PERSIAN Cohort Study Data Dictionary for Baseline Variables 1 Table of Contents Page Introduction ……………………………………………………………………………………………………………………… 5 General Questionnaire Personal Information ………………………………………………………………………………………………….. 7 Anthropometry …………………………………………………………….………………………………………….. 10 Socioeconomic Information ………………………………………………………………….……………………….. 11 Fuel Use and Living Standards …………………………...………………………………………………………….. 13 Life Style Exposures ………………………………………………………………………………………………….. 14 o Animal Contact ……………………………………………………………………………………………….. 16 Current Job Information ………………………………………………………………………………...…………….. 17 o Job History ………...………………………………………………………………………………………….. 17 Physical Activity …………………………..………………………………………………………………………….. 18 Sleeping Habits ……………………………………………………………………………………………………….. 20 Mobile Use ……………………..…………………………………………………………………………………….. 21 Pesticide Use ………………………………………………………………………………………………………….. 22 Medical Questionnaire Past Medical History ………………………………………………………………………………………………….. 25 Sign and Symptoms ………………………………………………………………………………………..………….. 30 Medication Use (Past and Present) ………………………………………………………………………..……….….. 34 o Selected Important Medications ………………………………………………………………………...….….. 34 Family Medical History …………………………………………………………………………….……..…...….….. 35 o Family Medical History (modified) ………….……………………………………………….……..…..….….. 36 2 Reproductive History (Women) ……………………………………………………...….………………..………….. 39 o Contraception History ………………………………………………………………...……………..……….. 41 o Hormonal Replacement Therapy ……………………………………………………...……………..………. 41 Physical Examinations …………………………………………………………………………………….………..... 42 o Disability or Amputations …………………………………………………………………………..…….….. 42 Oral Health ………………………………………………………………………………………..………………….. 43 Personal Habits ………………………………………………………………………………………..……….….…. 44 o Smoking History ……………………………………………………………………………….....………….. 45 o Non-Cigarette Tobacco Use History …………………………………………………………………..….….. 46 o Drug Use History …………………………………………………………………………………………….. 47 o Alcohol Use History ……………………………………………………………………………...………….. 48 o Dosage ……………………...……………………………………………………………………......……….. 49 Blood Pressure …………………………………………………………………………………………..…………... 50 Nutrition Questionnaire Food Frequency Questionnaire (FFQ) ……………………………………………………….…………..………….. 51 o Local Foods in the FFQ ………………………………………………………………………….………….. 55 Nutrients ………………………………………………………………………………………..………….……….. 59 Dietary Habits ………………………………………………………………………………………..…….……….. 62 Water Use ………………………………………………………………………………………..………………….. 68 Dietary Supplements ……………………………………………………………………………………..…………. 69 Biological Samples Biobank Samples ………………….……………………………………………………………………..………….. 71 Lab Test Results …………………………………………………………………………………….…..………….. 72 3 Supplementary Tables and Figurs Figure S1 ……………...…………………………………………………………………………..………………….. 75 Province ID ………………………………………………………………………………………..……….…..……. 76 County ID ………………………………………………………………………………………..………...…….….. 77 Medication ID …………………………………………………………………………………………...,……….…. 81 4 Introduction The PERSIAN Cohort is a prospective study aiming to include Iranians aged 35–70 years from 19 geographically distinct areas of Iran (Figure 1). While the Ministry of Health and Medical Education oversees the project, investigators at local universities carry it out. These include the Universities of Medical Sciences in Ahvaz, Ardabil, Bandar Abbas, Fasa, Guilan, Kermanshah, Kordestan, Mashhad, Mazandaran, Rafsanjan, Sabzevar, Shahrekord, Shiraz, Tabriz, Urmia, Yasuj, Yazd, and Zahedan. PERSIAN was designed to represent all of the major ethnic groups living in different geographical areas of Iran (Figure 1), enabling it to capture a wide range of environmental diversity, lifestyle, and socioeconomic differences, as well as many other exposures influencing disease patterns that maybe very unique to one area or highly prevalent in another. The PERSIAN Cohort baseline data collection consists of 32 questionnaires divided into 3 major parts: general, medical, and nutrition. Each part is administered by a trained interviewer and all study centers used the same devices and protocols for all data collection/measurements. Variables from each questionnaire are listed in the corresponding tables in this document. Each table includes 6 columns as defined below: 1. V Code: the unique code for each variable 2. Variable Name: the name given to each variable in the database 3. Variable Type: the type of variable as follows: . Categorical: for qualitative variables with more than 2 categories . Dichotomous: for qualitative variables with 2 categories . Discrete: for quantitative variables with integer values . Continuous: for quantitative variables with decimal . Characteristic: for variables which contain characters . Date: for date variables including month/day/year 4. Description: a brief description of the variable 5. Coding/Unit: the coding label for categorical and dichotomous variables and measurement units for continuous variables 6. Comment: includes any pertinent information, if necessary. 