Jimmy Wu, Ph.D. Curriculum vitae Associate Professor Department of Chemistry Dartmouth College 6128 Burke Laboratory Hanover, NH 03755 Tel: 603-646-6481 [email protected] Education: 2001 – 2005 Ph.D. in Organic Chemistry with Prof. David A. Evans Harvard University, Cambridge, MA 1994 – 1998 A.B. in Chemistry Princeton University, Princeton, NJ Professional Experience: 2013 – present Associate Professor Dartmouth College, Department of Chemistry, Hanover, NH . Phosphorothioate Esters as Useful Synthetic Intermediates . Novel Annulation and Alkylation Reactions of Indole and Related Heterocycles . Studies of the Nuphar Alkaloids - Potent Apoptosis-Inducing Compounds 2007 2013 Assistant Professor Dartmouth College, Department of Chemistry, Hanover, NH 2005 – 2007 Postdoctoral Fellow with Professor Barry M. Trost Stanford University, Stanford, CA . Studies Towards the Total Synthesis of Communesin B 2001 – 2005 Graduate Research Assistant with Professor David A. Evans Harvard University, Cambridge, MA . C2-Symmetric Sc(III)–Complexes as Chiral Lewis Acids; Catalytic Enantioselec- tive Aldol Additions to Glyoxylate Esters . A General Method for the Enantioselective Synthesis of Pantolactone Derivatives . Enantioselective Rare-Earth Catalyzed Quinone DielsAlder Reactions . Asymmetric Syn-Selective Scandium-Catalyzed Ene Reactions 1999 – 2001 Associate Chemist Merck Process Research, Rahway, NJ 1997 – 1998 Undergraduate Research with Professor Martin F. Semmelhack Princeton University, Princeton, NJ Professional Appointments and Memberships: 2012 – present Molecular Therapeutics Research Program (member) Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, NH Updated May 28, 2014 Awards and Honors: Douglas C. Floren Fellowship 2013 Thieme Chemistry Journal Award 2013 American Cancer Society – Research Scholar Grant (Jan 2013 Dec 2016) NSF Career Award (Feb 2011 Jan 2016) Dartmouth Junior Faculty Fellowship (Fall 2011) Ruth L. Kirschstein National Research Service Award for Postdoctoral Fellows (2005 2007) American Chemical Society Division of Organic Chemistry Graduate Fellowship (2004 2005) Department of Defense NDSEG Predoctoral Fellowship (2001 2004) Certificate of Distinction in Teaching, Harvard University (Fall 2003, 2004, Spring 2005) Research Grant Activity 1. NIH NIGMS – R01 (1R01GM111638-01) “Synthesis and Target Identification of Potent GLP1 Se- cretagogues” $1,500,000 total (April 2014 March 2019); PI: Jimmy Wu; (Collaborator: George Holz – SUNY Upstate Medical University) 2. American Cancer Society – Research Scholar Grant (RSG-13-011-01-CDD) “Studies of the Nuphar Alkaloids - Potent Apoptosis-Inducing Compounds” $720,000 total (Jan 2013 – Dec 2016); PI: Jimmy Wu; (Collaborator: Alan R. Eastman – Geisel School of Medicine) 3. National Science Foundation CAREER (CHE -1052824) “Versatility of Phosphorothioate Esters in the Synthesis of Sulfur-Containing Molecules” $550,000 total (Feb 2011 – Jan 2016); PI: Jimmy Wu 4. National Institutes of Health Lung Biology COBRE “Optimization of a Novel Compound with Activity against MRSA and P. Aeruginosa” $50,000 total (Sept 2013 July 2015): PI: Ambrose Cheung; OSC: Jimmy Wu 5. Burke Research Initiation Award “Enantioselective SN1 Reactions” $25,000 total (July 2007 June 2013); PI: Jimmy Wu Invited Lectures: Institutional and Companies 1. Amgen (Sept 11, 2013) “New Annulation and Alkylation Strategies for Indole: Application to a Type 2 Diabetes Therapeutics” 2. Hope College (Sept 6, 2013) “New Annulation and Alkylation Strategies for Indole: Application to a Type 2 Diabetes Therapeutics” 3. Calvin College (Sept 5, 2013) “New Annulation and Alkylation Strategies for Indole: Application to a Type 2 Diabetes Therapeutics” Updated May 28, 2014 4. University of Pittsburgh (May 30, 2013) “Sulfur and Indole: Old Friends, New Methods” 5. SUNY Potsdam (April 9, 2013) “Sulfur and Indole: Old Friends, New Methods” 6. University of Wisconsin-Madison School of Pharmacy (Mar 22, 2013) “Sulfur and Indole: Old Friends, New Methods” 7. UC Riverside (Mar 15, 2013) “Sulfur and Indole: Old Friends, New Methods” 8. University of Southern California (Mar 13, 2013) “Sulfur and Indole: Old Friends, New Methods” 9. Dartmouth College (Nov 8, 2012) “Sulfur and Indole: Old Friends, New Methods” 10. UT Austin (Oct 26, 2012) “Sulfur and Indole: Old Friends, New Methods” 11. UT Southwestern (Oct 25, 2012) “Sulfur and Indole: Old Friends, New Methods” 12. UC Davis (Oct 9, 2012) “Sulfur and Indole: Old Friends, New Methods” 13. UC Irvine (Oct 8, 2012) “Sulfur and Indole: Old Friends, New Methods” 14. Colorado State University (Aug 28, 2012) “Sulfur and Indole: Old Friends, New Methods” 15. Eli Lilly, Indianapolis, IN (10 July 2012) “Sulfur and Indole: Old Friends, New