Presents The 20th Annual Norman P. Salzman Memorial Award and Symposium in Virology Monday, November 5, 2018 The Warren Grant Magnuson Clinical Center Lipsett Auditorium National Institutes of Health Norman P. Salzman, Ph.D. Dr. Norman P. Salzman was a noted pioneer in the field of molecular virology and a founding editor of the Journal of Virology. In 1967 Dr. Salzman became Chief of the Laboratory of Biology of Viruses at the National Institute of Allergy and Infectious Diseases (NIAID) where he encouraged independence and excellence among his Fellows. Upon his retirement from NIH in 1986, Dr. Salzman moved to Georgetown University to head the Laboratory of Molecular Retrovirology, where he began his research on AIDS. This important work continued after he moved his laboratory in 1994 to the Frederick Cancer and Development Center (SAIC Program), where Dr. Salzman was appointed Director of an innovative mentoring program for post- doctoral fellows. Dr. Salzman was among the first to characterize viral mRNAs and to visualize replicating viral DNA. During his distinguished career at NIH, Dr. Salzman made many important and innovative contributions to our basic understanding of the replication of poliovirus, vaccinia virus, polyoma virus, SV40 virus and BK virus. Dr. Salzman’s studies on human immunodeficiency virus led to his discovery that ongoing evolution of viral quasi-species, despite combination antiretroviral therapy, characterized the relationship among viruses from different compartments and elucidated novel mechanisms of antiretroviral drug resistance. This work set the stage for todays’ work focusing on the role of viral reservoirs and challenges to HIV cure. Dr. Salzman’s memorable achievements in virology are paralleled by the recognition that his laboratory was a training ground for many young scientists, several of whom went on to become laboratory or section Chiefs at the NIH, and others to hold leadership positions in academia and industry all over the world. Six have been elected to the National Academy of Sciences and one received the Nobel Prize. - H. Clifford Lane, M.D., NIAID The Norman P. Salzman Memorial Award and Twentieth Annual Symposium in Virology 9:00 – 9:05 AM Welcome Eric O. Freed, Ph.D., NCI Frederick, NIH 9:05 – 9:15 AM Tribute to Dr. Norman P. Salzman Peter M. Howley, M.D., Dept. of Microbiology and Immunobiology, Harvard Medical School 9:15 – 9:55 AM Keynote Presentation HPV and Cancer: Searching for a Targeted Therapy Peter Howley, M.D., Dept. of Microbiology and Immunobiology, Harvard Medical School 9:55 – 10:25 AM The Potential of International Collaborations for HIV Prevention: Studies of Mother-Infant HIV Transmission Julie Overbaugh, Ph.D., Fred Hutchinson Cancer Research Center 10:25 – 10:40 AM Coffee Break and Poster Presentation 10:40 – 10:50 AM Appreciation Award to the Foundation for the NIH, Maria C. Freire, Ph.D., President and Executive Director, Lenore Salzman 10:50 – 11:00 AM Presentation of the 2018 Norman P. Salzman Memorial Award in Virology Lenore Salzman 11:00 – 11:20 AM Award Lecture Vesicle-Cloaked Virus Clusters are the Optimal Units for Inter-Organismal Viral Transmission Marianita Santiana, Ph.D., Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, NIH 11:20 – 11:50 AM Koch’s Postulates in the Age of Viral Metagenomics Eric L. Delwart, Ph.D., Department of Pathology & Laboratory Medicine, University of California, San Francisco 11:50 – 12:20 PM Single-Cell virology Craig E. Cameron, Ph.D., Department of Biochemistry and Molecular Biology, The Pennsylvania State University 12:20 – 12:30 PM Closing Remarks Arifa S. Khan, Ph.D., CBER, FDA 12:30 – 1:30 PM Luncheon at FAES Terrace and Poster Presentation The 2018 Norman P. Salzman Memorial Award in Virology Dr. Marianita Santiana, Laboratory of Host-Pathogen Dynamics, NHLBI Dr Santiana received her B.A. degree in Biology from Rutgers University in Newark, New Jersey and her M. Sc. and Ph.D. in Cellular and Molecular Biology from Rutgers Graduate School in Newark, New Jersey. Her Ph.D. thesis research was carried out at the National Institutes of Health, as part of the NIH Graduate Partnership Program, under the supervision of Dr. Nihal Altan-Bonnet. Dr. Santina’s Ph.D. thesis research focused on understanding the dynamics of cellular cholesterol redistribution from the plasma membrane to viral replication organelles during enteroviral infection, and the importance of cholesterol for enteroviral replication. After receiving her Ph.D. degree in 2015, she continued studying host-pathogen dynamics, and her present work focuses on the non-lytic release and transmission of enteric RNA viruses. Poster Presentation Awardees