5 Figure 1. PERSIAN Cohort Sites 6 Table A: Personal Information V Code Variable Name Variable Type Description Coding/Unit Comment The unique PERSIAN Cohort ID for A1 IRPC Discrete each participant A2 EnrollmentDate Date Date of enrollment 2= Ravansar 12= Shahrekord 3= Guilan 13= Bandare Kong 4= Fasa 14= Urmia Lake 5= Azar 15= Ardabil Unique code designated to each 6= Kharameh 16= Sabzevar A3 CohortCenterID Categorical cohort center 7= Mazandaran 17= Mashhad 8= Zahedan 18= Dena 9= Yazd 19= Kavar 10= Rafsanjan 20= Dehgolan 11= Hoveizeh A4 GenderID Dichotomous Participant gender 1= Male, 2= Female Date of birth based on national ID A5 BirthDate Date card Calculated using variables A6 Age_At_Interview Continuous Age on the date of interview Year A2 and A5 A7 BirthDateReal Date The self reported date of birth 1= Fars 9= Zaboli 2= Azari 10= Guilak 3= Balouch 11= Turk Nomad 4= Kurd 12= Arab Nomad A8 MotherEthnicityID Categorical Maternal ethnicity 5= Lor 13= Mazani 6= Arab 14= Tut 7= Turkman 15= Other 8= Talesh 16= Turk Specifies ethnicity if "Other" is A9 MotherEthnicityOther Characteristic reported for variable A8 1= Fars 9= Zaboli 2= Azari 10= Guilak 3= Balouch 11= Turk Nomad 4= Kurd 12= Arab Nomad A10 FatherEthnicityID Categorical Paternal ethnicity 5= Lor 13= Mazani 6= Arab 14= Tut 7= Turkman 15= Other 8= Talesh 16= Turk Specifies ethnicity if "Other" is A11 FatherEthnicityOther Characteristic reported for variable A10 7 Province in which participant was Coding is presented in supplementary table A12 BirthPlaceProvinceID Categorical born S1: "Province ID" Coding is presented in supplementary table A13 BirthPlaceCountyID Categorical County in which participant was born S2 "County ID" A14 BirthPlaceCity Characteristic City in which the participant was born A15 BirthPlaceVillage Characteristic Village in which participant was born Coding is presented in supplementary table A16 ProvinceID Categorical Province of residence S1: "Province ID" Coding is presented in supplementary table A17 CountyID Categorical County of residence S2 "County ID" A18 City Characteristic City of residence A19 Village Characteristic Village of residence The number of years the participant A20 EducationYears Discrete Year received education 1= Elementary School 2= Middle School 3= High School diploma The highest level of education the 4= Associate degree A21 LastEduID Categorical participant completed/ last degree 5= Bachelor’s degree obtained 6= Master’s degree 7= PhD 8= Illiterate 1= Father 2= Mother The participant’s status/relationship in 3= Child A22 FamilyStatusID Categorical the household (at the time of 4= Grandfather/grandmother enrollment) 5= Uncle/Aunt (father’s side) 6= Uncle/aunt (mother’s side) 7= Other Specifies family status, if "Other" is A23 FamilyStatusOther Characteristic recorded for variable A22 1= Single (never married) 2= Married A24 MaritalStatusID Categorical Marital status of the participant 3= Widowed 4= Divorced 5= Other Specifies marital status, if "Other" is A25 MaritalStatusOther Characteristic recorded for variable A24 The number of times the participant Variables A26-A28 only A26 MarriageNo Discrete has been married available when a category A27 FirstMarriageAge Discrete Age at first marriage Year other than “Single (never married)” is recorded for A28 FamilyMarriageID Categorical Having a consanguineous marriage 1= Yes (with first cousin) variable A24. 8 2= No 3= Yes (with second cousin) 1= Fars 9= Zaboli Created variable based on the 2= Azari 10= Guilak following: If the ethnicity of 3= Balouch 11= Turk Nomad both parents was the same 4= Kurd 12= Arab Nomad (variables A8 and A10), that A29 EthnicityID Categorical The participant's ethnicity 5= Lor 13= Mazani ethnicity was also taken for 6= Arab 14= Tut the individuals. If parents had 7= Turkman 15= Mixed different ethnicities, the 8= Talesh 16= Turk individual was considered to have a “Mixed” ethnicity. Specifies residence in urban vs. rural A30 ResidenceType Dichotomous 1= Urban, 2= Rural areas 9 Table B: Anthropometry* V Code Variable Name Variable Type Description Coding/Unit Comment B1 HeightCm Continuous Height Centimeter (cm) B2 WeightKg Continuous Weight Kilogram (kg) B3 WaistCircumference Continuous Waist circumference Centimeter B4 HipCircumference Continuous Hip circumference Centimeter B5 WristCircumference Continuous Wrist circumference Centimeter calculated using the formula below B6 BMI Continuous Body mass index Kg/(m2) = Weight (kg)/ Height