Melbourne Health Research Week 2012 24 – 31 May Melbourne Health Research Week 2012 Research Week is one of the highlights of the Melbourne Health Calendar. It provides a focus on research, where all members of our staff and the community can reflect on the value of research, and celebrate the advances in medical science. The week long programme varies in format from a formal symposium, plenary talks, and interactive research education. Light relief comes in the form of the Annual Great Research Debate. A new innovation this year is the Community engagement booth in the hospital foyer, to share research with people visiting the hospital. I would like to thank the Research Week Committee who comprise of people from all different RMH departments and include members from Ludwig Institute for Cancer Research; The Walter & Eliza Hall Institute and The University of Melbourne. This hard working team have managed to pull together a wonderful programme. Thank you to – Prof Danny Liew Dr Angela Watt A/Prof Marie Gerdtz Prof Nick Santamaria Prof Terry O’Brien Dr Clare Scott Ms Michelle Eunson Ms Catherine Lander Ms Morag Morrison Ms Carol Jewell Dr Nadia Warner Dr Matthias Ernst Ms Jessica Turner Ms Louise Berns Dr Nitya Jani In addition, the efforts of those involved in selecting the suitable abstracts and in the adjudication of the Awards and those coordinating and chairing sessions during Research Week are greatly appreciated. Melbourne Health Research Week is successful because of the generous contributions of time, energy and expertise by so many people – thank you. Professor Ingrid Winship Executive Director of Research Research Week 2012 24 – 31 May 2012 Page 1 DAY 1 – Thursday 24 May 2012 Opening Ceremony 1.00 pm – 1.45 pm, Charles La Trobe Lecture Theatre Welcome and opening ceremony of Melbourne Health Research Week with the opening plenary: 1. Professor Doug Hilton, Director Walter and Eliza Hall Research Institute "Melbourne Health: The Heart of Australia's Premier Medical Research Precinct" 2. Dr Peter Revill, Dept of Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne Health “Increased abundance of hepatitis B virus defective DNA in serum of patients with hepatocellular carcinoma” DAY 2 – Friday 25 May 2012 Research Symposium 9.15 am – 10.15 am, FIRST CONCURRENT RESEARCH SESSIONS Cancer Research Emergency and Critical Care Seminar Room 1 (Chair: Prof Mark Rosenthal) Seminar Room 2 (Chair: Dr Jonathan Knott) 3. Jeffrey Kam - A 5-year analysis of 7. Kate Fetterplace - Improving the Practice magnetic resonance imaging as a screening tool in of Nutrition Therapy in the Critically Ill: women at hereditary risk of breast cancer International Nutrition Survey 2011 4. Elizabeth Vincan - Frizzled7 functions as a 8. Wayne Hoskins - A ten year analysis of Wnt receptor in intestinal epithelium stem cells splenic injury and trauma management at a rural hospital 5. Matthew Hong - A Program to Obtain Metastatic Tissue Samples from Prostate Cancer 9. Michael Gilbertson - Urgent vitamin K Patients antagonist reversal and outcomes - implications for novel anticoagulants 6. Stephanie Amiridis - Targeting Dynamin to Treat Malignant Brain Tumours 10. Rebbecca Waite - Developing and implementing a quality improvement framework for emergency department triage 10.30 am – 11.30 am, SECOND CONCURRENT RESEARCH SESSIONS Cardio-Respiratory Musculoskeletal & Seminar Room 1 (Chair: A/Prof Abe Rubinfeld) Gastro-intestinal Research 11. Elsa Gladigau - Prevalence of Seminar Room 2 (Chair: A/Prof Geoff Hebbard) Cardiovascular Risk Factors in Patients with Serious Mental Illness Attending Psychiatric 15. John Moi - The prevalence of gout in a Rehabilitation Services in Melbourne's Inner-West large tertiary hospital and the impact of in- hospital attacks of acute gout on patient outcomes 12. John Wentworth - Body mass index and health resource utilization - a nested case- correlates with ischemic heart disease and control study albuminuria in long-standing type 2 diabetes 16. Gene Ngian - Arterial stiffness is increased 13. Sky Chew - Moderate microvascular in systemic sclerosis: a cross-sectional comparison retinopathy predicts future cardiac events in a with matched controls population of patients with chronic obstructive pulmonary disease 17. Ilana Ackerman - The impact of severe hip and knee joint disease on work status and health 14. Peter Wallbridge - The utility of serial care utilisation and costs: Results from a national venous blood gases to assess ventilatory status in Australian survey patients undergoing flexible bronchoscopy. 