US 20190224193A1 ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2019 /0224193 A1 REID et al. ( 43 ) Pub . Date: Jul. 25 , 2019 ( 54 ) COMPOSITIONS OF NATURAL EXTRACTS A61K 36 / 00 ( 2006 .01 ) AND USE THEREOF IN METHODS FOR A61K 31/ 122 ( 2006 .01 ) PREVENTING OR TREATING DISEASES A61K 38 /06 ( 2006 .01 ) ( 71) Applicant: Christopher Brian REID , (US ) A61K 31 /4164 ( 2006 .01 ) A61K 31 /375 (2006 . 01) ( 72 ) Inventors : Christopher Brian REID , Los A61K 31 / 355 ( 2006 .01 ) Angeles , CA (US ); Que T . Collins, A61K 31/ 12 Santa Monica , CA (US ) ( 2006 .01 ) 2 ) U . S . CI. (21 ) Appl . No .: 16 / 134 , 723 CPC .. .. .. .. A61K 31/ 496 (2013 . 01 ) ; A61K 45 / 06 (2013 .01 ) ; A61K 31/ 327 (2013 .01 ) ; A61K (22 ) Filed : Sep . 18 , 2018 31/ 194 ( 2013. 01 ) ; A61K 38 / 1816 ( 2013 .01 ) ; Related U . S . Application Data A61K 36 /00 (2013 .01 ) ; YO2A 50 / 389 (60 ) Continuation of application No . PCT /US2017 / (2018 .01 ) ; A61K 38/ 063 ( 2013 . 01 ) ; A61K 033234 , filed on May 18 , 2017 , Continuation of 31/ 4164 (2013 . 01 ) ; A61K 31/ 375 (2013 . 01 ) ; application No . 16 / 039 , 134 , filed on Jul. 18 , 2018 , A61K 31/ 355 ( 2013. 01 ) ; A61K 31/ 12 which is a division of application No. 15 / 241, 308 , ( 2013 .01 ) ; A61K 31 /122 (2013 .01 ) filed on Aug. 19 , 2016 , now abandoned , which is a division of application No . 13 /815 ,664 , filed on Mar . 14 , 2013 , now abandoned . (57 ) ABSTRACT (60 ) Provisional application No . 62 / 390 , 081, filed on Mar. 18 , 2016 , now abandoned , provisional application No. 62 /390 , 438 , filed on Mar. 29 , 2016 . A composition for reducing miR -3120 expression in a cell or tissue of a subject comprises at least one oil or extract Publication Classification selected from a group comprising an orange , frankincense ( 51 ) Int. Ci. and cannabis oil or extract. A method for reducing miR -3120 A61K 31/ 496 ( 2006 . 01 ) expression in a cell or tissue of a subject comprises admin A61K 45 / 06 ( 2006 .01 ) A61K 31/ 327 ( 2006 .01 ) istering to the subject a composition comprising at least one A61K 31 / 194 ( 2006 .01 ) oil or extract selected from the group comprising an orange , A61K 38 / 18 ( 2006 .01 ) frankincense and cannabis oil or extract . 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The present invention pro vides novel orange , frankincense , cannabis and other natural CROSS REFERENCE TO RELATED oil and extract related compositions and inexpensive drug APPLICATIONS compositions for preventing and / or treating various condi [0001 ] This application is a continuation of PCT/ US2017 / tions, diseases , and maladies especially metabolic diseases 033234 , filed May 18 , 2017 , which claims priority to U . S . and disorders, cancer, psoriasis and improving health and Provisional Patent App . No . 62 /390 , 081, filed Mar. 18 , 2016 , well -being in general. The present invention also provides and U . S . Provisional Patent App . No . 62 /390 ,438 , filed Mar . corresponding methods for producing such compositions 29 , 2016 ; and is a continuation of U . S . patent application and methods of preventing a condition , disorder or disease Ser . No . 16 / 039, 134 , filed Jul. 18 , 2018 , which is a divisional and treating a condition , disorder or disease in an animal or of Ser. No. 15 /241 , 308 filed Aug . 19 , 2016 , which is a human