinase 3 like protein 1 aln as1 chlorquinaldol plus promestriene alpha ketoglutarate dependent dioxygenase alkB cholesterol 24 hydroxylase homolog 2 citarinostat alpha ketoglutarate dependent dioxygenase alkB cosfroviximab homolog 3 coversin alpha ketoglutarate dependent dioxygenase FTO crs 207 alxn 1540 cupabimod alxn1007 cyclophilin C alxn1210 cytochrome P450 family 1 anakinra cytochrome P450 family 11 ancient DNA cytochrome P450 family 12 andecaliximab cytochrome P450 family 17 antibody drug conjugate cytochrome P450 family 19 antigen peptide transporter 2 cytochrome P450 family 2 apararenone cytochrome P450 family 21 apimostinel cytochrome P450 family 24 apolipoprotein B mRNA editing enzyme catalytic cytochrome P450 family 26 polypeptide like cytochrome P450 family 27 aprutumab cytochrome P450 family 3 aprutumab ixadotin cytochrome P450 family 4 asciminib cytochrome P450 family 46 at982 cytochrome P450 family 6 atesidorsen cytochrome P450 family 7 atir101 cytochrome P450 family 8 ATP dependent DNA ligase darolutamide Emtree Terms Added in January 2017 3 dezamizumab lanabecestat dezapelisib landipirdine diroximel fumarate larcaviximab discoidin domain receptor larotrectinib discoidin domain receptor 1 lentiglobin bb305 discoidin domain receptor 2 lesinidase alfa dtx301 letolizumab eccs 50 lidocaine plus phenylephrine plus tropicamide edetic acid plus sodium nitrite lidocaine plus prilocaine elacestrant lipid droplet associated protein elapegademase lisavanbulin elezanumab lumicitabine elivaldogene tavalentivec lupartumab emapalumab lupartumab amadotin ensartinib lutikizumab enzaplatovir lysine acetyltransferase epertinib lysophospholipid receptor affecting agent eptinezumab lysophospholipid receptor agonist Equisetum arvense extract lysophospholipid receptor antagonist eretidigene velentivec mannose 6 phosphate receptor binding protein 1 erythromycin plus isotretinoin mardepodect etanercept szzs mastic etrasimod mating factor evobrutinib mating hormone A factor fatty acid binding protein 7 methyl accepting chemotaxis protein fezolinetant midomafetamine fluorouracil plus salicylic acid miridesap flurdihydroergotamine mivebresib forkhead box protein M1 MutL protein homolog 1 fosmetpantotenate n carboxymethylglycylthreonylhistidyl 3,3 fremanezumab diphenylalanylpiperidincarboxy 3 furosemide plus spironolactone ylarginylmethylthiocystylarginyltryptophylamino fused ring compound hexanyl n carboxamidomethylglycine n germanium 68 plus gallium 68 hexadecylamide glucagon receptor agonist N Myc proto oncogene protein golodirsen nacubactam gs030 naltrexone plus oxycodone gsk 3377794 navoximod hemochromatosis protein nebivolol plus valsartan hemoglobin betafumaril neflamapimod heparesc nelatimotide hepastem NIMA interacting peptidylprolyl isomerase hepatitis A virus cellular receptor 2 NIMA related kinase homeobox protein Nkx-2.5 NIMA related kinase 1 homer scaffolding protein Nogo receptor house dist mite allergen extract Nogo receptor 1 ifabotuzumab Nogo receptor 2 ilmetropium iodide obicetrapib imlatoclax ogd 201 infliximab dyyb oleclumab inositol polyphosphate 5 phosphatase omidenepag isopropyl interferon induced helicase C domain containing padsevonil protein 1 palucorcel interleukin 1 receptor like 1 protein paracetamol plus thiocolchicoside inxn 3002 Parkinson disease associated protein ionis httrx pegapamodutide ionis ttrrx pegunigalsidase alfa isis sod1rx pegvorhyaluronidase alfa istiratumab Emtree Terms Added in January 2017 4 peptidyl prolyl cis trans isomerase NIMA Shc signaling adaptor protein interacting 1 SHC transforming protein 1 peptidylprolyl cis trans isomerase NIMA SHC transforming protein 2 interacting 4 SHC transforming protein 3 perilipin 1 shp655 perilipin 4 signaling lymphocytic activation molecule perilipin 5 sinecatechins phenylalanylserylarginyltyrosylalanylarginine small leucine rich proteoglycan acetate solute carrier protein phloroglucinol plus trimethylphloroglucinol somatrogon phosphatidylinositol 3,4,5 trisphosphate 5 splicing factor U2AF phosphatase squill extract phosphoinositide phosphatase stromal interaction molecule pimodivir suvratoxumab polygonum extract SWI/SNF related matrix associated actin dependent porgaviximab regulator of chromatin subfamily B member 1 poseltinib T guard (antibody) primula flower extract tavolixizumab prolylprolylthreonylvalylprolylthreonylarginine telisotuzumab proprotein convertase 9 telisotuzumab vedotin protein deglycase DJ-1 tenofovir exalidex protein Jagged 1 Thymus vulgaris extract protein Jagged 2 tirabrutinib protein phosphatase 2c tonabacase provitamin tonogenconcel PTB associated splicing factor tozuleristide pyrin transcription activator like effector qr 010 trastuzumab duocarmazine qr 110 trefoil factor rabbit haemorrhagic disease vaccine trefoil factor 1 ravoxertinib trefoil factor 2 recombinant parathyroid hormone[1-84] trefoil factor 3 regulatory factor X transcription factor tripartite motif protein regulatory factor X1 tumor necrosis factor alpha induced protein 3 reltecimod tumor protein p73 remtolumab tumor suppressor p53 binding protein 1 ribaxamase Twist related protein 1 RNA splicing factor Twist related protein 2 rogaratinib valnivudine rosiptor vandefitemcel rosmantuzumab velagliflozin rozanolixizumab veldoreotide sa237 vinorelbine tartrate satoreotide vorolanib seladelpar vunakizumab seltorexant Werner syndrome ATP dependent helicase sequestosome 1 xoma 358 serabelisib zalmoxis (drug) serine threonine protein kinase ULK1 zona pellucida glycoprotein serrate jagged protein Emtree Terms Added in January 2017 5 Non-drug terms 1 hour pad test benign male genital tract tumor A-375 cell line benign neoplasm A-549 cell line benign nervous system tumor abdominal wound closure benign respiratory tract tumor abnormal value benign urinary tract tumor Abrus precatorius benign urogenital tract tumor abuse deterrant formulation betel leaf activity tracker betel quid acute febrile encephalopathy Bifidobacterium longum subsp. infantis acute HIV infection Bifidobacterium longum subsp. longum acute myeloid leukemia Bifidobacterium pseudocatenulatum