Dissecting Hepatitis B Virus-Host Interactions Fellow: Yuchen Xia, Ph.D. Mentor: T. Jake Liang, M.D. Liver Diseases Virology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases Quaternary Contact in the Initial Interaction of CD4 with the HIV-1 Envelope Trimer Fellow: Qingbo Liu, Ph.D. Mentor: Paolo Lusso, M.D., Ph.D. Viral Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases HPV Integration Hijacks and Multimerizes a Cellular Enhancer to Generate a Viral-Cellular Super-Enhancer That Drives High Viral Oncogene Express Fellow: Alix Warburton, Ph.D. Mentor: Alison McBride Ph.D. DNA Tumor Virus Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases The 2018 Norman P. Salzman Memorial Mentor Award in Virology Nihal Altan-Bonnet, Ph.D. Senior Investigator, Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute (NHLBI) Dr. Nihal Altan-Bonnet received her PhD from The Rockefeller University and completed her post-doctoral studies at the National Institutes of Health in the laboratory of Dr. Jennifer Lippincott Schwartz. During both her PhD and post-doctoral investigations, Dr. Altan-Bonnet has focused on applying cutting edge cellular imaging techniques to understanding the dynamic workings of cells, including investigations into pH regulation, membrane trafficking and cell cycle transitions. In 2006 Dr. Altan-Bonnet was appointed Assistant Professor at Rutgers University where she applied her expertise in imaging to understanding the dramatic membrane remodeling events that take place within cells upon infection with Poliovirus, Rhinovirus and Hepatitis C virus. These and other RNA viruses, remodel host intracellular membranes in order to generate new organelles, which they subsequently use as platforms for replication and assembly reactions. Dr Altan-Bonnet investigated the mechanisms by which these organelles were generated and discovered that multiple different RNA viruses rely on the same lipid components to be present in these organelles for replication. These studies have led to the development of new classes of therapeutics centered on the idea of blocking the replication of multiple different viruses by targeting the production of these lipids. In 2013 Dr. Altan-Bonnet moved to the National Institutes of Health as an Earl Stadtman Investigator and Head of the Laboratory of Host-Pathogen Dynamics. In 2017 Dr. Altan-Bonnet became tenured and promoted to Senior Investigator. Dr. Altan- Bonnet has continued to do pioneering research into the virus-host interface and with her group recently discovered a new form of viral transmission among humans and animals whereby viruses enhance their virulence by transporting themselves in clusters inside vesicles. Dr. Altan-Bonnet has been recognized several times for her outstanding research, receiving the Young Investigator Award from the Theobald Smith Society of the American Society for Microbiology in 2011, and the Presidential Early Career Award in Science and Engineering (PECASE) in 2012. Dr. Altan-Bonnet was also appointed as a Kavli Fellow (2013) and a Scialog Fellow (2015-2017). Past Recipients Norman P. Salzman Memorial Award in Virology 1999 Joanna Shisler, NIAID* 2000 Herman Edskes, NIDDK* 2001 Alonzo Garcia, NIAID* 2002 Sonja Best, NIAID, Rocky Mountain Laboratories 2003 Kay Grünewald, NIAMS 2004 Jason Brenchley, NIAID 2005 Yamina Bennasser, NIAID 2006 Christopher Buck, NCI 2007 Adriano Boasso, NCI with Special Recognition of Audray Harris, NIAMS 2008 Alberto Bartesaghi, NCI 2009 Yu Liang, NIAID 2010 Silvia Kang, NINDS 2011 Tobias Paprotka, NCI 2012 Jason McLellan, VRC, NIAID 2013 Rachael M. Schowalter, NCI 2014 Darryl Falzarano, NIAID, Rocky Mountain Laboratories 2015 Christina Guzzo, NIAID*; Elisavet Serti, NIDDK 2016 Ashley Moseman, NINDS 2017 David Angeletti, NIAID; Tuoqi Wu, NHGRI Norman P. Salzman Memorial Mentor Award in Virology 1999 Bernard Moss, NIAID 2000 Reed Wickner, NIDDK 2001 Bernard Moss, NIAID 2002 Marshall Bloom, NIAID, Rocky Mountain Laboratories 2003 Alasdair Steven, NIAMS 2004 Daniel Douek, NIAID 2005 Kuan-Teh Jeang, NIAID 2006 Douglas Lowy, NCI and John Schiller, NCI 2007 Gene M. Shearer, NCI with Special Recognition of Alasdair C. Steven, NIAMS 2008 Sriram Subramaniam, NCI 2009 Thomas Kristie, NIAID 2010 Dorian McGavern, NINDS 2011 Vinay K. Pathak, NCI 2012 Peter Kwong, VRC, NIAID 2013 Chris Buck, NCI 2014 Heinz Feldmann, NIAID, Rocky Mountain Laboratories 2015 Paolo Lusso, NIAID; Barbara Rehermann, NIDDK 2016 Dorian McGavern, NINDS 2017 Jon Yewdell, NIAID; Pamela Schwartzberg, NHGRI Honoring Past Awardees Comments on Their Research “I think I was the first Norman Salzman award winner, and I was a post-doc in Bernie Moss' lab when I won the award.