18. Christopher Leung - Breaking the biopsy barrier in Barrett's: The use of Confocal Endomicroscopy to target oesophageal biopsies Research Week 2012 24 – 31 May 2012 Page 2 Lunch and Poster Viewing 12 – 12.45 pm Function and Convention Centre, Ground Floor, Royal Melbourne Hospital This year’s Melbourne Health Research Week will display 84 posters showcasing research under the themes of • Aged Care; • Blood; • Cancer; • Cardio-respiratory; • Emergency/Critical Care; • Endocrinology, Immunology & Allergy; • Gastro-intestinal; • Genetics; • Infectious Diseases; • Musculoskeletal; • Neurosciences; • Quality of Care; • Rehabilitation and Surgery. Presenters will be on-hand to answer your questions. The Great Debate 1.00 pm – 2.00 pm, Charles La Trobe Lecture Theatre “Ethics Schmethics” The requirements for ethical approval of research in 2012 are way over the top The need for diligent and rigorous ethical review of human research is indisputable. Everyone involved in human research has a responsibility to facilitate ethically good research that protects the rights and well being of the people who place their trust in the researchers and volunteer to participate in that research. We have come a long way since the world first cried out for ethical oversight of human research following World War 2 and the horrific Nazi war experiments, the notorious human radiation experiments conducted by the US army in the 1940s, the Thalidomide disaster of the 1950s and the US Syphilis Study of 1972, to name a few. Ethical milestones such as the Nuremberg Code of 1947 and the Declaration of Helsinki, which was first issued in 1964, were created in response to demands from people around the world for research to be regulated and researchers to be held accountable and to ensure that any research that was conducted was ethical and worthwhile. But have we now gone too far? In Australia, we are bound by the National Statement on Ethical Conduct in Human Research as well as no less than six other codes or regulations, a raft of legislation (both Commonwealth and State) governing privacy, guardianship and consent, genetics, radiation, ART and IVF, to name a few. On top of all the Australian laws and guidelines, we also have countless international guidelines and codes. And on top of all the ethical and good clinical practice guidelines, we now have a new “buzz” term to contend with - research governance! Institutions conducting research and the bodies that they are accountable to, their lawyers and the various levels of governments all resolved that research projects had to be governed! Researchers suddenly were faced with the challenges of finance and budgets, contract law, indemnities and insurance, joint appointments and rules of collaboration, clinical trials registries, version control of just about anything one can think of, and the list goes on… Is this modern day regulation of research truly a reassuring safety net or has it become a straight jacket of the most stifling proportions? Or perhaps this regulation is the life raft that has saved research, protecting it from greenies and scientologists and other crazed crusaders who view modern medicine as the greatest evil of our time? The Melbourne Health Research Week Committee has called together some of the greatest minds of our institution to use their collective intellect to tackle this most challenging issue in the form of a Great Debate. Research Week 2012 24 – 31 May 2012 Page 3 Master of Ceremonies (MC) Professor Ingrid Winship, Executive Director of Research, Melbourne Health The proceedings will be presided over by this panel of distinguished judges: Ms Christine Fitzherbert, Executive Director HR & Workplace Development, Melbourne Health. Ms Genevieve Juj, Director Allied Health, Melbourne Health (to be confirmed). Professor Bruce Mann, Director Cancer and Infection Medicine, Melbourne Health. Team for the Affirmative – “Team Get me out of this regulatory straight-jacket” Professor Peter Morley Ms Sharon McGowan, Executive Director Communications and Community Relations, Melbourne Health Mr Paul Anderson, MH Urologist and member of the MH HREC Team for the Negative – “Team We must proceed with every possible precaution” Dr Jayesh Desai, Oncologist, Melbourne Health. Ms Marian Lieschke, Nurse Unit Manager, Cancer Clinical Trials, Melbourne Health. Ms Sarah Bascomb, Cancer Trials Australia Research Symposium 2.30 pm – 4.00 pm, THIRD CONCURRENT RESEARCH SESSIONS Infectious Diseases Mind and Brain Seminar Room 1 (Chair: A/Prof Damon Eisen) Seminar Room 2 (Chair: Prof Terry O’Brien) 19. Phillipe Boeuf - Placental adhesion of 24. Iwan Bennett - Perfusion MRI predicts malaria-infected erythrocytes: more than just levels of circulating endothelial progenitor cells in VAR2CSA/CSA interaction? glioblastoma multiforme 20. Shamista Selverajah - The novel histone 25. Sinnatamby Sujeevan- Investigating the variant H2Bv in the malaria parasite