Methods” 16. Bristol-Myers Squibb: Process Research, New Brunswick, NJ (13 June 2012) “Sulfur and Indole: Old Friends, New Methods” 17. Bristol-Myers Squibb: Discovery Chemistry, Lawrenceville/Hopewell, NJ (12 June 2012) “Sulfur and Indole: Old Friends, New Methods” 18. Emory University (Mar 21, 2012) “New Methodologies in Sulfur Chemistry” 19. Georgia Institute of Technology (Mar 20, 2012) “New Methodologies in Sulfur Chemistry” 20. University of Florida (Mar 1, 2012) “New Methodologies in Sulfur Chemistry” 21. Florida State University (Feb 28, 2012) ”New Methodologies in Sulfur Chemistry” 22. Wesleyan University (Feb 24, 2012) “New Methodologies in Sulfur Chemistry” 23. Northwestern University (Feb 9, 2012 ) “New Methodologies in Sulfur Chemistry” 24. University of Michigan (Feb 7, 2012) “New Methodologies in Sulfur Chemistry” 25. University of New Hampshire (Jan 24, 2012) “New Methodologies in Sulfur Chemistry” 26. University of Pennsylvania (Nov 21, 2011) “New Methodologies in Sulfur Chemistry” 27. Rutgers University (Nov 18, 2011) “New Methodologies in Sulfur Chemistry” 28. Boston University (Nov 7, 2011) “New Methodologies in Sulfur Chemistry” 29. Ohio State University (Oct 27, 2011) “New Methodologies in Sulfur Chemistry” Updated May 28, 2014 30. West Virginia University (Oct 26, 2011) “New Methodologies in Sulfur Chemistry” 31. Middlebury College (Oct 7, 2011) “New Methodologies in Sulfur Chemistry” 32. University at Albany SUNY (Sept 20, 2011) “New Methodologies in Sulfur Chemistry” 33. University of Massachusetts Boston (Sept 14, 2011) “New Methodologies in Sulfur Chemistry” 34. Boston College (Sept 13, 2011) “New Methodologies in Sulfur Chemistry” 35. Notre Dame University (May 5, 2011) “New Methods for the Synthesis of CarbonSulfur Bonds” 36. University of Vermont (March 24, 2011) “New Methods for the Synthesis of CarbonSulfur Bonds” Conferences and Symposia 1. American Association of Pharmaceutical Scientists Annual Meeting & Exposition, San Diego, DA, (November 2–6, 2014) “Integrating OIDD into an Academic Research Program: Application to a Type 2 Diabetes Target” 2. Gordon Research Conference in Organic Reactions and Processes, Smithfield, RI, (July 1419, 2013) “New Annulation and Alkylation Strategies for Indole: Application to Diabetes Therapeutics” 3. Young Investigators Symposium (244th American Chemical Society National Meeting), Philadelphia, PA, (August 21, 2012) “Sulfur and Indole: Old Friends, New Methods” 4. Martin F. Semmelhack Symposium, Princeton, NJ (Nov 19, 2011) “New Methodologies in Sulfur Chemistry” 5. Gordon Research Conference in Heterocyclic Compounds, Newport, RI, (June 2630, 2011) “Explor- ing the Chemistry of Phosphorothioate Esters” 6. Florida Heterocyclic and Synthetic, Gainesville, FL, (March 69, 2011) “New Methods for the Syn- thesis of CarbonSulfur Bonds” 7. Session on Synthetic Organic Methods Across the Border (SOMAB). American Chemical Society Northeast Regional Meeting, Hartford, CT (October 710, 2009) “Allylic Alkylation of Alkenes and Al- lylic Ethers via Phosphorothioate Esters” 8. Session on Arthur C. Cope Scholar Award Symposium. American Chemical Society Northeast Re- gional Meeting, Burlington, VT (June 29 July 2, 2008) “Recent Advances in Asymmetric Brønsted- Acid Catalysis” Poster Presentations: 1. Gordon Research Conference in Organic Reactions and Processes, Smithfield, RI, (July 1317, 2014) Wu, J.; Li, H.; Hughes, R. P. “Dearomative (3+2) Indole Annulation Reactions” 2. Gordon Research Conference in Organic Reactions and Processes, Smithfield, RI (June 15 20, 2012) Wu, J.; Han, X.; Lauer, A. M.; Robertson, F. J.; Li, H.; Hughes, R. P. “Sulfur and Indole: Old Friends, New Methods” 3. Gordon Research Conference in Heterocyclic Compounds, Newport, RI (June 26 30, 2011) Wu, J.; Lauer, A. M.; Robertson, F. J.; Han, X. “Exploring the Chemistry of Phosphorothioate Esters” Updated May 28, 2014 4. Gordon Research Conference Natural Products, Tilton, NH (July 25 July 30, 2010) Wu, J.; Robert- son, F.; Han, X.; Savolainen, M.; Lauer, A. “Phosphorothioate Esters in Synthesis” 5. Gordon Research Conference in Heterocyclic Compounds, Newport, RI (June 28 July 3, 2009) Wu, J.; Zhang, Y.; Han, X. “Uncatalyzed Synthesis of CC Bonds from Allylic Ethers/Alcohols” Patents Pending 1. Compounds, Compositions and Methods for Treating Bacterial Infections. U.S. Provisional Patent Application No. 61/917,000; Filed Dec 17, 2013. 2. Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloal- kanyl[b]benzothiophenes, Compounds and Methods of Use. U.S. Provisional Patent Application No. 61/650,039; filed May 22, 2012. Patent Cooperation Treaty Application No. PCT/US2013/042148; filed May 22, 2013. 3. Hydrothiolation of Unactivated Alkenes. U.S. Provisional