IKZF3 Antibody Cat. No.: 61-999 IKZF3 Antibody Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody . Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human, Mouse HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 76-103 amino acids from the Central region of human IKZF3. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 58 kDa WEIGHT: September 28, 2021 1 https://www.prosci-inc.com/ikzf3-antibody-61-999.html Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: IKZF3 ALTERNATE NAMES: Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3 ACCESSION NO.: Q9UKT9 PROTEIN GI NO.: 212276437 GENE ID: 22806 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and BACKGROUND: differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. REFERENCES: 1) Billot, K., et al. Leuk. Res. 34(3):289-293(2010) 2) Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009) 3) Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009) 4) Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008) September 28, 2021 2 https://www.prosci-inc.com/ikzf3-antibody-61-999.html ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 28, 2021 3 https://www.prosci-inc.com/ikzf3-antibody-61-999.html.